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Protein

Calcium-binding mitochondrial carrier protein SCaMC-2-A

Gene

slc25a25a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Calcium-dependent mitochondrial solute carrier.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi60 – 711PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding mitochondrial carrier protein SCaMC-2-A
Alternative name(s):
Small calcium-binding mitochondrial carrier protein 2-A
Solute carrier family 25 member 25-A
Gene namesi
Name:slc25a25a
Synonyms:scamc2a, slc25a25
ORF Names:zgc:77454
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 8

Organism-specific databases

ZFINiZDB-GENE-040426-2396 slc25a25a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 189Mitochondrial intermembraneSequence analysisAdd BLAST189
Transmembranei190 – 207Helical; Name=1Sequence analysisAdd BLAST18
Topological domaini208 – 244Mitochondrial matrixSequence analysisAdd BLAST37
Transmembranei245 – 264Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini265 – 287Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei288 – 301Helical; Name=3Sequence analysisAdd BLAST14
Topological domaini302 – 337Mitochondrial matrixSequence analysisAdd BLAST36
Transmembranei338 – 357Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini358 – 380Mitochondrial intermembraneSequence analysisAdd BLAST23
Transmembranei381 – 398Helical; Name=5Sequence analysisAdd BLAST18
Topological domaini399 – 437Mitochondrial matrixSequence analysisAdd BLAST39
Transmembranei438 – 457Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini458 – 469Mitochondrial intermembraneSequence analysisAdd BLAST12

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003176051 – 469Calcium-binding mitochondrial carrier protein SCaMC-2-AAdd BLAST469

Proteomic databases

PaxDbiQ6NYZ6
PRIDEiQ6NYZ6

Expressioni

Gene expression databases

BgeeiENSDARG00000010572

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000008863

Structurei

3D structure databases

ProteinModelPortaliQ6NYZ6
SMRiQ6NYZ6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 80EF-hand 1PROSITE-ProRule annotationAdd BLAST34
Domaini78 – 113EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini114 – 149EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Repeati184 – 270Solcar 1Add BLAST87
Repeati278 – 363Solcar 2Add BLAST86
Repeati375 – 463Solcar 3Add BLAST89

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0036 Eukaryota
ENOG410XQ4P LUCA
GeneTreeiENSGT00880000137904
HOGENOMiHOG000165728
HOVERGENiHBG108464
InParanoidiQ6NYZ6
KOiK14684
OMAiEFTRYLQ
OrthoDBiEOG091G0C8S
PhylomeDBiQ6NYZ6
TreeFamiTF313492

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
IPR002167 Graves_DC
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00928 GRAVESDC
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
SSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Q6NYZ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLCLCLYVPV HNSDQIEVEY FESNGLPSEL KSLKSLSVLL PSQEFSTYRR
60 70 80 90 100
WRKKSLKTEE KEHDGQLDFE EFVHYLQDHE KDLKLVFKSM DRKIAGQVNA
110 120 130 140 150
NDIVNSLRDL GVHISLKQAE KVLKSMDKNG TMTIDWNEWK KYPTLQPAEN
160 170 180 190 200
IPEIILYWKH STIFDVGESL MVPDEFTVEE HLTGMWWRHL VSGGGAGAVS
210 220 230 240 250
RTCTAPLDRL KVLMQVHGCQ GKSMCLMSGL TQMIKEGGVR SLWRGNGINV
260 270 280 290 300
IKIAPETALK FMAYEQIKRV MGSSQETLGI SERFVAGSLA GVIAQSTIYP
310 320 330 340 350
MEVLKTRLAL RKTGQYKGIS DCAKHILKTE GMSAFYKGYV PNMLGIIPYA
360 370 380 390 400
GIDLAVYETL KNTWLQRYGT ENADPGVFVL LACGTVSSTC GQLASYPLAL
410 420 430 440 450
IRTRMQAQAS VEGSSQVSMT GLFKQIMKTE GPTGLYRGLT PNFLKVIPAV
460
SISYVVYEHI KSTLGVRSR
Length:469
Mass (Da):52,458
Last modified:July 5, 2004 - v1
Checksum:i7F583A75FA61B1EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC066404 mRNA Translation: AAH66404.1
RefSeqiNP_998422.1, NM_213257.1
UniGeneiDr.7614

Genome annotation databases

EnsembliENSDART00000027214; ENSDARP00000008863; ENSDARG00000010572
GeneIDi406541
KEGGidre:406541

Similar proteinsi

Entry informationi

Entry nameiSCM2A_DANRE
AccessioniPrimary (citable) accession number: Q6NYZ6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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