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Entry version 142 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Eukaryotic translation initiation factor 4 gamma 1

Gene

Eif4g1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis, Translation regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1169408 ISG15 antiviral mechanism
R-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-166208 mTORC1-mediated signalling
R-MMU-429947 Deadenylation of mRNA
R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-72649 Translation initiation complex formation
R-MMU-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-MMU-72702 Ribosomal scanning and start codon recognition
R-MMU-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-MMU-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4 gamma 1
Short name:
eIF-4-gamma 1
Short name:
eIF-4G 1
Short name:
eIF-4G1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Eif4g1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2384784 Eif4g1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002133221 – 1600Eukaryotic translation initiation factor 4 gamma 1Add BLAST1600

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei15PhosphoserineCombined sources1
Modified residuei80Omega-N-methylarginineBy similarity1
Modified residuei117Omega-N-methylarginineCombined sources1
Modified residuei214PhosphothreonineCombined sources1
Modified residuei230PhosphoserineCombined sources1
Modified residuei324PhosphoserineBy similarity1
Modified residuei606N6-acetyllysineCombined sources1
Modified residuei651PhosphothreonineBy similarity1
Modified residuei689Omega-N-methylarginineCombined sources1
Modified residuei698Omega-N-methylarginineBy similarity1
Modified residuei1032PhosphoserineBy similarity1
Modified residuei1036Omega-N-methylarginineCombined sources1
Modified residuei1046Omega-N-methylarginineCombined sources1
Modified residuei1081PhosphoserineBy similarity1
Modified residuei1096PhosphoserineCombined sources1
Modified residuei1099N6-acetyllysineBy similarity1
Modified residuei1147PhosphoserineBy similarity1
Modified residuei1149PhosphoserineBy similarity1
Modified residuei1187Phosphoserine; by PKC/PRKCABy similarity1
Modified residuei1189PhosphoserineCombined sources1
Modified residuei1196PhosphoserineBy similarity1
Modified residuei1211PhosphoserineCombined sources1
Modified residuei1213PhosphothreonineBy similarity1
Modified residuei1231PhosphoserineCombined sources1
Modified residuei1238PhosphoserineBy similarity1
Modified residuei1597PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at multiple sites in vivo. Phosphorylation at Ser-1187 by PRKCA induces binding to MKNK1 (By similarity).By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NZJ6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NZJ6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NZJ6

PeptideAtlas

More...
PeptideAtlasi
Q6NZJ6

PRoteomics IDEntifications database

More...
PRIDEi
Q6NZJ6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NZJ6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NZJ6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6NZJ6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045983 Expressed in 294 organ(s), highest expression level in liver

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6NZJ6 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NZJ6 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3.

Interacts with eIF3, mutually exclusive with EIF4A1 or EIFA2, EIF4E and through its N-terminus with PAPBC1.

Interacts through its C-terminus with the serine/threonine kinases MKNK1, and with MKNK2. Appears to act as a scaffold protein, holding these enzymes in place to phosphorylate EIF4E. Non-phosphorylated EIF4EBP1 competes with EIF4G1/EIF4G3 to interact with EIF4E; insulin stimulated MAP-kinase (MAPK1 and MAPK3) phosphorylation of EIF4EBP1 causes dissociation of the complex allowing EIF4G1/EIF4G3 to bind and consequent initiation of translation.

Interacts with CIRBP and MIF4GD.

Interacts with RBM4.

Interacts with EIF4E3.

Interacts with HNRNPD/AUF1; the interaction requires RNA.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
228998, 6 interactors

Database of interacting proteins

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DIPi
DIP-42771N

Protein interaction database and analysis system

More...
IntActi
Q6NZJ6, 12 interactors

Molecular INTeraction database

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MINTi
Q6NZJ6

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000047678

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NZJ6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini765 – 993MIF4GPROSITE-ProRule annotationAdd BLAST229
Domaini1241 – 1363MIPROSITE-ProRule annotationAdd BLAST123
Domaini1429 – 1599W2PROSITE-ProRule annotationAdd BLAST171

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni179 – 207PABPC1-bindingBy similarityAdd BLAST29
Regioni611 – 622EIF4E-bindingBy similarityAdd BLAST12
Regioni686 – 1089eIF3/EIF4A-bindingBy similarityAdd BLAST404
Regioni1450 – 1600EIF4A-bindingBy similarityAdd BLAST151
Regioni1585 – 1600Necessary but not sufficient for MKNK1-bindingBy similarityAdd BLAST16

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi464 – 487Asp/Glu-richAdd BLAST24

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0401 Eukaryota
ENOG410XS4P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154648

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231658

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NZJ6

KEGG Orthology (KO)

More...
KOi
K03260

Database of Orthologous Groups

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OrthoDBi
594395at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NZJ6

TreeFam database of animal gene trees

More...
TreeFami
TF101527

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.40.180, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024 ARM-type_fold
IPR037584 EIF4G1
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR003307 W2_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23253:SF10 PTHR23253:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
PF02020 W2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00515 eIF5C, 1 hit
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF48371 SSF48371, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51366 MI, 1 hit
PS51363 W2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 17 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NZJ6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKAPQPTGP PPARSPGLPQ PAFPPGQTAP VVFSTPQATQ MNTPSQPRQG
60 70 80 90 100
GFRSLQHFYP SRAQPPSSAA SRVQSAAPAR PGPAPHVYPA GSQVMMIPSQ
110 120 130 140 150
ISYSASQGAY YIPGQGRSTY VVPTQQYPVQ PGAPGFYPGA SPTEFGTYAG
160 170 180 190 200
AYYPAQGVQQ FPASVAPAPV LMNQPPQIAP KRERKTIRIR DPNQGGKDIT
210 220 230 240 250
EEIMSGARTA STPTPPQTGG SLEPQPNGES PQVAVIIRPD DRSQGAAIGG
260 270 280 290 300
RPGLPGPEHS PGTESQPSSP SPTPSPPPIL EPGSESNLGV LSIPGDTMTT
310 320 330 340 350
GMIPMSVEES TPISCETGEP YCLSPEPTLA EPILEVEVTL SKPIPESEFS
360 370 380 390 400
SSPLQVSTAL VPHKVETHEP NGVIPSEDLE PEVESSTEPA PPPLSPCASE
410 420 430 440 450
SLVPIAPTAQ PEELLNGAPS PPAVDLSPVS EPEEQAKKVS SAALASILSP
460 470 480 490 500
APPVAPSDTS PAQEEEMEED DDDEEGGEAE SEKGGEDVPL DSTPVPAQLS
510 520 530 540 550
QNLEVAAATQ VAVSVPKRRR KIKELNKKEA VGDLLDAFKE VDPAVPEVEN
560 570 580 590 600
QPPTGSNPSP ESEGSMVPTQ PEETEETWDS KEDKIHNAEN IQPGEQKYEY
610 620 630 640 650
KSDQWKPLNL EEKKRYDREF LLGFQFIFAS MQKPEGLPHI TDVVLDKANK
660 670 680 690 700
TPLRQLDPSR LPGINCGPDF TPSFANLGRP ALSNRGPPRG GPGGELPRGP
710 720 730 740 750
AGLGPRRSQQ GPRKETRKII SSVIMTEDIK LNKAEKAWKP SSKRTAADKD
760 770 780 790 800
RGEEDADGSK TQDLFRRVRS ILNKLTPQMF QQLMKQVTQL AIDTEERLKG
810 820 830 840 850
VIDLIFEKAI SEPNFSVAYA NMCRCLMALK VPTTEKPTVT VNFRKLLLNR
860 870 880 890 900
CQKEFEKDKD DDEVFEKKQK EMDEAATAEE RGRLKEELEE ARDIARRRSL
910 920 930 940 950
GNIKFIGELF KLKMLTEAIM HDCVVKLLKN HDEESLECLC RLLTTIGKDL
960 970 980 990 1000
DFAKAKPRMD QYFNQMEKII KEKKTSSRIR FMLQDVLDLR QSNWVPRRGD
1010 1020 1030 1040 1050
QGPKTIDQIH KEAEMEEHRE HIKVQQLMAK GSDKRRGGPP GPPINRGLPL
1060 1070 1080 1090 1100
VDDGGWNTVP ISKGSRPIDT SRLTKITKPG SIDSNNQLFA PGGRLSWGKG
1110 1120 1130 1140 1150
SSGGSGAKPS DTASEATRPA TLNRFSALQQ TLPAENTDNR RVVQRSSLSR
1160 1170 1180 1190 1200
ERGEKAGDRG DRLERSERGG DRGDRLDRAR TPATKRSFSK EVEERSRERP
1210 1220 1230 1240 1250
SQPEGLRKAA SLTEDRGRDP VKREATLPPV SPPKAALSVD EVEKKSKAII
1260 1270 1280 1290 1300
EEYLHLNDMK EAVQCVQELA SPSLLFIFVR LGIESTLERS TIAREHMGRL
1310 1320 1330 1340 1350
LHQLLCAGHL STAQYYQGLY ETLELAEDME IDIPHVWLYL AELITPILQE
1360 1370 1380 1390 1400
DGVPMGELFR EITKPLRPMG KATSLLLEIL GLLCKSMGPK KVGMLWREAG
1410 1420 1430 1440 1450
LSWREFLAEG QDVGSFVAEK KVEYTLGEES EAPGQRTLAF EELRRQLEKL
1460 1470 1480 1490 1500
LKDGGSNQRV FDWIDANLNE QQIASNTLVR ALMTTVCYSA IIFETPLRVD
1510 1520 1530 1540 1550
VQVLKVRARL LQKYLCDEQK ELQALYALQA LVVTLEQPAN LLRMFFDALY
1560 1570 1580 1590 1600
DEDVVKEDAF YSWESSKDPA EQQGKGVALK SVTAFFNWLR EAEDEESDHN
Length:1,600
Mass (Da):176,077
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8664A8B449C7A128
GO
Isoform 2 (identifier: Q6NZJ6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-55: Missing.
     1046-1052: Missing.

Show »
Length:1,586
Mass (Da):174,580
Checksum:i78C8FF512118F134
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 17 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PVC5E9PVC5_MOUSE
Eukaryotic translation initiation f...
Eif4g1
1,594Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q9E1E9Q9E1_MOUSE
Eukaryotic translation initiation f...
Eif4g1
1,593Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q770E9Q770_MOUSE
Eukaryotic translation initiation f...
Eif4g1
958Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PVC6E9PVC6_MOUSE
Eukaryotic translation initiation f...
Eif4g1
1,553Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUS5A0A0J9YUS5_MOUSE
Eukaryotic translation initiation f...
Eif4g1
1,303Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YUC1A0A0J9YUC1_MOUSE
Eukaryotic translation initiation f...
Eif4g1
900Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0J9YVC1A0A0J9YVC1_MOUSE
Eukaryotic translation initiation f...
Eif4g1
795Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YWY7D3YWY7_MOUSE
Eukaryotic translation initiation f...
Eif4g1
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YWM1D3YWM1_MOUSE
Eukaryotic translation initiation f...
Eif4g1
202Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z439D3Z439_MOUSE
Eukaryotic translation initiation f...
Eif4g1
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01397449 – 55Missing in isoform 2. 2 Publications7
Alternative sequenceiVSP_0139751046 – 1052Missing in isoform 2. 2 Publications7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
BC066038 mRNA Translation: AAH66038.1
BC066103 mRNA Translation: AAH66103.1
BC079675 mRNA Translation: AAH79675.1
AK053144 mRNA Translation: BAC35282.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28055.1 [Q6NZJ6-1]
CCDS84213.1 [Q6NZJ6-2]

NCBI Reference Sequences

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RefSeqi
NP_001291361.1, NM_001304432.1 [Q6NZJ6-2]
NP_666053.2, NM_145941.3 [Q6NZJ6-1]
XP_006522000.1, XM_006521937.1 [Q6NZJ6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000044783; ENSMUSP00000047678; ENSMUSG00000045983 [Q6NZJ6-1]
ENSMUST00000115460; ENSMUSP00000111120; ENSMUSG00000045983 [Q6NZJ6-1]
ENSMUST00000115463; ENSMUSP00000111123; ENSMUSG00000045983 [Q6NZJ6-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
208643

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:208643

UCSC genome browser

More...
UCSCi
uc007yqs.2 mouse [Q6NZJ6-1]
uc012acy.2 mouse [Q6NZJ6-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066038 mRNA Translation: AAH66038.1
BC066103 mRNA Translation: AAH66103.1
BC079675 mRNA Translation: AAH79675.1
AK053144 mRNA Translation: BAC35282.1
CCDSiCCDS28055.1 [Q6NZJ6-1]
CCDS84213.1 [Q6NZJ6-2]
RefSeqiNP_001291361.1, NM_001304432.1 [Q6NZJ6-2]
NP_666053.2, NM_145941.3 [Q6NZJ6-1]
XP_006522000.1, XM_006521937.1 [Q6NZJ6-1]

3D structure databases

SMRiQ6NZJ6
ModBaseiSearch...

Protein-protein interaction databases

BioGridi228998, 6 interactors
DIPiDIP-42771N
IntActiQ6NZJ6, 12 interactors
MINTiQ6NZJ6
STRINGi10090.ENSMUSP00000047678

PTM databases

iPTMnetiQ6NZJ6
PhosphoSitePlusiQ6NZJ6
SwissPalmiQ6NZJ6

Proteomic databases

EPDiQ6NZJ6
jPOSTiQ6NZJ6
PaxDbiQ6NZJ6
PeptideAtlasiQ6NZJ6
PRIDEiQ6NZJ6

Genome annotation databases

EnsembliENSMUST00000044783; ENSMUSP00000047678; ENSMUSG00000045983 [Q6NZJ6-1]
ENSMUST00000115460; ENSMUSP00000111120; ENSMUSG00000045983 [Q6NZJ6-1]
ENSMUST00000115463; ENSMUSP00000111123; ENSMUSG00000045983 [Q6NZJ6-2]
GeneIDi208643
KEGGimmu:208643
UCSCiuc007yqs.2 mouse [Q6NZJ6-1]
uc012acy.2 mouse [Q6NZJ6-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1981
MGIiMGI:2384784 Eif4g1

Phylogenomic databases

eggNOGiKOG0401 Eukaryota
ENOG410XS4P LUCA
GeneTreeiENSGT00940000154648
HOGENOMiHOG000231658
InParanoidiQ6NZJ6
KOiK03260
OrthoDBi594395at2759
PhylomeDBiQ6NZJ6
TreeFamiTF101527

Enzyme and pathway databases

ReactomeiR-MMU-1169408 ISG15 antiviral mechanism
R-MMU-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-MMU-166208 mTORC1-mediated signalling
R-MMU-429947 Deadenylation of mRNA
R-MMU-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA
R-MMU-72649 Translation initiation complex formation
R-MMU-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
R-MMU-72702 Ribosomal scanning and start codon recognition
R-MMU-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-MMU-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Eif4g1 mouse

Protein Ontology

More...
PROi
PR:Q6NZJ6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045983 Expressed in 294 organ(s), highest expression level in liver
ExpressionAtlasiQ6NZJ6 baseline and differential
GenevisibleiQ6NZJ6 MM

Family and domain databases

Gene3Di1.25.40.180, 3 hits
InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR037584 EIF4G1
IPR003891 Initiation_fac_eIF4g_MI
IPR016021 MIF4-like_sf
IPR003890 MIF4G-like_typ-3
IPR003307 W2_domain
PANTHERiPTHR23253:SF10 PTHR23253:SF10, 1 hit
PfamiView protein in Pfam
PF02847 MA3, 1 hit
PF02854 MIF4G, 1 hit
PF02020 W2, 1 hit
SMARTiView protein in SMART
SM00515 eIF5C, 1 hit
SM00544 MA3, 1 hit
SM00543 MIF4G, 1 hit
SUPFAMiSSF48371 SSF48371, 3 hits
PROSITEiView protein in PROSITE
PS51366 MI, 1 hit
PS51363 W2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIF4G1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NZJ6
Secondary accession number(s): Q6NZN8, Q8BW99
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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