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Entry version 135 (13 Feb 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Phostensin

Gene

PPP1R18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Isoform 1: May target protein phosphatase 1 to F-actin cytoskeleton.1 Publication
Isoform 4: May target protein phosphatase 1 to F-actin cytoskeleton.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phostensin
Alternative name(s):
Protein phosphatase 1 F-actin cytoskeleton-targeting subunit
Protein phosphatase 1 regulatory subunit 18
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPP1R18
Synonyms:HKMT1098, KIAA1949
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000146112.11

Human Gene Nomenclature Database

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HGNCi
HGNC:29413 PPP1R18

Online Mendelian Inheritance in Man (OMIM)

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MIMi
610990 gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q6NYC8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi540I → G: Decrease binding to PP1. Complete inhibition of PP1 binding; when associated with G-542. 1 Publication1
Mutagenesisi542F → G: Decrease binding to PP1. Decrease binding to PP1. Complete inhibition of PP1 binding; when associated with G-540. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
170954

Open Targets

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OpenTargetsi
ENSG00000146112

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134918172

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PPP1R18

Domain mapping of disease mutations (DMDM)

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DMDMi
68052323

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000508071 – 613PhostensinAdd BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei54PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei199PhosphothreonineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1
Modified residuei432PhosphoserineBy similarity1
Modified residuei457N6-acetyllysineBy similarity1
Modified residuei490PhosphoserineCombined sources1
Modified residuei530PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q6NYC8

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q6NYC8

MaxQB - The MaxQuant DataBase

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MaxQBi
Q6NYC8

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q6NYC8

PeptideAtlas

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PeptideAtlasi
Q6NYC8

PRoteomics IDEntifications database

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PRIDEi
Q6NYC8

ProteomicsDB human proteome resource

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ProteomicsDBi
66784
66785 [Q6NYC8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q6NYC8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q6NYC8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 4 is predominantly expressed in leukocytes and spleen.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000146112 Expressed in 178 organ(s), highest expression level in blood

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q6NYC8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q6NYC8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA044745
HPA051000

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with Protein phosphatase 1 (PP1).1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
128092, 69 interactors

Protein interaction database and analysis system

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IntActi
Q6NYC8, 104 interactors

Molecular INTeraction database

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MINTi
Q6NYC8

STRING: functional protein association networks

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STRINGi
9606.ENSP00000274853

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q6NYC8

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 103Poly-Gln8

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IJQY Eukaryota
ENOG410ZUB8 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000064035

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG080180

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q6NYC8

KEGG Orthology (KO)

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KOi
K17559

Identification of Orthologs from Complete Genome Data

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OMAi
WTPRDTE

Database of Orthologous Groups

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OrthoDBi
592905at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q6NYC8

TreeFam database of animal gene trees

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TreeFami
TF337604

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR025903 Phostensin/Taperin_N_dom
IPR025907 Phostensin/Taperin_PP1-bd_dom
IPR026671 PPP1R18/Tprn

The PANTHER Classification System

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PANTHERi
PTHR21685 PTHR21685, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13914 Phostensin, 1 hit
PF13916 Phostensin_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NYC8-1) [UniParc]FASTAAdd to basket
Also known as: 110 kDa, phostensin-beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATIPDWKLQ LLARRRQEEA SVRGREKAER ERLSQMPAWK RGLLERRRAK
60 70 80 90 100
LGLSPGEPSP VLGTVEAGPP DPDESAVLLE AIGPVHQNRF IRQERQQQQQ
110 120 130 140 150
QQQRSEELLA ERKPGPLEAR ERRPSPGEMR DQSPKGRESR EERLSPRETR
160 170 180 190 200
ERRLGIGGAQ ELSLRPLEAR DWRQSPGEVG DRSSRLSEAW KWRLSPGETP
210 220 230 240 250
ERSLRLAESR EQSPRRKEVE SRLSPGESAY QKLGLTEAHK WRPDSRESQE
260 270 280 290 300
QSLVQLEATE WRLRSGEERQ DYSEECGRKE EWPVPGVAPK ETAELSETLT
310 320 330 340 350
REAQGNSSAG VEAAEQRPVE DGERGMKPTE GWKWTLNSGK AREWTPRDIE
360 370 380 390 400
AQTQKPEPPE SAEKLLESPG VEAGEGEAEK EEAGAQGRPL RALQNCCSVP
410 420 430 440 450
SPLPPEDAGT GGLRQQEEEA VELQPPPPAP LSPPPPAPTA PQPPGDPLMS
460 470 480 490 500
RLFYGVKAGP GVGAPRRSGH TFTVNPRRSV PPATPATPTS PATVDAAVPG
510 520 530 540 550
AGKKRYPTAE EILVLGGYLR LSRSCLAKGS PERHHKQLKI SFSETALETT
560 570 580 590 600
YQYPSESSVL EELGPEPEVP SAPNPPAAQP DDEEDEEELL LLQPELQGGL
610
RTKALIVDES CRR
Length:613
Mass (Da):67,943
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB1F7C82DD50BB66
GO
Isoform 2 (identifier: Q6NYC8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-377: NSGKAREWTP...SPGVEAGEGE → IMSLAGKGNQ...LIQSPWCGWG
     378-613: Missing.

Show »
Length:377
Mass (Da):42,833
Checksum:i604591F8FB80F24D
GO
Isoform 3 (identifier: Q6NYC8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-325: Missing.
     562-582: ELGPEPEVPSAPNPPAAQPDD → RRRAKLGLSP...DQSPKGRESR

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):39,373
Checksum:iB48C33E8148B37BB
GO
Isoform 4 (identifier: Q6NYC8-4) [UniParc]FASTAAdd to basket
Also known as: 26kDa, phostensin-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-448: Missing.

Show »
Length:165
Mass (Da):17,771
Checksum:iB207EF0F57B36324
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JHC2A0A0G2JHC2_HUMAN
PPP1R18
PPP1R18
613Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JKF1A0A0G2JKF1_HUMAN
Phostensin
PPP1R18
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB85535 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti81A → T in BAC86229 (PubMed:14702039).Curated1
Sequence conflicti237E → G in BAC86229 (PubMed:14702039).Curated1
Sequence conflicti307S → G in BAD38640 (PubMed:15221005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_046132222R → G1 PublicationCorresponds to variant dbSNP:rs9262144Ensembl.1
Natural variantiVAR_046133339G → R2 PublicationsCorresponds to variant dbSNP:rs9262143Ensembl.1
Natural variantiVAR_034045356P → L. Corresponds to variant dbSNP:rs2213944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0571171 – 448Missing in isoform 4. Add BLAST448
Alternative sequenceiVSP_0571181 – 325Missing in isoform 3. Add BLAST325
Alternative sequenceiVSP_014258337 – 377NSGKA…AGEGE → IMSLAGKGNQHLVTCFPHPV SGGRANCPISTLIQSPWCGW G in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_014259378 – 613Missing in isoform 2. 1 PublicationAdd BLAST236
Alternative sequenceiVSP_057119562 – 582ELGPE…AQPDD → RRRAKLGLSPGEPSPVLGTV EAGPPDPDESAVLLEAIGPV HQNRFIRQERQQQQQQQQRS EELLAERKPGPLEARERRPS PGEMRDQSPKGRESR in isoform 3. Add BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ988947 mRNA Translation: ABL61261.1
AB075829 mRNA Translation: BAB85535.1 Different initiation.
AB073600 mRNA Translation: BAD38640.1
AK124880 mRNA Translation: BAG54110.1
AK125639 mRNA Translation: BAC86229.1
AK126182 mRNA Translation: BAC86478.1
AL832318 mRNA Translation: CAD38613.1
BX647622 mRNA Translation: CAI46080.1
AL662797 Genomic DNA No translation available.
AL662798 Genomic DNA No translation available.
AL732442 Genomic DNA No translation available.
AL845353 Genomic DNA No translation available.
BX908728 Genomic DNA No translation available.
CR753328 Genomic DNA No translation available.
CR759873 Genomic DNA No translation available.
CR788240 Genomic DNA No translation available.
CR936878 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03318.1
BC006176 mRNA Translation: AAH06176.1
BC066644 mRNA Translation: AAH66644.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS43444.1 [Q6NYC8-1]

NCBI Reference Sequences

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RefSeqi
NP_001128342.1, NM_001134870.1 [Q6NYC8-1]
NP_597728.1, NM_133471.3 [Q6NYC8-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.101150

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000274853; ENSP00000274853; ENSG00000146112 [Q6NYC8-1]
ENST00000383573; ENSP00000373067; ENSG00000206485
ENST00000399199; ENSP00000382150; ENSG00000146112 [Q6NYC8-1]
ENST00000400554; ENSP00000383400; ENSG00000206485
ENST00000437121; ENSP00000405234; ENSG00000225060 [Q6NYC8-1]
ENST00000438815; ENSP00000413596; ENSG00000230341 [Q6NYC8-1]
ENST00000438945; ENSP00000400990; ENSG00000234000 [Q6NYC8-1]
ENST00000443517; ENSP00000404066; ENSG00000229998 [Q6NYC8-1]
ENST00000444206; ENSP00000416648; ENSG00000230341 [Q6NYC8-1]
ENST00000449705; ENSP00000388790; ENSG00000229998 [Q6NYC8-1]
ENST00000451544; ENSP00000400129; ENSG00000225060 [Q6NYC8-1]
ENST00000455935; ENSP00000412456; ENSG00000234000 [Q6NYC8-1]
ENST00000548255; ENSP00000446851; ENSG00000231247
ENST00000615527; ENSP00000480270; ENSG00000146112 [Q6NYC8-1]
ENST00000615892; ENSP00000482578; ENSG00000146112 [Q6NYC8-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
170954

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:170954

UCSC genome browser

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UCSCi
uc003nra.4 human [Q6NYC8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ988947 mRNA Translation: ABL61261.1
AB075829 mRNA Translation: BAB85535.1 Different initiation.
AB073600 mRNA Translation: BAD38640.1
AK124880 mRNA Translation: BAG54110.1
AK125639 mRNA Translation: BAC86229.1
AK126182 mRNA Translation: BAC86478.1
AL832318 mRNA Translation: CAD38613.1
BX647622 mRNA Translation: CAI46080.1
AL662797 Genomic DNA No translation available.
AL662798 Genomic DNA No translation available.
AL732442 Genomic DNA No translation available.
AL845353 Genomic DNA No translation available.
BX908728 Genomic DNA No translation available.
CR753328 Genomic DNA No translation available.
CR759873 Genomic DNA No translation available.
CR788240 Genomic DNA No translation available.
CR936878 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03318.1
BC006176 mRNA Translation: AAH06176.1
BC066644 mRNA Translation: AAH66644.1
CCDSiCCDS43444.1 [Q6NYC8-1]
RefSeqiNP_001128342.1, NM_001134870.1 [Q6NYC8-1]
NP_597728.1, NM_133471.3 [Q6NYC8-1]
UniGeneiHs.101150

3D structure databases

ProteinModelPortaliQ6NYC8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128092, 69 interactors
IntActiQ6NYC8, 104 interactors
MINTiQ6NYC8
STRINGi9606.ENSP00000274853

PTM databases

iPTMnetiQ6NYC8
PhosphoSitePlusiQ6NYC8

Polymorphism and mutation databases

BioMutaiPPP1R18
DMDMi68052323

Proteomic databases

EPDiQ6NYC8
jPOSTiQ6NYC8
MaxQBiQ6NYC8
PaxDbiQ6NYC8
PeptideAtlasiQ6NYC8
PRIDEiQ6NYC8
ProteomicsDBi66784
66785 [Q6NYC8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274853; ENSP00000274853; ENSG00000146112 [Q6NYC8-1]
ENST00000383573; ENSP00000373067; ENSG00000206485
ENST00000399199; ENSP00000382150; ENSG00000146112 [Q6NYC8-1]
ENST00000400554; ENSP00000383400; ENSG00000206485
ENST00000437121; ENSP00000405234; ENSG00000225060 [Q6NYC8-1]
ENST00000438815; ENSP00000413596; ENSG00000230341 [Q6NYC8-1]
ENST00000438945; ENSP00000400990; ENSG00000234000 [Q6NYC8-1]
ENST00000443517; ENSP00000404066; ENSG00000229998 [Q6NYC8-1]
ENST00000444206; ENSP00000416648; ENSG00000230341 [Q6NYC8-1]
ENST00000449705; ENSP00000388790; ENSG00000229998 [Q6NYC8-1]
ENST00000451544; ENSP00000400129; ENSG00000225060 [Q6NYC8-1]
ENST00000455935; ENSP00000412456; ENSG00000234000 [Q6NYC8-1]
ENST00000548255; ENSP00000446851; ENSG00000231247
ENST00000615527; ENSP00000480270; ENSG00000146112 [Q6NYC8-1]
ENST00000615892; ENSP00000482578; ENSG00000146112 [Q6NYC8-4]
GeneIDi170954
KEGGihsa:170954
UCSCiuc003nra.4 human [Q6NYC8-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
170954
DisGeNETi170954
EuPathDBiHostDB:ENSG00000146112.11

GeneCards: human genes, protein and diseases

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GeneCardsi
PPP1R18
HGNCiHGNC:29413 PPP1R18
HPAiHPA044745
HPA051000
MIMi610990 gene
neXtProtiNX_Q6NYC8
OpenTargetsiENSG00000146112
PharmGKBiPA134918172

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJQY Eukaryota
ENOG410ZUB8 LUCA
GeneTreeiENSGT00530000064035
HOVERGENiHBG080180
InParanoidiQ6NYC8
KOiK17559
OMAiWTPRDTE
OrthoDBi592905at2759
PhylomeDBiQ6NYC8
TreeFamiTF337604

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
PPP1R18 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
KIAA1949

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
170954

Protein Ontology

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PROi
PR:Q6NYC8

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000146112 Expressed in 178 organ(s), highest expression level in blood
ExpressionAtlasiQ6NYC8 baseline and differential
GenevisibleiQ6NYC8 HS

Family and domain databases

InterProiView protein in InterPro
IPR025903 Phostensin/Taperin_N_dom
IPR025907 Phostensin/Taperin_PP1-bd_dom
IPR026671 PPP1R18/Tprn
PANTHERiPTHR21685 PTHR21685, 1 hit
PfamiView protein in Pfam
PF13914 Phostensin, 1 hit
PF13916 Phostensin_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPR18_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NYC8
Secondary accession number(s): A2AB01
, A2AIB8, A4UBI6, A6NCB7, A8MSS7, B7ZCV7, Q68CK8, Q6ZTV1, Q6ZUJ6, Q8NDQ4, Q8TF52, Q9BRL9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 5, 2004
Last modified: February 13, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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