UniProtKB - Q6P093 (ADCL2_HUMAN)
Protein
Arylacetamide deacetylase-like 2
Gene
AADACL2
Organism
Homo sapiens (Human)
Status
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 189 | PROSITE-ProRule annotationBy similarity | 1 | |
Active sitei | 341 | By similarity | 1 | |
Active sitei | 371 | By similarity | 1 |
GO - Molecular functioni
- carboxylic ester hydrolase activity Source: InterPro
- hydrolase activity Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Enzyme and pathway databases
PathwayCommonsi | Q6P093 |
SABIO-RKi | Q6P093 |
Protein family/group databases
ESTHERi | human-AADACL2, Arylacetamide_deacetylase |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:AADACL2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000197953.5 |
HGNCi | HGNC:24427, AADACL2 |
neXtProti | NX_Q6P093 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: InterPro
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000197953 |
PharmGKBi | PA142670463 |
Miscellaneous databases
Pharosi | Q6P093, Tdark |
Chemistry databases
DrugBanki | DB07814, Gibberellic acid DB07815, Gibberellin A4 |
Polymorphism and mutation databases
BioMutai | AADACL2 |
DMDMi | 269849709 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_0000314960 | 19 – 401 | Arylacetamide deacetylase-like 2Add BLAST | 383 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 116 ↔ 338 | By similarity |
Keywords - PTMi
Disulfide bondProteomic databases
jPOSTi | Q6P093 |
MassIVEi | Q6P093 |
PaxDbi | Q6P093 |
PeptideAtlasi | Q6P093 |
PRIDEi | Q6P093 |
ProteomicsDBi | 66809 [Q6P093-1] 66810 [Q6P093-3] |
PTM databases
iPTMneti | Q6P093 |
PhosphoSitePlusi | Q6P093 |
Expressioni
Gene expression databases
Bgeei | ENSG00000197953, Expressed in upper arm skin and 79 other tissues |
ExpressionAtlasi | Q6P093, baseline and differential |
Genevisiblei | Q6P093, HS |
Organism-specific databases
HPAi | ENSG00000197953, Group enriched (placenta, skin, tongue) |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000348911 |
Miscellaneous databases
RNActi | Q6P093, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 111 – 113 | Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity | 3 |
Sequence similaritiesi
Belongs to the 'GDXG' lipolytic enzyme family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1515, Eukaryota |
GeneTreei | ENSGT00940000161405 |
HOGENOMi | CLU_012494_12_0_1 |
InParanoidi | Q6P093 |
OMAi | WKVMALD |
OrthoDBi | 1263520at2759 |
PhylomeDBi | Q6P093 |
TreeFami | TF314978 |
Family and domain databases
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR013094, AB_hydrolase_3 IPR017157, Arylacetamide_deacetylase IPR033140, Lipase_GDXG_put_SER_AS |
Pfami | View protein in Pfam PF07859, Abhydrolase_3, 2 hits |
PIRSFi | PIRSF037251, Arylacetamide_deacetylase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS01174, LIPASE_GDXG_SER, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6P093-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGLKALCLGL LCVLFVSHFY TPMPDNIEES WKIMALDAIA KTCTFTAMCF
60 70 80 90 100
ENMRIMRYEE FISMIFRLDY TQPLSDEYIT VTDTTFVDIP VRLYLPKRKS
110 120 130 140 150
ETRRRAVIYF HGGGFCFGSS KQRAFDFLNR WTANTLDAVV VGVDYRLAPQ
160 170 180 190 200
HHFPAQFEDG LAAVKFFLLE KILTKYGVDP TRICIAGDSS GGNLATAVTQ
210 220 230 240 250
QVQNDAEIKH KIKMQVLLYP GLQITDSYLP SHRENEHGIV LTRDVAIKLV
260 270 280 290 300
SLYFTKDEAL PWAMRRNQHM PLESRHLFKF VNWSILLPEK YRKDYVYTEP
310 320 330 340 350
ILGGLSYSLP GLTDSRALPL LANDSQLQNL PLTYILTCQH DLLRDDGLMY
360 370 380 390 400
VTRLRNVGVQ VVHEHIEDGI HGALSFMTSP FYLRLGLRIR DMYVSWLDKN
L
Isoform 2 (identifier: Q6P093-3) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
47-53: AMCFENM → NRGPLTS
54-401: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF8WFE5 | F8WFE5_HUMAN | Arylacetamide deacetylase-like 2 | AADACL2 | 53 | Annotation score: |
Sequence cautioni
The sequence AAH65724 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 26 | N → S in CAI46075 (PubMed:17974005).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_038140 | 186 | A → S1 PublicationCorresponds to variant dbSNP:rs1972977Ensembl. | 1 | |
Natural variantiVAR_038141 | 343 | L → I. Corresponds to variant dbSNP:rs1052562Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038389 | 47 – 53 | AMCFENM → NRGPLTS in isoform 2. 1 Publication | 7 | |
Alternative sequenceiVSP_038390 | 54 – 401 | Missing in isoform 2. 1 PublicationAdd BLAST | 348 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX647585 mRNA Translation: CAI46075.1 Sequence problems. AC069067 Genomic DNA No translation available. BC065724 mRNA Translation: AAH65724.1 Different initiation. |
CCDSi | CCDS3161.2 [Q6P093-1] |
RefSeqi | NP_997248.2, NM_207365.3 [Q6P093-1] |
Genome annotation databases
Ensembli | ENST00000356517; ENSP00000348911; ENSG00000197953 [Q6P093-1] ENST00000570799; ENSP00000461239; ENSG00000261846 [Q6P093-1] |
GeneIDi | 344752 |
KEGGi | hsa:344752 |
UCSCi | uc003ezc.4, human [Q6P093-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX647585 mRNA Translation: CAI46075.1 Sequence problems. AC069067 Genomic DNA No translation available. BC065724 mRNA Translation: AAH65724.1 Different initiation. |
CCDSi | CCDS3161.2 [Q6P093-1] |
RefSeqi | NP_997248.2, NM_207365.3 [Q6P093-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000348911 |
Chemistry databases
DrugBanki | DB07814, Gibberellic acid DB07815, Gibberellin A4 |
Protein family/group databases
ESTHERi | human-AADACL2, Arylacetamide_deacetylase |
PTM databases
iPTMneti | Q6P093 |
PhosphoSitePlusi | Q6P093 |
Polymorphism and mutation databases
BioMutai | AADACL2 |
DMDMi | 269849709 |
Proteomic databases
jPOSTi | Q6P093 |
MassIVEi | Q6P093 |
PaxDbi | Q6P093 |
PeptideAtlasi | Q6P093 |
PRIDEi | Q6P093 |
ProteomicsDBi | 66809 [Q6P093-1] 66810 [Q6P093-3] |
Protocols and materials databases
Antibodypediai | 33616, 113 antibodies |
DNASUi | 344752 |
Genome annotation databases
Ensembli | ENST00000356517; ENSP00000348911; ENSG00000197953 [Q6P093-1] ENST00000570799; ENSP00000461239; ENSG00000261846 [Q6P093-1] |
GeneIDi | 344752 |
KEGGi | hsa:344752 |
UCSCi | uc003ezc.4, human [Q6P093-1] |
Organism-specific databases
CTDi | 344752 |
EuPathDBi | HostDB:ENSG00000197953.5 |
GeneCardsi | AADACL2 |
HGNCi | HGNC:24427, AADACL2 |
HPAi | ENSG00000197953, Group enriched (placenta, skin, tongue) |
neXtProti | NX_Q6P093 |
OpenTargetsi | ENSG00000197953 |
PharmGKBi | PA142670463 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1515, Eukaryota |
GeneTreei | ENSGT00940000161405 |
HOGENOMi | CLU_012494_12_0_1 |
InParanoidi | Q6P093 |
OMAi | WKVMALD |
OrthoDBi | 1263520at2759 |
PhylomeDBi | Q6P093 |
TreeFami | TF314978 |
Enzyme and pathway databases
PathwayCommonsi | Q6P093 |
SABIO-RKi | Q6P093 |
Miscellaneous databases
BioGRID-ORCSi | 344752, 3 hits in 843 CRISPR screens |
ChiTaRSi | AADACL2, human |
GenomeRNAii | 344752 |
Pharosi | Q6P093, Tdark |
PROi | PR:Q6P093 |
RNActi | Q6P093, protein |
Gene expression databases
Bgeei | ENSG00000197953, Expressed in upper arm skin and 79 other tissues |
ExpressionAtlasi | Q6P093, baseline and differential |
Genevisiblei | Q6P093, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR013094, AB_hydrolase_3 IPR017157, Arylacetamide_deacetylase IPR033140, Lipase_GDXG_put_SER_AS |
Pfami | View protein in Pfam PF07859, Abhydrolase_3, 2 hits |
PIRSFi | PIRSF037251, Arylacetamide_deacetylase, 1 hit |
SUPFAMi | SSF53474, SSF53474, 1 hit |
PROSITEi | View protein in PROSITE PS01174, LIPASE_GDXG_SER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADCL2_HUMAN | |
Accessioni | Q6P093Primary (citable) accession number: Q6P093 Secondary accession number(s): Q5HYJ4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | November 24, 2009 | |
Last modified: | December 2, 2020 | |
This is version 121 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations