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UniProtKB - Q6NZQ6 (ZN740_MOUSE)
Protein
Zinc finger protein 740
Gene
Znf740
Organism
Mus musculus (Mouse)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 88 – 110 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 116 – 138 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 144 – 166 | C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 740 |
Gene namesi | Name:Znf740 Synonyms:Zfp740 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915994, Zfp740 |
VEuPathDBi | HostDB:ENSMUSG00000046897 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000251402 | 1 – 180 | Zinc finger protein 740Add BLAST | 180 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 9 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 19 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q6NZQ6 |
jPOSTi | Q6NZQ6 |
MaxQBi | Q6NZQ6 |
PaxDbi | Q6NZQ6 |
PeptideAtlasi | Q6NZQ6 |
PRIDEi | Q6NZQ6 |
ProteomicsDBi | 302143 [Q6NZQ6-1] 302144 [Q6NZQ6-2] 302145 [Q6NZQ6-3] |
PTM databases
iPTMneti | Q6NZQ6 |
PhosphoSitePlusi | Q6NZQ6 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000046897, Expressed in intestine and 323 other tissues |
ExpressionAtlasi | Q6NZQ6, baseline and differential |
Genevisiblei | Q6NZQ6, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000113770 |
Miscellaneous databases
RNActi | Q6NZQ6, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 62 | DisorderedSequence analysisAdd BLAST | 62 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 35 – 62 | Basic and acidic residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 88 – 110 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 116 – 138 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 144 – 166 | C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159609 |
HOGENOMi | CLU_093195_0_0_1 |
InParanoidi | Q6NZQ6 |
OMAi | QCERCLQ |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6NZQ6 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6NZQ6-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMLSQIASKQ AENGERAGSP DVLRCSSQMD CKPRFDLSSK GHRKDSDKSR
60 70 80 90 100
NRKEDDSLAE ASHSKKTVKK VVVVEQNGSF QVKIPKNFIC EHCFGAFRSS
110 120 130 140 150
YHLKRHVLIH TGEKPFECDV CDMRFIQKYH LERHKRVHSG EKPYQCERCH
160 170 180
QCFSRTDRLL RHKRMCQGCQ SKTSEGQFSL
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z4A3 | D3Z4A3_MOUSE | Zinc finger protein 740 | Zfp740 | 191 | Annotation score: | ||
D3Z4S9 | D3Z4S9_MOUSE | Zinc finger protein 740 | Zfp740 | 144 | Annotation score: | ||
D3Z6P2 | D3Z6P2_MOUSE | Zinc finger protein 740 | Zfp740 | 107 | Annotation score: | ||
D3Z606 | D3Z606_MOUSE | Zinc finger protein 740 | Zfp740 | 74 | Annotation score: | ||
A0A2R8VK26 | A0A2R8VK26_MOUSE | Zinc finger protein 740 | Zfp740 | 79 | Annotation score: | ||
A0A2R8W747 | A0A2R8W747_MOUSE | Zinc finger protein 740 | Zfp740 | 143 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 8 | S → T in BAE26025 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 154 | S → P in BAE26025 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020756 | 1 – 63 | Missing in isoform 3. 1 PublicationAdd BLAST | 63 | |
Alternative sequenceiVSP_020757 | 29 – 40 | Missing in isoform 2. 1 PublicationAdd BLAST | 12 | |
Alternative sequenceiVSP_020758 | 64 – 70 | SKKTVKK → MPDCCPQ in isoform 3. 1 Publication | 7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK144707 mRNA Translation: BAE26025.1 BC030410 mRNA Translation: AAH30410.1 BC066011 mRNA Translation: AAH66011.1 |
CCDSi | CCDS70672.1 [Q6NZQ6-1] CCDS79416.1 [Q6NZQ6-2] |
RefSeqi | NP_001276620.1, NM_001289691.1 [Q6NZQ6-2] NP_001276624.1, NM_001289695.1 [Q6NZQ6-1] XP_006521399.1, XM_006521336.2 [Q6NZQ6-2] XP_011244021.1, XM_011245719.1 XP_017172230.1, XM_017316741.1 [Q6NZQ6-1] |
Genome annotation databases
Ensembli | ENSMUST00000118729; ENSMUSP00000112985; ENSMUSG00000046897 [Q6NZQ6-2] ENSMUST00000119800; ENSMUSP00000113770; ENSMUSG00000046897 [Q6NZQ6-1] |
GeneIDi | 68744 |
KEGGi | mmu:68744 |
UCSCi | uc007xuw.2, mouse [Q6NZQ6-2] uc007xuz.2, mouse [Q6NZQ6-1] uc007xva.2, mouse [Q6NZQ6-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK144707 mRNA Translation: BAE26025.1 BC030410 mRNA Translation: AAH30410.1 BC066011 mRNA Translation: AAH66011.1 |
CCDSi | CCDS70672.1 [Q6NZQ6-1] CCDS79416.1 [Q6NZQ6-2] |
RefSeqi | NP_001276620.1, NM_001289691.1 [Q6NZQ6-2] NP_001276624.1, NM_001289695.1 [Q6NZQ6-1] XP_006521399.1, XM_006521336.2 [Q6NZQ6-2] XP_011244021.1, XM_011245719.1 XP_017172230.1, XM_017316741.1 [Q6NZQ6-1] |
3D structure databases
AlphaFoldDBi | Q6NZQ6 |
SMRi | Q6NZQ6 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000113770 |
PTM databases
iPTMneti | Q6NZQ6 |
PhosphoSitePlusi | Q6NZQ6 |
Proteomic databases
EPDi | Q6NZQ6 |
jPOSTi | Q6NZQ6 |
MaxQBi | Q6NZQ6 |
PaxDbi | Q6NZQ6 |
PeptideAtlasi | Q6NZQ6 |
PRIDEi | Q6NZQ6 |
ProteomicsDBi | 302143 [Q6NZQ6-1] 302144 [Q6NZQ6-2] 302145 [Q6NZQ6-3] |
Protocols and materials databases
Antibodypediai | 48331, 57 antibodies from 15 providers |
DNASUi | 68744 |
Genome annotation databases
Ensembli | ENSMUST00000118729; ENSMUSP00000112985; ENSMUSG00000046897 [Q6NZQ6-2] ENSMUST00000119800; ENSMUSP00000113770; ENSMUSG00000046897 [Q6NZQ6-1] |
GeneIDi | 68744 |
KEGGi | mmu:68744 |
UCSCi | uc007xuw.2, mouse [Q6NZQ6-2] uc007xuz.2, mouse [Q6NZQ6-1] uc007xva.2, mouse [Q6NZQ6-3] |
Organism-specific databases
CTDi | 68744 |
MGIi | MGI:1915994, Zfp740 |
VEuPathDBi | HostDB:ENSMUSG00000046897 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000159609 |
HOGENOMi | CLU_093195_0_0_1 |
InParanoidi | Q6NZQ6 |
OMAi | QCERCLQ |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6NZQ6 |
Enzyme and pathway databases
Reactomei | R-MMU-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 68744, 3 hits in 72 CRISPR screens |
ChiTaRSi | Zfp740, mouse |
PROi | PR:Q6NZQ6 |
RNActi | Q6NZQ6, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000046897, Expressed in intestine and 323 other tissues |
ExpressionAtlasi | Q6NZQ6, baseline and differential |
Genevisiblei | Q6NZQ6, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 1 hit |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 2 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN740_MOUSE | |
Accessioni | Q6NZQ6Primary (citable) accession number: Q6NZQ6 Secondary accession number(s): Q3UMS3, Q8JZR3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families