Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 156 (22 Apr 2020)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Mis18-binding protein 1

Gene

MIS18BP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mis18-binding protein 1
Alternative name(s):
Kinetochore-associated protein KNL-2 homolog1 Publication
Short name:
HsKNL-21 Publication
P243
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MIS18BP1
Synonyms:C14orf106, KIAA1903, KNL2, M18BP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20190 MIS18BP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
618139 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6P0N0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000129534

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134927557

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6P0N0 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MIS18BP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
68052324

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001971401 – 1132Mis18-binding protein 1Add BLAST1132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9PhosphoserineCombined sources1
Cross-linki65Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei110PhosphoserineCombined sources1
Modified residuei131PhosphoserineCombined sources1
Modified residuei135PhosphoserineCombined sources1
Modified residuei172PhosphoserineCombined sources1
Modified residuei192PhosphoserineCombined sources1
Cross-linki211Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki262Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei299PhosphoserineCombined sources1
Modified residuei365PhosphoserineCombined sources1
Cross-linki534Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki612Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki639Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki647Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei653PhosphothreonineCombined sources1
Cross-linki727Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki742Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei772PhosphoserineCombined sources1
Modified residuei773PhosphoserineCombined sources1
Modified residuei821PhosphothreonineCombined sources1
Modified residuei824PhosphoserineCombined sources1
Cross-linki840Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei860PhosphoserineCombined sources1
Cross-linki899Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki956Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki964Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki983Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1008PhosphoserineCombined sources1
Cross-linki1079Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei1086PhosphoserineCombined sources1
Modified residuei1087PhosphothreonineCombined sources1
Modified residuei1089PhosphothreonineCombined sources1
Modified residuei1104PhosphoserineCombined sources1
Modified residuei1116PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6P0N0

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6P0N0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6P0N0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6P0N0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6P0N0

PeptideAtlas

More...
PeptideAtlasi
Q6P0N0

PRoteomics IDEntifications database

More...
PRIDEi
Q6P0N0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66813 [Q6P0N0-1]
66814 [Q6P0N0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6P0N0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6P0N0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000129534 Expressed in intestine and 181 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6P0N0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6P0N0 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000129534 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with SP1 (PubMed:10976766).

Interacts with MIS18A.

Identified in a complex containing MIS18A, OIP5/MIS18B, MIS18BP1, RBBP7 and RBBP4 (PubMed:17199038).

Interacts with KAT7/HBO1 (PubMed:27270040).

Interacts (via N-terminus) with FLNA (via N-terminus) (By similarity).

By similarity3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
120601, 29 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3272 Mis18 complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q6P0N0

Protein interaction database and analysis system

More...
IntActi
Q6P0N0, 14 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000309790

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6P0N0 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11132
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6P0N0

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q6P0N0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini383 – 469SANTAAdd BLAST87
Domaini875 – 930SANTPROSITE-ProRule annotationAdd BLAST56

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1010 – 1013Poly-Asp4

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410II9U Eukaryota
ENOG41120B5 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007395

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009019_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6P0N0

Identification of Orthologs from Complete Genome Data

More...
OMAi
MCHSNCQ

Database of Orthologous Groups

More...
OrthoDBi
815579at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6P0N0

TreeFam database of animal gene trees

More...
TreeFami
TF106401

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00167 SANT, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009057 Homeobox-like_sf
IPR039110 KNL2-like
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR015216 SANTA

The PANTHER Classification System

More...
PANTHERi
PTHR16124 PTHR16124, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PF09133 SANTA, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00717 SANT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51293 SANT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P0N0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIATPLKHSR IYLPPEASSQ RRNLPMDAIF FDSIPSGTLT PVKDLVKYQN
60 70 80 90 100
SSLKLNDHKK NQFLKMTTFN NKNIFQSTML TEATTSNSSL DISAIKPNKD
110 120 130 140 150
GLKNKANYES PGKIFLRMKE KVLRDKQEQP SRNSSLLEPQ KSGNNETFTP
160 170 180 190 200
NRVEKKKLQH TYLCEEKENN KSFQSDDSSL RASVQGVPLE SSNNDIFLPV
210 220 230 240 250
KQKIQCQQEK KAPLHNLTYE LPTLNQEQEN FLAVEARNKT LTRAQLAKQI
260 270 280 290 300
FHSKESIVAT TKSKKDTFVL ESVDSADEQF QNTNAETLST NCIPIKNGSL
310 320 330 340 350
LMVSDSERTT EGTSQQKVKE GNGKTVPGET GLPGSMKDTC KIVLATPRLH
360 370 380 390 400
ITIPRRSKRN ISKLSPPRIF QTVTNGLKKN QVVQLQEWMI KSINNNTAIC
410 420 430 440 450
VEGKLIDVTN IYWHSNVIIE RIEHNKLRTI SGNVYILKGM IDQISMKEAG
460 470 480 490 500
YPNYLIRKFM FGFPENWKEH IDNFLEQLRA GEKNREKTKQ KQKTGRSVRD
510 520 530 540 550
IRKSMKNDAR ENQTDTAQRA TTTYDFDCDN LELKSNKHSE SPGATELNMC
560 570 580 590 600
HSNCQNKPTL RFPDDQVNNT IQNGGGDDLS NQELIGKKEY KMSSKKLKIG
610 620 630 640 650
ERTNERIIKS QKQETTEELD VSIDILTSRE QFFSDEERKY MAINQKKAYI
660 670 680 690 700
LVTPLKSRKV IEQRCMRYNL SAGTIKAVTD FVIPECQKKS PISKSMGTLE
710 720 730 740 750
NTFEGHKSKN KEDCDERDLL TVNRKIKISN LEKEQMLTSD FKKNTRLLPK
760 770 780 790 800
LKKIENQVAM SFYKHQSSPD LSSEESETEK EIKRKAEVKK TKAGNTKEAV
810 820 830 840 850
VHLRKSTRNT SNIPVILEPE TEESENEFYI KQKKARPSVK ETLQKSGVRK
860 870 880 890 900
EFPITEAVGS DKTNRHPLEC LPGLIQDKEW NEKELQKLHC AFASLPKHKP
910 920 930 940 950
GFWSEVAAAV GSRSPEECQR KYMENPRGKG SQKHVTKKKP ANSKGQNGKR
960 970 980 990 1000
GDADQKQTIK ITAKVGTLKR KQQMREFLEQ LPKDDHDDFF STTPLQHQRI
1010 1020 1030 1040 1050
LLPSFQDSED DDDILPNMDK NPTTPSSVIF PLVKTPQCQH VSPGMLGSIN
1060 1070 1080 1090 1100
RNDCDKYVFR MQKYHKSNGG IVWGNIKKKL VETDFSTPTP RRKTPFNTDL
1110 1120 1130
GENSGIGKLF TNAVESLDEE EKDYYFSNSD SA
Length:1,132
Mass (Da):129,085
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i92F2787CD4687059
GO
Isoform 2 (identifier: Q6P0N0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     391-1132: Missing.

Show »
Length:390
Mass (Da):43,994
Checksum:iB4B1B945CE91C8A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9K5G5E9K5_HUMAN
Chromosome 14 open reading frame 10...
MIS18BP1 C14orf106, hCG_1812025
496Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C1S6H7C1S6_HUMAN
Mis18-binding protein 1
MIS18BP1
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J2Q8C9J2Q8_HUMAN
Mis18-binding protein 1
MIS18BP1
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YJM1H0YJM1_HUMAN
Mis18-binding protein 1
MIS18BP1
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AK002048 differs from that shown. Reason: Frameshift.Curated
The sequence BAB67796 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti510R → Q in BAB67796 (PubMed:11572484).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_050184164C → R. Corresponds to variant dbSNP:rs1269008Ensembl.1
Natural variantiVAR_050185347P → R. Corresponds to variant dbSNP:rs34168608Ensembl.1
Natural variantiVAR_050186583E → D. Corresponds to variant dbSNP:rs34101857Ensembl.1
Natural variantiVAR_050187851E → Q. Corresponds to variant dbSNP:rs34402741Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014105391 – 1132Missing in isoform 2. 1 PublicationAdd BLAST742

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB067490 mRNA Translation: BAB67796.1 Frameshift.
AK002048 mRNA No translation available.
AL121809 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65778.1
CH471078 Genomic DNA Translation: EAW65779.1
CH471078 Genomic DNA Translation: EAW65780.1
BC051885 mRNA Translation: AAH51885.1
BC065544 mRNA Translation: AAH65544.1
AJ242977 mRNA Translation: CAB45134.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9684.1 [Q6P0N0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060823.3, NM_018353.4 [Q6P0N0-1]
XP_005267890.1, XM_005267833.4 [Q6P0N0-1]
XP_016876914.1, XM_017021425.1 [Q6P0N0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000310806; ENSP00000309790; ENSG00000129534 [Q6P0N0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55320

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55320

UCSC genome browser

More...
UCSCi
uc001wwf.3 human [Q6P0N0-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB067490 mRNA Translation: BAB67796.1 Frameshift.
AK002048 mRNA No translation available.
AL121809 Genomic DNA No translation available.
CH471078 Genomic DNA Translation: EAW65778.1
CH471078 Genomic DNA Translation: EAW65779.1
CH471078 Genomic DNA Translation: EAW65780.1
BC051885 mRNA Translation: AAH51885.1
BC065544 mRNA Translation: AAH65544.1
AJ242977 mRNA Translation: CAB45134.1
CCDSiCCDS9684.1 [Q6P0N0-1]
RefSeqiNP_060823.3, NM_018353.4 [Q6P0N0-1]
XP_005267890.1, XM_005267833.4 [Q6P0N0-1]
XP_016876914.1, XM_017021425.1 [Q6P0N0-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGXNMR-A877-936[»]
SMRiQ6P0N0
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi120601, 29 interactors
ComplexPortaliCPX-3272 Mis18 complex
CORUMiQ6P0N0
IntActiQ6P0N0, 14 interactors
STRINGi9606.ENSP00000309790

PTM databases

iPTMnetiQ6P0N0
PhosphoSitePlusiQ6P0N0

Polymorphism and mutation databases

BioMutaiMIS18BP1
DMDMi68052324

Proteomic databases

EPDiQ6P0N0
jPOSTiQ6P0N0
MassIVEiQ6P0N0
MaxQBiQ6P0N0
PaxDbiQ6P0N0
PeptideAtlasiQ6P0N0
PRIDEiQ6P0N0
ProteomicsDBi66813 [Q6P0N0-1]
66814 [Q6P0N0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
12 57 antibodies

Genome annotation databases

EnsembliENST00000310806; ENSP00000309790; ENSG00000129534 [Q6P0N0-1]
GeneIDi55320
KEGGihsa:55320
UCSCiuc001wwf.3 human [Q6P0N0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55320

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MIS18BP1
HGNCiHGNC:20190 MIS18BP1
HPAiENSG00000129534 Low tissue specificity
MIMi618139 gene
neXtProtiNX_Q6P0N0
OpenTargetsiENSG00000129534
PharmGKBiPA134927557

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410II9U Eukaryota
ENOG41120B5 LUCA
GeneTreeiENSGT00390000007395
HOGENOMiCLU_009019_1_0_1
InParanoidiQ6P0N0
OMAiMCHSNCQ
OrthoDBi815579at2759
PhylomeDBiQ6P0N0
TreeFamiTF106401

Enzyme and pathway databases

ReactomeiR-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MIS18BP1 human
EvolutionaryTraceiQ6P0N0

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
C14orf106

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55320
PharosiQ6P0N0 Tdark

Protein Ontology

More...
PROi
PR:Q6P0N0
RNActiQ6P0N0 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000129534 Expressed in intestine and 181 other tissues
ExpressionAtlasiQ6P0N0 baseline and differential
GenevisibleiQ6P0N0 HS

Family and domain databases

CDDicd00167 SANT, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR039110 KNL2-like
IPR001005 SANT/Myb
IPR017884 SANT_dom
IPR015216 SANTA
PANTHERiPTHR16124 PTHR16124, 1 hit
PfamiView protein in Pfam
PF00249 Myb_DNA-binding, 1 hit
PF09133 SANTA, 1 hit
SMARTiView protein in SMART
SM00717 SANT, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51293 SANT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiM18BP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6P0N0
Secondary accession number(s): D3DSA7
, Q86V14, Q96PY4, Q9NUR5, Q9Y4X9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 5, 2004
Last modified: April 22, 2020
This is version 156 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again