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UniProtKB - Q6NYR1 (Q6NYR1_DANRE)
Protein
P2X purinoceptor
Gene
p2rx4a
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Receptor for ATP that acts as a ligand-gated ion channel.
UniRule annotationCaution
Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 189 | ATPUniRule annotation | 1 | |
Binding sitei | 316 | ATPUniRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 70 – 72 | ATPUniRule annotation | 3 | |
Nucleotide bindingi | 296 – 298 | ATPUniRule annotation | 3 |
GO - Molecular functioni
- ATP binding Source: ZFIN
- ATP-gated ion channel activity Source: ZFIN
- CTP binding Source: ZFIN
- extracellularly ATP-gated cation channel activity Source: ZFIN
- identical protein binding Source: IntAct
- ligand-gated ion channel activity Source: ZFIN
- purine nucleotide binding Source: ZFIN
- purinergic nucleotide receptor activity Source: UniProtKB-UniRule
GO - Biological processi
- calcium ion transport Source: ZFIN
- cation transport Source: ZFIN
- response to ATP Source: InterPro
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channelUniRule annotation, ReceptorUniRule annotationImported |
Biological process | Ion transport, Transport |
Ligand | ATP-bindingUniRule annotation, Nucleotide-binding |
Protein family/group databases
TCDBi | 1.A.7.1.8, the atp-gated p2x receptor cation channel (p2x receptor) family |
Names & Taxonomyi
Protein namesi | Recommended name: P2X purinoceptorUniRule annotation |
Gene namesi | Name:p2rx4aImported |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Organism-specific databases
ZFINi | ZDB-GENE-020806-2, p2rx4a |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Nucleus
- integral component of nuclear inner membrane Source: GO_Central
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB-UniRule
Other locations
- integral component of membrane Source: ZFIN
- ion channel complex Source: ZFIN
- postsynapse Source: GOC
- transmembrane transporter complex Source: ZFIN
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 342 – 364 | HelicalUniRule annotationAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePTM / Processingi
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 78 | N-linked (GlcNAc...) asparagineCombined sources | 1 | |
Glycosylationi | 113 | N-linked (GlcNAc...) asparagineCombined sources | 1 | |
Disulfide bondi | 119 ↔ 168 | UniRule annotationCombined sources | ||
Disulfide bondi | 129 ↔ 152 | UniRule annotationCombined sources | ||
Disulfide bondi | 135 ↔ 162 | UniRule annotationCombined sources | ||
Glycosylationi | 187 | N-linked (GlcNAc...) asparagineUniRule annotationCombined sources | 1 | |
Glycosylationi | 213 | N-linked (GlcNAc...) asparagineCombined sources | 1 | |
Disulfide bondi | 220 ↔ 230 | UniRule annotationCombined sources | ||
Disulfide bondi | 264 ↔ 273 | UniRule annotationCombined sources |
Keywords - PTMi
Disulfide bondUniRule annotationInteractioni
Subunit structurei
Functional P2XRs are organized as homomeric and heteromeric trimers.
UniRule annotationBinary interactionsi
Q6NYR1
With | #Exp. | IntAct |
---|---|---|
itself | 5 | EBI-15795948,EBI-15795948 |
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
DIPi | DIP-59282N |
Structurei
3D structure databases
SMRi | Q6NYR1 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q6NYR1 |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixUniRule annotationFamily and domain databases
Gene3Di | 2.60.490.10, 1 hit |
InterProi | View protein in InterPro IPR003047, P2X4_purnocptor IPR027309, P2X_extracellular_dom_sf IPR001429, P2X_purnocptor |
PIRSFi | PIRSF005713, P2X_purinoceptor, 1 hit |
PRINTSi | PR01311, P2X4RECEPTOR PR01307, P2XRECEPTOR |
TIGRFAMsi | TIGR00863, P2X, 1 hit |
PROSITEi | View protein in PROSITE PS01212, P2X_RECEPTOR, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6NYR1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSESVGCCDS VSQCFFDYYT SKILIIRSKK VGTLNRFTQA LVIAYVIGYV
60 70 80 90 100
CVYNKGYQDT DTVLSSVTTK VKGIALTNTS ELGERIWDVA DYIIPPQEDG
110 120 130 140 150
SFFVLTNMII TTNQTQSKCA ENPTPASTCT SHRDCKRGFN DARGDGVRTG
160 170 180 190 200
RCVSYSASVK TCEVLSWCPL EKIVDPPNPP LLADAENFTV LIKNNIRYPK
210 220 230 240 250
FNFNKRNILP NINSSYLTHC VFSRKTDPDC PIFRLGDIVG EAEEDFQIMA
260 270 280 290 300
VHGGVMGVQI RWDCDLDMPQ SWCVPRYTFR RLDNKDPDNN VAPGYNFRFA
310 320 330 340 350
KYYKNSDGTE TRTLIKGYGI RFDVMVFGQA GKFNIIPTLL NIGAGLALLG
360 370 380
LVNVICDWIV LTFMKRKQHY KEQKYTYVDD FGLLHNEDK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC066495 mRNA Translation: AAH66495.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC066495 mRNA Translation: AAH66495.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3H9V | X-ray | 3.10 | A | 28-381 | [»] | |
3I5D | X-ray | 3.46 | A/B/C | 28-381 | [»] | |
SMRi | Q6NYR1 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
DIPi | DIP-59282N |
Protein family/group databases
TCDBi | 1.A.7.1.8, the atp-gated p2x receptor cation channel (p2x receptor) family |
Organism-specific databases
ZFINi | ZDB-GENE-020806-2, p2rx4a |
Miscellaneous databases
EvolutionaryTracei | Q6NYR1 |
Family and domain databases
Gene3Di | 2.60.490.10, 1 hit |
InterProi | View protein in InterPro IPR003047, P2X4_purnocptor IPR027309, P2X_extracellular_dom_sf IPR001429, P2X_purnocptor |
PIRSFi | PIRSF005713, P2X_purinoceptor, 1 hit |
PRINTSi | PR01311, P2X4RECEPTOR PR01307, P2XRECEPTOR |
TIGRFAMsi | TIGR00863, P2X, 1 hit |
PROSITEi | View protein in PROSITE PS01212, P2X_RECEPTOR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6NYR1_DANRE | |
Accessioni | Q6NYR1Primary (citable) accession number: Q6NYR1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | January 19, 2022 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |