UniProtKB - Q6NYK3 (SPRE2_DANRE)
Protein
Sprouty-related, EVH1 domain-containing protein 2
Gene
spred2
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Negatively regulates Ras signaling pathways and downstream activation of MAP kinases.By similarity
GO - Molecular functioni
- protein kinase binding Source: GO_Central
GO - Biological processi
- inactivation of MAPK activity Source: GO_Central
- multicellular organism development Source: InterPro
- negative regulation of peptidyl-threonine phosphorylation Source: GO_Central
- positive regulation of DNA damage response, signal transduction by p53 class mediator Source: GO_Central
- regulation of protein deacetylation Source: GO_Central
Enzyme and pathway databases
Reactomei | R-DRE-5658442, Regulation of RAS by GAPs R-DRE-5658623, FGFRL1 modulation of FGFR1 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Sprouty-related, EVH1 domain-containing protein 2Short name: Spred-2 |
Gene namesi | Name:spred2 ORF Names:zgc:77284 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040426-2342, spred2b |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Other locations
- secretory vesicle membrane By similarity; Peripheral membrane protein By similarity; Cytoplasmic side By similarity
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- transport vesicle membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Cytoplasmic vesicle, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076913 | 1 – 413 | Sprouty-related, EVH1 domain-containing protein 2Add BLAST | 413 |
Proteomic databases
PaxDbi | Q6NYK3 |
Interactioni
GO - Molecular functioni
- protein kinase binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000045291 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 122 | WH1PROSITE-ProRule annotationAdd BLAST | 118 | |
Domaini | 195 – 248 | KBDPROSITE-ProRule annotationAdd BLAST | 54 | |
Domaini | 303 – 411 | SPRPROSITE-ProRule annotationAdd BLAST | 109 |
Phylogenomic databases
eggNOGi | KOG4590, Eukaryota |
InParanoidi | Q6NYK3 |
OrthoDBi | 759156at2759 |
PhylomeDBi | Q6NYK3 |
Family and domain databases
CDDi | cd10574, EVH1_SPRED-like, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR023337, KBD IPR011993, PH-like_dom_sf IPR041937, SPRE_EVH1 IPR007875, Sprouty IPR000697, WH1/EVH1_dom |
Pfami | View protein in Pfam PF05210, Sprouty, 1 hit PF00568, WH1, 1 hit |
SMARTi | View protein in SMART SM00461, WH1, 1 hit |
PROSITEi | View protein in PROSITE PS51488, KBD, 1 hit PS51227, SPR, 1 hit PS50229, WH1, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6NYK3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIEETHPNDD SYIVRVKAVV MTRDDSSGGW LAQEGGGLSR VGVCKVMPAE
60 70 80 90 100
LTGRSDFLIH GERLKDKQVI LECFVRKDLI YTKATPTFHH WKVDNKKCGL
110 120 130 140 150
TFQSPADARA FDRGVRKALE DLTEGSTTSS STLQNEAELG DDDVFTTATD
160 170 180 190 200
SSSNSSQKKD HSTQLVATST FYEPHPHRCI LQYRPPERYT LDQKFSRNLF
210 220 230 240 250
PFEDEEIVRI NPRERWMITG YEDYRYAAVP DKFIQPEDSD SYVQISKNDP
260 270 280 290 300
VKHDYTYPYV PSPDFTQCDL KRPCGGGSTV VSTQPRAFIL KGKRRKEDGE
310 320 330 340 350
RSRCVYCRDM FNHEENRRGQ CHDAPDPIRT CIHRVSFMWC ADSMLYHCMS
360 370 380 390 400
DPEGDYSDPC SCDTSEERFC LRWTALLGLA MLAPCLCCYP PLHGCHRCGV
410
ACGCCGGKHK AVG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA5PMN3 | A5PMN3_DANRE | Sprouty-related EVH1 domain-contain... | spred2b spred2 | 413 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC066561 mRNA Translation: AAH66561.1 |
RefSeqi | NP_998399.1, NM_213234.1 |
Genome annotation databases
GeneIDi | 793290 |
KEGGi | dre:793290 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC066561 mRNA Translation: AAH66561.1 |
RefSeqi | NP_998399.1, NM_213234.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000045291 |
Proteomic databases
PaxDbi | Q6NYK3 |
Genome annotation databases
GeneIDi | 793290 |
KEGGi | dre:793290 |
Organism-specific databases
CTDi | 793290 |
ZFINi | ZDB-GENE-040426-2342, spred2b |
Phylogenomic databases
eggNOGi | KOG4590, Eukaryota |
InParanoidi | Q6NYK3 |
OrthoDBi | 759156at2759 |
PhylomeDBi | Q6NYK3 |
Enzyme and pathway databases
Reactomei | R-DRE-5658442, Regulation of RAS by GAPs R-DRE-5658623, FGFRL1 modulation of FGFR1 signaling |
Miscellaneous databases
PROi | PR:Q6NYK3 |
Family and domain databases
CDDi | cd10574, EVH1_SPRED-like, 1 hit |
Gene3Di | 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR023337, KBD IPR011993, PH-like_dom_sf IPR041937, SPRE_EVH1 IPR007875, Sprouty IPR000697, WH1/EVH1_dom |
Pfami | View protein in Pfam PF05210, Sprouty, 1 hit PF00568, WH1, 1 hit |
SMARTi | View protein in SMART SM00461, WH1, 1 hit |
PROSITEi | View protein in PROSITE PS51488, KBD, 1 hit PS51227, SPR, 1 hit PS50229, WH1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPRE2_DANRE | |
Accessioni | Q6NYK3Primary (citable) accession number: Q6NYK3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |