UniProtKB - Q6NZN1 (PPRC1_MOUSE)

BLAST

>sp|Q6NZN1|PPRC1_MOUSE Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 OS=Mus musculus OX=10090 GN=Pprc1 PE=1 SV=1
MAARRGRRDRVAPPPTGGPGPDPGGGVRGGSWASRSQAPYGTGGSVSAAEQVHEEGNDSS
FVSLSRLGPSLREKDLEMEELILQDETLLETMQSYMDASLISLIEDFGESRLSLEDQNEM
SLLTALTEILDNADSENLSPFDTIPDSELLVSPRESSSLHKLLNLSRTPPERDLITPIDP
LGPSTGSSRVSGVEVPLADSPWDFSPPPFLETSSPKLPSWRPSRPRPRWGQSPPPQQRSD
GEEEEEVAGFSGQMLAGKLDNSVNNVLDFPMHLACPEEEGTAEGADAPASAPGDESISSL
SELVRAMHPYCLPNLTHLASLEGELEGQADADADELTLPEGCVVLEIVGQAATTGDDLEI
PVVVRQIPSGSQSVLLDESLGSSPALQLLMPTMESETEAAVPEVAPCPDEELPLSSACLL
EPREIMESLTPKEPQSLPASASQGSQKVPRKGRKKKNKEQPTACVEACTRRLRSSSRGQS
TVSAEVNSQAGSSQKQPQEELQREAAALQSRGKPRAWARAWAAALEKTGSENLERSAGQD
SPAEEDALDLCPKLLETSQANPTLSLNDSAQADSMPVDSVEGDSPAVGNAAPGDQASSGT
ELVGSLPVGPNLTSPVLADKKGIEPAVAIPTSDNLSPADVLANTVAADPVPNDPAPADPV
LVKCRPTDPRRAAAAAAAAAQGSRPSLQSADHPKVVSPEGKDVVGPLKVEGSTSATTQEA
KPRPLSLSEYRQRRQQRQTEAEDRNSQPPVVGKWPSLPETPTELADIPCLVPSAPARKTA
PQRSPIAVPETVSVGSNPVSPTPEPSASKLMVSTHSEQVSSHEMPLAVRPPPPPLPSVSP
AGPIPSTVPAPLPPFPPSVPPLLPLPSGGHGVPRLPPPPLQPPGLPVSMRQMPPDPYTQY
APVPPWSCYPSVSPPGYSCLPPPPTMPIVSGTPGTYAVPPTCNVPWVPPPAPVSPYSSSC
AYGSLGWGPGLQQPPFWSTVSPPPLSSVPTGRAVPPTPVEPSGDPAGPPEDVLPGPVTPS
LSSGPASPAAPPVEPTKPEAQPVPVSPQPKHKVSTLVQSPQIKAPPTLSTEGVVFEESVS
ERLKSETQENRPKEKPISTAIKSVPVPKQSAVAKLPAVHPARLRKLSFLPTPRAQGPEDV
VQAFISEIGIEASDLSSLLEQFEKSEAKKECPLPASADSLAVGNSGIDIPQEKKPLDRLQ
APELANVAGLTPPATPPHQLWKPLAAVSLLAKAKSPKSTAQEGTLKPEGITEAKPPATAC
LQEGAHSPSPVHVGSGDHDYCVRSRTPPKRMPALVISEVGSRWNVKRHQDITIKPVLSLG
SAAPPLPCTATSQEPLDHRTSVEQADPSAPCFAPSTLLSPEASPCRSEMNARTPPEPSDK
QQSMRCYRKACRSVSPSSRGWQGRRGRSSRSVSSGSSRTSEASSSSSVSSSSRSRSRSRS
RSFSPPNKRWRRSSCSSSGRSRRCSSSSSSSSSSSSCSSRSRSPSVSPCRRSDRRRRYSS
YRANDHYQRQRVLQKERAIEERRVVFIGKIPGRMTRSELKQRFSVFGEIEECTIHFRVQG
DNYGFVTYRYAEEAFAAIESGHKLRQADEQPFDLCFGGRRQFCKRSYSDLDSNREDFDPA
PVKSKFDSLDFDTLLKQAQKNLRR

Align

Format
Add to basket Added to basket
History
Entry version 125 (12 Sep 2018)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
Other tutorials and videos
Help video
Feedback

Protein

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

Gene

Pprc1

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes (By similarity).By similarity

GO - Molecular functionⁱ

nuclear receptor transcription coactivator activity Source: GO_Central
RNA binding Source: UniProtKB-KW
transcription factor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

positive regulation of DNA-binding transcription factor activity Source: GO_Central
positive regulation of transcription by RNA polymerase II Source: GO_Central
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, RNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 Alternative name(s): PGC-1-related coactivator Short name: PRC
Gene namesⁱ	Name:Pprc1 Synonyms:Kiaa0595
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 19

Organism-specific databases

MGIⁱ	MGI:2385096 Pprc1

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000296667	1 – 1644	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1Add BLAST		1644

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	232	PhosphoserineBy similarity	1
Modified residueⁱ	541	PhosphoserineBy similarity	1
Modified residueⁱ	1059	PhosphoserineBy similarity	1
Modified residueⁱ	1393	PhosphoserineBy similarity	1
Modified residueⁱ	1395	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q6NZN1
PaxDbⁱ	Q6NZN1
PeptideAtlas More...PeptideAtlasⁱ	Q6NZN1
PRIDEⁱ	Q6NZN1

PTM databases

iPTMnetⁱ	Q6NZN1
PhosphoSitePlusⁱ	Q6NZN1

Expressionⁱ

Tissue specificityⁱ

Expressed in liver, heart, skeletal muscle, kidney and white and brown adipose tissues.1 Publication

Inductionⁱ

Up-regulated by serum (at protein level). Up-regulated by serum. Up-regulated weakly in brown adipose tissue by exposure of animals to cold.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000055491 Expressed in 289 organ(s), highest expression level in embryo
ExpressionAtlasⁱ	Q6NZN1 baseline and differential
Genevisibleⁱ	Q6NZN1 MM

Interactionⁱ

Subunit structureⁱ

Interacts with CREB1 and NRF1.By similarity

GO - Molecular functionⁱ

transcription factor binding Source: GO_Central

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	Q6NZN1, 1 interactor
STRINGⁱ	10090.ENSMUSP00000107530

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6NZN1
SMRⁱ	Q6NZN1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	1523 – 1599	RRMPROSITE-ProRule annotationAdd BLAST		77

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	425 – 460	Necessary for interaction with CREB1 and NRF1 and for transcriptional coactivationBy similarityAdd BLAST		36
Regionⁱ	1361 – 1432	Necessary for interaction with CREB1 and NRF1By similarityAdd BLAST		72

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	748 – 1066	Pro-richAdd BLAST	319
Compositional biasⁱ	1385 – 1523	Arg-richAdd BLAST	139
Compositional biasⁱ	1393 – 1500	Ser-richAdd BLAST	108

Phylogenomic databases

eggNOGⁱ	ENOG410IK9Y Eukaryota ENOG4111HH9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063196
HOGENOMⁱ	HOG000115672
HOVERGENⁱ	HBG103282
InParanoidⁱ	Q6NZN1
KEGG Orthology (KO) More...KOⁱ	K17963
OMAⁱ	CTIHFRV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G029M
TreeFamⁱ	TF343068

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12624 RRM_PRC, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR034605 PGC-1 IPR034597 PRC IPR034834 PRC_RRM IPR035979 RBD_domain_sf IPR000504 RRM_dom
PANTHERⁱ	PTHR15528 PTHR15528, 1 hit PTHR15528:SF5 PTHR15528:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q6NZN1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAARRGRRDR VAPPPTGGPG PDPGGGVRGG SWASRSQAPY GTGGSVSAAE 
        60         70         80         90        100
QVHEEGNDSS FVSLSRLGPS LREKDLEMEE LILQDETLLE TMQSYMDASL 
       110        120        130        140        150
ISLIEDFGES RLSLEDQNEM SLLTALTEIL DNADSENLSP FDTIPDSELL 
       160        170        180        190        200
VSPRESSSLH KLLNLSRTPP ERDLITPIDP LGPSTGSSRV SGVEVPLADS 
       210        220        230        240        250
PWDFSPPPFL ETSSPKLPSW RPSRPRPRWG QSPPPQQRSD GEEEEEVAGF 
       260        270        280        290        300
SGQMLAGKLD NSVNNVLDFP MHLACPEEEG TAEGADAPAS APGDESISSL 
       310        320        330        340        350
SELVRAMHPY CLPNLTHLAS LEGELEGQAD ADADELTLPE GCVVLEIVGQ 
       360        370        380        390        400
AATTGDDLEI PVVVRQIPSG SQSVLLDESL GSSPALQLLM PTMESETEAA 
       410        420        430        440        450
VPEVAPCPDE ELPLSSACLL EPREIMESLT PKEPQSLPAS ASQGSQKVPR 
       460        470        480        490        500
KGRKKKNKEQ PTACVEACTR RLRSSSRGQS TVSAEVNSQA GSSQKQPQEE 
       510        520        530        540        550
LQREAAALQS RGKPRAWARA WAAALEKTGS ENLERSAGQD SPAEEDALDL 
       560        570        580        590        600
CPKLLETSQA NPTLSLNDSA QADSMPVDSV EGDSPAVGNA APGDQASSGT 
       610        620        630        640        650
ELVGSLPVGP NLTSPVLADK KGIEPAVAIP TSDNLSPADV LANTVAADPV 
       660        670        680        690        700
PNDPAPADPV LVKCRPTDPR RAAAAAAAAA QGSRPSLQSA DHPKVVSPEG 
       710        720        730        740        750
KDVVGPLKVE GSTSATTQEA KPRPLSLSEY RQRRQQRQTE AEDRNSQPPV 
       760        770        780        790        800
VGKWPSLPET PTELADIPCL VPSAPARKTA PQRSPIAVPE TVSVGSNPVS 
       810        820        830        840        850
PTPEPSASKL MVSTHSEQVS SHEMPLAVRP PPPPLPSVSP AGPIPSTVPA 
       860        870        880        890        900
PLPPFPPSVP PLLPLPSGGH GVPRLPPPPL QPPGLPVSMR QMPPDPYTQY 
       910        920        930        940        950
APVPPWSCYP SVSPPGYSCL PPPPTMPIVS GTPGTYAVPP TCNVPWVPPP 
       960        970        980        990       1000
APVSPYSSSC AYGSLGWGPG LQQPPFWSTV SPPPLSSVPT GRAVPPTPVE 
      1010       1020       1030       1040       1050
PSGDPAGPPE DVLPGPVTPS LSSGPASPAA PPVEPTKPEA QPVPVSPQPK 
      1060       1070       1080       1090       1100
HKVSTLVQSP QIKAPPTLST EGVVFEESVS ERLKSETQEN RPKEKPISTA 
      1110       1120       1130       1140       1150
IKSVPVPKQS AVAKLPAVHP ARLRKLSFLP TPRAQGPEDV VQAFISEIGI 
      1160       1170       1180       1190       1200
EASDLSSLLE QFEKSEAKKE CPLPASADSL AVGNSGIDIP QEKKPLDRLQ 
      1210       1220       1230       1240       1250
APELANVAGL TPPATPPHQL WKPLAAVSLL AKAKSPKSTA QEGTLKPEGI 
      1260       1270       1280       1290       1300
TEAKPPATAC LQEGAHSPSP VHVGSGDHDY CVRSRTPPKR MPALVISEVG 
      1310       1320       1330       1340       1350
SRWNVKRHQD ITIKPVLSLG SAAPPLPCTA TSQEPLDHRT SVEQADPSAP 
      1360       1370       1380       1390       1400
CFAPSTLLSP EASPCRSEMN ARTPPEPSDK QQSMRCYRKA CRSVSPSSRG 
      1410       1420       1430       1440       1450
WQGRRGRSSR SVSSGSSRTS EASSSSSVSS SSRSRSRSRS RSFSPPNKRW 
      1460       1470       1480       1490       1500
RRSSCSSSGR SRRCSSSSSS SSSSSSCSSR SRSPSVSPCR RSDRRRRYSS 
      1510       1520       1530       1540       1550
YRANDHYQRQ RVLQKERAIE ERRVVFIGKI PGRMTRSELK QRFSVFGEIE 
      1560       1570       1580       1590       1600
ECTIHFRVQG DNYGFVTYRY AEEAFAAIES GHKLRQADEQ PFDLCFGGRR 
      1610       1620       1630       1640 
QFCKRSYSDL DSNREDFDPA PVKSKFDSLD FDTLLKQAQK NLRR

Length:1,644

Mass (Da):175,074

Last modified:July 5, 2004 - v1

Checksum:ⁱB00165FEE51311A9

Isoform 2 (identifier: Q6NZN1-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
109-109: E → EQ
1186-1186: G → GS

« Hide

        10         20         30         40         50
MAARRGRRDR VAPPPTGGPG PDPGGGVRGG SWASRSQAPY GTGGSVSAAE 
        60         70         80         90        100
QVHEEGNDSS FVSLSRLGPS LREKDLEMEE LILQDETLLE TMQSYMDASL 
       110        120        130        140        150
ISLIEDFGEQ SRLSLEDQNE MSLLTALTEI LDNADSENLS PFDTIPDSEL 
       160        170        180        190        200
LVSPRESSSL HKLLNLSRTP PERDLITPID PLGPSTGSSR VSGVEVPLAD 
       210        220        230        240        250
SPWDFSPPPF LETSSPKLPS WRPSRPRPRW GQSPPPQQRS DGEEEEEVAG 
       260        270        280        290        300
FSGQMLAGKL DNSVNNVLDF PMHLACPEEE GTAEGADAPA SAPGDESISS 
       310        320        330        340        350
LSELVRAMHP YCLPNLTHLA SLEGELEGQA DADADELTLP EGCVVLEIVG 
       360        370        380        390        400
QAATTGDDLE IPVVVRQIPS GSQSVLLDES LGSSPALQLL MPTMESETEA 
       410        420        430        440        450
AVPEVAPCPD EELPLSSACL LEPREIMESL TPKEPQSLPA SASQGSQKVP 
       460        470        480        490        500
RKGRKKKNKE QPTACVEACT RRLRSSSRGQ STVSAEVNSQ AGSSQKQPQE 
       510        520        530        540        550
ELQREAAALQ SRGKPRAWAR AWAAALEKTG SENLERSAGQ DSPAEEDALD 
       560        570        580        590        600
LCPKLLETSQ ANPTLSLNDS AQADSMPVDS VEGDSPAVGN AAPGDQASSG 
       610        620        630        640        650
TELVGSLPVG PNLTSPVLAD KKGIEPAVAI PTSDNLSPAD VLANTVAADP 
       660        670        680        690        700
VPNDPAPADP VLVKCRPTDP RRAAAAAAAA AQGSRPSLQS ADHPKVVSPE 
       710        720        730        740        750
GKDVVGPLKV EGSTSATTQE AKPRPLSLSE YRQRRQQRQT EAEDRNSQPP 
       760        770        780        790        800
VVGKWPSLPE TPTELADIPC LVPSAPARKT APQRSPIAVP ETVSVGSNPV 
       810        820        830        840        850
SPTPEPSASK LMVSTHSEQV SSHEMPLAVR PPPPPLPSVS PAGPIPSTVP 
       860        870        880        890        900
APLPPFPPSV PPLLPLPSGG HGVPRLPPPP LQPPGLPVSM RQMPPDPYTQ 
       910        920        930        940        950
YAPVPPWSCY PSVSPPGYSC LPPPPTMPIV SGTPGTYAVP PTCNVPWVPP 
       960        970        980        990       1000
PAPVSPYSSS CAYGSLGWGP GLQQPPFWST VSPPPLSSVP TGRAVPPTPV 
      1010       1020       1030       1040       1050
EPSGDPAGPP EDVLPGPVTP SLSSGPASPA APPVEPTKPE AQPVPVSPQP 
      1060       1070       1080       1090       1100
KHKVSTLVQS PQIKAPPTLS TEGVVFEESV SERLKSETQE NRPKEKPIST 
      1110       1120       1130       1140       1150
AIKSVPVPKQ SAVAKLPAVH PARLRKLSFL PTPRAQGPED VVQAFISEIG 
      1160       1170       1180       1190       1200
IEASDLSSLL EQFEKSEAKK ECPLPASADS LAVGNSGSID IPQEKKPLDR 
      1210       1220       1230       1240       1250
LQAPELANVA GLTPPATPPH QLWKPLAAVS LLAKAKSPKS TAQEGTLKPE 
      1260       1270       1280       1290       1300
GITEAKPPAT ACLQEGAHSP SPVHVGSGDH DYCVRSRTPP KRMPALVISE 
      1310       1320       1330       1340       1350
VGSRWNVKRH QDITIKPVLS LGSAAPPLPC TATSQEPLDH RTSVEQADPS 
      1360       1370       1380       1390       1400
APCFAPSTLL SPEASPCRSE MNARTPPEPS DKQQSMRCYR KACRSVSPSS 
      1410       1420       1430       1440       1450
RGWQGRRGRS SRSVSSGSSR TSEASSSSSV SSSSRSRSRS RSRSFSPPNK 
      1460       1470       1480       1490       1500
RWRRSSCSSS GRSRRCSSSS SSSSSSSSCS SRSRSPSVSP CRRSDRRRRY 
      1510       1520       1530       1540       1550
SSYRANDHYQ RQRVLQKERA IEERRVVFIG KIPGRMTRSE LKQRFSVFGE 
      1560       1570       1580       1590       1600
IEECTIHFRV QGDNYGFVTY RYAEEAFAAI ESGHKLRQAD EQPFDLCFGG 
      1610       1620       1630       1640 
RRQFCKRSYS DLDSNREDFD PAPVKSKFDS LDFDTLLKQA QKNLRR

Show »

Length:1,646

Mass (Da):175,289

Checksum:ⁱE9F2DEE414392F26

Isoform 3 (identifier: Q6NZN1-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-192: Missing.
     1187-1207: IDIPQEKKPLDRLQAPELANV → SSARGVTLTLTPIGKTLILLL
     1208-1644: Missing.

« Hide

        10         20         30         40         50
MAARRGRRDR VAPPPTGGPG PDPGGGVRGG SWASRSQAPY GTGGSVSAAE 
        60         70         80         90        100
QVHEEGNDSS FVSLSRLGPS LREKDLEMEE LILQDETLLE TMQSYMDASL 
       110        120        130        140        150
ISLIEDFGES RLSLEDQNEM SLLTALTEIL DNADSENLSP FDTIPDSELL 
       160        170        180        190        200
VSPRESSSLH KLLNLSRTPP ERDLITPIDP LGPSTGSSRV EVPLADSPWD 
       210        220        230        240        250
FSPPPFLETS SPKLPSWRPS RPRPRWGQSP PPQQRSDGEE EEEVAGFSGQ 
       260        270        280        290        300
MLAGKLDNSV NNVLDFPMHL ACPEEEGTAE GADAPASAPG DESISSLSEL 
       310        320        330        340        350
VRAMHPYCLP NLTHLASLEG ELEGQADADA DELTLPEGCV VLEIVGQAAT 
       360        370        380        390        400
TGDDLEIPVV VRQIPSGSQS VLLDESLGSS PALQLLMPTM ESETEAAVPE 
       410        420        430        440        450
VAPCPDEELP LSSACLLEPR EIMESLTPKE PQSLPASASQ GSQKVPRKGR 
       460        470        480        490        500
KKKNKEQPTA CVEACTRRLR SSSRGQSTVS AEVNSQAGSS QKQPQEELQR 
       510        520        530        540        550
EAAALQSRGK PRAWARAWAA ALEKTGSENL ERSAGQDSPA EEDALDLCPK 
       560        570        580        590        600
LLETSQANPT LSLNDSAQAD SMPVDSVEGD SPAVGNAAPG DQASSGTELV 
       610        620        630        640        650
GSLPVGPNLT SPVLADKKGI EPAVAIPTSD NLSPADVLAN TVAADPVPND 
       660        670        680        690        700
PAPADPVLVK CRPTDPRRAA AAAAAAAQGS RPSLQSADHP KVVSPEGKDV 
       710        720        730        740        750
VGPLKVEGST SATTQEAKPR PLSLSEYRQR RQQRQTEAED RNSQPPVVGK 
       760        770        780        790        800
WPSLPETPTE LADIPCLVPS APARKTAPQR SPIAVPETVS VGSNPVSPTP 
       810        820        830        840        850
EPSASKLMVS THSEQVSSHE MPLAVRPPPP PLPSVSPAGP IPSTVPAPLP 
       860        870        880        890        900
PFPPSVPPLL PLPSGGHGVP RLPPPPLQPP GLPVSMRQMP PDPYTQYAPV 
       910        920        930        940        950
PPWSCYPSVS PPGYSCLPPP PTMPIVSGTP GTYAVPPTCN VPWVPPPAPV 
       960        970        980        990       1000
SPYSSSCAYG SLGWGPGLQQ PPFWSTVSPP PLSSVPTGRA VPPTPVEPSG 
      1010       1020       1030       1040       1050
DPAGPPEDVL PGPVTPSLSS GPASPAAPPV EPTKPEAQPV PVSPQPKHKV 
      1060       1070       1080       1090       1100
STLVQSPQIK APPTLSTEGV VFEESVSERL KSETQENRPK EKPISTAIKS 
      1110       1120       1130       1140       1150
VPVPKQSAVA KLPAVHPARL RKLSFLPTPR AQGPEDVVQA FISEIGIEAS 
      1160       1170       1180       1190       1200
DLSSLLEQFE KSEAKKECPL PASADSLAVG NSGSSARGVT LTLTPIGKTL 

ILLL

Show »

Length:1,204

Mass (Da):126,159

Checksum:ⁱ13EA108D569D3E5A

Isoform 4 (identifier: Q6NZN1-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-925: Missing.

« Hide

        10         20         30         40         50
MPIVSGTPGT YAVPPTCNVP WVPPPAPVSP YSSSCAYGSL GWGPGLQQPP 
        60         70         80         90        100
FWSTVSPPPL SSVPTGRAVP PTPVEPSGDP AGPPEDVLPG PVTPSLSSGP 
       110        120        130        140        150
ASPAAPPVEP TKPEAQPVPV SPQPKHKVST LVQSPQIKAP PTLSTEGVVF 
       160        170        180        190        200
EESVSERLKS ETQENRPKEK PISTAIKSVP VPKQSAVAKL PAVHPARLRK 
       210        220        230        240        250
LSFLPTPRAQ GPEDVVQAFI SEIGIEASDL SSLLEQFEKS EAKKECPLPA 
       260        270        280        290        300
SADSLAVGNS GIDIPQEKKP LDRLQAPELA NVAGLTPPAT PPHQLWKPLA 
       310        320        330        340        350
AVSLLAKAKS PKSTAQEGTL KPEGITEAKP PATACLQEGA HSPSPVHVGS 
       360        370        380        390        400
GDHDYCVRSR TPPKRMPALV ISEVGSRWNV KRHQDITIKP VLSLGSAAPP 
       410        420        430        440        450
LPCTATSQEP LDHRTSVEQA DPSAPCFAPS TLLSPEASPC RSEMNARTPP 
       460        470        480        490        500
EPSDKQQSMR CYRKACRSVS PSSRGWQGRR GRSSRSVSSG SSRTSEASSS 
       510        520        530        540        550
SSVSSSSRSR SRSRSRSFSP PNKRWRRSSC SSSGRSRRCS SSSSSSSSSS 
       560        570        580        590        600
SCSSRSRSPS VSPCRRSDRR RRYSSYRAND HYQRQRVLQK ERAIEERRVV 
       610        620        630        640        650
FIGKIPGRMT RSELKQRFSV FGEIEECTIH FRVQGDNYGF VTYRYAEEAF 
       660        670        680        690        700
AAIESGHKLR QADEQPFDLC FGGRRQFCKR SYSDLDSNRE DFDPAPVKSK 
       710 
FDSLDFDTLL KQAQKNLRR

Show »

Length:719

Mass (Da):77,821

Checksum:ⁱDAA29FE3AB55079A

Isoform 5 (identifier: Q6NZN1-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
109-109: E → EQ

« Hide

        10         20         30         40         50
MAARRGRRDR VAPPPTGGPG PDPGGGVRGG SWASRSQAPY GTGGSVSAAE 
        60         70         80         90        100
QVHEEGNDSS FVSLSRLGPS LREKDLEMEE LILQDETLLE TMQSYMDASL 
       110        120        130        140        150
ISLIEDFGEQ SRLSLEDQNE MSLLTALTEI LDNADSENLS PFDTIPDSEL 
       160        170        180        190        200
LVSPRESSSL HKLLNLSRTP PERDLITPID PLGPSTGSSR VSGVEVPLAD 
       210        220        230        240        250
SPWDFSPPPF LETSSPKLPS WRPSRPRPRW GQSPPPQQRS DGEEEEEVAG 
       260        270        280        290        300
FSGQMLAGKL DNSVNNVLDF PMHLACPEEE GTAEGADAPA SAPGDESISS 
       310        320        330        340        350
LSELVRAMHP YCLPNLTHLA SLEGELEGQA DADADELTLP EGCVVLEIVG 
       360        370        380        390        400
QAATTGDDLE IPVVVRQIPS GSQSVLLDES LGSSPALQLL MPTMESETEA 
       410        420        430        440        450
AVPEVAPCPD EELPLSSACL LEPREIMESL TPKEPQSLPA SASQGSQKVP 
       460        470        480        490        500
RKGRKKKNKE QPTACVEACT RRLRSSSRGQ STVSAEVNSQ AGSSQKQPQE 
       510        520        530        540        550
ELQREAAALQ SRGKPRAWAR AWAAALEKTG SENLERSAGQ DSPAEEDALD 
       560        570        580        590        600
LCPKLLETSQ ANPTLSLNDS AQADSMPVDS VEGDSPAVGN AAPGDQASSG 
       610        620        630        640        650
TELVGSLPVG PNLTSPVLAD KKGIEPAVAI PTSDNLSPAD VLANTVAADP 
       660        670        680        690        700
VPNDPAPADP VLVKCRPTDP RRAAAAAAAA AQGSRPSLQS ADHPKVVSPE 
       710        720        730        740        750
GKDVVGPLKV EGSTSATTQE AKPRPLSLSE YRQRRQQRQT EAEDRNSQPP 
       760        770        780        790        800
VVGKWPSLPE TPTELADIPC LVPSAPARKT APQRSPIAVP ETVSVGSNPV 
       810        820        830        840        850
SPTPEPSASK LMVSTHSEQV SSHEMPLAVR PPPPPLPSVS PAGPIPSTVP 
       860        870        880        890        900
APLPPFPPSV PPLLPLPSGG HGVPRLPPPP LQPPGLPVSM RQMPPDPYTQ 
       910        920        930        940        950
YAPVPPWSCY PSVSPPGYSC LPPPPTMPIV SGTPGTYAVP PTCNVPWVPP 
       960        970        980        990       1000
PAPVSPYSSS CAYGSLGWGP GLQQPPFWST VSPPPLSSVP TGRAVPPTPV 
      1010       1020       1030       1040       1050
EPSGDPAGPP EDVLPGPVTP SLSSGPASPA APPVEPTKPE AQPVPVSPQP 
      1060       1070       1080       1090       1100
KHKVSTLVQS PQIKAPPTLS TEGVVFEESV SERLKSETQE NRPKEKPIST 
      1110       1120       1130       1140       1150
AIKSVPVPKQ SAVAKLPAVH PARLRKLSFL PTPRAQGPED VVQAFISEIG 
      1160       1170       1180       1190       1200
IEASDLSSLL EQFEKSEAKK ECPLPASADS LAVGNSGIDI PQEKKPLDRL 
      1210       1220       1230       1240       1250
QAPELANVAG LTPPATPPHQ LWKPLAAVSL LAKAKSPKST AQEGTLKPEG 
      1260       1270       1280       1290       1300
ITEAKPPATA CLQEGAHSPS PVHVGSGDHD YCVRSRTPPK RMPALVISEV 
      1310       1320       1330       1340       1350
GSRWNVKRHQ DITIKPVLSL GSAAPPLPCT ATSQEPLDHR TSVEQADPSA 
      1360       1370       1380       1390       1400
PCFAPSTLLS PEASPCRSEM NARTPPEPSD KQQSMRCYRK ACRSVSPSSR 
      1410       1420       1430       1440       1450
GWQGRRGRSS RSVSSGSSRT SEASSSSSVS SSSRSRSRSR SRSFSPPNKR 
      1460       1470       1480       1490       1500
WRRSSCSSSG RSRRCSSSSS SSSSSSSCSS RSRSPSVSPC RRSDRRRRYS 
      1510       1520       1530       1540       1550
SYRANDHYQR QRVLQKERAI EERRVVFIGK IPGRMTRSEL KQRFSVFGEI 
      1560       1570       1580       1590       1600
EECTIHFRVQ GDNYGFVTYR YAEEAFAAIE SGHKLRQADE QPFDLCFGGR 
      1610       1620       1630       1640 
RQFCKRSYSD LDSNREDFDP APVKSKFDSL DFDTLLKQAQ KNLRR

Show »

Length:1,645

Mass (Da):175,202

Checksum:ⁱ4250C7322C399714

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3Z2D9	D3Z2D9_MOUSE	Peroxisome proliferator-activated r... Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	Pprc1	120	Annotation score:
D3YYR7	D3YYR7_MOUSE	Peroxisome proliferator-activated r... Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	Pprc1	145	Annotation score:
D3Z1R3	D3Z1R3_MOUSE	Peroxisome proliferator-activated r... Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	Pprc1	93	Annotation score:
D3Z1F1	D3Z1F1_MOUSE	Peroxisome proliferator-activated r... Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	Pprc1	43	Annotation score:

Sequence cautionⁱ

The sequence BAC65604 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	242	Missing in BAC31964 (PubMed:16141072).Curated	1
Sequence conflictⁱ	258	K → E in BAC65604 (PubMed:12693553).Curated	1
Sequence conflictⁱ	409	D → N in BAC65604 (PubMed:12693553).Curated	1
Sequence conflictⁱ	437	L → I in BAE28245 (PubMed:16141072).Curated	1
Sequence conflictⁱ	461	P → S in BAC65604 (PubMed:12693553).Curated	1
Sequence conflictⁱ	508	L → P in BAC65604 (PubMed:12693553).Curated	1
Sequence conflictⁱ	629	I → V in BAC65604 (PubMed:12693553).Curated	1
Sequence conflictⁱ	864	P → S in BAC65604 (PubMed:12693553).Curated	1
Sequence conflictⁱ	1007	G → S in BAC65604 (PubMed:12693553).Curated	1
Sequence conflictⁱ	1432 – 1433	Missing in BAC65604 (PubMed:12693553).Curated	2

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_027232	1 – 925	Missing in isoform 4. 1 PublicationAdd BLAST	925
Alternative sequenceⁱVSP_027233	109	E → EQ in isoform 2 and isoform 5. 2 Publications	1
Alternative sequenceⁱVSP_027234	190 – 192	Missing in isoform 3. 1 Publication	3
Alternative sequenceⁱVSP_027235	1186	G → GS in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_027236	1187 – 1207	IDIPQ…ELANV → SSARGVTLTLTPIGKTLILL L in isoform 3. 1 PublicationAdd BLAST	21
Alternative sequenceⁱVSP_027237	1208 – 1644	Missing in isoform 3. 1 PublicationAdd BLAST	437

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK122322 mRNA Translation: BAC65604.1 Different initiation. AK044522 mRNA Translation: BAC31964.1 AK147947 mRNA Translation: BAE28245.1 BC013720 mRNA Translation: AAH13720.1 BC066048 mRNA Translation: AAH66048.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS38005.1 [Q6NZN1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001074683.1, NM_001081214.1 [Q6NZN1-1] NP_001333730.1, NM_001346801.1 [Q6NZN1-2] XP_017173655.1, XM_017318166.1 [Q6NZN1-5]
UniGeneⁱ	Mm.2415

Genome annotation databases

Ensemblⁱ	ENSMUST00000062322; ENSMUSP00000079389; ENSMUSG00000055491 [Q6NZN1-2] ENSMUST00000099392; ENSMUSP00000096990; ENSMUSG00000055491 [Q6NZN1-3] ENSMUST00000111899; ENSMUSP00000107530; ENSMUSG00000055491 [Q6NZN1-1]
GeneIDⁱ	226169
KEGGⁱ	mmu:226169
UCSC genome browser More...UCSCⁱ	uc008hsb.1 mouse [Q6NZN1-5] uc008hsc.1 mouse [Q6NZN1-2] uc008hsd.1 mouse [Q6NZN1-1] uc008hse.1 mouse [Q6NZN1-3]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6NZN1	Isoform 2 of Peroxisome proliferator-activated receptor gamma coactivator-related protein 1		MOUSE		1646	UniRef90_Q6NZN1
UPI000A30BC96		MUSPA		1652
UPI000A319825		MUSCR		1640
Isoform 5 of Peroxisome proliferator-activated receptor gamma coactivator-related protein 1		MOUSE		1645
Isoform 4 of Peroxisome proliferator-activated receptor gamma coactivator-related protein 1		MOUSE		719
+17

Protein	Similar proteins		Species	Score	Length	Source
Q6NZN1	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1		HUMAN		1664	UniRef50_Q5VV67
Uncharacterized protein		MACFA		1667
Uncharacterized protein		PAPAN		1667
Uncharacterized protein		MACNE		1667
Uncharacterized protein		MANLE		1667
+423
Q6NZN1-3	Uncharacterized protein		CAVPO		1388	UniRef50_Q6NZN1-3
peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X10		MESAU		1426
peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6		ODORO		1384
peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X6		LEPWE		1384
peroxisome proliferator-activated receptor gamma coactivator-related protein 1 isoform X2		DIPOR		1368
+29

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK122322 mRNA Translation: BAC65604.1 Different initiation. AK044522 mRNA Translation: BAC31964.1 AK147947 mRNA Translation: BAE28245.1 BC013720 mRNA Translation: AAH13720.1 BC066048 mRNA Translation: AAH66048.1
CCDSⁱ	CCDS38005.1 [Q6NZN1-1]
RefSeqⁱ	NP_001074683.1, NM_001081214.1 [Q6NZN1-1] NP_001333730.1, NM_001346801.1 [Q6NZN1-2] XP_017173655.1, XM_017318166.1 [Q6NZN1-5]
UniGeneⁱ	Mm.2415

3D structure databases

ProteinModelPortalⁱ	Q6NZN1
SMRⁱ	Q6NZN1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	Q6NZN1, 1 interactor
STRINGⁱ	10090.ENSMUSP00000107530

PTM databases

iPTMnetⁱ	Q6NZN1
PhosphoSitePlusⁱ	Q6NZN1

Proteomic databases

EPDⁱ	Q6NZN1
PaxDbⁱ	Q6NZN1
PeptideAtlasⁱ	Q6NZN1
PRIDEⁱ	Q6NZN1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000062322; ENSMUSP00000079389; ENSMUSG00000055491 [Q6NZN1-2] ENSMUST00000099392; ENSMUSP00000096990; ENSMUSG00000055491 [Q6NZN1-3] ENSMUST00000111899; ENSMUSP00000107530; ENSMUSG00000055491 [Q6NZN1-1]
GeneIDⁱ	226169
KEGGⁱ	mmu:226169
UCSCⁱ	uc008hsb.1 mouse [Q6NZN1-5] uc008hsc.1 mouse [Q6NZN1-2] uc008hsd.1 mouse [Q6NZN1-1] uc008hse.1 mouse [Q6NZN1-3]

Organism-specific databases

CTDⁱ	23082
MGIⁱ	MGI:2385096 Pprc1
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IK9Y Eukaryota ENOG4111HH9 LUCA
GeneTreeⁱ	ENSGT00530000063196
HOGENOMⁱ	HOG000115672
HOVERGENⁱ	HBG103282
InParanoidⁱ	Q6NZN1
KOⁱ	K17963
OMAⁱ	CTIHFRV
OrthoDBⁱ	EOG091G029M
TreeFamⁱ	TF343068

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q6NZN1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000055491 Expressed in 289 organ(s), highest expression level in embryo
ExpressionAtlasⁱ	Q6NZN1 baseline and differential
Genevisibleⁱ	Q6NZN1 MM

Family and domain databases

CDDⁱ	cd12624 RRM_PRC, 1 hit
Gene3Dⁱ	3.30.70.330, 1 hit
InterProⁱ	View protein in InterPro IPR012677 Nucleotide-bd_a/b_plait_sf IPR034605 PGC-1 IPR034597 PRC IPR034834 PRC_RRM IPR035979 RBD_domain_sf IPR000504 RRM_dom
PANTHERⁱ	PTHR15528 PTHR15528, 1 hit PTHR15528:SF5 PTHR15528:SF5, 1 hit
Pfamⁱ	View protein in Pfam PF00076 RRM_1, 1 hit
SMARTⁱ	View protein in SMART SM00360 RRM, 1 hit
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPRC1_MOUSE
Accessionⁱ	Q6NZN1Primary (citable) accession number: Q6NZN1 Secondary accession number(s): Q3UGG3 , Q80TW6, Q8BXP6, Q91YW8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 24, 2007
	Last sequence update:	July 5, 2004
	Last modified:	September 12, 2018
	This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q6NZN1 (PPRC1_MOUSE)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

Pprc1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ