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Protein

Cdc42 effector protein 5

Gene

CDC42EP5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity).By similarity

GO - Molecular functioni

  • GTP-Rho binding Source: UniProtKB

GO - Biological processi

  • JNK cascade Source: Ensembl
  • positive regulation of actin filament polymerization Source: UniProtKB
  • positive regulation of pseudopodium assembly Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • Rho protein signal transduction Source: GO_Central

Keywordsi

Biological processCell shape

Enzyme and pathway databases

ReactomeiR-HSA-5687128 MAPK6/MAPK4 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Cdc42 effector protein 5
Alternative name(s):
Binder of Rho GTPases 3
Gene namesi
Name:CDC42EP5
Synonyms:BORG3, CEP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167617.2
HGNCiHGNC:17408 CDC42EP5
MIMi609171 gene
neXtProtiNX_Q6NZY7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167617
PharmGKBiPA134989100

Polymorphism and mutation databases

DMDMi71152342

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126531 – 148Cdc42 effector protein 5Add BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei38Omega-N-methylarginineBy similarity1

Keywords - PTMi

Methylation

Proteomic databases

MaxQBiQ6NZY7
PaxDbiQ6NZY7
PeptideAtlasiQ6NZY7
PRIDEiQ6NZY7
ProteomicsDBi66800

PTM databases

iPTMnetiQ6NZY7
PhosphoSitePlusiQ6NZY7

Expressioni

Gene expression databases

BgeeiENSG00000167617 Expressed in 165 organ(s), highest expression level in colonic mucosa
CleanExiHS_CDC42EP5
GenevisibleiQ6NZY7 HS

Organism-specific databases

HPAiHPA043449

Interactioni

Subunit structurei

Interacts with CDC42, in a GTP-dependent manner, and with SEPT7.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi127125, 5 interactors
STRINGi9606.ENSP00000301200

Structurei

3D structure databases

ProteinModelPortaliQ6NZY7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 37CRIBPROSITE-ProRule annotationAdd BLAST15

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi56 – 87Pro-richAdd BLAST32
Compositional biasi114 – 117Poly-Ala4

Domaini

The CRIB domain mediates interaction with CDC42.By similarity

Sequence similaritiesi

Belongs to the BORG/CEP family.Curated

Phylogenomic databases

eggNOGiENOG410J2KV Eukaryota
ENOG410ZF7J LUCA
GeneTreeiENSGT00730000110869
HOGENOMiHOG000043688
HOVERGENiHBG080905
InParanoidiQ6NZY7
OMAiQHPRARC
OrthoDBiEOG091G11DR
PhylomeDBiQ6NZY7
TreeFamiTF331725

Family and domain databases

InterProiView protein in InterPro
IPR029273 Cdc42_effect
IPR000095 CRIB_dom
PfamiView protein in Pfam
PF14957 BORG_CEP, 1 hit
PF00786 PBD, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6NZY7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPVLKQLGPA QPKKRPDRGA LSISAPLGDF RHTLHVGRGG DAFGDTSFLS
60 70 80 90 100
RHGGGPPPEP RAPPAGAPRS PPPPAVPQSA APSPADPLLS FHLDLGPSML
110 120 130 140
DAVLGVMDAA RPEAAAAKPD AEPRPGTQPP QARCRPNADL ELNDVIGL
Length:148
Mass (Da):15,207
Last modified:July 5, 2004 - v1
Checksum:i48BC1A9B9307CEEC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JPE9A0A0G2JPE9_HUMAN
Cdc42 effector protein 5
CDC42EP5
17Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti59E → Q in AAH24327 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU467002 Genomic DNA No translation available.
CU207370 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72252.1
BC024327 mRNA Translation: AAH24327.1
BC065910 mRNA Translation: AAH65910.1
CCDSiCCDS12896.1
RefSeqiNP_659494.2, NM_145057.3
UniGeneiHs.415791

Genome annotation databases

EnsembliENST00000301200; ENSP00000301200; ENSG00000167617
ENST00000611094; ENSP00000484985; ENSG00000273622
ENST00000617756; ENSP00000484158; ENSG00000273633
ENST00000619217; ENSP00000479726; ENSG00000278444
GeneIDi148170
KEGGihsa:148170
UCSCiuc002qfz.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU467002 Genomic DNA No translation available.
CU207370 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW72252.1
BC024327 mRNA Translation: AAH24327.1
BC065910 mRNA Translation: AAH65910.1
CCDSiCCDS12896.1
RefSeqiNP_659494.2, NM_145057.3
UniGeneiHs.415791

3D structure databases

ProteinModelPortaliQ6NZY7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127125, 5 interactors
STRINGi9606.ENSP00000301200

PTM databases

iPTMnetiQ6NZY7
PhosphoSitePlusiQ6NZY7

Polymorphism and mutation databases

DMDMi71152342

Proteomic databases

MaxQBiQ6NZY7
PaxDbiQ6NZY7
PeptideAtlasiQ6NZY7
PRIDEiQ6NZY7
ProteomicsDBi66800

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000301200; ENSP00000301200; ENSG00000167617
ENST00000611094; ENSP00000484985; ENSG00000273622
ENST00000617756; ENSP00000484158; ENSG00000273633
ENST00000619217; ENSP00000479726; ENSG00000278444
GeneIDi148170
KEGGihsa:148170
UCSCiuc002qfz.3 human

Organism-specific databases

CTDi148170
EuPathDBiHostDB:ENSG00000167617.2
GeneCardsiCDC42EP5
HGNCiHGNC:17408 CDC42EP5
HPAiHPA043449
MIMi609171 gene
neXtProtiNX_Q6NZY7
OpenTargetsiENSG00000167617
PharmGKBiPA134989100
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J2KV Eukaryota
ENOG410ZF7J LUCA
GeneTreeiENSGT00730000110869
HOGENOMiHOG000043688
HOVERGENiHBG080905
InParanoidiQ6NZY7
OMAiQHPRARC
OrthoDBiEOG091G11DR
PhylomeDBiQ6NZY7
TreeFamiTF331725

Enzyme and pathway databases

ReactomeiR-HSA-5687128 MAPK6/MAPK4 signaling

Miscellaneous databases

ChiTaRSiCDC42EP5 human
GenomeRNAii148170
PROiPR:Q6NZY7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167617 Expressed in 165 organ(s), highest expression level in colonic mucosa
CleanExiHS_CDC42EP5
GenevisibleiQ6NZY7 HS

Family and domain databases

InterProiView protein in InterPro
IPR029273 Cdc42_effect
IPR000095 CRIB_dom
PfamiView protein in Pfam
PF14957 BORG_CEP, 1 hit
PF00786 PBD, 1 hit
SMARTiView protein in SMART
SM00285 PBD, 1 hit
PROSITEiView protein in PROSITE
PS50108 CRIB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBORG3_HUMAN
AccessioniPrimary (citable) accession number: Q6NZY7
Secondary accession number(s): B0VJZ2, Q8TB51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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