UniProtKB - Q6NZN1 (PPRC1_MOUSE)
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Pprc1
Functioni
Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes (By similarity).
By similarityGO - Molecular functioni
- nuclear receptor coactivator activity Source: GO_Central
- RNA binding Source: UniProtKB-KW
GO - Biological processi
- positive regulation of DNA-binding transcription factor activity Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, RNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisome proliferator-activated receptor gamma coactivator-related protein 1Alternative name(s): PGC-1-related coactivator Short name: PRC |
Gene namesi | Name:Pprc1 Synonyms:Kiaa0595 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2385096, Pprc1 |
VEuPathDBi | HostDB:ENSMUSG00000055491 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: Colocalizes with NRF1.
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000296667 | 1 – 1644 | Peroxisome proliferator-activated receptor gamma coactivator-related protein 1Add BLAST | 1644 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 232 | PhosphoserineBy similarity | 1 | |
Modified residuei | 541 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1059 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1393 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1395 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6NZN1 |
PaxDbi | Q6NZN1 |
PeptideAtlasi | Q6NZN1 |
PRIDEi | Q6NZN1 |
ProteomicsDBi | 291845 [Q6NZN1-1] 291846 [Q6NZN1-2] 291847 [Q6NZN1-3] 291848 [Q6NZN1-4] 291849 [Q6NZN1-5] |
PTM databases
iPTMneti | Q6NZN1 |
PhosphoSitePlusi | Q6NZN1 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000055491, Expressed in embryo and 311 other tissues |
ExpressionAtlasi | Q6NZN1, baseline and differential |
Genevisiblei | Q6NZN1, MM |
Interactioni
Subunit structurei
Interacts with CREB1 and NRF1.
By similarityProtein-protein interaction databases
IntActi | Q6NZN1, 1 interactor |
STRINGi | 10090.ENSMUSP00000107530 |
Miscellaneous databases
RNActi | Q6NZN1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1523 – 1599 | RRMPROSITE-ProRule annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 61 | DisorderedSequence analysisAdd BLAST | 61 | |
Regioni | 170 – 249 | DisorderedSequence analysisAdd BLAST | 80 | |
Regioni | 425 – 460 | Necessary for interaction with CREB1 and NRF1 and for transcriptional coactivationBy similarityAdd BLAST | 36 | |
Regioni | 429 – 616 | DisorderedSequence analysisAdd BLAST | 188 | |
Regioni | 646 – 761 | DisorderedSequence analysisAdd BLAST | 116 | |
Regioni | 773 – 887 | DisorderedSequence analysisAdd BLAST | 115 | |
Regioni | 978 – 1074 | DisorderedSequence analysisAdd BLAST | 97 | |
Regioni | 1322 – 1507 | DisorderedSequence analysisAdd BLAST | 186 | |
Regioni | 1361 – 1432 | Necessary for interaction with CREB1 and NRF1By similarityAdd BLAST | 72 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 433 – 447 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 472 – 500 | Polar residuesSequence analysisAdd BLAST | 29 | |
Compositional biasi | 556 – 574 | Polar residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 726 – 741 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 789 – 821 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 826 – 887 | Pro residuesSequence analysisAdd BLAST | 62 | |
Compositional biasi | 978 – 1015 | Pro residuesSequence analysisAdd BLAST | 38 | |
Compositional biasi | 1025 – 1045 | Pro residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 1051 – 1066 | Polar residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1395 – 1486 | Polar residuesSequence analysisAdd BLAST | 92 | |
Compositional biasi | 1487 – 1507 | Basic and acidic residuesSequence analysisAdd BLAST | 21 |
Phylogenomic databases
eggNOGi | ENOG502QQME, Eukaryota |
GeneTreei | ENSGT00950000183137 |
HOGENOMi | CLU_001907_0_0_1 |
InParanoidi | Q6NZN1 |
OMAi | IGECHTV |
OrthoDBi | 94418at2759 |
TreeFami | TF343068 |
Family and domain databases
CDDi | cd12624, RRM_PRC, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR034605, PGC-1 IPR034597, PRC IPR034834, PRC_RRM IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR15528, PTHR15528, 1 hit PTHR15528:SF5, PTHR15528:SF5, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAARRGRRDR VAPPPTGGPG PDPGGGVRGG SWASRSQAPY GTGGSVSAAE
60 70 80 90 100
QVHEEGNDSS FVSLSRLGPS LREKDLEMEE LILQDETLLE TMQSYMDASL
110 120 130 140 150
ISLIEDFGES RLSLEDQNEM SLLTALTEIL DNADSENLSP FDTIPDSELL
160 170 180 190 200
VSPRESSSLH KLLNLSRTPP ERDLITPIDP LGPSTGSSRV SGVEVPLADS
210 220 230 240 250
PWDFSPPPFL ETSSPKLPSW RPSRPRPRWG QSPPPQQRSD GEEEEEVAGF
260 270 280 290 300
SGQMLAGKLD NSVNNVLDFP MHLACPEEEG TAEGADAPAS APGDESISSL
310 320 330 340 350
SELVRAMHPY CLPNLTHLAS LEGELEGQAD ADADELTLPE GCVVLEIVGQ
360 370 380 390 400
AATTGDDLEI PVVVRQIPSG SQSVLLDESL GSSPALQLLM PTMESETEAA
410 420 430 440 450
VPEVAPCPDE ELPLSSACLL EPREIMESLT PKEPQSLPAS ASQGSQKVPR
460 470 480 490 500
KGRKKKNKEQ PTACVEACTR RLRSSSRGQS TVSAEVNSQA GSSQKQPQEE
510 520 530 540 550
LQREAAALQS RGKPRAWARA WAAALEKTGS ENLERSAGQD SPAEEDALDL
560 570 580 590 600
CPKLLETSQA NPTLSLNDSA QADSMPVDSV EGDSPAVGNA APGDQASSGT
610 620 630 640 650
ELVGSLPVGP NLTSPVLADK KGIEPAVAIP TSDNLSPADV LANTVAADPV
660 670 680 690 700
PNDPAPADPV LVKCRPTDPR RAAAAAAAAA QGSRPSLQSA DHPKVVSPEG
710 720 730 740 750
KDVVGPLKVE GSTSATTQEA KPRPLSLSEY RQRRQQRQTE AEDRNSQPPV
760 770 780 790 800
VGKWPSLPET PTELADIPCL VPSAPARKTA PQRSPIAVPE TVSVGSNPVS
810 820 830 840 850
PTPEPSASKL MVSTHSEQVS SHEMPLAVRP PPPPLPSVSP AGPIPSTVPA
860 870 880 890 900
PLPPFPPSVP PLLPLPSGGH GVPRLPPPPL QPPGLPVSMR QMPPDPYTQY
910 920 930 940 950
APVPPWSCYP SVSPPGYSCL PPPPTMPIVS GTPGTYAVPP TCNVPWVPPP
960 970 980 990 1000
APVSPYSSSC AYGSLGWGPG LQQPPFWSTV SPPPLSSVPT GRAVPPTPVE
1010 1020 1030 1040 1050
PSGDPAGPPE DVLPGPVTPS LSSGPASPAA PPVEPTKPEA QPVPVSPQPK
1060 1070 1080 1090 1100
HKVSTLVQSP QIKAPPTLST EGVVFEESVS ERLKSETQEN RPKEKPISTA
1110 1120 1130 1140 1150
IKSVPVPKQS AVAKLPAVHP ARLRKLSFLP TPRAQGPEDV VQAFISEIGI
1160 1170 1180 1190 1200
EASDLSSLLE QFEKSEAKKE CPLPASADSL AVGNSGIDIP QEKKPLDRLQ
1210 1220 1230 1240 1250
APELANVAGL TPPATPPHQL WKPLAAVSLL AKAKSPKSTA QEGTLKPEGI
1260 1270 1280 1290 1300
TEAKPPATAC LQEGAHSPSP VHVGSGDHDY CVRSRTPPKR MPALVISEVG
1310 1320 1330 1340 1350
SRWNVKRHQD ITIKPVLSLG SAAPPLPCTA TSQEPLDHRT SVEQADPSAP
1360 1370 1380 1390 1400
CFAPSTLLSP EASPCRSEMN ARTPPEPSDK QQSMRCYRKA CRSVSPSSRG
1410 1420 1430 1440 1450
WQGRRGRSSR SVSSGSSRTS EASSSSSVSS SSRSRSRSRS RSFSPPNKRW
1460 1470 1480 1490 1500
RRSSCSSSGR SRRCSSSSSS SSSSSSCSSR SRSPSVSPCR RSDRRRRYSS
1510 1520 1530 1540 1550
YRANDHYQRQ RVLQKERAIE ERRVVFIGKI PGRMTRSELK QRFSVFGEIE
1560 1570 1580 1590 1600
ECTIHFRVQG DNYGFVTYRY AEEAFAAIES GHKLRQADEQ PFDLCFGGRR
1610 1620 1630 1640
QFCKRSYSDL DSNREDFDPA PVKSKFDSLD FDTLLKQAQK NLRR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3Z2D9 | D3Z2D9_MOUSE | Peroxisome proliferator-activated r... | Pprc1 | 120 | Annotation score: | ||
D3YYR7 | D3YYR7_MOUSE | Peroxisome proliferator-activated r... | Pprc1 | 145 | Annotation score: | ||
D3Z1R3 | D3Z1R3_MOUSE | Peroxisome proliferator-activated r... | Pprc1 | 93 | Annotation score: | ||
D3Z1F1 | D3Z1F1_MOUSE | Peroxisome proliferator-activated r... | Pprc1 | 43 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 242 | Missing in BAC31964 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 258 | K → E in BAC65604 (PubMed:12693553).Curated | 1 | |
Sequence conflicti | 409 | D → N in BAC65604 (PubMed:12693553).Curated | 1 | |
Sequence conflicti | 437 | L → I in BAE28245 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 461 | P → S in BAC65604 (PubMed:12693553).Curated | 1 | |
Sequence conflicti | 508 | L → P in BAC65604 (PubMed:12693553).Curated | 1 | |
Sequence conflicti | 629 | I → V in BAC65604 (PubMed:12693553).Curated | 1 | |
Sequence conflicti | 864 | P → S in BAC65604 (PubMed:12693553).Curated | 1 | |
Sequence conflicti | 1007 | G → S in BAC65604 (PubMed:12693553).Curated | 1 | |
Sequence conflicti | 1432 – 1433 | Missing in BAC65604 (PubMed:12693553).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_027232 | 1 – 925 | Missing in isoform 4. 1 PublicationAdd BLAST | 925 | |
Alternative sequenceiVSP_027233 | 109 | E → EQ in isoform 2 and isoform 5. 2 Publications | 1 | |
Alternative sequenceiVSP_027234 | 190 – 192 | Missing in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_027235 | 1186 | G → GS in isoform 2. 1 Publication | 1 | |
Alternative sequenceiVSP_027236 | 1187 – 1207 | IDIPQ…ELANV → SSARGVTLTLTPIGKTLILL L in isoform 3. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_027237 | 1208 – 1644 | Missing in isoform 3. 1 PublicationAdd BLAST | 437 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK122322 mRNA Translation: BAC65604.1 Different initiation. AK044522 mRNA Translation: BAC31964.1 AK147947 mRNA Translation: BAE28245.1 BC013720 mRNA Translation: AAH13720.1 BC066048 mRNA Translation: AAH66048.1 |
CCDSi | CCDS38005.1 [Q6NZN1-1] CCDS89404.1 [Q6NZN1-2] |
RefSeqi | NP_001074683.1, NM_001081214.1 [Q6NZN1-1] NP_001333730.1, NM_001346801.1 [Q6NZN1-2] XP_017173655.1, XM_017318166.1 [Q6NZN1-5] |
Genome annotation databases
Ensembli | ENSMUST00000062322; ENSMUSP00000079389; ENSMUSG00000055491 [Q6NZN1-2] ENSMUST00000099392; ENSMUSP00000096990; ENSMUSG00000055491 [Q6NZN1-3] ENSMUST00000111899; ENSMUSP00000107530; ENSMUSG00000055491 [Q6NZN1-1] |
GeneIDi | 226169 |
KEGGi | mmu:226169 |
UCSCi | uc008hsb.1, mouse [Q6NZN1-5] uc008hsc.1, mouse [Q6NZN1-2] uc008hsd.1, mouse [Q6NZN1-1] uc008hse.1, mouse [Q6NZN1-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK122322 mRNA Translation: BAC65604.1 Different initiation. AK044522 mRNA Translation: BAC31964.1 AK147947 mRNA Translation: BAE28245.1 BC013720 mRNA Translation: AAH13720.1 BC066048 mRNA Translation: AAH66048.1 |
CCDSi | CCDS38005.1 [Q6NZN1-1] CCDS89404.1 [Q6NZN1-2] |
RefSeqi | NP_001074683.1, NM_001081214.1 [Q6NZN1-1] NP_001333730.1, NM_001346801.1 [Q6NZN1-2] XP_017173655.1, XM_017318166.1 [Q6NZN1-5] |
3D structure databases
AlphaFoldDBi | Q6NZN1 |
SMRi | Q6NZN1 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q6NZN1, 1 interactor |
STRINGi | 10090.ENSMUSP00000107530 |
PTM databases
iPTMneti | Q6NZN1 |
PhosphoSitePlusi | Q6NZN1 |
Proteomic databases
EPDi | Q6NZN1 |
PaxDbi | Q6NZN1 |
PeptideAtlasi | Q6NZN1 |
PRIDEi | Q6NZN1 |
ProteomicsDBi | 291845 [Q6NZN1-1] 291846 [Q6NZN1-2] 291847 [Q6NZN1-3] 291848 [Q6NZN1-4] 291849 [Q6NZN1-5] |
Protocols and materials databases
Antibodypediai | 48608, 126 antibodies from 25 providers |
Genome annotation databases
Ensembli | ENSMUST00000062322; ENSMUSP00000079389; ENSMUSG00000055491 [Q6NZN1-2] ENSMUST00000099392; ENSMUSP00000096990; ENSMUSG00000055491 [Q6NZN1-3] ENSMUST00000111899; ENSMUSP00000107530; ENSMUSG00000055491 [Q6NZN1-1] |
GeneIDi | 226169 |
KEGGi | mmu:226169 |
UCSCi | uc008hsb.1, mouse [Q6NZN1-5] uc008hsc.1, mouse [Q6NZN1-2] uc008hsd.1, mouse [Q6NZN1-1] uc008hse.1, mouse [Q6NZN1-3] |
Organism-specific databases
CTDi | 23082 |
MGIi | MGI:2385096, Pprc1 |
VEuPathDBi | HostDB:ENSMUSG00000055491 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQME, Eukaryota |
GeneTreei | ENSGT00950000183137 |
HOGENOMi | CLU_001907_0_0_1 |
InParanoidi | Q6NZN1 |
OMAi | IGECHTV |
OrthoDBi | 94418at2759 |
TreeFami | TF343068 |
Miscellaneous databases
BioGRID-ORCSi | 226169, 23 hits in 75 CRISPR screens |
ChiTaRSi | Pprc1, mouse |
PROi | PR:Q6NZN1 |
RNActi | Q6NZN1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000055491, Expressed in embryo and 311 other tissues |
ExpressionAtlasi | Q6NZN1, baseline and differential |
Genevisiblei | Q6NZN1, MM |
Family and domain databases
CDDi | cd12624, RRM_PRC, 1 hit |
Gene3Di | 3.30.70.330, 1 hit |
InterProi | View protein in InterPro IPR012677, Nucleotide-bd_a/b_plait_sf IPR034605, PGC-1 IPR034597, PRC IPR034834, PRC_RRM IPR035979, RBD_domain_sf IPR000504, RRM_dom |
PANTHERi | PTHR15528, PTHR15528, 1 hit PTHR15528:SF5, PTHR15528:SF5, 1 hit |
Pfami | View protein in Pfam PF00076, RRM_1, 1 hit |
SMARTi | View protein in SMART SM00360, RRM, 1 hit |
SUPFAMi | SSF54928, SSF54928, 1 hit |
PROSITEi | View protein in PROSITE PS50102, RRM, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PPRC1_MOUSE | |
Accessioni | Q6NZN1Primary (citable) accession number: Q6NZN1 Secondary accession number(s): Q3UGG3 Q91YW8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 24, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot