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Entry version 129 (23 Feb 2022)
Sequence version 1 (05 Jul 2004)
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Protein

DNA annealing helicase and endonuclease ZRANB3

Gene

Zranb3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events. Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase. In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks.

By similarity

Miscellaneous

In contrast to classical helicases that unwing DNA, annealing helicases rewind it.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi59 – 66ATPPROSITE-ProRule annotation8
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri617 – 646RanBP2-typePROSITE-ProRule annotationAdd BLAST30

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Helicase, Hydrolase, Multifunctional enzyme, Nuclease
Biological processDNA damage, DNA repair
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA annealing helicase and endonuclease ZRANB3
Alternative name(s):
Annealing helicase 2
Short name:
AH2
Zinc finger Ran-binding domain-containing protein 3
Including the following 2 domains:
DNA annealing helicase ZRANB3 (EC:3.6.4.-)
Endonuclease ZRANB3 (EC:3.1.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zranb3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918362, Zranb3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000036086

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002781831 – 1069DNA annealing helicase and endonuclease ZRANB3Add BLAST1069

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NZP1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NZP1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NZP1

PeptideAtlas

More...
PeptideAtlasi
Q6NZP1

PRoteomics IDEntifications database

More...
PRIDEi
Q6NZP1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
275160

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NZP1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NZP1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036086, Expressed in dorsal pancreas and 205 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NZP1, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via PIP-box and RanBP2-type zinc finger) with PCNA (when PCNA is polyubiquitinated via 'Lys-63'-linked polyubiquitin).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
230505, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000083806

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6NZP1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NZP1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 208Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST163
Domaini325 – 485Helicase C-terminalPROSITE-ProRule annotationAdd BLAST161
Domaini1001 – 1041HNHAdd BLAST41

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 481DNA annealing helicase activityBy similarityAdd BLAST436
Regioni648 – 720DisorderedSequence analysisAdd BLAST73
Regioni1001 – 1069Endonuclease activityBy similarityAdd BLAST69

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi157 – 160DEAH box4
Motifi518 – 525PIP-box8
Motifi1064 – 1068APIM motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi651 – 667Basic and acidic residuesSequence analysisAdd BLAST17
Compositional biasi677 – 703Basic and acidic residuesSequence analysisAdd BLAST27

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The PIP-box mediates the interaction with PCNA, while the RanBP2-type zinc finger mediates binding to 'Lys-63'-linked polyubiquitin.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SNF2/RAD54 helicase family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri617 – 646RanBP2-typePROSITE-ProRule annotationAdd BLAST30

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1000, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158559

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004251_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NZP1

Identification of Orthologs from Complete Genome Data

More...
OMAi
PGFSEWF

Database of Orthologous Groups

More...
OrthoDBi
1082831at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NZP1

TreeFam database of animal gene trees

More...
TreeFami
TF354227

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00085, HNHc, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.10810, 1 hit
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR002711, HNH
IPR003615, HNH_nuc
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00271, Helicase_C, 1 hit
PF01844, HNH, 1 hit
PF00176, SNF2-rel_dom, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00507, HNHc, 1 hit
SM00547, ZnF_RBZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits
SSF90209, SSF90209, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS01358, ZF_RANBP2_1, 1 hit
PS50199, ZF_RANBP2_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6NZP1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTAGSKKKA PTPQISCLTS ESYTQLDFLP DKLRTKLLPF QKDGIVFALR
60 70 80 90 100
RDGRCMVADE MGLGKTIQAI AIAYFYKEEW PLLIVVPSSL RYPWIEELEK
110 120 130 140 150
WIPELEPEEI NVVMNKTDIG RIPGSRVTVL GYGLLTTDAE TLLDALNTQN
160 170 180 190 200
FRVVIVDESH YMKSRTAARS KILLPMVQKA RRAILLTGTP ALGRPEELFM
210 220 230 240 250
QIEALFPQKF GTWIEYAKRY CNAHVRYFGK RRQWDCRGAS NLSELHQLLN
260 270 280 290 300
DIMIRRLKSE VLSQLPPKVR QRIPFDLPPA AVKELNASFE EWQKLMRAPN
310 320 330 340 350
SGAMETVMGL ITRMFKQTAI AKAGAVKDYI KMLLQNDSLK FLVFAHHLSM
360 370 380 390 400
LQACTEAVIE SKSRYIRIDG SVPSSERIHL VNQFQKDPDT RVAILSIQAA
410 420 430 440 450
GQGLTFTAAS HVVFAELYWD PGHIKQAEDR AHRIGQCSSV NIHYLIANGT
460 470 480 490 500
LDSLMWAMLN RKAQVTGSTL NGRKEKLQAT EDDKEKWGFL QFAEAWTPSD
510 520 530 540 550
SFEELKDSVF THFEKEKQHD IRSFFLPKLK KRQLETTCDD PEAFKEKITV
560 570 580 590 600
ASDPRKMATS DSTADKNGCE PEAKRLKSLS TEDHSSALEE GPSLQARATS
610 620 630 640 650
MEVVHEVKPP LASPALPEKG WQCGFCTFLN NPGLPYCEMC ENPRSRAAGR
660 670 680 690 700
NHLQDNNKND EDAAQESTSK SDQAGLECER QCPERLEAEQ SANSKEEALE
710 720 730 740 750
GGGEDRLPSQ PEIGQLNNSG TLPVRETFMF CASRNTDRIH LYTKDGKPMN
760 770 780 790 800
CNFIPLDIKL DLWEDLPATF QLKQNRSLIL RFVREWSSLT AMKQRVLRKS
810 820 830 840 850
GQLFCSPLLA SEEITKQQAK ENNTRRYITK EDVAKASMNK VKSDGGHIRL
860 870 880 890 900
ITKESMTQDS SLKKIDSACV PSLNPCPADL TVEPSPSKGY IQAVDKEGRP
910 920 930 940 950
LCLRCQHPTC QPEQTAKASA WDSRFCSLKC QEEFWIRSNN SYLRAQVFAT
960 970 980 990 1000
EHGVCQHCGV DAQELFLRMR DAPKSHRKSL LNAAWTAKLP LEQLNEMLRN
1010 1020 1030 1040 1050
PGEGHFWQVD HIRPVYEGGG QCSLDNLQTL CTVCHKERTA QQAKERSQVR
1060
RLSLATKHGS DITRFLVKK
Length:1,069
Mass (Da):120,896
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA12C95AE382A4E75
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti311I → M in BAC34042 (PubMed:16141072).Curated1
Sequence conflicti435G → R in BAC38978 (PubMed:16141072).Curated1
Sequence conflicti865I → L in AAI17923 (PubMed:15489334).Curated1
Sequence conflicti865I → L in AAI17922 (PubMed:15489334).Curated1
Sequence conflicti887S → T in AAI17923 (PubMed:15489334).Curated1
Sequence conflicti887S → T in AAI17922 (PubMed:15489334).Curated1
Sequence conflicti957H → R in AAI17923 (PubMed:15489334).Curated1
Sequence conflicti957H → R in AAI17922 (PubMed:15489334).Curated1
Sequence conflicti968R → W in AAI17923 (PubMed:15489334).Curated1
Sequence conflicti968R → W in AAI17922 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK050039 mRNA Translation: BAC34042.1
AK083641 mRNA Translation: BAC38978.1
BC066035 mRNA Translation: AAH66035.1
BC117921 mRNA Translation: AAI17922.1
BC117922 mRNA Translation: AAI17923.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS35697.1

NCBI Reference Sequences

More...
RefSeqi
NP_001272874.1, NM_001285945.1
NP_081954.1, NM_027678.3
XP_006529475.1, XM_006529412.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000086614; ENSMUSP00000083806; ENSMUSG00000036086
ENSMUST00000112538; ENSMUSP00000108157; ENSMUSG00000036086

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
226409

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:226409

UCSC genome browser

More...
UCSCi
uc007cld.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK050039 mRNA Translation: BAC34042.1
AK083641 mRNA Translation: BAC38978.1
BC066035 mRNA Translation: AAH66035.1
BC117921 mRNA Translation: AAI17922.1
BC117922 mRNA Translation: AAI17923.1
CCDSiCCDS35697.1
RefSeqiNP_001272874.1, NM_001285945.1
NP_081954.1, NM_027678.3
XP_006529475.1, XM_006529412.2

3D structure databases

SMRiQ6NZP1
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi230505, 2 interactors
STRINGi10090.ENSMUSP00000083806

PTM databases

iPTMnetiQ6NZP1
PhosphoSitePlusiQ6NZP1

Proteomic databases

EPDiQ6NZP1
MaxQBiQ6NZP1
PaxDbiQ6NZP1
PeptideAtlasiQ6NZP1
PRIDEiQ6NZP1
ProteomicsDBi275160

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
56175, 78 antibodies from 18 providers

Genome annotation databases

EnsembliENSMUST00000086614; ENSMUSP00000083806; ENSMUSG00000036086
ENSMUST00000112538; ENSMUSP00000108157; ENSMUSG00000036086
GeneIDi226409
KEGGimmu:226409
UCSCiuc007cld.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84083
MGIiMGI:1918362, Zranb3
VEuPathDBiHostDB:ENSMUSG00000036086

Phylogenomic databases

eggNOGiKOG1000, Eukaryota
GeneTreeiENSGT00940000158559
HOGENOMiCLU_004251_0_0_1
InParanoidiQ6NZP1
OMAiPGFSEWF
OrthoDBi1082831at2759
PhylomeDBiQ6NZP1
TreeFamiTF354227

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
226409, 3 hits in 100 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Zranb3, mouse

Protein Ontology

More...
PROi
PR:Q6NZP1
RNActiQ6NZP1, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036086, Expressed in dorsal pancreas and 205 other tissues
GenevisibleiQ6NZP1, MM

Family and domain databases

CDDicd00085, HNHc, 1 hit
Gene3Di3.40.50.10810, 1 hit
3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR002711, HNH
IPR003615, HNH_nuc
IPR027417, P-loop_NTPase
IPR038718, SNF2-like_sf
IPR000330, SNF2_N
IPR001876, Znf_RanBP2
IPR036443, Znf_RanBP2_sf
PfamiView protein in Pfam
PF00271, Helicase_C, 1 hit
PF01844, HNH, 1 hit
PF00176, SNF2-rel_dom, 1 hit
SMARTiView protein in SMART
SM00487, DEXDc, 1 hit
SM00490, HELICc, 1 hit
SM00507, HNHc, 1 hit
SM00547, ZnF_RBZ, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits
SSF90209, SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit
PS01358, ZF_RANBP2_1, 1 hit
PS50199, ZF_RANBP2_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZRAB3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NZP1
Secondary accession number(s): Q148X9, Q8BJJ3, Q8BWT6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: February 23, 2022
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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