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Protein

Arylacetamide deacetylase-like 2

Gene

AADACL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei189PROSITE-ProRule annotationBy similarity1
Active sitei341By similarity1
Active sitei371By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

SABIO-RKiQ6P093

Protein family/group databases

ESTHERihuman-AADACL2 Arylacetamide_deacetylase

Names & Taxonomyi

Protein namesi
Recommended name:
Arylacetamide deacetylase-like 2 (EC:3.1.1.-)
Gene namesi
Name:AADACL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000197953.5
HGNCiHGNC:24427 AADACL2
neXtProtiNX_Q6P093

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000197953
PharmGKBiPA142670463

Chemistry databases

DrugBankiDB07814 GIBBERELLIN A3
DB07815 GIBBERELLIN A4

Polymorphism and mutation databases

BioMutaiAADACL2
DMDMi269849709

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000031496019 – 401Arylacetamide deacetylase-like 2Add BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi116 ↔ 338By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ6P093
PeptideAtlasiQ6P093
PRIDEiQ6P093
ProteomicsDBi66809
66810 [Q6P093-3]

PTM databases

iPTMnetiQ6P093
PhosphoSitePlusiQ6P093

Expressioni

Gene expression databases

BgeeiENSG00000197953 Expressed in 67 organ(s), highest expression level in upper arm skin
CleanExiHS_AADACL2
ExpressionAtlasiQ6P093 baseline and differential
GenevisibleiQ6P093 HS

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000348911

Structurei

3D structure databases

ProteinModelPortaliQ6P093
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi111 – 113Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity3

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1515 Eukaryota
COG0657 LUCA
GeneTreeiENSGT00550000074556
HOGENOMiHOG000033738
HOVERGENiHBG058974
InParanoidiQ6P093
KOiK14350
OMAiDMYISWL
OrthoDBiEOG091G082E
PhylomeDBiQ6P093
TreeFamiTF314978

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR017157 Arylacetamide_deacetylase
IPR033140 Lipase_GDXG_put_SER_AS
PfamiView protein in Pfam
PF07859 Abhydrolase_3, 2 hits
PIRSFiPIRSF037251 Arylacetamide_deacetylase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS01174 LIPASE_GDXG_SER, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6P093-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGLKALCLGL LCVLFVSHFY TPMPDNIEES WKIMALDAIA KTCTFTAMCF
60 70 80 90 100
ENMRIMRYEE FISMIFRLDY TQPLSDEYIT VTDTTFVDIP VRLYLPKRKS
110 120 130 140 150
ETRRRAVIYF HGGGFCFGSS KQRAFDFLNR WTANTLDAVV VGVDYRLAPQ
160 170 180 190 200
HHFPAQFEDG LAAVKFFLLE KILTKYGVDP TRICIAGDSS GGNLATAVTQ
210 220 230 240 250
QVQNDAEIKH KIKMQVLLYP GLQITDSYLP SHRENEHGIV LTRDVAIKLV
260 270 280 290 300
SLYFTKDEAL PWAMRRNQHM PLESRHLFKF VNWSILLPEK YRKDYVYTEP
310 320 330 340 350
ILGGLSYSLP GLTDSRALPL LANDSQLQNL PLTYILTCQH DLLRDDGLMY
360 370 380 390 400
VTRLRNVGVQ VVHEHIEDGI HGALSFMTSP FYLRLGLRIR DMYVSWLDKN

L
Length:401
Mass (Da):46,099
Last modified:November 24, 2009 - v3
Checksum:i801AF004D9E6A3DA
GO
Isoform 2 (identifier: Q6P093-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     47-53: AMCFENM → NRGPLTS
     54-401: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:53
Mass (Da):5,863
Checksum:iC99D84CA5DBDA963
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WFE5F8WFE5_HUMAN
Arylacetamide deacetylase-like 2
AADACL2
53Annotation score:

Sequence cautioni

The sequence AAH65724 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI46075 differs from that shown. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26N → S in CAI46075 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038140186A → S1 PublicationCorresponds to variant dbSNP:rs1972977Ensembl.1
Natural variantiVAR_038141343L → I. Corresponds to variant dbSNP:rs1052562Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03838947 – 53AMCFENM → NRGPLTS in isoform 2. 1 Publication7
Alternative sequenceiVSP_03839054 – 401Missing in isoform 2. 1 PublicationAdd BLAST348

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX647585 mRNA Translation: CAI46075.1 Sequence problems.
AC069067 Genomic DNA No translation available.
BC065724 mRNA Translation: AAH65724.1 Different initiation.
CCDSiCCDS3161.2 [Q6P093-1]
RefSeqiNP_997248.2, NM_207365.3 [Q6P093-1]
UniGeneiHs.144710

Genome annotation databases

EnsembliENST00000356517; ENSP00000348911; ENSG00000197953 [Q6P093-1]
ENST00000570799; ENSP00000461239; ENSG00000261846 [Q6P093-1]
GeneIDi344752
KEGGihsa:344752
UCSCiuc003ezc.4 human [Q6P093-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX647585 mRNA Translation: CAI46075.1 Sequence problems.
AC069067 Genomic DNA No translation available.
BC065724 mRNA Translation: AAH65724.1 Different initiation.
CCDSiCCDS3161.2 [Q6P093-1]
RefSeqiNP_997248.2, NM_207365.3 [Q6P093-1]
UniGeneiHs.144710

3D structure databases

ProteinModelPortaliQ6P093
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000348911

Chemistry databases

DrugBankiDB07814 GIBBERELLIN A3
DB07815 GIBBERELLIN A4

Protein family/group databases

ESTHERihuman-AADACL2 Arylacetamide_deacetylase

PTM databases

iPTMnetiQ6P093
PhosphoSitePlusiQ6P093

Polymorphism and mutation databases

BioMutaiAADACL2
DMDMi269849709

Proteomic databases

PaxDbiQ6P093
PeptideAtlasiQ6P093
PRIDEiQ6P093
ProteomicsDBi66809
66810 [Q6P093-3]

Protocols and materials databases

DNASUi344752
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356517; ENSP00000348911; ENSG00000197953 [Q6P093-1]
ENST00000570799; ENSP00000461239; ENSG00000261846 [Q6P093-1]
GeneIDi344752
KEGGihsa:344752
UCSCiuc003ezc.4 human [Q6P093-1]

Organism-specific databases

CTDi344752
EuPathDBiHostDB:ENSG00000197953.5
GeneCardsiAADACL2
H-InvDBiHIX0024523
HGNCiHGNC:24427 AADACL2
neXtProtiNX_Q6P093
OpenTargetsiENSG00000197953
PharmGKBiPA142670463
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1515 Eukaryota
COG0657 LUCA
GeneTreeiENSGT00550000074556
HOGENOMiHOG000033738
HOVERGENiHBG058974
InParanoidiQ6P093
KOiK14350
OMAiDMYISWL
OrthoDBiEOG091G082E
PhylomeDBiQ6P093
TreeFamiTF314978

Enzyme and pathway databases

SABIO-RKiQ6P093

Miscellaneous databases

GenomeRNAii344752
PROiPR:Q6P093

Gene expression databases

BgeeiENSG00000197953 Expressed in 67 organ(s), highest expression level in upper arm skin
CleanExiHS_AADACL2
ExpressionAtlasiQ6P093 baseline and differential
GenevisibleiQ6P093 HS

Family and domain databases

InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR017157 Arylacetamide_deacetylase
IPR033140 Lipase_GDXG_put_SER_AS
PfamiView protein in Pfam
PF07859 Abhydrolase_3, 2 hits
PIRSFiPIRSF037251 Arylacetamide_deacetylase, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS01174 LIPASE_GDXG_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADCL2_HUMAN
AccessioniPrimary (citable) accession number: Q6P093
Secondary accession number(s): Q5HYJ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: November 24, 2009
Last modified: September 12, 2018
This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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