UniProtKB - Q6NZY7 (BORG3_HUMAN)
Protein
Cdc42 effector protein 5
Gene
CDC42EP5
Organism
Homo sapiens (Human)
Status
Functioni
Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42 (By similarity).By similarity
GO - Molecular functioni
- GTP-Rho binding Source: UniProtKB
GO - Biological processi
- JNK cascade Source: Ensembl
- positive regulation of actin filament polymerization Source: UniProtKB
- positive regulation of pseudopodium assembly Source: UniProtKB
- regulation of cell shape Source: UniProtKB
- Rho protein signal transduction Source: GO_Central
Keywordsi
Biological process | Cell shape |
Enzyme and pathway databases
PathwayCommonsi | Q6NZY7 |
Reactomei | R-HSA-5687128, MAPK6/MAPK4 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Cdc42 effector protein 5Alternative name(s): Binder of Rho GTPases 3 |
Gene namesi | Name:CDC42EP5 Synonyms:BORG3, CEP5 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000167617.2 |
HGNCi | HGNC:17408, CDC42EP5 |
MIMi | 609171, gene |
neXtProti | NX_Q6NZY7 |
Subcellular locationi
Cytoskeleton
- cytoskeleton By similarity
Other locations
- Endomembrane system By similarity; Peripheral membrane protein By similarity
Cytoskeleton
- cytoskeleton Source: GO_Central
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: UniProtKB
- endomembrane system Source: UniProtKB-SubCell
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 148170 |
OpenTargetsi | ENSG00000167617 |
PharmGKBi | PA134989100 |
Miscellaneous databases
Pharosi | Q6NZY7, Tbio |
Polymorphism and mutation databases
BioMutai | CDC42EP5 |
DMDMi | 71152342 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212653 | 1 – 148 | Cdc42 effector protein 5Add BLAST | 148 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 38 | Omega-N-methylarginineBy similarity | 1 |
Keywords - PTMi
MethylationProteomic databases
jPOSTi | Q6NZY7 |
MassIVEi | Q6NZY7 |
MaxQBi | Q6NZY7 |
PaxDbi | Q6NZY7 |
PeptideAtlasi | Q6NZY7 |
PRIDEi | Q6NZY7 |
ProteomicsDBi | 66800 |
PTM databases
iPTMneti | Q6NZY7 |
PhosphoSitePlusi | Q6NZY7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167617, Expressed in colonic mucosa and 179 other tissues |
Genevisiblei | Q6NZY7, HS |
Organism-specific databases
HPAi | ENSG00000167617, Tissue enhanced (intestine) |
Interactioni
Subunit structurei
Interacts with CDC42, in a GTP-dependent manner, and with SEPT7.
By similarityGO - Molecular functioni
- GTP-Rho binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 127125, 5 interactors |
IntActi | Q6NZY7, 1 interactor |
STRINGi | 9606.ENSP00000301200 |
Miscellaneous databases
RNActi | Q6NZY7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 37 | CRIBPROSITE-ProRule annotationAdd BLAST | 15 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 56 – 87 | Pro-richAdd BLAST | 32 | |
Compositional biasi | 114 – 117 | Poly-Ala | 4 |
Domaini
The CRIB domain mediates interaction with CDC42.By similarity
Sequence similaritiesi
Belongs to the BORG/CEP family.Curated
Phylogenomic databases
eggNOGi | ENOG502S9WH, Eukaryota |
GeneTreei | ENSGT00940000162969 |
HOGENOMi | CLU_067835_1_0_1 |
InParanoidi | Q6NZY7 |
OMAi | QHPRARC |
OrthoDBi | 1500881at2759 |
PhylomeDBi | Q6NZY7 |
TreeFami | TF331725 |
Family and domain databases
InterProi | View protein in InterPro IPR029273, Cdc42_effect IPR000095, CRIB_dom |
Pfami | View protein in Pfam PF14957, BORG_CEP, 1 hit PF00786, PBD, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6NZY7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPVLKQLGPA QPKKRPDRGA LSISAPLGDF RHTLHVGRGG DAFGDTSFLS
60 70 80 90 100
RHGGGPPPEP RAPPAGAPRS PPPPAVPQSA APSPADPLLS FHLDLGPSML
110 120 130 140
DAVLGVMDAA RPEAAAAKPD AEPRPGTQPP QARCRPNADL ELNDVIGL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JPE9 | A0A0G2JPE9_HUMAN | Cdc42 effector protein 5 | CDC42EP5 | 17 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 59 | E → Q in AAH24327 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU467002 Genomic DNA No translation available. CU207370 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72252.1 BC024327 mRNA Translation: AAH24327.1 BC065910 mRNA Translation: AAH65910.1 |
CCDSi | CCDS12896.1 |
RefSeqi | NP_659494.2, NM_145057.3 |
Genome annotation databases
Ensembli | ENST00000301200; ENSP00000301200; ENSG00000167617 ENST00000611094; ENSP00000484985; ENSG00000273622 ENST00000617756; ENSP00000484158; ENSG00000273633 ENST00000619217; ENSP00000479726; ENSG00000278444 |
GeneIDi | 148170 |
KEGGi | hsa:148170 |
UCSCi | uc002qfz.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CU467002 Genomic DNA No translation available. CU207370 Genomic DNA No translation available. CH471135 Genomic DNA Translation: EAW72252.1 BC024327 mRNA Translation: AAH24327.1 BC065910 mRNA Translation: AAH65910.1 |
CCDSi | CCDS12896.1 |
RefSeqi | NP_659494.2, NM_145057.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 127125, 5 interactors |
IntActi | Q6NZY7, 1 interactor |
STRINGi | 9606.ENSP00000301200 |
PTM databases
iPTMneti | Q6NZY7 |
PhosphoSitePlusi | Q6NZY7 |
Polymorphism and mutation databases
BioMutai | CDC42EP5 |
DMDMi | 71152342 |
Proteomic databases
jPOSTi | Q6NZY7 |
MassIVEi | Q6NZY7 |
MaxQBi | Q6NZY7 |
PaxDbi | Q6NZY7 |
PeptideAtlasi | Q6NZY7 |
PRIDEi | Q6NZY7 |
ProteomicsDBi | 66800 |
Protocols and materials databases
Antibodypediai | 50438, 73 antibodies |
Genome annotation databases
Ensembli | ENST00000301200; ENSP00000301200; ENSG00000167617 ENST00000611094; ENSP00000484985; ENSG00000273622 ENST00000617756; ENSP00000484158; ENSG00000273633 ENST00000619217; ENSP00000479726; ENSG00000278444 |
GeneIDi | 148170 |
KEGGi | hsa:148170 |
UCSCi | uc002qfz.3, human |
Organism-specific databases
CTDi | 148170 |
DisGeNETi | 148170 |
EuPathDBi | HostDB:ENSG00000167617.2 |
GeneCardsi | CDC42EP5 |
HGNCi | HGNC:17408, CDC42EP5 |
HPAi | ENSG00000167617, Tissue enhanced (intestine) |
MIMi | 609171, gene |
neXtProti | NX_Q6NZY7 |
OpenTargetsi | ENSG00000167617 |
PharmGKBi | PA134989100 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S9WH, Eukaryota |
GeneTreei | ENSGT00940000162969 |
HOGENOMi | CLU_067835_1_0_1 |
InParanoidi | Q6NZY7 |
OMAi | QHPRARC |
OrthoDBi | 1500881at2759 |
PhylomeDBi | Q6NZY7 |
TreeFami | TF331725 |
Enzyme and pathway databases
PathwayCommonsi | Q6NZY7 |
Reactomei | R-HSA-5687128, MAPK6/MAPK4 signaling |
Miscellaneous databases
BioGRID-ORCSi | 148170, 5 hits in 841 CRISPR screens |
ChiTaRSi | CDC42EP5, human |
GenomeRNAii | 148170 |
Pharosi | Q6NZY7, Tbio |
PROi | PR:Q6NZY7 |
RNActi | Q6NZY7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000167617, Expressed in colonic mucosa and 179 other tissues |
Genevisiblei | Q6NZY7, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029273, Cdc42_effect IPR000095, CRIB_dom |
Pfami | View protein in Pfam PF14957, BORG_CEP, 1 hit PF00786, PBD, 1 hit |
SMARTi | View protein in SMART SM00285, PBD, 1 hit |
PROSITEi | View protein in PROSITE PS50108, CRIB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BORG3_HUMAN | |
Accessioni | Q6NZY7Primary (citable) accession number: Q6NZY7 Secondary accession number(s): B0VJZ2, Q8TB51 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 19, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM