UniProtKB - Q6P093 (ADCL2_HUMAN)

BLAST

>sp|Q6P093|ADCL2_HUMAN Arylacetamide deacetylase-like 2 OS=Homo sapiens OX=9606 GN=AADACL2 PE=2 SV=3
MGLKALCLGLLCVLFVSHFYTPMPDNIEESWKIMALDAIAKTCTFTAMCFENMRIMRYEE
FISMIFRLDYTQPLSDEYITVTDTTFVDIPVRLYLPKRKSETRRRAVIYFHGGGFCFGSS
KQRAFDFLNRWTANTLDAVVVGVDYRLAPQHHFPAQFEDGLAAVKFFLLEKILTKYGVDP
TRICIAGDSSGGNLATAVTQQVQNDAEIKHKIKMQVLLYPGLQITDSYLPSHRENEHGIV
LTRDVAIKLVSLYFTKDEALPWAMRRNQHMPLESRHLFKFVNWSILLPEKYRKDYVYTEP
ILGGLSYSLPGLTDSRALPLLANDSQLQNLPLTYILTCQHDLLRDDGLMYVTRLRNVGVQ
VVHEHIEDGIHGALSFMTSPFYLRLGLRIRDMYVSWLDKNL

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History
Entry version 106 (12 Sep 2018)
Sequence version 3 (24 Nov 2009)
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Protein

Arylacetamide deacetylase-like 2

Gene

AADACL2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Active siteⁱ	189	PROSITE-ProRule annotationBy similarity	1
Active siteⁱ	341	By similarity	1
Active siteⁱ	371	By similarity	1

GO - Molecular functionⁱ

carboxylic ester hydrolase activity Source: InterPro
hydrolase activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

catabolic process Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase

Molecular function

Hydrolase

Enzyme and pathway databases

SABIO-RKⁱ	Q6P093

SABIO-RKⁱ

Q6P093

Protein family/group databases

ESTHERⁱ	human-AADACL2 Arylacetamide_deacetylase

ESTHERⁱ

human-AADACL2 Arylacetamide_deacetylase

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Arylacetamide deacetylase-like 2 (EC:3.1.1.-)
Gene namesⁱ	Name:AADACL2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000197953.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:24427 AADACL2
neXtProtⁱ	NX_Q6P093

Keywords - Cellular componentⁱ

Secreted

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000197953
PharmGKBⁱ	PA142670463

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB07814 GIBBERELLIN A3 DB07815 GIBBERELLIN A4

DrugBankⁱ

DB07814 GIBBERELLIN A3
DB07815 GIBBERELLIN A4

Polymorphism and mutation databases

BioMutaⁱ	AADACL2
DMDMⁱ	269849709

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 18	Sequence analysisAdd BLAST		18
ChainⁱPRO_0000314960	19 – 401	Arylacetamide deacetylase-like 2Add BLAST		383

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Disulfide bondⁱ	116 ↔ 338	By similarity

Keywords - PTMⁱ

Disulfide bond

Proteomic databases

PaxDbⁱ	Q6P093
PeptideAtlas More...PeptideAtlasⁱ	Q6P093
PRIDEⁱ	Q6P093
ProteomicsDBⁱ	66809 66810 [Q6P093-3]

PTM databases

iPTMnetⁱ	Q6P093
PhosphoSitePlusⁱ	Q6P093

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000197953 Expressed in 67 organ(s), highest expression level in upper arm skin
CleanExⁱ	HS_AADACL2
ExpressionAtlasⁱ	Q6P093 baseline and differential
Genevisibleⁱ	Q6P093 HS

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000348911

STRINGⁱ

9606.ENSP00000348911

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6P093
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	111 – 113	Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity		3

Sequence similaritiesⁱ

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG1515 Eukaryota COG0657 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074556
HOGENOMⁱ	HOG000033738
HOVERGENⁱ	HBG058974
InParanoidⁱ	Q6P093
KEGG Orthology (KO) More...KOⁱ	K14350
OMAⁱ	DMYISWL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G082E
PhylomeDBⁱ	Q6P093
TreeFamⁱ	TF314978

Family and domain databases

InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR013094 AB_hydrolase_3 IPR017157 Arylacetamide_deacetylase IPR033140 Lipase_GDXG_put_SER_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF07859 Abhydrolase_3, 2 hits
PIRSFⁱ	PIRSF037251 Arylacetamide_deacetylase, 1 hit
SUPFAMⁱ	SSF53474 SSF53474, 1 hit
PROSITEⁱ	View protein in PROSITE PS01174 LIPASE_GDXG_SER, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q6P093-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLKALCLGL LCVLFVSHFY TPMPDNIEES WKIMALDAIA KTCTFTAMCF 
        60         70         80         90        100
ENMRIMRYEE FISMIFRLDY TQPLSDEYIT VTDTTFVDIP VRLYLPKRKS 
       110        120        130        140        150
ETRRRAVIYF HGGGFCFGSS KQRAFDFLNR WTANTLDAVV VGVDYRLAPQ 
       160        170        180        190        200
HHFPAQFEDG LAAVKFFLLE KILTKYGVDP TRICIAGDSS GGNLATAVTQ 
       210        220        230        240        250
QVQNDAEIKH KIKMQVLLYP GLQITDSYLP SHRENEHGIV LTRDVAIKLV 
       260        270        280        290        300
SLYFTKDEAL PWAMRRNQHM PLESRHLFKF VNWSILLPEK YRKDYVYTEP 
       310        320        330        340        350
ILGGLSYSLP GLTDSRALPL LANDSQLQNL PLTYILTCQH DLLRDDGLMY 
       360        370        380        390        400
VTRLRNVGVQ VVHEHIEDGI HGALSFMTSP FYLRLGLRIR DMYVSWLDKN 

L

Length:401

Mass (Da):46,099

Last modified:November 24, 2009 - v3

Checksum:ⁱ801AF004D9E6A3DA

Isoform 2 (identifier: Q6P093-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
47-53: AMCFENM → NRGPLTS
54-401: Missing.

« Hide

        10         20         30         40         50
MGLKALCLGL LCVLFVSHFY TPMPDNIEES WKIMALDAIA KTCTFTNRGP 

LTS

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Show »

Length:53

Mass (Da):5,863

Checksum:ⁱC99D84CA5DBDA963

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F8WFE5	F8WFE5_HUMAN		Arylacetamide deacetylase-like 2 Arylacetamide deacetylase-like 2	AADACL2	53	Annotation score:

Sequence cautionⁱ

The sequence AAH65724 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence CAI46075 differs from that shown. Wrong choice of CDS.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	26	N → S in CAI46075 (PubMed:17974005).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_038140	186	A → S1 PublicationCorresponds to variant dbSNP:rs1972977Ensembl.		1
Natural variantⁱVAR_038141	343	L → I. Corresponds to variant dbSNP:rs1052562Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_038389	47 – 53	AMCFENM → NRGPLTS in isoform 2. 1 Publication		7
Alternative sequenceⁱVSP_038390	54 – 401	Missing in isoform 2. 1 PublicationAdd BLAST		348

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX647585 mRNA Translation: CAI46075.1 Sequence problems. AC069067 Genomic DNA No translation available. BC065724 mRNA Translation: AAH65724.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3161.2 [Q6P093-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_997248.2, NM_207365.3 [Q6P093-1]
UniGeneⁱ	Hs.144710

Genome annotation databases

Ensemblⁱ	ENST00000356517; ENSP00000348911; ENSG00000197953 [Q6P093-1] ENST00000570799; ENSP00000461239; ENSG00000261846 [Q6P093-1]
GeneIDⁱ	344752
KEGGⁱ	hsa:344752
UCSC genome browser More...UCSCⁱ	uc003ezc.4 human [Q6P093-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6P093	AADACL2 isoform 2		PANTR		401	UniRef90_Q6P093
Uncharacterized protein		PANPA		401
Arylacetamide deacetylase like 2		MACMU		401
Arylacetamide deacetylase like 2		MACFA		401
Uncharacterized protein		CHLSB		401
+21
Q6P093-3	Arylacetamide deacetylase-like 2		HUMAN		53	UniRef90_Q6P093-3
AADACL2 isoform 1		PONAB		53
AADACL2 isoform 1		PANTR		53

Protein	Similar proteins		Species	Score	Length	Source
Q6P093	Uncharacterized protein		COLAP		401	UniRef50_Q6P093
Uncharacterized protein		CERAT		401
Uncharacterized protein		MANLE		401
Uncharacterized protein		RHIRO		401
Arylacetamide deacetylase like 2		CALJA		401
+154
Q6P093-3	Arylacetamide deacetylase-like 2		HUMAN		53	UniRef50_Q6P093-3
AADACL2 isoform 1		PONAB		53
AADACL2 isoform 1		PANTR		53

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	BX647585 mRNA Translation: CAI46075.1 Sequence problems. AC069067 Genomic DNA No translation available. BC065724 mRNA Translation: AAH65724.1 Different initiation.
CCDSⁱ	CCDS3161.2 [Q6P093-1]
RefSeqⁱ	NP_997248.2, NM_207365.3 [Q6P093-1]
UniGeneⁱ	Hs.144710

3D structure databases

ProteinModelPortalⁱ	Q6P093
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000348911

STRINGⁱ

9606.ENSP00000348911

Chemistry databases

DrugBankⁱ	DB07814 GIBBERELLIN A3 DB07815 GIBBERELLIN A4

DrugBankⁱ

DB07814 GIBBERELLIN A3
DB07815 GIBBERELLIN A4

Protein family/group databases

ESTHERⁱ	human-AADACL2 Arylacetamide_deacetylase

ESTHERⁱ

human-AADACL2 Arylacetamide_deacetylase

PTM databases

iPTMnetⁱ	Q6P093
PhosphoSitePlusⁱ	Q6P093

Polymorphism and mutation databases

BioMutaⁱ	AADACL2
DMDMⁱ	269849709

Proteomic databases

PaxDbⁱ	Q6P093
PeptideAtlasⁱ	Q6P093
PRIDEⁱ	Q6P093
ProteomicsDBⁱ	66809 66810 [Q6P093-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	344752
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000356517; ENSP00000348911; ENSG00000197953 [Q6P093-1] ENST00000570799; ENSP00000461239; ENSG00000261846 [Q6P093-1]
GeneIDⁱ	344752
KEGGⁱ	hsa:344752
UCSCⁱ	uc003ezc.4 human [Q6P093-1]

Organism-specific databases

CTDⁱ	344752
EuPathDBⁱ	HostDB:ENSG00000197953.5
GeneCardsⁱ	AADACL2
H-InvDBⁱ	HIX0024523
HGNCⁱ	HGNC:24427 AADACL2
neXtProtⁱ	NX_Q6P093
OpenTargetsⁱ	ENSG00000197953
PharmGKBⁱ	PA142670463
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1515 Eukaryota COG0657 LUCA
GeneTreeⁱ	ENSGT00550000074556
HOGENOMⁱ	HOG000033738
HOVERGENⁱ	HBG058974
InParanoidⁱ	Q6P093
KOⁱ	K14350
OMAⁱ	DMYISWL
OrthoDBⁱ	EOG091G082E
PhylomeDBⁱ	Q6P093
TreeFamⁱ	TF314978

Enzyme and pathway databases

SABIO-RKⁱ	Q6P093

SABIO-RKⁱ

Q6P093

Miscellaneous databases

GenomeRNAiⁱ	344752
Protein Ontology More...PROⁱ	PR:Q6P093

Gene expression databases

Bgeeⁱ	ENSG00000197953 Expressed in 67 organ(s), highest expression level in upper arm skin
CleanExⁱ	HS_AADACL2
ExpressionAtlasⁱ	Q6P093 baseline and differential
Genevisibleⁱ	Q6P093 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR029058 AB_hydrolase IPR013094 AB_hydrolase_3 IPR017157 Arylacetamide_deacetylase IPR033140 Lipase_GDXG_put_SER_AS
Pfamⁱ	View protein in Pfam PF07859 Abhydrolase_3, 2 hits
PIRSFⁱ	PIRSF037251 Arylacetamide_deacetylase, 1 hit
SUPFAMⁱ	SSF53474 SSF53474, 1 hit
PROSITEⁱ	View protein in PROSITE PS01174 LIPASE_GDXG_SER, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ADCL2_HUMAN
Accessionⁱ	Q6P093Primary (citable) accession number: Q6P093 Secondary accession number(s): Q5HYJ4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
	Last sequence update:	November 24, 2009
	Last modified:	September 12, 2018
	This is version 106 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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Supporting data

UniProtKB - Q6P093 (ADCL2_HUMAN)

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Arylacetamide deacetylase-like 2

AADACL2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ