Jup

Functionⁱ

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).By similarity

GO - Molecular functionⁱ

alpha-catenin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cadherin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nuclear hormone receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase binding
Source: RGD
Inferred from physical interactionⁱ
- 12700184
protein phosphatase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
structural molecule activity
Source: RGD
Inferred from direct assayⁱ
- 9023350
transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: Ensembl
cell-cell adhesion
Source: RGD
Inferred from direct assayⁱ
- 9023350
cell migration Source: Ensembl
cellular response to indole-3-methanol Source: Ensembl
desmosome assembly Source: Ensembl
detection of mechanical stimulus Source: Ensembl
negative regulation of blood vessel endothelial cell migration Source: Ensembl
positive regulation of angiogenesis Source: Ensembl
positive regulation of cell-matrix adhesion Source: Ensembl
positive regulation of DNA-binding transcription factor activity Source: Ensembl
positive regulation of protein import into nucleus Source: Ensembl
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterooligomerization
Source: RGD
Inferred from physical interactionⁱ
- 8834786
protein localization to plasma membrane Source: Ensembl
regulation of cell proliferation Source: Ensembl
regulation of heart rate by cardiac conduction Source: Ensembl
regulation of ventricular cardiac muscle cell action potential Source: Ensembl
skin development Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-RNO-418990 Adherens junctions interactions R-RNO-5218920 VEGFR2 mediated vascular permeability R-RNO-6798695 Neutrophil degranulation R-RNO-6805567 Keratinization R-RNO-6809371 Formation of the cornified envelope

Reactomeⁱ

R-RNO-418990 Adherens junctions interactions
R-RNO-5218920 VEGFR2 mediated vascular permeability
R-RNO-6798695 Neutrophil degranulation
R-RNO-6805567 Keratinization
R-RNO-6809371 Formation of the cornified envelope

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Junction plakoglobin
Gene namesⁱ	Name:Jup
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 10

Organism-specific databases

Rat genome database More...RGDⁱ	620412 Jup

RGDⁱ

620412 Jup

Keywords - Cellular componentⁱ

Cell junction, Cytoplasm, Cytoskeleton, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000064281	1 – 745	Junction plakoglobinAdd BLAST		745

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Glycosylationⁱ	14	O-linked (GlcNAc) threonineBy similarity	1
Modified residueⁱ	99	PhosphoserineBy similarity	1
Modified residueⁱ	125	PhosphoserineBy similarity	1
Modified residueⁱ	182	PhosphoserineCombined sources	1
Modified residueⁱ	665	PhosphoserineCombined sources	1
Modified residueⁱ	730	PhosphoserineBy similarity	1

Post-translational modificationⁱ

May be phosphorylated by FER.By similarity

Keywords - PTMⁱ

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q6P0K8
PRIDEⁱ	Q6P0K8

PTM databases

iPTMnetⁱ	Q6P0K8
PhosphoSitePlusⁱ	Q6P0K8

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000015380 Expressed in 10 organ(s), highest expression level in lung
Genevisibleⁱ	Q6P0K8 RN

Interactionⁱ

Subunit structureⁱ

Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1. Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2 (By similarity).By similarity

GO - Molecular functionⁱ

alpha-catenin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cadherin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
nuclear hormone receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein kinase binding
Source: RGD
Inferred from physical interactionⁱ
- 12700184
protein phosphatase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q6P0K8, 2 interactors
STRINGⁱ	10116.ENSRNOP00000043950

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P0K8
SMRⁱ	Q6P0K8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	132 – 171	ARM 1Add BLAST	40
Repeatⁱ	172 – 215	ARM 2Add BLAST	44
Repeatⁱ	216 – 255	ARM 3Add BLAST	40
Repeatⁱ	258 – 297	ARM 4Add BLAST	40
Repeatⁱ	298 – 341	ARM 5Add BLAST	44
Repeatⁱ	342 – 381	ARM 6Add BLAST	40
Repeatⁱ	383 – 420	ARM 7Add BLAST	38
Repeatⁱ	423 – 464	ARM 8Add BLAST	42
Repeatⁱ	470 – 510	ARM 9Add BLAST	41
Repeatⁱ	512 – 551	ARM 10Add BLAST	40
Repeatⁱ	574 – 613	ARM 11Add BLAST	40
Repeatⁱ	615 – 661	ARM 12Add BLAST	47

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	132 – 297	Interaction with DSC1 and DSG1By similarityAdd BLAST		166
Regionⁱ	574 – 661	Interaction with DSC1By similarityAdd BLAST		88

Domainⁱ

The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region (By similarity).By similarity

Sequence similaritiesⁱ

Belongs to the beta-catenin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	KOG4203 Eukaryota COG0035 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110821
HOGENOMⁱ	HOG000230958
HOVERGENⁱ	HBG000919
InParanoidⁱ	Q6P0K8
KEGG Orthology (KO) More...KOⁱ	K10056
OMAⁱ	NEPYADD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03A5
PhylomeDBⁱ	Q6P0K8
TreeFamⁱ	TF317997

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR000225 Armadillo IPR013284 Beta-catenin IPR030461 Plakoglobin/HMP-2
PANTHERⁱ	PTHR23315:SF12 PTHR23315:SF12, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00514 Arm, 3 hits
PRINTSⁱ	PR01869 BCATNINFAMLY
SMARTⁱ	View protein in SMART SM00185 ARM, 12 hits
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS50176 ARM_REPEAT, 9 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6P0K8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEVMNLIEQP IKVTEWQQTY TYDSGIHSGV NTCVPSVSSK GLLDEDDTCG 
        60         70         80         90        100
RQYTLKKTTT YTQGVPQSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL 
       110        120        130        140        150
LLATQVEGQT TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL 
       160        170        180        190        200
LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD 
       210        220        230        240        250
TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL 
       260        270        280        290        300
HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ 
       310        320        330        340        350
ESKLIILANG GPQGLVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE 
       360        370        380        390        400
AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE NVLKILVNQL 
       410        420        430        440        450
SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD 
       460        470        480        490        500
ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA 
       510        520        530        540        550
TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY 
       560        570        580        590        600
TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI 
       610        620        630        640        650
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF 
       660        670        680        690        700
RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYADDMDAT 
       710        720        730        740 
YRPMYSSDVP LDPLDMHMDM DGDYPMDTYS DGLRPPYPAA DHMLA

Length:745

Mass (Da):81,801

Last modified:July 5, 2004 - v1

Checksum:ⁱBF8673E1B797954D

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC065580 mRNA Translation: AAH65580.1
NCBI Reference Sequences More...RefSeqⁱ	NP_112309.2, NM_031047.2 XP_006247491.1, XM_006247429.2 XP_006247492.1, XM_006247430.3 XP_017453037.1, XM_017597548.1
UniGeneⁱ	Rn.11255

Genome annotation databases

Ensemblⁱ	ENSRNOT00000040845; ENSRNOP00000043950; ENSRNOG00000015380 ENSRNOT00000089933; ENSRNOP00000070840; ENSRNOG00000015380
GeneIDⁱ	81679
KEGGⁱ	rno:81679
UCSC genome browser More...UCSCⁱ	RGD:620412 rat

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6P0K8	Junction plakoglobin	)	HUMAN		745	UniRef90_P14923
Junction plakoglobin		BOVIN		745
Junction plakoglobin		MOUSE		745
Junction plakoglobin		PIG		745
JUP isoform 1		PONAB		745
+128

Protein	Similar proteins		Species	Score	Length	Source
Q6P0K8	Junction plakoglobin	)	HUMAN		745	UniRef50_P14923
Junction plakoglobin		BOVIN		745
Junction plakoglobin		MOUSE		745
Junction plakoglobin		PIG		745
Armadillo segment polarity protein		DROME		843
+706

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BC065580 mRNA Translation: AAH65580.1
RefSeqⁱ	NP_112309.2, NM_031047.2 XP_006247491.1, XM_006247429.2 XP_006247492.1, XM_006247430.3 XP_017453037.1, XM_017597548.1
UniGeneⁱ	Rn.11255

3D structure databases

ProteinModelPortalⁱ	Q6P0K8
SMRⁱ	Q6P0K8
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q6P0K8, 2 interactors
STRINGⁱ	10116.ENSRNOP00000043950

PTM databases

iPTMnetⁱ	Q6P0K8
PhosphoSitePlusⁱ	Q6P0K8

Proteomic databases

PaxDbⁱ	Q6P0K8
PRIDEⁱ	Q6P0K8

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000040845; ENSRNOP00000043950; ENSRNOG00000015380 ENSRNOT00000089933; ENSRNOP00000070840; ENSRNOG00000015380
GeneIDⁱ	81679
KEGGⁱ	rno:81679
UCSCⁱ	RGD:620412 rat

Organism-specific databases

CTDⁱ	3728
RGDⁱ	620412 Jup

Phylogenomic databases

eggNOGⁱ	KOG4203 Eukaryota COG0035 LUCA
GeneTreeⁱ	ENSGT00730000110821
HOGENOMⁱ	HOG000230958
HOVERGENⁱ	HBG000919
InParanoidⁱ	Q6P0K8
KOⁱ	K10056
OMAⁱ	NEPYADD
OrthoDBⁱ	EOG091G03A5
PhylomeDBⁱ	Q6P0K8
TreeFamⁱ	TF317997

Enzyme and pathway databases

Reactomeⁱ	R-RNO-418990 Adherens junctions interactions R-RNO-5218920 VEGFR2 mediated vascular permeability R-RNO-6798695 Neutrophil degranulation R-RNO-6805567 Keratinization R-RNO-6809371 Formation of the cornified envelope

Reactomeⁱ

R-RNO-418990 Adherens junctions interactions
R-RNO-5218920 VEGFR2 mediated vascular permeability
R-RNO-6798695 Neutrophil degranulation
R-RNO-6805567 Keratinization
R-RNO-6809371 Formation of the cornified envelope

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6P0K8

PROⁱ

PR:Q6P0K8

Gene expression databases

Bgeeⁱ	ENSRNOG00000015380 Expressed in 10 organ(s), highest expression level in lung
Genevisibleⁱ	Q6P0K8 RN

Family and domain databases

Gene3Dⁱ	1.25.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR011989 ARM-like IPR016024 ARM-type_fold IPR000225 Armadillo IPR013284 Beta-catenin IPR030461 Plakoglobin/HMP-2
PANTHERⁱ	PTHR23315:SF12 PTHR23315:SF12, 1 hit
Pfamⁱ	View protein in Pfam PF00514 Arm, 3 hits
PRINTSⁱ	PR01869 BCATNINFAMLY
SMARTⁱ	View protein in SMART SM00185 ARM, 12 hits
SUPFAMⁱ	SSF48371 SSF48371, 1 hit
PROSITEⁱ	View protein in PROSITE PS50176 ARM_REPEAT, 9 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PLAK_RAT
Accessionⁱ	Q6P0K8Primary (citable) accession number: Q6P0K8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6P0K8 (PLAK_RAT)

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Junction plakoglobin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ