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Protein

Junction plakoglobin

Gene

Jup

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).By similarity

GO - Molecular functioni

  • alpha-catenin binding Source: GO_Central
  • cadherin binding Source: GO_Central
  • nuclear hormone receptor binding Source: GO_Central
  • protein kinase binding Source: RGD
  • protein phosphatase binding Source: GO_Central
  • structural molecule activity Source: RGD
  • transcription coactivator activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-RNO-418990 Adherens junctions interactions
R-RNO-5218920 VEGFR2 mediated vascular permeability
R-RNO-6798695 Neutrophil degranulation
R-RNO-6805567 Keratinization
R-RNO-6809371 Formation of the cornified envelope

Names & Taxonomyi

Protein namesi
Recommended name:
Junction plakoglobin
Gene namesi
Name:Jup
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi620412 Jup

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000642811 – 745Junction plakoglobinAdd BLAST745

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Glycosylationi14O-linked (GlcNAc) threonineBy similarity1
Modified residuei99PhosphoserineBy similarity1
Modified residuei125PhosphoserineBy similarity1
Modified residuei182PhosphoserineCombined sources1
Modified residuei665PhosphoserineCombined sources1
Modified residuei730PhosphoserineBy similarity1

Post-translational modificationi

May be phosphorylated by FER.By similarity

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ6P0K8
PRIDEiQ6P0K8

PTM databases

iPTMnetiQ6P0K8
PhosphoSitePlusiQ6P0K8

Expressioni

Gene expression databases

BgeeiENSRNOG00000015380 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiQ6P0K8 RN

Interactioni

Subunit structurei

Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6P0K8, 2 interactors
STRINGi10116.ENSRNOP00000043950

Structurei

3D structure databases

ProteinModelPortaliQ6P0K8
SMRiQ6P0K8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati132 – 171ARM 1Add BLAST40
Repeati172 – 215ARM 2Add BLAST44
Repeati216 – 255ARM 3Add BLAST40
Repeati258 – 297ARM 4Add BLAST40
Repeati298 – 341ARM 5Add BLAST44
Repeati342 – 381ARM 6Add BLAST40
Repeati383 – 420ARM 7Add BLAST38
Repeati423 – 464ARM 8Add BLAST42
Repeati470 – 510ARM 9Add BLAST41
Repeati512 – 551ARM 10Add BLAST40
Repeati574 – 613ARM 11Add BLAST40
Repeati615 – 661ARM 12Add BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni132 – 297Interaction with DSC1 and DSG1By similarityAdd BLAST166
Regioni574 – 661Interaction with DSC1By similarityAdd BLAST88

Domaini

The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region (By similarity).By similarity

Sequence similaritiesi

Belongs to the beta-catenin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4203 Eukaryota
COG0035 LUCA
GeneTreeiENSGT00730000110821
HOGENOMiHOG000230958
HOVERGENiHBG000919
InParanoidiQ6P0K8
KOiK10056
OMAiNEPYADD
OrthoDBiEOG091G03A5
PhylomeDBiQ6P0K8
TreeFamiTF317997

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR013284 Beta-catenin
IPR030461 Plakoglobin/HMP-2
PANTHERiPTHR23315:SF12 PTHR23315:SF12, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 3 hits
PRINTSiPR01869 BCATNINFAMLY
SMARTiView protein in SMART
SM00185 ARM, 12 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 9 hits

Sequencei

Sequence statusi: Complete.

Q6P0K8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVMNLIEQP IKVTEWQQTY TYDSGIHSGV NTCVPSVSSK GLLDEDDTCG
60 70 80 90 100
RQYTLKKTTT YTQGVPQSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL
110 120 130 140 150
LLATQVEGQT TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL
160 170 180 190 200
LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD
210 220 230 240 250
TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL
260 270 280 290 300
HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ
310 320 330 340 350
ESKLIILANG GPQGLVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE
360 370 380 390 400
AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE NVLKILVNQL
410 420 430 440 450
SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD
460 470 480 490 500
ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA
510 520 530 540 550
TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY
560 570 580 590 600
TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI
610 620 630 640 650
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF
660 670 680 690 700
RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYADDMDAT
710 720 730 740
YRPMYSSDVP LDPLDMHMDM DGDYPMDTYS DGLRPPYPAA DHMLA
Length:745
Mass (Da):81,801
Last modified:July 5, 2004 - v1
Checksum:iBF8673E1B797954D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065580 mRNA Translation: AAH65580.1
RefSeqiNP_112309.2, NM_031047.2
XP_006247491.1, XM_006247429.2
XP_006247492.1, XM_006247430.3
XP_017453037.1, XM_017597548.1
UniGeneiRn.11255

Genome annotation databases

EnsembliENSRNOT00000040845; ENSRNOP00000043950; ENSRNOG00000015380
ENSRNOT00000089933; ENSRNOP00000070840; ENSRNOG00000015380
GeneIDi81679
KEGGirno:81679
UCSCiRGD:620412 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC065580 mRNA Translation: AAH65580.1
RefSeqiNP_112309.2, NM_031047.2
XP_006247491.1, XM_006247429.2
XP_006247492.1, XM_006247430.3
XP_017453037.1, XM_017597548.1
UniGeneiRn.11255

3D structure databases

ProteinModelPortaliQ6P0K8
SMRiQ6P0K8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6P0K8, 2 interactors
STRINGi10116.ENSRNOP00000043950

PTM databases

iPTMnetiQ6P0K8
PhosphoSitePlusiQ6P0K8

Proteomic databases

PaxDbiQ6P0K8
PRIDEiQ6P0K8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000040845; ENSRNOP00000043950; ENSRNOG00000015380
ENSRNOT00000089933; ENSRNOP00000070840; ENSRNOG00000015380
GeneIDi81679
KEGGirno:81679
UCSCiRGD:620412 rat

Organism-specific databases

CTDi3728
RGDi620412 Jup

Phylogenomic databases

eggNOGiKOG4203 Eukaryota
COG0035 LUCA
GeneTreeiENSGT00730000110821
HOGENOMiHOG000230958
HOVERGENiHBG000919
InParanoidiQ6P0K8
KOiK10056
OMAiNEPYADD
OrthoDBiEOG091G03A5
PhylomeDBiQ6P0K8
TreeFamiTF317997

Enzyme and pathway databases

ReactomeiR-RNO-418990 Adherens junctions interactions
R-RNO-5218920 VEGFR2 mediated vascular permeability
R-RNO-6798695 Neutrophil degranulation
R-RNO-6805567 Keratinization
R-RNO-6809371 Formation of the cornified envelope

Miscellaneous databases

PROiPR:Q6P0K8

Gene expression databases

BgeeiENSRNOG00000015380 Expressed in 10 organ(s), highest expression level in lung
GenevisibleiQ6P0K8 RN

Family and domain databases

Gene3Di1.25.10.10, 1 hit
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR013284 Beta-catenin
IPR030461 Plakoglobin/HMP-2
PANTHERiPTHR23315:SF12 PTHR23315:SF12, 1 hit
PfamiView protein in Pfam
PF00514 Arm, 3 hits
PRINTSiPR01869 BCATNINFAMLY
SMARTiView protein in SMART
SM00185 ARM, 12 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 9 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPLAK_RAT
AccessioniPrimary (citable) accession number: Q6P0K8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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