UniProtKB - Q6P0K8 (PLAK_RAT)
Protein
Junction plakoglobin
Gene
Jup
Organism
Rattus norvegicus (Rat)
Status
Functioni
Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).By similarity
GO - Molecular functioni
- alpha-catenin binding Source: RGD
- cadherin binding Source: RGD
- cell adhesion molecule binding Source: RGD
- cytoskeletal protein-membrane anchor activity Source: RGD
- nuclear hormone receptor binding Source: GO_Central
- protein-containing complex binding Source: RGD
- protein kinase binding Source: RGD
- protein phosphatase binding Source: RGD
- structural molecule activity Source: InterPro
- transcription coactivator activity Source: RGD
GO - Biological processi
- bundle of His cell-Purkinje myocyte adhesion involved in cell communication Source: RGD
- cell adhesion Source: RGD
- cell-cell adhesion Source: RGD
- cell migration Source: RGD
- cellular response to indole-3-methanol Source: RGD
- desmosome assembly Source: RGD
- detection of mechanical stimulus Source: RGD
- negative regulation of blood vessel endothelial cell migration Source: RGD
- positive regulation of angiogenesis Source: RGD
- positive regulation of cell-matrix adhesion Source: RGD
- positive regulation of DNA-binding transcription factor activity Source: RGD
- positive regulation of protein import into nucleus Source: RGD
- positive regulation of transcription by RNA polymerase II Source: GO_Central
- protein localization to plasma membrane Source: RGD
- regulation of cell population proliferation Source: RGD
- regulation of heart rate by cardiac conduction Source: RGD
- regulation of ventricular cardiac muscle cell action potential Source: RGD
- skin development Source: RGD
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
Reactomei | R-RNO-418990, Adherens junctions interactions R-RNO-5218920, VEGFR2 mediated vascular permeability R-RNO-6798695, Neutrophil degranulation R-RNO-6805567, Keratinization R-RNO-6809371, Formation of the cornified envelope |
Names & Taxonomyi
Protein namesi | Recommended name: Junction plakoglobin |
Gene namesi | Name:Jup |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620412, Jup |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
- adherens junction By similarity
- desmosome By similarity
- Membrane By similarity; Peripheral membrane protein By similarity
Note: Cytoplasmic in a soluble and membrane-associated form.By similarity
Cytoskeleton
- intermediate filament Source: RGD
Cytosol
- cytosol Source: RGD
Nucleus
- gamma-catenin-TCF7L2 complex Source: RGD
- nucleus Source: RGD
Plasma Membrane
- apicolateral plasma membrane Source: RGD
- catenin complex Source: RGD
- cytoplasmic side of plasma membrane Source: RGD
- lateral plasma membrane Source: RGD
- plasma membrane Source: RGD
Other locations
- adherens junction Source: RGD
- cell-cell junction Source: RGD
- cytoplasm Source: RGD
- desmosome Source: RGD
- fascia adherens Source: RGD
- intercalated disc Source: RGD
- protein-DNA complex Source: RGD
- Z disc Source: RGD
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoskeleton, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064281 | 1 – 745 | Junction plakoglobinAdd BLAST | 745 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Glycosylationi | 14 | O-linked (GlcNAc) threonineBy similarity | 1 | |
Modified residuei | 99 | PhosphoserineBy similarity | 1 | |
Modified residuei | 125 | PhosphoserineBy similarity | 1 | |
Modified residuei | 182 | PhosphoserineCombined sources | 1 | |
Modified residuei | 665 | PhosphoserineCombined sources | 1 | |
Modified residuei | 730 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
May be phosphorylated by FER.By similarity
Keywords - PTMi
Acetylation, Glycoprotein, PhosphoproteinProteomic databases
jPOSTi | Q6P0K8 |
PaxDbi | Q6P0K8 |
PRIDEi | Q6P0K8 |
PTM databases
GlyGeni | Q6P0K8, 1 site |
iPTMneti | Q6P0K8 |
PhosphoSitePlusi | Q6P0K8 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000015380, Expressed in esophagus and 21 other tissues |
Genevisiblei | Q6P0K8, RN |
Interactioni
Subunit structurei
Homodimer.
Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex.
Interacts with MUC1.
Interacts with CAV1.
Interacts with PTPRJ.
Interacts with DSG1.
Interacts with DSC1 and DSC2.
Interacts with PKP2 (By similarity).
By similarityGO - Molecular functioni
- alpha-catenin binding Source: RGD
- cadherin binding Source: RGD
- cell adhesion molecule binding Source: RGD
- nuclear hormone receptor binding Source: GO_Central
- protein kinase binding Source: RGD
- protein phosphatase binding Source: RGD
Protein-protein interaction databases
IntActi | Q6P0K8, 2 interactors |
STRINGi | 10116.ENSRNOP00000043950 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 132 – 171 | ARM 1Add BLAST | 40 | |
Repeati | 172 – 215 | ARM 2Add BLAST | 44 | |
Repeati | 216 – 255 | ARM 3Add BLAST | 40 | |
Repeati | 258 – 297 | ARM 4Add BLAST | 40 | |
Repeati | 298 – 341 | ARM 5Add BLAST | 44 | |
Repeati | 342 – 381 | ARM 6Add BLAST | 40 | |
Repeati | 383 – 420 | ARM 7Add BLAST | 38 | |
Repeati | 423 – 464 | ARM 8Add BLAST | 42 | |
Repeati | 470 – 510 | ARM 9Add BLAST | 41 | |
Repeati | 512 – 551 | ARM 10Add BLAST | 40 | |
Repeati | 574 – 613 | ARM 11Add BLAST | 40 | |
Repeati | 615 – 661 | ARM 12Add BLAST | 47 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 132 – 297 | Interaction with DSC1 and DSG1By similarityAdd BLAST | 166 | |
Regioni | 574 – 661 | Interaction with DSC1By similarityAdd BLAST | 88 |
Domaini
The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region (By similarity).By similarity
Sequence similaritiesi
Belongs to the beta-catenin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4203, Eukaryota |
GeneTreei | ENSGT00940000156395 |
InParanoidi | Q6P0K8 |
OMAi | PYPTSDH |
OrthoDBi | 321213at2759 |
PhylomeDBi | Q6P0K8 |
TreeFami | TF317997 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR013284, Beta-catenin IPR030461, Plakoglobin |
PANTHERi | PTHR45976, PTHR45976, 1 hit PTHR45976:SF3, PTHR45976:SF3, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 3 hits |
PRINTSi | PR01869, BCATNINFAMLY |
SMARTi | View protein in SMART SM00185, ARM, 12 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 9 hits |
i Sequence
Sequence statusi: Complete.
Q6P0K8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEVMNLIEQP IKVTEWQQTY TYDSGIHSGV NTCVPSVSSK GLLDEDDTCG
60 70 80 90 100
RQYTLKKTTT YTQGVPQSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL
110 120 130 140 150
LLATQVEGQT TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL
160 170 180 190 200
LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD
210 220 230 240 250
TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL
260 270 280 290 300
HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ
310 320 330 340 350
ESKLIILANG GPQGLVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE
360 370 380 390 400
AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE NVLKILVNQL
410 420 430 440 450
SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD
460 470 480 490 500
ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA
510 520 530 540 550
TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY
560 570 580 590 600
TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI
610 620 630 640 650
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF
660 670 680 690 700
RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYADDMDAT
710 720 730 740
YRPMYSSDVP LDPLDMHMDM DGDYPMDTYS DGLRPPYPAA DHMLA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC065580 mRNA Translation: AAH65580.1 |
RefSeqi | NP_112309.2, NM_031047.2 XP_006247491.1, XM_006247429.2 XP_006247492.1, XM_006247430.3 XP_017453037.1, XM_017597548.1 |
Genome annotation databases
Ensembli | ENSRNOT00000040845; ENSRNOP00000043950; ENSRNOG00000015380 ENSRNOT00000089933; ENSRNOP00000070840; ENSRNOG00000015380 |
GeneIDi | 81679 |
KEGGi | rno:81679 |
UCSCi | RGD:620412, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC065580 mRNA Translation: AAH65580.1 |
RefSeqi | NP_112309.2, NM_031047.2 XP_006247491.1, XM_006247429.2 XP_006247492.1, XM_006247430.3 XP_017453037.1, XM_017597548.1 |
3D structure databases
SMRi | Q6P0K8 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q6P0K8, 2 interactors |
STRINGi | 10116.ENSRNOP00000043950 |
PTM databases
GlyGeni | Q6P0K8, 1 site |
iPTMneti | Q6P0K8 |
PhosphoSitePlusi | Q6P0K8 |
Proteomic databases
jPOSTi | Q6P0K8 |
PaxDbi | Q6P0K8 |
PRIDEi | Q6P0K8 |
Genome annotation databases
Ensembli | ENSRNOT00000040845; ENSRNOP00000043950; ENSRNOG00000015380 ENSRNOT00000089933; ENSRNOP00000070840; ENSRNOG00000015380 |
GeneIDi | 81679 |
KEGGi | rno:81679 |
UCSCi | RGD:620412, rat |
Organism-specific databases
CTDi | 3728 |
RGDi | 620412, Jup |
Phylogenomic databases
eggNOGi | KOG4203, Eukaryota |
GeneTreei | ENSGT00940000156395 |
InParanoidi | Q6P0K8 |
OMAi | PYPTSDH |
OrthoDBi | 321213at2759 |
PhylomeDBi | Q6P0K8 |
TreeFami | TF317997 |
Enzyme and pathway databases
Reactomei | R-RNO-418990, Adherens junctions interactions R-RNO-5218920, VEGFR2 mediated vascular permeability R-RNO-6798695, Neutrophil degranulation R-RNO-6805567, Keratinization R-RNO-6809371, Formation of the cornified envelope |
Miscellaneous databases
PROi | PR:Q6P0K8 |
Gene expression databases
Bgeei | ENSRNOG00000015380, Expressed in esophagus and 21 other tissues |
Genevisiblei | Q6P0K8, RN |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit |
InterProi | View protein in InterPro IPR011989, ARM-like IPR016024, ARM-type_fold IPR000225, Armadillo IPR013284, Beta-catenin IPR030461, Plakoglobin |
PANTHERi | PTHR45976, PTHR45976, 1 hit PTHR45976:SF3, PTHR45976:SF3, 1 hit |
Pfami | View protein in Pfam PF00514, Arm, 3 hits |
PRINTSi | PR01869, BCATNINFAMLY |
SMARTi | View protein in SMART SM00185, ARM, 12 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit |
PROSITEi | View protein in PROSITE PS50176, ARM_REPEAT, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PLAK_RAT | |
Accessioni | Q6P0K8Primary (citable) accession number: Q6P0K8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families