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UniProtKB - Q6P0N6 (Q6P0N6_HUMAN)
Protein
Submitted name:
DST protein
Gene
DST
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: DST proteinImportedSubmitted name: Dystonin |
Gene namesi | Name:DSTImported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1090, DST |
VEuPathDBi | HostDB:ENSG00000151914 |
Subcellular locationi
Cytoskeleton
- cytoskeleton ARBA annotation
Cytoskeleton
- cytoskeleton Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-KW
Keywords - Cellular componenti
CytoplasmARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000151914, Expressed in corpus callosum and 246 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 561 – 618 | SH3InterPro annotationAdd BLAST | 58 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 133 – 153 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 351 – 371 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 408 – 442 | Sequence analysisAdd BLAST | 35 | |
Coiled coili | 514 – 537 | Sequence analysisAdd BLAST | 24 | |
Coiled coili | 783 – 803 | Sequence analysisAdd BLAST | 21 | |
Coiled coili | 882 – 916 | Sequence analysisAdd BLAST | 35 |
Keywords - Domaini
Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155008 |
OrthoDBi | 24858at2759 |
Family and domain databases
CDDi | cd00176, SPEC, 1 hit |
InterProi | View protein in InterPro IPR041615, Desmoplakin_SH3 IPR041573, Desmoplakin_Spectrin-like IPR043197, Plakin IPR001452, SH3_domain IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat |
PANTHERi | PTHR23169, PTHR23169, 1 hit |
Pfami | View protein in Pfam PF17902, SH3_10, 1 hit PF00435, Spectrin, 1 hit PF18373, Spectrin_like, 1 hit |
SMARTi | View protein in SMART SM00150, SPEC, 3 hits |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 16 potential isoforms that are computationally mapped.Show allAlign All
Q6P0N6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHSSSYSYRS SDSVFSNTTS TRTSLDSNEN LLLVHCGPTL INSCISFGSE
60 70 80 90 100
SFDGHRLEML QQIANRVQRD SVICEDKLIL AGNALQSDSK RLESGVQFQN
110 120 130 140 150
EAEIAGYILE CENLLRQHVI DVQILIDGKY YQADQLVQRV AKLRDEIMAL
160 170 180 190 200
RNECSSVYSK GRILTTEQTK LMISGITQSL NSGFAQTLHP SLTSGLTQSL
210 220 230 240 250
TPSLTSSSMT SGLSSGMTSR LTPSVTPAYT PGFPSGLVPN FSSGVEPNSL
260 270 280 290 300
QTLKLMQIRK PLLKSSLLDQ NLTEEEINMK FVQDLLNWVD EMQVQLDRTE
310 320 330 340 350
WGSDLPSVES HLENHKNVHR AIEEFESSLK EAKISEIQMT APLKLTYAEK
360 370 380 390 400
LHRLESQYAK LLNTSRNQER HLDTLHNFVS RATNELIWLN EKEEEEVAYD
410 420 430 440 450
WSERNTNIAR KKDYHAELMR ELDQKEENIK SVQEIAEQLL LENHPARLTI
460 470 480 490 500
EAYRAAMQTQ WSWILQLCQC VEQHIKENTA YFEFFNDAKE ATDYLRNLKD
510 520 530 540 550
AIQRKYSCDR SSSIHKLEDL VQESMEEKEE LLQYKSTIAN LMGKAKTIIQ
560 570 580 590 600
LKPRNSDCPL KTSIPIKAIC DYRQIEITIY KDDECVLANN SHRAKWKVIS
610 620 630 640 650
PTGNEAMVPS VCFTVPPPNK EAVDLANRIE QQYQNVLTLW HESHINMKSV
660 670 680 690 700
VSWHYLINEI DRIRASNVAS IKTMLPGEHQ QVLSNLQSRF EDFLEDSQES
710 720 730 740 750
QVFSGSDITQ LEKEVNVCKQ YYQELLKSAE REEQEESVYN LYISEVRNIR
760 770 780 790 800
LRLENCEDRL IRQIRTPLER DDLHESVFRI TEQEKLKKEL ERLKDDLGTI
810 820 830 840 850
TNKCEEFFSQ AAASSSVPTL RSELNVVLQN MNQVYSMSST YIDKLKTVNL
860 870 880 890 900
VLKNTQAAEA LVKLYETKLC EEEAVIADKN NIENLISTLK QWRSEVDEKR
910 920 930 940 950
QVFHALEDEL QKAKAISDEM FKTYKERDLD FDWHKEKADQ LVERWQNVHV
960 970 980 990 1000
QIDNRLRDLE GIGKSLKYYR DTYHPLDDWI QQVETTQRKI QENQPENSKT
1010 1020 1030 1040 1050
LATQLNQQKM LVSEIEMKQS KMDECQKYAE QYSATVKDYE LQTMTYRAMV
1060 1070 1080 1090 1100
DSQQKSPVKR RRMQSSADLI IQEFMDLRTR YTALVTLMTQ YIKFAGDSLK
1110 1120 1130 1140
RLEEEEVIIN SEHPVNIKEL EMSSNYSVVW ESKTCFMINL CGR
Computationally mapped potential isoform sequencesi
There are 16 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ03001 | DYST_HUMAN | Dystonin | DST BP230, BP240, BPAG1, DMH, DT | 7,570 | Annotation score: | ||
F8W9J4 | F8W9J4_HUMAN | Dystonin | DST | 7,461 | Annotation score: | ||
E9PHM6 | E9PHM6_HUMAN | Dystonin | DST | 5,497 | Annotation score: | ||
F6QMI7 | F6QMI7_HUMAN | Dystonin | DST | 5,537 | Annotation score: | ||
A0A7P0T890 | A0A7P0T890_HUMAN | Dystonin | DST | 7,818 | Annotation score: | ||
A0A0U1RQJ2 | A0A0U1RQJ2_HUMAN | Dystonin | DST | 2,676 | Annotation score: | ||
A0A494C073 | A0A494C073_HUMAN | Dystonin | DST | 1,347 | Annotation score: | ||
A0A494C1U5 | A0A494C1U5_HUMAN | Dystonin | DST | 625 | Annotation score: | ||
Q5T0V7 | Q5T0V7_HUMAN | Dystonin | DST | 689 | Annotation score: | ||
A0A494C1D7 | A0A494C1D7_HUMAN | Dystonin | DST | 2,383 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL096710 Genomic DNA No translation available. AL137008 Genomic DNA No translation available. AL512422 Genomic DNA No translation available. AL512448 Genomic DNA No translation available. AL590005 Genomic DNA No translation available. AL590037 Genomic DNA No translation available. KF458172 Genomic DNA No translation available. BC065536 mRNA Translation: AAH65536.1 |
RefSeqi | NP_001138241.1, NM_001144769.2 NP_001138242.1, NM_001144770.1 NP_899236.1, NM_183380.3 |
Genome annotation databases
Ensembli | ENST00000518935.5; ENSP00000431003.1; ENSG00000151914.22 |
GeneIDi | 667 |
KEGGi | hsa:667 |
UCSCi | uc003pdd.6, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL096710 Genomic DNA No translation available. AL137008 Genomic DNA No translation available. AL512422 Genomic DNA No translation available. AL512448 Genomic DNA No translation available. AL590005 Genomic DNA No translation available. AL590037 Genomic DNA No translation available. KF458172 Genomic DNA No translation available. BC065536 mRNA Translation: AAH65536.1 |
RefSeqi | NP_001138241.1, NM_001144769.2 NP_001138242.1, NM_001144770.1 NP_899236.1, NM_183380.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 66815 |
Protocols and materials databases
Antibodypediai | 31066, 184 antibodies from 22 providers |
DNASUi | 667 |
Genome annotation databases
Ensembli | ENST00000518935.5; ENSP00000431003.1; ENSG00000151914.22 |
GeneIDi | 667 |
KEGGi | hsa:667 |
UCSCi | uc003pdd.6, human |
Organism-specific databases
CTDi | 667 |
HGNCi | HGNC:1090, DST |
OpenTargetsi | ENSG00000151914 |
VEuPathDBi | HostDB:ENSG00000151914 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155008 |
OrthoDBi | 24858at2759 |
Miscellaneous databases
BioGRID-ORCSi | 667, 16 hits in 1086 CRISPR screens |
ChiTaRSi | DST, human |
GenomeRNAii | 667 |
Gene expression databases
Bgeei | ENSG00000151914, Expressed in corpus callosum and 246 other tissues |
Family and domain databases
CDDi | cd00176, SPEC, 1 hit |
InterProi | View protein in InterPro IPR041615, Desmoplakin_SH3 IPR041573, Desmoplakin_Spectrin-like IPR043197, Plakin IPR001452, SH3_domain IPR018159, Spectrin/alpha-actinin IPR002017, Spectrin_repeat |
PANTHERi | PTHR23169, PTHR23169, 1 hit |
Pfami | View protein in Pfam PF17902, SH3_10, 1 hit PF00435, Spectrin, 1 hit PF18373, Spectrin_like, 1 hit |
SMARTi | View protein in SMART SM00150, SPEC, 3 hits |
PROSITEi | View protein in PROSITE PS50002, SH3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6P0N6_HUMAN | |
Accessioni | Q6P0N6Primary (citable) accession number: Q6P0N6 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |