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Protein

Uncharacterized protein C8orf74

Gene

C8orf74

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Uncharacterized protein C8orf74
Gene namesi
Name:C8orf74
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000171060.10
HGNCiHGNC:32296 C8orf74
neXtProtiNX_Q6P047

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000171060
PharmGKBiPA142672337

Polymorphism and mutation databases

BioMutaiC8orf74
DMDMi296439406

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002709311 – 294Uncharacterized protein C8orf74Add BLAST294

Proteomic databases

PaxDbiQ6P047
PeptideAtlasiQ6P047
PRIDEiQ6P047
ProteomicsDBi66801

PTM databases

iPTMnetiQ6P047
PhosphoSitePlusiQ6P047

Expressioni

Gene expression databases

BgeeiENSG00000171060 Expressed in 44 organ(s), highest expression level in testis
CleanExiHS_C8orf74
ExpressionAtlasiQ6P047 baseline and differential
GenevisibleiQ6P047 HS

Organism-specific databases

HPAiHPA027986

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi128447, 7 interactors
IntActiQ6P047, 5 interactors
MINTiQ6P047
STRINGi9606.ENSP00000307129

Structurei

3D structure databases

ProteinModelPortaliQ6P047
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IWQV Eukaryota
ENOG4111WVS LUCA
GeneTreeiENSGT00390000010548
HOGENOMiHOG000111621
HOVERGENiHBG080723
InParanoidiQ6P047
OMAiLCDYFHN
OrthoDBiEOG091G0W9Y
PhylomeDBiQ6P047
TreeFamiTF343725

Family and domain databases

InterProiView protein in InterPro
IPR032727 CLAMP
PfamiView protein in Pfam
PF14769 CLAMP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6P047-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALLTPQGVK EVFQLQRPQG RERLRRLLNW EEFDEQRDSR RSILLDTLYE
60 70 80 90 100
SIIFAVGKGF PWVEVAQVVK FTEELLRETK GCSITEAVTI LGNKLRDYRG
110 120 130 140 150
HFNTTHLLAL CDYFHHTFIR HYKLYQYVLG QDQQVDLTVA HLEVCMPPHP
160 170 180 190 200
LPLAEGMDRD LWIHEQQVAT LTEAEAQKRA DVLLLKEALR LERENSLQKA
210 220 230 240 250
FAAAAPAQPG QVLERQELES LICQAVHTQM ELLQELLQRQ IQNTFAILDL
260 270 280 290
KLQKKTLNLN APTPIPPPIT SHAGQEEALK PQRASKGKKA KARK
Length:294
Mass (Da):33,735
Last modified:May 18, 2010 - v3
Checksum:i555321ACEF4927C2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YBH0H0YBH0_HUMAN
Uncharacterized protein C8orf74
C8orf74
99Annotation score:
E5RJ53E5RJ53_HUMAN
Uncharacterized protein C8orf74
C8orf74
99Annotation score:

Sequence cautioni

The sequence AAH65837 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03368415L → F2 PublicationsCorresponds to variant dbSNP:rs11250058Ensembl.1
Natural variantiVAR_061596222I → V. Corresponds to variant dbSNP:rs57041981Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105001 Genomic DNA No translation available.
CH471157 Genomic DNA Translation: EAW65593.1
BC065837 mRNA Translation: AAH65837.1 Different initiation.
BC132852 mRNA Translation: AAI32853.1
BC132854 mRNA Translation: AAI32855.1
CCDSiCCDS47800.1
RefSeqiNP_001035121.1, NM_001040032.1
UniGeneiHs.371776

Genome annotation databases

EnsembliENST00000304519; ENSP00000307129; ENSG00000171060
GeneIDi203076
KEGGihsa:203076
UCSCiuc003wtd.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC105001 Genomic DNA No translation available.
CH471157 Genomic DNA Translation: EAW65593.1
BC065837 mRNA Translation: AAH65837.1 Different initiation.
BC132852 mRNA Translation: AAI32853.1
BC132854 mRNA Translation: AAI32855.1
CCDSiCCDS47800.1
RefSeqiNP_001035121.1, NM_001040032.1
UniGeneiHs.371776

3D structure databases

ProteinModelPortaliQ6P047
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128447, 7 interactors
IntActiQ6P047, 5 interactors
MINTiQ6P047
STRINGi9606.ENSP00000307129

PTM databases

iPTMnetiQ6P047
PhosphoSitePlusiQ6P047

Polymorphism and mutation databases

BioMutaiC8orf74
DMDMi296439406

Proteomic databases

PaxDbiQ6P047
PeptideAtlasiQ6P047
PRIDEiQ6P047
ProteomicsDBi66801

Protocols and materials databases

DNASUi203076
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304519; ENSP00000307129; ENSG00000171060
GeneIDi203076
KEGGihsa:203076
UCSCiuc003wtd.1 human

Organism-specific databases

CTDi203076
EuPathDBiHostDB:ENSG00000171060.10
GeneCardsiC8orf74
HGNCiHGNC:32296 C8orf74
HPAiHPA027986
neXtProtiNX_Q6P047
OpenTargetsiENSG00000171060
PharmGKBiPA142672337
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IWQV Eukaryota
ENOG4111WVS LUCA
GeneTreeiENSGT00390000010548
HOGENOMiHOG000111621
HOVERGENiHBG080723
InParanoidiQ6P047
OMAiLCDYFHN
OrthoDBiEOG091G0W9Y
PhylomeDBiQ6P047
TreeFamiTF343725

Miscellaneous databases

ChiTaRSiC8orf74 human
GenomeRNAii203076
PROiPR:Q6P047

Gene expression databases

BgeeiENSG00000171060 Expressed in 44 organ(s), highest expression level in testis
CleanExiHS_C8orf74
ExpressionAtlasiQ6P047 baseline and differential
GenevisibleiQ6P047 HS

Family and domain databases

InterProiView protein in InterPro
IPR032727 CLAMP
PfamiView protein in Pfam
PF14769 CLAMP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCH074_HUMAN
AccessioniPrimary (citable) accession number: Q6P047
Secondary accession number(s): A2RUD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 87 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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