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Protein
Submitted name:

RAS, guanyl-releasing protein 3

Gene

Rasgrp3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi433 – 444PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi462 – 473PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • GTPase activator activity Source: MGI
  • kinase binding Source: MGI
  • Ras GTPase binding Source: MGI
  • Ras guanyl-nucleotide exchange factor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factorPROSITE-ProRule annotationSAAS annotation
LigandCalciumPROSITE-ProRule annotation, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-1169092 Activation of RAS in B cells
R-MMU-5673001 RAF/MAP kinase cascade

Names & Taxonomyi

Protein namesi
Submitted name:
RAS, guanyl-releasing protein 3Imported
Gene namesi
Name:Rasgrp3Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:3028579 Rasgrp3

Subcellular locationi

Expressioni

Gene expression databases

BgeeiENSMUSG00000071042 Expressed in 217 organ(s), highest expression level in brain blood vessel

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092828

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 125N-terminal Ras-GEFInterPro annotationAdd BLAST123
Domaini152 – 383Ras-GEFInterPro annotationAdd BLAST232
Domaini420 – 455EF-handInterPro annotationAdd BLAST36
Domaini458 – 484EF-handInterPro annotationAdd BLAST27
Domaini494 – 544Phorbol-ester/DAG-typeInterPro annotationAdd BLAST51

Keywords - Domaini

Zinc-fingerSAAS annotation

Phylogenomic databases

eggNOGiENOG410KD39 Eukaryota
ENOG410XTGZ LUCA
GeneTreeiENSGT00880000137870
HOVERGENiHBG007513
KOiK12362
OMAiSFTDYQS
OrthoDBiEOG091G03RN
TreeFamiTF312918

Family and domain databases

CDDicd00029 C1, 1 hit
cd00051 EFh, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002219 PE/DAG-bd
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR029645 RASGRP1/RASGRP3
PANTHERiPTHR23113 PTHR23113, 1 hit
PTHR23113:SF178 PTHR23113:SF178, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF13202 EF-hand_5, 2 hits
PF00617 RasGEF, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00054 EFh, 2 hits
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NZH9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSNGLGKAA TLDELLSTCI EMFDDNGDLN DSYLPRIVLL MHRWYLSSTE
60 70 80 90 100
LAGKLLCMYR NASGESCDEF RLKICYFMRY WILKFPAEFN LDLGLIRMTE
110 120 130 140 150
EFREVASQLG HEKHISLMDI SSVPSYDWMR RVTQRKKVSK RGKACLLFDH
160 170 180 190 200
LEPIELAEHL TFLEHKSFRR ISFTDYQSYV IHGCLENNPT LERSIALFNG
210 220 230 240 250
ISKWVQLMVL SKPSAQQRAE VITKFINVAQ KLLQLKNFNT LMAVVGGLSH
260 270 280 290 300
SSISRLKDTH SHLSSEVTKN WNEMTELVSS NGNYCNYRKA FADCDGFKIP
310 320 330 340 350
ILGVHLKDLI AVHVIFPDWM EENKVNVVKM HQLSVTLSEL VSLQNASHHL
360 370 380 390 400
EPNMDLINLL TLSLDLYHTE DDIYKLSLVL EPRNSKSQPT SPTTPNKPVV
410 420 430 440 450
PLEWASEVVP KPDPTIINKH IRKLVESVFR NYDHDHDGYI SQEDFESIAA
460 470 480 490 500
NFPFLDSFCV LDKDQDGLIS KDEMMAYFLR AKSQLHCKMG PGFIHNFQEM
510 520 530 540 550
NYLKPTFCEH CAGFLWGIIK QGYKCKDCGA NCHKQCKDLL VLACRRLARA
560 570 580 590 600
PSLSSNPGSL PGSPALPPVQ DEVFEFPGVT AGHRDLDSRA ITLVTGSSRK
610 620 630 640 650
ISVRLQRATT SQATQTEPVW SEAVWGDSGS HTFPKMKSKF HDKAAKDKGF
660 670 680 690
AKWENEKPTV QAGVDVVDRG TAFEPDQDDG QDEAKQGGED G
Length:691
Mass (Da):78,149
Last modified:July 5, 2004 - v1
Checksum:iEAED6E4690200DEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118018 Genomic DNA No translation available.
CT010501 Genomic DNA No translation available.
BC066069 mRNA Translation: AAH66069.1
BC066127 mRNA Translation: AAH66127.1
RefSeqiNP_001159965.1, NM_001166493.1
NP_997129.1, NM_207246.4
XP_006524334.1, XM_006524271.3
XP_006524335.1, XM_006524272.3
UniGeneiMm.329203

Genome annotation databases

EnsembliENSMUST00000095204; ENSMUSP00000092828; ENSMUSG00000071042
ENSMUST00000164192; ENSMUSP00000129393; ENSMUSG00000071042
GeneIDi240168
KEGGimmu:240168
UCSCiuc008dop.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118018 Genomic DNA No translation available.
CT010501 Genomic DNA No translation available.
BC066069 mRNA Translation: AAH66069.1
BC066127 mRNA Translation: AAH66127.1
RefSeqiNP_001159965.1, NM_001166493.1
NP_997129.1, NM_207246.4
XP_006524334.1, XM_006524271.3
XP_006524335.1, XM_006524272.3
UniGeneiMm.329203

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092828

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000095204; ENSMUSP00000092828; ENSMUSG00000071042
ENSMUST00000164192; ENSMUSP00000129393; ENSMUSG00000071042
GeneIDi240168
KEGGimmu:240168
UCSCiuc008dop.2 mouse

Organism-specific databases

CTDi25780
MGIiMGI:3028579 Rasgrp3

Phylogenomic databases

eggNOGiENOG410KD39 Eukaryota
ENOG410XTGZ LUCA
GeneTreeiENSGT00880000137870
HOVERGENiHBG007513
KOiK12362
OMAiSFTDYQS
OrthoDBiEOG091G03RN
TreeFamiTF312918

Enzyme and pathway databases

ReactomeiR-MMU-1169092 Activation of RAS in B cells
R-MMU-5673001 RAF/MAP kinase cascade

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000071042 Expressed in 217 organ(s), highest expression level in brain blood vessel

Family and domain databases

CDDicd00029 C1, 1 hit
cd00051 EFh, 1 hit
cd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR020454 DAG/PE-bd
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR002219 PE/DAG-bd
IPR008937 Ras-like_GEF
IPR000651 Ras-like_Gua-exchang_fac_N
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR029645 RASGRP1/RASGRP3
PANTHERiPTHR23113 PTHR23113, 1 hit
PTHR23113:SF178 PTHR23113:SF178, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF13202 EF-hand_5, 2 hits
PF00617 RasGEF, 1 hit
PRINTSiPR00008 DAGPEDOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00054 EFh, 2 hits
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
SSF48366 SSF48366, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6NZH9_MOUSE
AccessioniPrimary (citable) accession number: Q6NZH9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 144 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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