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Entry version 122 (12 Aug 2020)
Sequence version 1 (05 Jul 2004)
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Protein

3'-phosphoadenosine-5'-phosphosulfate synthase

Gene

Papss1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: sulfate assimilation

This protein is involved in the pathway sulfate assimilation, which is part of Sulfur metabolism.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway sulfate assimilation and in Sulfur metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMultifunctional enzymeARBA annotation, NucleotidyltransferaseARBA annotation, Transferase
LigandATP-bindingARBA annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00097

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3'-phosphoadenosine-5'-phosphosulfate synthaseARBA annotation (EC:2.7.1.25ARBA annotation, EC:2.7.7.4ARBA annotation)
Alternative name(s):
APS kinaseARBA annotation
ATP-sulfurylaseARBA annotation
Adenosine-5'-phosphosulfate 3'-phosphotransferaseARBA annotation
Adenylyl-sulfate kinaseARBA annotation
Adenylylsulfate 3'-phosphotransferaseARBA annotation
Sulfate adenylyltransferaseARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Papss1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1330587, Papss1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000028032, Expressed in vestibular membrane of cochlear duct and 322 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini212 – 364PUA_2InterPro annotationAdd BLAST153
Domaini373 – 595ATP-sulfurylaseInterPro annotationAdd BLAST223

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

In the C-terminal section; belongs to the sulfate adenylyltransferase family.ARBA annotation
In the N-terminal section; belongs to the APS kinase family.ARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009613

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009463_3_0_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QDYDFIS

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02027, APSK, 1 hit
cd00517, ATPS, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.620, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_00065, Adenylyl_sulf_kinase, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002891, APS_kinase
IPR025980, ATP-Sase_PUA-like_dom
IPR027417, P-loop_NTPase
IPR015947, PUA-like_sf
IPR014729, Rossmann-like_a/b/a_fold
IPR024951, Sulfurylase_cat_dom
IPR002650, Sulphate_adenylyltransferase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01747, ATP-sulfurylase, 1 hit
PF14306, PUA_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit
SSF88697, SSF88697, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00455, apsK, 1 hit
TIGR00339, sopT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q6NZM8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQRATNVTYQ AHHVSRNKRG QVVGTRGGFR GCTVWLTGLS GAGKTTVSMA
60 70 80 90 100
LEEYLVCHGI PCYTLDGDNI RQGLNKNLGF SPEDREENVR RIAEVAKLFA
110 120 130 140 150
DAGLVCITSF ISPYTQDRNN ARQIHEGASL PFFEVFVDAP LHVCEQRDVK
160 170 180 190 200
GLYKKARAGE IKGFTGIDSE YEKPEAPELV LKTDSCDVND CVQQVVELLQ
210 220 230 240 250
ERDIVPVDAS YEVKELYVPE NKLHLAKTDA EALPALKINK VDMQWVQVLA
260 270 280 290 300
EGWATPLNGF MREREYLQCL HFDCLLDGGV INLSVPIVLT ATHEDKERLD
310 320 330 340 350
GCTAFALVYE GRRVAILRNP EFFEHRKEER CARQWGTTCK NHPYIKMVLE
360 370 380 390 400
QGDWLIGGDL QVLDRIYWND GLDQYRLTPT ELKQKFKDMN ADAVFAFQLR
410 420 430 440 450
NPVHNGHALL MQDTHKQLLE RGYRRPVLLL HPLGGWTKDD DVPLMWRMKQ
460 470 480 490 500
HAAVLEEGIL DPETTVVAIF PSPMMYAGPT EVQWHCRARM VAGANFYIVG
510 520 530 540 550
RDPAGMPHPE TGKDLYEPTH GAKVLTMAPG LITLEIVPFR VAAYNKKKKR
560 570 580 590 600
MDYYDSEHHE DFEFISGTRM RKLAREGQKP PEGFMAPKAW TVLVEYYKSL

EKA
Length:603
Mass (Da):68,494
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3EB4714F7FC2CD00
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q60967PAPS1_MOUSE
Bifunctional 3'-phosphoadenosine 5'...
Papss1 Asapk, Atpsk1, Papss
624Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFK8A0A0G2JFK8_MOUSE
Bifunctional 3'-phosphoadenosine 5'...
Papss1
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JFM1A0A0G2JFM1_MOUSE
Bifunctional 3'-phosphoadenosine 5'...
Papss1
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC127686 Genomic DNA No translation available.
BC066055 mRNA Translation: AAH66055.1
AK169117 mRNA Translation: BAE40897.1
AK169204 mRNA Translation: BAE40977.1

NCBI Reference Sequences

More...
RefSeqi
NP_001276406.1, NM_001289477.1
NP_001276407.1, NM_001289478.1
NP_001276408.1, NM_001289479.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000199878; ENSMUSP00000142533; ENSMUSG00000028032
ENSMUST00000200527; ENSMUSP00000142616; ENSMUSG00000028032

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23971

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC127686 Genomic DNA No translation available.
BC066055 mRNA Translation: AAH66055.1
AK169117 mRNA Translation: BAE40897.1
AK169204 mRNA Translation: BAE40977.1
RefSeqiNP_001276406.1, NM_001289477.1
NP_001276407.1, NM_001289478.1
NP_001276408.1, NM_001289479.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26233, 167 antibodies

Genome annotation databases

EnsembliENSMUST00000199878; ENSMUSP00000142533; ENSMUSG00000028032
ENSMUST00000200527; ENSMUSP00000142616; ENSMUSG00000028032
GeneIDi23971

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9061
MGIiMGI:1330587, Papss1

Phylogenomic databases

GeneTreeiENSGT00390000009613
HOGENOMiCLU_009463_3_0_1
OMAiQDYDFIS

Enzyme and pathway databases

UniPathwayiUPA00097

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
23971, 1 hit in 21 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Papss1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000028032, Expressed in vestibular membrane of cochlear duct and 322 other tissues

Family and domain databases

CDDicd02027, APSK, 1 hit
cd00517, ATPS, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00065, Adenylyl_sulf_kinase, 1 hit
InterProiView protein in InterPro
IPR002891, APS_kinase
IPR025980, ATP-Sase_PUA-like_dom
IPR027417, P-loop_NTPase
IPR015947, PUA-like_sf
IPR014729, Rossmann-like_a/b/a_fold
IPR024951, Sulfurylase_cat_dom
IPR002650, Sulphate_adenylyltransferase
PfamiView protein in Pfam
PF01747, ATP-sulfurylase, 1 hit
PF14306, PUA_2, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
SSF88697, SSF88697, 1 hit
TIGRFAMsiTIGR00455, apsK, 1 hit
TIGR00339, sopT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6NZM8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NZM8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: August 12, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health

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