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Entry version 135 (22 Apr 2020)
Sequence version 1 (05 Jul 2004)
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Protein

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

Gene

Pprc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, RNA-binding
Biological processTranscription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Alternative name(s):
PGC-1-related coactivator
Short name:
PRC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pprc1
Synonyms:Kiaa0595
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2385096 Pprc1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002966671 – 1644Peroxisome proliferator-activated receptor gamma coactivator-related protein 1Add BLAST1644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei232PhosphoserineBy similarity1
Modified residuei541PhosphoserineBy similarity1
Modified residuei1059PhosphoserineBy similarity1
Modified residuei1393PhosphoserineBy similarity1
Modified residuei1395PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NZN1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NZN1

PeptideAtlas

More...
PeptideAtlasi
Q6NZN1

PRoteomics IDEntifications database

More...
PRIDEi
Q6NZN1

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NZN1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NZN1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in liver, heart, skeletal muscle, kidney and white and brown adipose tissues.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by serum (at protein level). Up-regulated by serum. Up-regulated weakly in brown adipose tissue by exposure of animals to cold.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000055491 Expressed in embryo and 288 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NZN1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NZN1 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CREB1 and NRF1.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q6NZN1, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000107530

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6NZN1 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NZN1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1523 – 1599RRMPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni425 – 460Necessary for interaction with CREB1 and NRF1 and for transcriptional coactivationBy similarityAdd BLAST36
Regioni1361 – 1432Necessary for interaction with CREB1 and NRF1By similarityAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi748 – 1066Pro-richAdd BLAST319
Compositional biasi1385 – 1523Arg-richAdd BLAST139
Compositional biasi1393 – 1500Ser-richAdd BLAST108

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IK9Y Eukaryota
ENOG4111HH9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000183137

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001907_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NZN1

KEGG Orthology (KO)

More...
KOi
K17963

Identification of Orthologs from Complete Genome Data

More...
OMAi
IGECHTV

Database of Orthologous Groups

More...
OrthoDBi
94418at2759

TreeFam database of animal gene trees

More...
TreeFami
TF343068

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12624 RRM_PRC, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034597 PRC
IPR034834 PRC_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

The PANTHER Classification System

More...
PANTHERi
PTHR15528 PTHR15528, 1 hit
PTHR15528:SF5 PTHR15528:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00076 RRM_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NZN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAARRGRRDR VAPPPTGGPG PDPGGGVRGG SWASRSQAPY GTGGSVSAAE
60 70 80 90 100
QVHEEGNDSS FVSLSRLGPS LREKDLEMEE LILQDETLLE TMQSYMDASL
110 120 130 140 150
ISLIEDFGES RLSLEDQNEM SLLTALTEIL DNADSENLSP FDTIPDSELL
160 170 180 190 200
VSPRESSSLH KLLNLSRTPP ERDLITPIDP LGPSTGSSRV SGVEVPLADS
210 220 230 240 250
PWDFSPPPFL ETSSPKLPSW RPSRPRPRWG QSPPPQQRSD GEEEEEVAGF
260 270 280 290 300
SGQMLAGKLD NSVNNVLDFP MHLACPEEEG TAEGADAPAS APGDESISSL
310 320 330 340 350
SELVRAMHPY CLPNLTHLAS LEGELEGQAD ADADELTLPE GCVVLEIVGQ
360 370 380 390 400
AATTGDDLEI PVVVRQIPSG SQSVLLDESL GSSPALQLLM PTMESETEAA
410 420 430 440 450
VPEVAPCPDE ELPLSSACLL EPREIMESLT PKEPQSLPAS ASQGSQKVPR
460 470 480 490 500
KGRKKKNKEQ PTACVEACTR RLRSSSRGQS TVSAEVNSQA GSSQKQPQEE
510 520 530 540 550
LQREAAALQS RGKPRAWARA WAAALEKTGS ENLERSAGQD SPAEEDALDL
560 570 580 590 600
CPKLLETSQA NPTLSLNDSA QADSMPVDSV EGDSPAVGNA APGDQASSGT
610 620 630 640 650
ELVGSLPVGP NLTSPVLADK KGIEPAVAIP TSDNLSPADV LANTVAADPV
660 670 680 690 700
PNDPAPADPV LVKCRPTDPR RAAAAAAAAA QGSRPSLQSA DHPKVVSPEG
710 720 730 740 750
KDVVGPLKVE GSTSATTQEA KPRPLSLSEY RQRRQQRQTE AEDRNSQPPV
760 770 780 790 800
VGKWPSLPET PTELADIPCL VPSAPARKTA PQRSPIAVPE TVSVGSNPVS
810 820 830 840 850
PTPEPSASKL MVSTHSEQVS SHEMPLAVRP PPPPLPSVSP AGPIPSTVPA
860 870 880 890 900
PLPPFPPSVP PLLPLPSGGH GVPRLPPPPL QPPGLPVSMR QMPPDPYTQY
910 920 930 940 950
APVPPWSCYP SVSPPGYSCL PPPPTMPIVS GTPGTYAVPP TCNVPWVPPP
960 970 980 990 1000
APVSPYSSSC AYGSLGWGPG LQQPPFWSTV SPPPLSSVPT GRAVPPTPVE
1010 1020 1030 1040 1050
PSGDPAGPPE DVLPGPVTPS LSSGPASPAA PPVEPTKPEA QPVPVSPQPK
1060 1070 1080 1090 1100
HKVSTLVQSP QIKAPPTLST EGVVFEESVS ERLKSETQEN RPKEKPISTA
1110 1120 1130 1140 1150
IKSVPVPKQS AVAKLPAVHP ARLRKLSFLP TPRAQGPEDV VQAFISEIGI
1160 1170 1180 1190 1200
EASDLSSLLE QFEKSEAKKE CPLPASADSL AVGNSGIDIP QEKKPLDRLQ
1210 1220 1230 1240 1250
APELANVAGL TPPATPPHQL WKPLAAVSLL AKAKSPKSTA QEGTLKPEGI
1260 1270 1280 1290 1300
TEAKPPATAC LQEGAHSPSP VHVGSGDHDY CVRSRTPPKR MPALVISEVG
1310 1320 1330 1340 1350
SRWNVKRHQD ITIKPVLSLG SAAPPLPCTA TSQEPLDHRT SVEQADPSAP
1360 1370 1380 1390 1400
CFAPSTLLSP EASPCRSEMN ARTPPEPSDK QQSMRCYRKA CRSVSPSSRG
1410 1420 1430 1440 1450
WQGRRGRSSR SVSSGSSRTS EASSSSSVSS SSRSRSRSRS RSFSPPNKRW
1460 1470 1480 1490 1500
RRSSCSSSGR SRRCSSSSSS SSSSSSCSSR SRSPSVSPCR RSDRRRRYSS
1510 1520 1530 1540 1550
YRANDHYQRQ RVLQKERAIE ERRVVFIGKI PGRMTRSELK QRFSVFGEIE
1560 1570 1580 1590 1600
ECTIHFRVQG DNYGFVTYRY AEEAFAAIES GHKLRQADEQ PFDLCFGGRR
1610 1620 1630 1640
QFCKRSYSDL DSNREDFDPA PVKSKFDSLD FDTLLKQAQK NLRR
Length:1,644
Mass (Da):175,074
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB00165FEE51311A9
GO
Isoform 2 (identifier: Q6NZN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: E → EQ
     1186-1186: G → GS

Show »
Length:1,646
Mass (Da):175,289
Checksum:iE9F2DEE414392F26
GO
Isoform 3 (identifier: Q6NZN1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-192: Missing.
     1187-1207: IDIPQEKKPLDRLQAPELANV → SSARGVTLTLTPIGKTLILLL
     1208-1644: Missing.

Show »
Length:1,204
Mass (Da):126,159
Checksum:i13EA108D569D3E5A
GO
Isoform 4 (identifier: Q6NZN1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-925: Missing.

Show »
Length:719
Mass (Da):77,821
Checksum:iDAA29FE3AB55079A
GO
Isoform 5 (identifier: Q6NZN1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: E → EQ

Show »
Length:1,645
Mass (Da):175,202
Checksum:i4250C7322C399714
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YYR7D3YYR7_MOUSE
Peroxisome proliferator-activated r...
Pprc1
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z2D9D3Z2D9_MOUSE
Peroxisome proliferator-activated r...
Pprc1
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z1R3D3Z1R3_MOUSE
Peroxisome proliferator-activated r...
Pprc1
93Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z1F1D3Z1F1_MOUSE
Peroxisome proliferator-activated r...
Pprc1
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC65604 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti242Missing in BAC31964 (PubMed:16141072).Curated1
Sequence conflicti258K → E in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti409D → N in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti437L → I in BAE28245 (PubMed:16141072).Curated1
Sequence conflicti461P → S in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti508L → P in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti629I → V in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti864P → S in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti1007G → S in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti1432 – 1433Missing in BAC65604 (PubMed:12693553).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0272321 – 925Missing in isoform 4. 1 PublicationAdd BLAST925
Alternative sequenceiVSP_027233109E → EQ in isoform 2 and isoform 5. 2 Publications1
Alternative sequenceiVSP_027234190 – 192Missing in isoform 3. 1 Publication3
Alternative sequenceiVSP_0272351186G → GS in isoform 2. 1 Publication1
Alternative sequenceiVSP_0272361187 – 1207IDIPQ…ELANV → SSARGVTLTLTPIGKTLILL L in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0272371208 – 1644Missing in isoform 3. 1 PublicationAdd BLAST437

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK122322 mRNA Translation: BAC65604.1 Different initiation.
AK044522 mRNA Translation: BAC31964.1
AK147947 mRNA Translation: BAE28245.1
BC013720 mRNA Translation: AAH13720.1
BC066048 mRNA Translation: AAH66048.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS38005.1 [Q6NZN1-1]
CCDS89404.1 [Q6NZN1-2]

NCBI Reference Sequences

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RefSeqi
NP_001074683.1, NM_001081214.1 [Q6NZN1-1]
NP_001333730.1, NM_001346801.1 [Q6NZN1-2]
XP_017173655.1, XM_017318166.1 [Q6NZN1-5]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000062322; ENSMUSP00000079389; ENSMUSG00000055491 [Q6NZN1-2]
ENSMUST00000099392; ENSMUSP00000096990; ENSMUSG00000055491 [Q6NZN1-3]
ENSMUST00000111899; ENSMUSP00000107530; ENSMUSG00000055491 [Q6NZN1-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
226169

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:226169

UCSC genome browser

More...
UCSCi
uc008hsb.1 mouse [Q6NZN1-5]
uc008hsc.1 mouse [Q6NZN1-2]
uc008hsd.1 mouse [Q6NZN1-1]
uc008hse.1 mouse [Q6NZN1-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122322 mRNA Translation: BAC65604.1 Different initiation.
AK044522 mRNA Translation: BAC31964.1
AK147947 mRNA Translation: BAE28245.1
BC013720 mRNA Translation: AAH13720.1
BC066048 mRNA Translation: AAH66048.1
CCDSiCCDS38005.1 [Q6NZN1-1]
CCDS89404.1 [Q6NZN1-2]
RefSeqiNP_001074683.1, NM_001081214.1 [Q6NZN1-1]
NP_001333730.1, NM_001346801.1 [Q6NZN1-2]
XP_017173655.1, XM_017318166.1 [Q6NZN1-5]

3D structure databases

SMRiQ6NZN1
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ6NZN1, 1 interactor
STRINGi10090.ENSMUSP00000107530

PTM databases

iPTMnetiQ6NZN1
PhosphoSitePlusiQ6NZN1

Proteomic databases

EPDiQ6NZN1
PaxDbiQ6NZN1
PeptideAtlasiQ6NZN1
PRIDEiQ6NZN1

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48608 119 antibodies

Genome annotation databases

EnsembliENSMUST00000062322; ENSMUSP00000079389; ENSMUSG00000055491 [Q6NZN1-2]
ENSMUST00000099392; ENSMUSP00000096990; ENSMUSG00000055491 [Q6NZN1-3]
ENSMUST00000111899; ENSMUSP00000107530; ENSMUSG00000055491 [Q6NZN1-1]
GeneIDi226169
KEGGimmu:226169
UCSCiuc008hsb.1 mouse [Q6NZN1-5]
uc008hsc.1 mouse [Q6NZN1-2]
uc008hsd.1 mouse [Q6NZN1-1]
uc008hse.1 mouse [Q6NZN1-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23082
MGIiMGI:2385096 Pprc1

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiENOG410IK9Y Eukaryota
ENOG4111HH9 LUCA
GeneTreeiENSGT00950000183137
HOGENOMiCLU_001907_0_0_1
InParanoidiQ6NZN1
KOiK17963
OMAiIGECHTV
OrthoDBi94418at2759
TreeFamiTF343068

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Pprc1 mouse

Protein Ontology

More...
PROi
PR:Q6NZN1
RNActiQ6NZN1 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000055491 Expressed in embryo and 288 other tissues
ExpressionAtlasiQ6NZN1 baseline and differential
GenevisibleiQ6NZN1 MM

Family and domain databases

CDDicd12624 RRM_PRC, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034597 PRC
IPR034834 PRC_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR15528 PTHR15528, 1 hit
PTHR15528:SF5 PTHR15528:SF5, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPRC1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NZN1
Secondary accession number(s): Q3UGG3
, Q80TW6, Q8BXP6, Q91YW8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: April 22, 2020
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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