Znf740

Functionⁱ

May be involved in transcriptional regulation.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	88 – 110	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	116 – 138	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	144 – 166	C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
metal ion binding Source: UniProtKB-KW
transcription regulatory region DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger protein 740
Gene namesⁱ	Name:Znf740 Synonyms:Zfp740
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:1915994 Zfp740

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000251402	1 – 180	Zinc finger protein 740Add BLAST		180

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	9	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	19	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q6NZQ6
PeptideAtlas More...PeptideAtlasⁱ	Q6NZQ6
PRIDEⁱ	Q6NZQ6

PTM databases

iPTMnetⁱ	Q6NZQ6
PhosphoSitePlusⁱ	Q6NZQ6

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000046897 Expressed in 301 organ(s), highest expression level in retina
CleanExⁱ	MM_ZFP740
ExpressionAtlasⁱ	Q6NZQ6 baseline and differential
Genevisibleⁱ	Q6NZQ6 MM

Interactionⁱ

Protein-protein interaction databases

IntActⁱ	Q6NZQ6, 1 interactor
Molecular INTeraction database More...MINTⁱ	Q6NZQ6
STRINGⁱ	10090.ENSMUSP00000113281

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6NZQ6
SMRⁱ	Q6NZQ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	88 – 110	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	116 – 138	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	144 – 166	C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063238
HOGENOMⁱ	HOG000013198
HOVERGENⁱ	HBG061583
InParanoidⁱ	Q6NZQ6
OMAⁱ	EPSHSKK
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L6G
PhylomeDBⁱ	Q6NZQ6

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 2 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6NZQ6-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMLSQIASKQ AENGERAGSP DVLRCSSQMD CKPRFDLSSK GHRKDSDKSR 
        60         70         80         90        100
NRKEDDSLAE ASHSKKTVKK VVVVEQNGSF QVKIPKNFIC EHCFGAFRSS 
       110        120        130        140        150
YHLKRHVLIH TGEKPFECDV CDMRFIQKYH LERHKRVHSG EKPYQCERCH 
       160        170        180
QCFSRTDRLL RHKRMCQGCQ SKTSEGQFSL

Length:180

Mass (Da):20,892

Last modified:July 5, 2004 - v1

Checksum:ⁱDE801DFFC2C98BCE

GO

Isoform 2 (identifier: Q6NZQ6-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
29-40: Missing.

« Hide

        10         20         30         40         50
MMLSQIASKQ AENGERAGSP DVLRCSSQGH RKDSDKSRNR KEDDSLAEAS 
        60         70         80         90        100
HSKKTVKKVV VVEQNGSFQV KIPKNFICEH CFGAFRSSYH LKRHVLIHTG 
       110        120        130        140        150
EKPFECDVCD MRFIQKYHLE RHKRVHSGEK PYQCERCHQC FSRTDRLLRH 
       160 
KRMCQGCQSK TSEGQFSL

Note: No experimental confirmation available.

Show »

Length:168

Mass (Da):19,483

Checksum:ⁱ44736030DC093ACE

GO

Isoform 3 (identifier: Q6NZQ6-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-63: Missing.
64-70: SKKTVKK → MPDCCPQ

« Hide

        10         20         30         40         50
MPDCCPQVVV VEQNGSFQVK IPKNFICEHC FGAFRSSYHL KRHVLIHTGE 
        60         70         80         90        100
KPFECDVCDM RFIQKYHLER HKRVHSGEKP YQCERCHQCF SRTDRLLRHK 
       110 
RMCQGCQSKT SEGQFSL

Note: No experimental confirmation available.

Show »

Length:117

Mass (Da):13,861

Checksum:ⁱB53A582BA3518277

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3Z4A3	D3Z4A3_MOUSE	Zinc finger protein 740 Zinc finger protein 740	Zfp740	191	Annotation score:
A0A2R8W747	A0A2R8W747_MOUSE	Zinc finger protein 740 Zinc finger protein 740	Zfp740	143	Annotation score:
D3Z4S9	D3Z4S9_MOUSE	Zinc finger protein 740 Zinc finger protein 740	Zfp740	144	Annotation score:
D3Z6P2	D3Z6P2_MOUSE	Zinc finger protein 740 Zinc finger protein 740	Zfp740	107	Annotation score:
D3Z606	D3Z606_MOUSE	Zinc finger protein 740 Zinc finger protein 740	Zfp740	74	Annotation score:
A0A2R8VK26	A0A2R8VK26_MOUSE	Zinc finger protein 740 Zinc finger protein 740	Zfp740	79	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	8	S → T in BAE26025 (PubMed:16141072).Curated		1
Sequence conflictⁱ	154	S → P in BAE26025 (PubMed:16141072).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_020756	1 – 63	Missing in isoform 3. 1 PublicationAdd BLAST	63
Alternative sequenceⁱVSP_020757	29 – 40	Missing in isoform 2. 1 PublicationAdd BLAST	12
Alternative sequenceⁱVSP_020758	64 – 70	SKKTVKK → MPDCCPQ in isoform 3. 1 Publication	7

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK144707 mRNA Translation: BAE26025.1 BC030410 mRNA Translation: AAH30410.1 BC066011 mRNA Translation: AAH66011.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS70672.1 [Q6NZQ6-1] CCDS79416.1 [Q6NZQ6-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001276620.1, NM_001289691.1 [Q6NZQ6-2] NP_001276624.1, NM_001289695.1 [Q6NZQ6-1] XP_006521399.1, XM_006521336.2 [Q6NZQ6-2] XP_011244021.1, XM_011245719.1 [Q6NZQ6-1] XP_017172230.1, XM_017316741.1 [Q6NZQ6-1]
UniGeneⁱ	Mm.352945

Genome annotation databases

Ensemblⁱ	ENSMUST00000118729; ENSMUSP00000112985; ENSMUSG00000046897 [Q6NZQ6-2] ENSMUST00000119800; ENSMUSP00000113770; ENSMUSG00000046897 [Q6NZQ6-1]
GeneIDⁱ	68744
KEGGⁱ	mmu:68744
UCSC genome browser More...UCSCⁱ	uc007xuw.2 mouse [Q6NZQ6-2] uc007xuz.2 mouse [Q6NZQ6-1] uc007xva.2 mouse [Q6NZQ6-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6NZQ6	Zinc finger protein 740 (Fragment)		MOUSE		191	UniRef100_Q6NZQ6
Zinc finger protein 740 (Fragment)		MOUSE		107
Zinc finger protein 740 (Fragment)		MOUSE		74
UPI00001E9F58		MOUSE		205

Protein	Similar proteins		Species	Score	Length	Source
Q6NZQ6	Zinc finger protein 740 (Fragment)		MOUSE		191	UniRef90_Q6NZQ6
UPI000A305C4A		MUSPA		205
UPI00064C1030		OCHPR		180
UPI0006B3E309		CANLF		165
Zinc finger protein 740 (Fragment)		MOUSE		107
+4
Q6NZQ6-2	Zinc finger protein 740		HUMAN		193	UniRef90_Q6NZQ6-2
Zinc finger protein 740		MYOBR		207
Uncharacterized protein		NOMLE		205
Zinc finger protein 740		RAT		205
zinc finger protein 740 isoform X1		Yangtze finless porpoise		204
+159

Protein	Similar proteins		Species	Score	Length	Source
Q6NZQ6	Zinc finger protein 740		HUMAN		193	UniRef50_Q6NZQ6
Zinc finger protein 740 (Fragment)		MOUSE		191
zinc finger protein 740 isoform X1		URSMA		241
Zinc finger protein 740 (Fragment)		NEOVI		128
Zinc finger protein 740		MUSPF		197
+253
Q6NZQ6-3	Zinc finger protein 740a		DANRE		115	UniRef50_Q6NZQ6-3
UPI0008FA6AF9		CYPCA		135

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK144707 mRNA Translation: BAE26025.1 BC030410 mRNA Translation: AAH30410.1 BC066011 mRNA Translation: AAH66011.1
CCDSⁱ	CCDS70672.1 [Q6NZQ6-1] CCDS79416.1 [Q6NZQ6-2]
RefSeqⁱ	NP_001276620.1, NM_001289691.1 [Q6NZQ6-2] NP_001276624.1, NM_001289695.1 [Q6NZQ6-1] XP_006521399.1, XM_006521336.2 [Q6NZQ6-2] XP_011244021.1, XM_011245719.1 [Q6NZQ6-1] XP_017172230.1, XM_017316741.1 [Q6NZQ6-1]
UniGeneⁱ	Mm.352945

3D structure databases

ProteinModelPortalⁱ	Q6NZQ6
SMRⁱ	Q6NZQ6
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q6NZQ6, 1 interactor
MINTⁱ	Q6NZQ6
STRINGⁱ	10090.ENSMUSP00000113281

PTM databases

iPTMnetⁱ	Q6NZQ6
PhosphoSitePlusⁱ	Q6NZQ6

Proteomic databases

PaxDbⁱ	Q6NZQ6
PeptideAtlasⁱ	Q6NZQ6
PRIDEⁱ	Q6NZQ6

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000118729; ENSMUSP00000112985; ENSMUSG00000046897 [Q6NZQ6-2] ENSMUST00000119800; ENSMUSP00000113770; ENSMUSG00000046897 [Q6NZQ6-1]
GeneIDⁱ	68744
KEGGⁱ	mmu:68744
UCSCⁱ	uc007xuw.2 mouse [Q6NZQ6-2] uc007xuz.2 mouse [Q6NZQ6-1] uc007xva.2 mouse [Q6NZQ6-3]

Organism-specific databases

CTDⁱ	68744
MGIⁱ	MGI:1915994 Zfp740

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00530000063238
HOGENOMⁱ	HOG000013198
HOVERGENⁱ	HBG061583
InParanoidⁱ	Q6NZQ6
OMAⁱ	EPSHSKK
OrthoDBⁱ	EOG091G0L6G
PhylomeDBⁱ	Q6NZQ6

Enzyme and pathway databases

Reactomeⁱ	R-MMU-212436 Generic Transcription Pathway

Reactomeⁱ

R-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSⁱ	Zfp740 mouse
Protein Ontology More...PROⁱ	PR:Q6NZQ6
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000046897 Expressed in 301 organ(s), highest expression level in retina
CleanExⁱ	MM_ZFP740
ExpressionAtlasⁱ	Q6NZQ6 baseline and differential
Genevisibleⁱ	Q6NZQ6 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00096 zf-C2H2, 1 hit
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 2 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZN740_MOUSE
Accessionⁱ	Q6NZQ6Primary (citable) accession number: Q6NZQ6 Secondary accession number(s): Q3UMS3, Q8JZR3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
	Last sequence update:	July 5, 2004
	Last modified:	November 7, 2018
	This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6NZQ6 (ZN740_MOUSE)

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Zinc finger protein 740

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ