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Protein

SEC23-interacting protein

Gene

Sec23ip

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the organization of endoplasmic reticulum exit sites. Specifically binds to phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P).By similarity

GO - Molecular functioni

  • metal ion binding Source: InterPro
  • phospholipase activity Source: GO_Central

GO - Biological processi

  • acrosome assembly Source: MGI
  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • single fertilization Source: MGI
  • spermatid development Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
SEC23-interacting protein
Gene namesi
Name:Sec23ip
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2450915 Sec23ip

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000975551 – 998SEC23-interacting proteinAdd BLAST998

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei600PhosphoserineCombined sources1
Modified residuei735PhosphoserineCombined sources1
Modified residuei748PhosphoserineCombined sources1
Modified residuei924PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6NZC7
MaxQBiQ6NZC7
PaxDbiQ6NZC7
PeptideAtlasiQ6NZC7
PRIDEiQ6NZC7

PTM databases

iPTMnetiQ6NZC7
PhosphoSitePlusiQ6NZC7

Expressioni

Gene expression databases

CleanExiMM_SEC23IP

Interactioni

Subunit structurei

Interacts with SEC23A.By similarity

Protein-protein interaction databases

IntActiQ6NZC7, 2 interactors
STRINGi10090.ENSMUSP00000035610

Structurei

3D structure databases

ProteinModelPortaliQ6NZC7
SMRiQ6NZC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini640 – 703SAMAdd BLAST64
Domaini777 – 987DDHDPROSITE-ProRule annotationAdd BLAST211

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 363Interaction with SEC23ABy similarityAdd BLAST363

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi132 – 255Pro-richAdd BLAST124

Sequence similaritiesi

Belongs to the PA-PLA1 family.Curated

Phylogenomic databases

eggNOGiKOG2308 Eukaryota
ENOG410YDSX LUCA
HOGENOMiHOG000007725
HOVERGENiHBG057256
InParanoidiQ6NZC7
PhylomeDBiQ6NZC7

Family and domain databases

InterProiView protein in InterPro
IPR004177 DDHD_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF02862 DDHD, 1 hit
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM01127 DDHD, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51043 DDHD, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q6NZC7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADRKANGGG ASASSSGTNL LFSSSATEFS FNVPFIPVTQ AAASPASLLL
60 70 80 90 100
PGEDSTDVGE EDSFLGQTST HTSTPQTFSY FSQVSSSSDP FGNIGQSPLT
110 120 130 140 150
TSAMSAGQSA LPKPPATLAF TTGSQDALSA FPPSVSKAPG ATPPSQMGTS
160 170 180 190 200
TYSPSQPSSL PPNFGSPPQG IPQQGHNPYR HTPVSSRANP YITPPQLQQC
210 220 230 240 250
QMPGHSSYPP PSGPPVQTYQ MPPGPLPPLP TAMQSPAQQQ VPARPAGPLV
260 270 280 290 300
QGPSPFVLQN QYEPVQPHWF YCKEVEYKQL WMPFSVLDSL NLEEIYNSVQ
310 320 330 340 350
PDPESVVLGT DGGRYDVYLY DRMRKSVYWE EEPTEVRRCT WFYKGDTDSR
360 370 380 390 400
FIPYTEEFSE KLEAEYKKAV STNQWHRRLE FPSGETIVMH NPKVIVQFQP
410 420 430 440 450
SSVPDEWGTT QDGQTRPRVV KRGIDDSLDE IPDGEMPQVD HLVFMVHGIG
460 470 480 490 500
PVCDLRFRSI IECVDDFRVV SLKLLQTHFK KSVDEGKVSR VEFLPVHWHS
510 520 530 540 550
ALGGHATGVD RNIKKITLPS IGRFRHFTNE TLLDVLFYNS PTYCQAIVEK
560 570 580 590 600
VEVEINRLHS LFMSRNPNFK GKVSVAGHSL GSLILFDILS NQRDMCVSKS
610 620 630 640 650
PGSVAVSNGV IKHSQFQEKL ISEESKLMSD ESCDLDVEDE EPLTLHGTLE
660 670 680 690 700
ALSLFDYIST FEKEKIDMES LLMCTVDDLK EMGIPLGPRK KIANFVKLKA
710 720 730 740 750
AKLEQKKAAA EKKAALAALT KGQDESAPKT KEMASPSSES NESKRKLSVG
760 770 780 790 800
AYVSSVRVDY ESFEVGTGQV SVAYSSLDFE PEIFFALGSP IGMLLTIRGV
810 820 830 840 850
ARIDEKYRLP TCKGFFNIYH PLDPVAYRLE PMIAPDLDLK AVLVPHHKGR
860 870 880 890 900
KRLHLELKES LSRMGSDLKQ GFISSLKSAW QTLNEFARAH TSTTQLQEEL
910 920 930 940 950
EKVANQIKEE EEKQVVEAKK KKESPELSKD EDYLGKVGML NGGRRIDYVL
960 970 980 990
QEKPIESFNE YLFALQSHLC YWGSEDTALL LLKEIYRTMN ISPEQPQH
Length:998
Mass (Da):110,780
Last modified:November 9, 2004 - v2
Checksum:iC8C61ED1E74E0060
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X928G3X928_MOUSE
SEC23-interacting protein
Sec23ip mCG_21024
998Annotation score:
A0A0U1RPB3A0A0U1RPB3_MOUSE
SEC23-interacting protein
Sec23ip
56Annotation score:
A0A0U1RP39A0A0U1RP39_MOUSE
SEC23-interacting protein
Sec23ip
97Annotation score:

Sequence cautioni

The sequence AAH66195 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BY726433 mRNA No translation available.
AK042851 mRNA Translation: BAC31382.1
BC066195 mRNA Translation: AAH66195.1 Sequence problems.
CCDSiCCDS21900.1
UniGeneiMm.297105

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BY726433 mRNA No translation available.
AK042851 mRNA Translation: BAC31382.1
BC066195 mRNA Translation: AAH66195.1 Sequence problems.
CCDSiCCDS21900.1
UniGeneiMm.297105

3D structure databases

ProteinModelPortaliQ6NZC7
SMRiQ6NZC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6NZC7, 2 interactors
STRINGi10090.ENSMUSP00000035610

PTM databases

iPTMnetiQ6NZC7
PhosphoSitePlusiQ6NZC7

Proteomic databases

EPDiQ6NZC7
MaxQBiQ6NZC7
PaxDbiQ6NZC7
PeptideAtlasiQ6NZC7
PRIDEiQ6NZC7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:2450915 Sec23ip

Phylogenomic databases

eggNOGiKOG2308 Eukaryota
ENOG410YDSX LUCA
HOGENOMiHOG000007725
HOVERGENiHBG057256
InParanoidiQ6NZC7
PhylomeDBiQ6NZC7

Miscellaneous databases

ChiTaRSiSec23ip mouse
PROiPR:Q6NZC7
SOURCEiSearch...

Gene expression databases

CleanExiMM_SEC23IP

Family and domain databases

InterProiView protein in InterPro
IPR004177 DDHD_dom
IPR001660 SAM
IPR013761 SAM/pointed_sf
PfamiView protein in Pfam
PF02862 DDHD, 1 hit
PF00536 SAM_1, 1 hit
SMARTiView protein in SMART
SM01127 DDHD, 1 hit
SM00454 SAM, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
PROSITEiView protein in PROSITE
PS51043 DDHD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS23IP_MOUSE
AccessioniPrimary (citable) accession number: Q6NZC7
Secondary accession number(s): Q8BXY6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: November 9, 2004
Last modified: November 7, 2018
This is version 105 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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