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Protein

Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

Gene

Pprc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Alternative name(s):
PGC-1-related coactivator
Short name:
PRC
Gene namesi
Name:Pprc1
Synonyms:Kiaa0595
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:2385096 Pprc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002966671 – 1644Peroxisome proliferator-activated receptor gamma coactivator-related protein 1Add BLAST1644

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei232PhosphoserineBy similarity1
Modified residuei541PhosphoserineBy similarity1
Modified residuei1059PhosphoserineBy similarity1
Modified residuei1393PhosphoserineBy similarity1
Modified residuei1395PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6NZN1
PaxDbiQ6NZN1
PeptideAtlasiQ6NZN1
PRIDEiQ6NZN1

PTM databases

iPTMnetiQ6NZN1
PhosphoSitePlusiQ6NZN1

Expressioni

Tissue specificityi

Expressed in liver, heart, skeletal muscle, kidney and white and brown adipose tissues.1 Publication

Inductioni

Up-regulated by serum (at protein level). Up-regulated by serum. Up-regulated weakly in brown adipose tissue by exposure of animals to cold.2 Publications

Gene expression databases

BgeeiENSMUSG00000055491 Expressed in 289 organ(s), highest expression level in embryo
ExpressionAtlasiQ6NZN1 baseline and differential
GenevisibleiQ6NZN1 MM

Interactioni

Subunit structurei

Interacts with CREB1 and NRF1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ6NZN1, 1 interactor
STRINGi10090.ENSMUSP00000107530

Structurei

3D structure databases

ProteinModelPortaliQ6NZN1
SMRiQ6NZN1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1523 – 1599RRMPROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni425 – 460Necessary for interaction with CREB1 and NRF1 and for transcriptional coactivationBy similarityAdd BLAST36
Regioni1361 – 1432Necessary for interaction with CREB1 and NRF1By similarityAdd BLAST72

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi748 – 1066Pro-richAdd BLAST319
Compositional biasi1385 – 1523Arg-richAdd BLAST139
Compositional biasi1393 – 1500Ser-richAdd BLAST108

Phylogenomic databases

eggNOGiENOG410IK9Y Eukaryota
ENOG4111HH9 LUCA
GeneTreeiENSGT00530000063196
HOGENOMiHOG000115672
HOVERGENiHBG103282
InParanoidiQ6NZN1
KOiK17963
OMAiCTIHFRV
OrthoDBiEOG091G029M
TreeFamiTF343068

Family and domain databases

CDDicd12624 RRM_PRC, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034597 PRC
IPR034834 PRC_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR15528 PTHR15528, 1 hit
PTHR15528:SF5 PTHR15528:SF5, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NZN1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAARRGRRDR VAPPPTGGPG PDPGGGVRGG SWASRSQAPY GTGGSVSAAE
60 70 80 90 100
QVHEEGNDSS FVSLSRLGPS LREKDLEMEE LILQDETLLE TMQSYMDASL
110 120 130 140 150
ISLIEDFGES RLSLEDQNEM SLLTALTEIL DNADSENLSP FDTIPDSELL
160 170 180 190 200
VSPRESSSLH KLLNLSRTPP ERDLITPIDP LGPSTGSSRV SGVEVPLADS
210 220 230 240 250
PWDFSPPPFL ETSSPKLPSW RPSRPRPRWG QSPPPQQRSD GEEEEEVAGF
260 270 280 290 300
SGQMLAGKLD NSVNNVLDFP MHLACPEEEG TAEGADAPAS APGDESISSL
310 320 330 340 350
SELVRAMHPY CLPNLTHLAS LEGELEGQAD ADADELTLPE GCVVLEIVGQ
360 370 380 390 400
AATTGDDLEI PVVVRQIPSG SQSVLLDESL GSSPALQLLM PTMESETEAA
410 420 430 440 450
VPEVAPCPDE ELPLSSACLL EPREIMESLT PKEPQSLPAS ASQGSQKVPR
460 470 480 490 500
KGRKKKNKEQ PTACVEACTR RLRSSSRGQS TVSAEVNSQA GSSQKQPQEE
510 520 530 540 550
LQREAAALQS RGKPRAWARA WAAALEKTGS ENLERSAGQD SPAEEDALDL
560 570 580 590 600
CPKLLETSQA NPTLSLNDSA QADSMPVDSV EGDSPAVGNA APGDQASSGT
610 620 630 640 650
ELVGSLPVGP NLTSPVLADK KGIEPAVAIP TSDNLSPADV LANTVAADPV
660 670 680 690 700
PNDPAPADPV LVKCRPTDPR RAAAAAAAAA QGSRPSLQSA DHPKVVSPEG
710 720 730 740 750
KDVVGPLKVE GSTSATTQEA KPRPLSLSEY RQRRQQRQTE AEDRNSQPPV
760 770 780 790 800
VGKWPSLPET PTELADIPCL VPSAPARKTA PQRSPIAVPE TVSVGSNPVS
810 820 830 840 850
PTPEPSASKL MVSTHSEQVS SHEMPLAVRP PPPPLPSVSP AGPIPSTVPA
860 870 880 890 900
PLPPFPPSVP PLLPLPSGGH GVPRLPPPPL QPPGLPVSMR QMPPDPYTQY
910 920 930 940 950
APVPPWSCYP SVSPPGYSCL PPPPTMPIVS GTPGTYAVPP TCNVPWVPPP
960 970 980 990 1000
APVSPYSSSC AYGSLGWGPG LQQPPFWSTV SPPPLSSVPT GRAVPPTPVE
1010 1020 1030 1040 1050
PSGDPAGPPE DVLPGPVTPS LSSGPASPAA PPVEPTKPEA QPVPVSPQPK
1060 1070 1080 1090 1100
HKVSTLVQSP QIKAPPTLST EGVVFEESVS ERLKSETQEN RPKEKPISTA
1110 1120 1130 1140 1150
IKSVPVPKQS AVAKLPAVHP ARLRKLSFLP TPRAQGPEDV VQAFISEIGI
1160 1170 1180 1190 1200
EASDLSSLLE QFEKSEAKKE CPLPASADSL AVGNSGIDIP QEKKPLDRLQ
1210 1220 1230 1240 1250
APELANVAGL TPPATPPHQL WKPLAAVSLL AKAKSPKSTA QEGTLKPEGI
1260 1270 1280 1290 1300
TEAKPPATAC LQEGAHSPSP VHVGSGDHDY CVRSRTPPKR MPALVISEVG
1310 1320 1330 1340 1350
SRWNVKRHQD ITIKPVLSLG SAAPPLPCTA TSQEPLDHRT SVEQADPSAP
1360 1370 1380 1390 1400
CFAPSTLLSP EASPCRSEMN ARTPPEPSDK QQSMRCYRKA CRSVSPSSRG
1410 1420 1430 1440 1450
WQGRRGRSSR SVSSGSSRTS EASSSSSVSS SSRSRSRSRS RSFSPPNKRW
1460 1470 1480 1490 1500
RRSSCSSSGR SRRCSSSSSS SSSSSSCSSR SRSPSVSPCR RSDRRRRYSS
1510 1520 1530 1540 1550
YRANDHYQRQ RVLQKERAIE ERRVVFIGKI PGRMTRSELK QRFSVFGEIE
1560 1570 1580 1590 1600
ECTIHFRVQG DNYGFVTYRY AEEAFAAIES GHKLRQADEQ PFDLCFGGRR
1610 1620 1630 1640
QFCKRSYSDL DSNREDFDPA PVKSKFDSLD FDTLLKQAQK NLRR
Length:1,644
Mass (Da):175,074
Last modified:July 5, 2004 - v1
Checksum:iB00165FEE51311A9
GO
Isoform 2 (identifier: Q6NZN1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: E → EQ
     1186-1186: G → GS

Show »
Length:1,646
Mass (Da):175,289
Checksum:iE9F2DEE414392F26
GO
Isoform 3 (identifier: Q6NZN1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     190-192: Missing.
     1187-1207: IDIPQEKKPLDRLQAPELANV → SSARGVTLTLTPIGKTLILLL
     1208-1644: Missing.

Show »
Length:1,204
Mass (Da):126,159
Checksum:i13EA108D569D3E5A
GO
Isoform 4 (identifier: Q6NZN1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-925: Missing.

Show »
Length:719
Mass (Da):77,821
Checksum:iDAA29FE3AB55079A
GO
Isoform 5 (identifier: Q6NZN1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     109-109: E → EQ

Show »
Length:1,645
Mass (Da):175,202
Checksum:i4250C7322C399714
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z2D9D3Z2D9_MOUSE
Peroxisome proliferator-activated r...
Pprc1
120Annotation score:
D3YYR7D3YYR7_MOUSE
Peroxisome proliferator-activated r...
Pprc1
145Annotation score:
D3Z1R3D3Z1R3_MOUSE
Peroxisome proliferator-activated r...
Pprc1
93Annotation score:
D3Z1F1D3Z1F1_MOUSE
Peroxisome proliferator-activated r...
Pprc1
43Annotation score:

Sequence cautioni

The sequence BAC65604 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti242Missing in BAC31964 (PubMed:16141072).Curated1
Sequence conflicti258K → E in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti409D → N in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti437L → I in BAE28245 (PubMed:16141072).Curated1
Sequence conflicti461P → S in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti508L → P in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti629I → V in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti864P → S in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti1007G → S in BAC65604 (PubMed:12693553).Curated1
Sequence conflicti1432 – 1433Missing in BAC65604 (PubMed:12693553).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0272321 – 925Missing in isoform 4. 1 PublicationAdd BLAST925
Alternative sequenceiVSP_027233109E → EQ in isoform 2 and isoform 5. 2 Publications1
Alternative sequenceiVSP_027234190 – 192Missing in isoform 3. 1 Publication3
Alternative sequenceiVSP_0272351186G → GS in isoform 2. 1 Publication1
Alternative sequenceiVSP_0272361187 – 1207IDIPQ…ELANV → SSARGVTLTLTPIGKTLILL L in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0272371208 – 1644Missing in isoform 3. 1 PublicationAdd BLAST437

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122322 mRNA Translation: BAC65604.1 Different initiation.
AK044522 mRNA Translation: BAC31964.1
AK147947 mRNA Translation: BAE28245.1
BC013720 mRNA Translation: AAH13720.1
BC066048 mRNA Translation: AAH66048.1
CCDSiCCDS38005.1 [Q6NZN1-1]
RefSeqiNP_001074683.1, NM_001081214.1 [Q6NZN1-1]
NP_001333730.1, NM_001346801.1 [Q6NZN1-2]
XP_017173655.1, XM_017318166.1 [Q6NZN1-5]
UniGeneiMm.2415

Genome annotation databases

EnsembliENSMUST00000062322; ENSMUSP00000079389; ENSMUSG00000055491 [Q6NZN1-2]
ENSMUST00000099392; ENSMUSP00000096990; ENSMUSG00000055491 [Q6NZN1-3]
ENSMUST00000111899; ENSMUSP00000107530; ENSMUSG00000055491 [Q6NZN1-1]
GeneIDi226169
KEGGimmu:226169
UCSCiuc008hsb.1 mouse [Q6NZN1-5]
uc008hsc.1 mouse [Q6NZN1-2]
uc008hsd.1 mouse [Q6NZN1-1]
uc008hse.1 mouse [Q6NZN1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK122322 mRNA Translation: BAC65604.1 Different initiation.
AK044522 mRNA Translation: BAC31964.1
AK147947 mRNA Translation: BAE28245.1
BC013720 mRNA Translation: AAH13720.1
BC066048 mRNA Translation: AAH66048.1
CCDSiCCDS38005.1 [Q6NZN1-1]
RefSeqiNP_001074683.1, NM_001081214.1 [Q6NZN1-1]
NP_001333730.1, NM_001346801.1 [Q6NZN1-2]
XP_017173655.1, XM_017318166.1 [Q6NZN1-5]
UniGeneiMm.2415

3D structure databases

ProteinModelPortaliQ6NZN1
SMRiQ6NZN1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6NZN1, 1 interactor
STRINGi10090.ENSMUSP00000107530

PTM databases

iPTMnetiQ6NZN1
PhosphoSitePlusiQ6NZN1

Proteomic databases

EPDiQ6NZN1
PaxDbiQ6NZN1
PeptideAtlasiQ6NZN1
PRIDEiQ6NZN1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000062322; ENSMUSP00000079389; ENSMUSG00000055491 [Q6NZN1-2]
ENSMUST00000099392; ENSMUSP00000096990; ENSMUSG00000055491 [Q6NZN1-3]
ENSMUST00000111899; ENSMUSP00000107530; ENSMUSG00000055491 [Q6NZN1-1]
GeneIDi226169
KEGGimmu:226169
UCSCiuc008hsb.1 mouse [Q6NZN1-5]
uc008hsc.1 mouse [Q6NZN1-2]
uc008hsd.1 mouse [Q6NZN1-1]
uc008hse.1 mouse [Q6NZN1-3]

Organism-specific databases

CTDi23082
MGIiMGI:2385096 Pprc1
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IK9Y Eukaryota
ENOG4111HH9 LUCA
GeneTreeiENSGT00530000063196
HOGENOMiHOG000115672
HOVERGENiHBG103282
InParanoidiQ6NZN1
KOiK17963
OMAiCTIHFRV
OrthoDBiEOG091G029M
TreeFamiTF343068

Miscellaneous databases

PROiPR:Q6NZN1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055491 Expressed in 289 organ(s), highest expression level in embryo
ExpressionAtlasiQ6NZN1 baseline and differential
GenevisibleiQ6NZN1 MM

Family and domain databases

CDDicd12624 RRM_PRC, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR034605 PGC-1
IPR034597 PRC
IPR034834 PRC_RRM
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PANTHERiPTHR15528 PTHR15528, 1 hit
PTHR15528:SF5 PTHR15528:SF5, 1 hit
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPRC1_MOUSE
AccessioniPrimary (citable) accession number: Q6NZN1
Secondary accession number(s): Q3UGG3
, Q80TW6, Q8BXP6, Q91YW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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