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Protein

Zinc finger protein 740

Gene

Znf740

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 110C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri116 – 138C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri144 – 166C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA-binding transcription factor activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • transcription regulatory region DNA binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 740
Gene namesi
Name:Znf740
Synonyms:Zfp740
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1915994 Zfp740

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514021 – 180Zinc finger protein 740Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki9Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei19PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6NZQ6
PeptideAtlasiQ6NZQ6
PRIDEiQ6NZQ6

PTM databases

iPTMnetiQ6NZQ6
PhosphoSitePlusiQ6NZQ6

Expressioni

Gene expression databases

BgeeiENSMUSG00000046897 Expressed in 301 organ(s), highest expression level in retina
CleanExiMM_ZFP740
ExpressionAtlasiQ6NZQ6 baseline and differential
GenevisibleiQ6NZQ6 MM

Interactioni

Protein-protein interaction databases

IntActiQ6NZQ6, 1 interactor
MINTiQ6NZQ6
STRINGi10090.ENSMUSP00000113281

Structurei

3D structure databases

ProteinModelPortaliQ6NZQ6
SMRiQ6NZQ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri88 – 110C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri116 – 138C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri144 – 166C2H2-type 3; atypicalPROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063238
HOGENOMiHOG000013198
HOVERGENiHBG061583
InParanoidiQ6NZQ6
OMAiEPSHSKK
OrthoDBiEOG091G0L6G
PhylomeDBiQ6NZQ6

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NZQ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMLSQIASKQ AENGERAGSP DVLRCSSQMD CKPRFDLSSK GHRKDSDKSR
60 70 80 90 100
NRKEDDSLAE ASHSKKTVKK VVVVEQNGSF QVKIPKNFIC EHCFGAFRSS
110 120 130 140 150
YHLKRHVLIH TGEKPFECDV CDMRFIQKYH LERHKRVHSG EKPYQCERCH
160 170 180
QCFSRTDRLL RHKRMCQGCQ SKTSEGQFSL
Length:180
Mass (Da):20,892
Last modified:July 5, 2004 - v1
Checksum:iDE801DFFC2C98BCE
GO
Isoform 2 (identifier: Q6NZQ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-40: Missing.

Note: No experimental confirmation available.
Show »
Length:168
Mass (Da):19,483
Checksum:i44736030DC093ACE
GO
Isoform 3 (identifier: Q6NZQ6-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-63: Missing.
     64-70: SKKTVKK → MPDCCPQ

Note: No experimental confirmation available.
Show »
Length:117
Mass (Da):13,861
Checksum:iB53A582BA3518277
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z4A3D3Z4A3_MOUSE
Zinc finger protein 740
Zfp740
191Annotation score:
A0A2R8W747A0A2R8W747_MOUSE
Zinc finger protein 740
Zfp740
143Annotation score:
D3Z4S9D3Z4S9_MOUSE
Zinc finger protein 740
Zfp740
144Annotation score:
D3Z6P2D3Z6P2_MOUSE
Zinc finger protein 740
Zfp740
107Annotation score:
D3Z606D3Z606_MOUSE
Zinc finger protein 740
Zfp740
74Annotation score:
A0A2R8VK26A0A2R8VK26_MOUSE
Zinc finger protein 740
Zfp740
79Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8S → T in BAE26025 (PubMed:16141072).Curated1
Sequence conflicti154S → P in BAE26025 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0207561 – 63Missing in isoform 3. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_02075729 – 40Missing in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_02075864 – 70SKKTVKK → MPDCCPQ in isoform 3. 1 Publication7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144707 mRNA Translation: BAE26025.1
BC030410 mRNA Translation: AAH30410.1
BC066011 mRNA Translation: AAH66011.1
CCDSiCCDS70672.1 [Q6NZQ6-1]
CCDS79416.1 [Q6NZQ6-2]
RefSeqiNP_001276620.1, NM_001289691.1 [Q6NZQ6-2]
NP_001276624.1, NM_001289695.1 [Q6NZQ6-1]
XP_006521399.1, XM_006521336.2 [Q6NZQ6-2]
XP_011244021.1, XM_011245719.1 [Q6NZQ6-1]
XP_017172230.1, XM_017316741.1 [Q6NZQ6-1]
UniGeneiMm.352945

Genome annotation databases

EnsembliENSMUST00000118729; ENSMUSP00000112985; ENSMUSG00000046897 [Q6NZQ6-2]
ENSMUST00000119800; ENSMUSP00000113770; ENSMUSG00000046897 [Q6NZQ6-1]
GeneIDi68744
KEGGimmu:68744
UCSCiuc007xuw.2 mouse [Q6NZQ6-2]
uc007xuz.2 mouse [Q6NZQ6-1]
uc007xva.2 mouse [Q6NZQ6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144707 mRNA Translation: BAE26025.1
BC030410 mRNA Translation: AAH30410.1
BC066011 mRNA Translation: AAH66011.1
CCDSiCCDS70672.1 [Q6NZQ6-1]
CCDS79416.1 [Q6NZQ6-2]
RefSeqiNP_001276620.1, NM_001289691.1 [Q6NZQ6-2]
NP_001276624.1, NM_001289695.1 [Q6NZQ6-1]
XP_006521399.1, XM_006521336.2 [Q6NZQ6-2]
XP_011244021.1, XM_011245719.1 [Q6NZQ6-1]
XP_017172230.1, XM_017316741.1 [Q6NZQ6-1]
UniGeneiMm.352945

3D structure databases

ProteinModelPortaliQ6NZQ6
SMRiQ6NZQ6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6NZQ6, 1 interactor
MINTiQ6NZQ6
STRINGi10090.ENSMUSP00000113281

PTM databases

iPTMnetiQ6NZQ6
PhosphoSitePlusiQ6NZQ6

Proteomic databases

PaxDbiQ6NZQ6
PeptideAtlasiQ6NZQ6
PRIDEiQ6NZQ6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000118729; ENSMUSP00000112985; ENSMUSG00000046897 [Q6NZQ6-2]
ENSMUST00000119800; ENSMUSP00000113770; ENSMUSG00000046897 [Q6NZQ6-1]
GeneIDi68744
KEGGimmu:68744
UCSCiuc007xuw.2 mouse [Q6NZQ6-2]
uc007xuz.2 mouse [Q6NZQ6-1]
uc007xva.2 mouse [Q6NZQ6-3]

Organism-specific databases

CTDi68744
MGIiMGI:1915994 Zfp740

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063238
HOGENOMiHOG000013198
HOVERGENiHBG061583
InParanoidiQ6NZQ6
OMAiEPSHSKK
OrthoDBiEOG091G0L6G
PhylomeDBiQ6NZQ6

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZfp740 mouse
PROiPR:Q6NZQ6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046897 Expressed in 301 organ(s), highest expression level in retina
CleanExiMM_ZFP740
ExpressionAtlasiQ6NZQ6 baseline and differential
GenevisibleiQ6NZQ6 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 1 hit
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN740_MOUSE
AccessioniPrimary (citable) accession number: Q6NZQ6
Secondary accession number(s): Q3UMS3, Q8JZR3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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