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Entry version 118 (18 Sep 2019)
Sequence version 2 (05 Feb 2008)
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Protein

Fanconi anemia core complex-associated protein 20

Gene

FAAP20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.4 Publications

Caution

According to a report, ubiquitin-binding is dispensable for function (PubMed:22396592). However, such data are not confirmed by PubMed:22705371.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri144 – 174UBZ-typeAdd BLAST31

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6783310 Fanconi Anemia Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fanconi anemia core complex-associated protein 20Imported
Alternative name(s):
FANCA-associated protein of 20 kDa1 Publication
Fanconi anemia-associated protein of 20 kDa1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FAAP201 PublicationImported
Synonyms:C1orf86
ORF Names:FP7162
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:26428 FAAP20

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615183 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NZ36

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi147C → A: Abolishes binding to ubiquitin. Abolishes binding to ubiquitin; when associated with A-150. 3 Publications1
Mutagenesisi150C → A: Abolishes binding to ubiquitin; when associated with A-147. 2 Publications1
Mutagenesisi164D → A: Abolishes binding to ubiquitin. 1 Publication1
Mutagenesisi170C → A: Abolishes binding to ubiquitin. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
199990

Open Targets

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OpenTargetsi
ENSG00000162585

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672470

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FAAP20

Domain mapping of disease mutations (DMDM)

More...
DMDMi
166991449

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003168821 – 180Fanconi anemia core complex-associated protein 20Add BLAST180

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei113PhosphoserineCombined sources1
Modified residuei137PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NZ36

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q6NZ36

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NZ36

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6NZ36

PeptideAtlas

More...
PeptideAtlasi
Q6NZ36

PRoteomics IDEntifications database

More...
PRIDEi
Q6NZ36

ProteomicsDB human proteome resource

More...
ProteomicsDBi
1952
23749
66786 [Q6NZ36-1]
66787 [Q6NZ36-2]
66788 [Q6NZ36-3]
66789 [Q6NZ36-4]
66790 [Q6NZ36-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NZ36

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000162585 Expressed in 194 organ(s), highest expression level in pituitary gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NZ36 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6NZ36 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038829

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Fanconi anemia (FA) complex.

Interacts with FANCA; interaction is direct.

Interacts with REV1. Reported to bind monoubiquitinated REV1; however it binds better to non-ubiquitinated REV1 (PubMed:22266823).

4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
128288, 25 interactors

Database of interacting proteins

More...
DIPi
DIP-59917N

Protein interaction database and analysis system

More...
IntActi
Q6NZ36, 35 interactors

Molecular INTeraction database

More...
MINTi
Q6NZ36

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q6NZ36

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The UBZ-type zinc finger binds both 'Lys-48'- and 'Lys-63'-linked polyubiquitin with preference for 'Lys-63'-linked polyubiquitin.4 Publications

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri144 – 174UBZ-typeAdd BLAST31

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J1M8 Eukaryota
ENOG410Y5B2 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00910000148335

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111230

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NZ36

Identification of Orthologs from Complete Genome Data

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OMAi
ALQSCPM

Database of Orthologous Groups

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OrthoDBi
1051670at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NZ36

TreeFam database of animal gene trees

More...
TreeFami
TF336358

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031491 FANCA_interact
IPR031490 UBZ_FAAP20

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15751 FANCA_interact, 1 hit
PF15750 UBZ_FAAP20, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NZ36-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEAARRPRLG LSRRRPRPAG GPSGGRPWFL LGGDERERLW AELLRTVSPE
60 70 80 90 100
LILDHEVPSL PAFPGQEPRC GPEPTEVFTV GPKTFSWTPF PPDLWGPGRS
110 120 130 140 150
YRLLHGAGGH LESPARSLPQ RPAPDPCRAP RVEQQPSVEG AAALRSCPMC
160 170 180
QKEFAPRLTQ LDVDSHLAQC LAESTEDVTW
Length:180
Mass (Da):19,869
Last modified:February 5, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD8FC889A20AF732F
GO
Isoform 2 (identifier: Q6NZ36-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MEAARRPRLGLSRRRPRPAGG → MCGPEHLLCC...ADNLRTGRTR

Show »
Length:283
Mass (Da):31,209
Checksum:i8FF8997665B31D6C
GO
Isoform 3 (identifier: Q6NZ36-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-21: MEAARRPRLGLSRRRPRPAGG → MNFGLEKTHF...ADNLRTGRTR

Note: No experimental confirmation available.
Show »
Length:230
Mass (Da):25,473
Checksum:i2727C4B213BE0838
GO
Isoform 4 (identifier: Q6NZ36-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     180-180: W → CLSWMCKTLNDPGSQG

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:195
Mass (Da):21,404
Checksum:i365E26323B5A7EDB
GO
Isoform 5 (identifier: Q6NZ36-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     158-158: L → YFNSRPHLCPAGS
     159-180: Missing.

Note: No experimental confirmation available.
Show »
Length:170
Mass (Da):18,742
Checksum:i12370B74D47CFB68
GO
Isoform 6 (identifier: Q6NZ36-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     22-180: PSGGRPWFLL...LAESTEDVTW → SPGAARSPLK...PCARRSSPPG

Note: Gene prediction based on EST data.
Show »
Length:112
Mass (Da):11,834
Checksum:i71D4D88F8542A1BD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C2E6H7C2E6_HUMAN
Fanconi anemia core complex-associa...
FAAP20
193Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3A6H7C3A6_HUMAN
Fanconi anemia core complex-associa...
FAAP20
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C361H7C361_HUMAN
Fanconi anemia core complex-associa...
FAAP20
195Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6S8H2F6S8H2_HUMAN
Fanconi anemia core complex-associa...
FAAP20
189Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH66360 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → V in AAH66360 (PubMed:15489334).Curated1
Sequence conflicti17R → P in BAB70965 (PubMed:14702039).Curated1
Sequence conflicti17R → P in EAW56125 (Ref. 4) Curated1
Sequence conflicti17R → P in AAH66360 (PubMed:15489334).Curated1
Sequence conflicti17R → P in AAI03993 (PubMed:15489334).Curated1
Sequence conflicti146S → N in AAQ04817 (PubMed:15498874).Curated1
Sequence conflicti176 – 177ED → KN in AAQ04817 (PubMed:15498874).Curated2
Isoform 2 (identifier: Q6NZ36-2)
Sequence conflicti65R → H in BAC86730 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_038434126P → S. Corresponds to variant dbSNP:rs1058411Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0308121 – 21MEAAR…RPAGG → MCGPEHLLCCPKDLAMFPRQ LSLTACLPGTPVSHKCHHIW LWVGVPAWHPRASRCGGAQP SSWLRQKAARAFWLSLPAAK LRHHSSRWLRRSGAFSSGST LKPPPSPSPAPLCHADNLRT GRTR in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_0308131 – 21MEAAR…RPAGG → MNFGLEKTHFHCARVSPNQK LFSNKAKLRHHSSRWLRRSG AFSSGSTLKPPPSPSPAPLC HADNLRTGRTR in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_04726422 – 180PSGGR…EDVTW → SPGAARSPLKSSLSDPRPFP GHPFRRTCGARAVPTGCFTG QEGTWNPPPGPCPSARHLIP AGPPGWSSSRLWRVPRPCAA APCARRSSPPG in isoform 6. CuratedAdd BLAST159
Alternative sequenceiVSP_030814158L → YFNSRPHLCPAGS in isoform 5. 1 Publication1
Alternative sequenceiVSP_030815159 – 180Missing in isoform 5. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_030816180W → CLSWMCKTLNDPGSQG in isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK055593 mRNA Translation: BAB70965.1
AK126870 mRNA Translation: BAC86730.1
AF461903 mRNA Translation: AAQ04817.1
AL590822 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56125.1
BC066360 mRNA Translation: AAH66360.1 Different initiation.
BC078145 mRNA No translation available.
BC103992 mRNA Translation: AAI03993.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38.2 [Q6NZ36-1]
CCDS57965.1 [Q6NZ36-6]
CCDS72687.1 [Q6NZ36-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001243874.1, NM_001256945.1
NP_001243875.1, NM_001256946.1
NP_001243876.1, NM_001256947.1
NP_001269599.1, NM_001282670.1 [Q6NZ36-2]
NP_001269600.1, NM_001282671.1
NP_001269601.1, NM_001282672.1
NP_001269602.1, NM_001282673.1
NP_872339.2, NM_182533.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378543; ENSP00000367804; ENSG00000162585 [Q6NZ36-6]
ENST00000378546; ENSP00000367808; ENSG00000162585 [Q6NZ36-1]
ENST00000400918; ENSP00000383709; ENSG00000162585 [Q6NZ36-5]
ENST00000414253; ENSP00000410450; ENSG00000162585 [Q6NZ36-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
199990

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:199990

UCSC genome browser

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UCSCi
uc001aiy.4 human [Q6NZ36-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055593 mRNA Translation: BAB70965.1
AK126870 mRNA Translation: BAC86730.1
AF461903 mRNA Translation: AAQ04817.1
AL590822 Genomic DNA No translation available.
CH471183 Genomic DNA Translation: EAW56125.1
BC066360 mRNA Translation: AAH66360.1 Different initiation.
BC078145 mRNA No translation available.
BC103992 mRNA Translation: AAI03993.1
CCDSiCCDS38.2 [Q6NZ36-1]
CCDS57965.1 [Q6NZ36-6]
CCDS72687.1 [Q6NZ36-5]
RefSeqiNP_001243874.1, NM_001256945.1
NP_001243875.1, NM_001256946.1
NP_001243876.1, NM_001256947.1
NP_001269599.1, NM_001282670.1 [Q6NZ36-2]
NP_001269600.1, NM_001282671.1
NP_001269601.1, NM_001282672.1
NP_001269602.1, NM_001282673.1
NP_872339.2, NM_182533.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MUQNMR-A140-180[»]
2MURNMR-A140-180[»]
3WWQX-ray1.90C/F/I/L142-180[»]
SMRiQ6NZ36
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128288, 25 interactors
DIPiDIP-59917N
IntActiQ6NZ36, 35 interactors
MINTiQ6NZ36

PTM databases

iPTMnetiQ6NZ36

Polymorphism and mutation databases

BioMutaiFAAP20
DMDMi166991449

Proteomic databases

jPOSTiQ6NZ36
MassIVEiQ6NZ36
MaxQBiQ6NZ36
PaxDbiQ6NZ36
PeptideAtlasiQ6NZ36
PRIDEiQ6NZ36
ProteomicsDBi1952
23749
66786 [Q6NZ36-1]
66787 [Q6NZ36-2]
66788 [Q6NZ36-3]
66789 [Q6NZ36-4]
66790 [Q6NZ36-5]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378543; ENSP00000367804; ENSG00000162585 [Q6NZ36-6]
ENST00000378546; ENSP00000367808; ENSG00000162585 [Q6NZ36-1]
ENST00000400918; ENSP00000383709; ENSG00000162585 [Q6NZ36-5]
ENST00000414253; ENSP00000410450; ENSG00000162585 [Q6NZ36-4]
GeneIDi199990
KEGGihsa:199990
UCSCiuc001aiy.4 human [Q6NZ36-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
199990
DisGeNETi199990

GeneCards: human genes, protein and diseases

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GeneCardsi
FAAP20
HGNCiHGNC:26428 FAAP20
HPAiHPA038829
MIMi615183 gene
neXtProtiNX_Q6NZ36
OpenTargetsiENSG00000162585
PharmGKBiPA142672470

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J1M8 Eukaryota
ENOG410Y5B2 LUCA
GeneTreeiENSGT00910000148335
HOGENOMiHOG000111230
InParanoidiQ6NZ36
OMAiALQSCPM
OrthoDBi1051670at2759
PhylomeDBiQ6NZ36
TreeFamiTF336358

Enzyme and pathway databases

ReactomeiR-HSA-6783310 Fanconi Anemia Pathway

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
FAAP20 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
199990

Pharos

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Pharosi
Q6NZ36

Protein Ontology

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PROi
PR:Q6NZ36

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162585 Expressed in 194 organ(s), highest expression level in pituitary gland
ExpressionAtlasiQ6NZ36 baseline and differential
GenevisibleiQ6NZ36 HS

Family and domain databases

InterProiView protein in InterPro
IPR031491 FANCA_interact
IPR031490 UBZ_FAAP20
PfamiView protein in Pfam
PF15751 FANCA_interact, 1 hit
PF15750 UBZ_FAAP20, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFAP20_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NZ36
Secondary accession number(s): A6PW39
, A6PW40, A6PW41, A8MQT6, F2Z2L4, Q6ZT64, Q71M24, Q96ND7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 18, 2019
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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