Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phostensin

Gene

PPP1R18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Isoform 1: May target protein phosphatase 1 to F-actin cytoskeleton.1 Publication
Isoform 4: May target protein phosphatase 1 to F-actin cytoskeleton.1 Publication

GO - Molecular functioni

Keywordsi

Molecular functionActin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phostensin
Alternative name(s):
Protein phosphatase 1 F-actin cytoskeleton-targeting subunit
Protein phosphatase 1 regulatory subunit 18
Gene namesi
Name:PPP1R18
Synonyms:HKMT1098, KIAA1949
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000146112.11
HGNCiHGNC:29413 PPP1R18
MIMi610990 gene
neXtProtiNX_Q6NYC8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi540I → G: Decrease binding to PP1. Complete inhibition of PP1 binding; when associated with G-542. 1 Publication1
Mutagenesisi542F → G: Decrease binding to PP1. Decrease binding to PP1. Complete inhibition of PP1 binding; when associated with G-540. 1 Publication1

Organism-specific databases

DisGeNETi170954
OpenTargetsiENSG00000146112
PharmGKBiPA134918172

Polymorphism and mutation databases

BioMutaiPPP1R18
DMDMi68052323

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000508071 – 613PhostensinAdd BLAST613

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineCombined sources1
Modified residuei125PhosphoserineCombined sources1
Modified residuei133PhosphoserineCombined sources1
Modified residuei175PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei199PhosphothreonineCombined sources1
Modified residuei224PhosphoserineCombined sources1
Modified residuei368PhosphoserineCombined sources1
Modified residuei432PhosphoserineBy similarity1
Modified residuei457N6-acetyllysineBy similarity1
Modified residuei490PhosphoserineCombined sources1
Modified residuei530PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6NYC8
MaxQBiQ6NYC8
PaxDbiQ6NYC8
PeptideAtlasiQ6NYC8
PRIDEiQ6NYC8
ProteomicsDBi66784
66785 [Q6NYC8-2]

PTM databases

iPTMnetiQ6NYC8
PhosphoSitePlusiQ6NYC8

Expressioni

Tissue specificityi

Isoform 4 is predominantly expressed in leukocytes and spleen.1 Publication

Gene expression databases

BgeeiENSG00000146112 Expressed in 178 organ(s), highest expression level in blood
ExpressionAtlasiQ6NYC8 baseline and differential
GenevisibleiQ6NYC8 HS

Organism-specific databases

HPAiHPA044745
HPA051000

Interactioni

Subunit structurei

Interacts with Protein phosphatase 1 (PP1).1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi128092, 69 interactors
IntActiQ6NYC8, 103 interactors
MINTiQ6NYC8
STRINGi9606.ENSP00000274853

Structurei

3D structure databases

ProteinModelPortaliQ6NYC8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 103Poly-Gln8

Phylogenomic databases

eggNOGiENOG410IJQY Eukaryota
ENOG410ZUB8 LUCA
GeneTreeiENSGT00530000064035
HOVERGENiHBG080180
InParanoidiQ6NYC8
KOiK17559
OMAiWTPRDTE
OrthoDBiEOG091G0B2C
PhylomeDBiQ6NYC8
TreeFamiTF337604

Family and domain databases

InterProiView protein in InterPro
IPR025903 Phostensin/Taperin_N_dom
IPR025907 Phostensin/Taperin_PP1-bd_dom
IPR026671 PPP1R18/Tprn
PANTHERiPTHR21685 PTHR21685, 1 hit
PfamiView protein in Pfam
PF13914 Phostensin, 1 hit
PF13916 Phostensin_N, 1 hit

Sequences (4+)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NYC8-1) [UniParc]FASTAAdd to basket
Also known as: 110 kDa, phostensin-beta

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATIPDWKLQ LLARRRQEEA SVRGREKAER ERLSQMPAWK RGLLERRRAK
60 70 80 90 100
LGLSPGEPSP VLGTVEAGPP DPDESAVLLE AIGPVHQNRF IRQERQQQQQ
110 120 130 140 150
QQQRSEELLA ERKPGPLEAR ERRPSPGEMR DQSPKGRESR EERLSPRETR
160 170 180 190 200
ERRLGIGGAQ ELSLRPLEAR DWRQSPGEVG DRSSRLSEAW KWRLSPGETP
210 220 230 240 250
ERSLRLAESR EQSPRRKEVE SRLSPGESAY QKLGLTEAHK WRPDSRESQE
260 270 280 290 300
QSLVQLEATE WRLRSGEERQ DYSEECGRKE EWPVPGVAPK ETAELSETLT
310 320 330 340 350
REAQGNSSAG VEAAEQRPVE DGERGMKPTE GWKWTLNSGK AREWTPRDIE
360 370 380 390 400
AQTQKPEPPE SAEKLLESPG VEAGEGEAEK EEAGAQGRPL RALQNCCSVP
410 420 430 440 450
SPLPPEDAGT GGLRQQEEEA VELQPPPPAP LSPPPPAPTA PQPPGDPLMS
460 470 480 490 500
RLFYGVKAGP GVGAPRRSGH TFTVNPRRSV PPATPATPTS PATVDAAVPG
510 520 530 540 550
AGKKRYPTAE EILVLGGYLR LSRSCLAKGS PERHHKQLKI SFSETALETT
560 570 580 590 600
YQYPSESSVL EELGPEPEVP SAPNPPAAQP DDEEDEEELL LLQPELQGGL
610
RTKALIVDES CRR
Length:613
Mass (Da):67,943
Last modified:July 5, 2004 - v1
Checksum:iAB1F7C82DD50BB66
GO
Isoform 2 (identifier: Q6NYC8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     337-377: NSGKAREWTP...SPGVEAGEGE → IMSLAGKGNQ...LIQSPWCGWG
     378-613: Missing.

Show »
Length:377
Mass (Da):42,833
Checksum:i604591F8FB80F24D
GO
Isoform 3 (identifier: Q6NYC8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-325: Missing.
     562-582: ELGPEPEVPSAPNPPAAQPDD → RRRAKLGLSP...DQSPKGRESR

Note: No experimental confirmation available.
Show »
Length:362
Mass (Da):39,373
Checksum:iB48C33E8148B37BB
GO
Isoform 4 (identifier: Q6NYC8-4) [UniParc]FASTAAdd to basket
Also known as: 26kDa, phostensin-alpha

The sequence of this isoform differs from the canonical sequence as follows:
     1-448: Missing.

Show »
Length:165
Mass (Da):17,771
Checksum:iB207EF0F57B36324
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JHC2A0A0G2JHC2_HUMAN
PPP1R18
PPP1R18
613Annotation score:
A0A0G2JKF1A0A0G2JKF1_HUMAN
Phostensin
PPP1R18
76Annotation score:

Sequence cautioni

The sequence BAB85535 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81A → T in BAC86229 (PubMed:14702039).Curated1
Sequence conflicti237E → G in BAC86229 (PubMed:14702039).Curated1
Sequence conflicti307S → G in BAD38640 (PubMed:15221005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_046132222R → G1 PublicationCorresponds to variant dbSNP:rs9262144Ensembl.1
Natural variantiVAR_046133339G → R2 PublicationsCorresponds to variant dbSNP:rs9262143Ensembl.1
Natural variantiVAR_034045356P → L. Corresponds to variant dbSNP:rs2213944Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0571171 – 448Missing in isoform 4. Add BLAST448
Alternative sequenceiVSP_0571181 – 325Missing in isoform 3. Add BLAST325
Alternative sequenceiVSP_014258337 – 377NSGKA…AGEGE → IMSLAGKGNQHLVTCFPHPV SGGRANCPISTLIQSPWCGW G in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_014259378 – 613Missing in isoform 2. 1 PublicationAdd BLAST236
Alternative sequenceiVSP_057119562 – 582ELGPE…AQPDD → RRRAKLGLSPGEPSPVLGTV EAGPPDPDESAVLLEAIGPV HQNRFIRQERQQQQQQQQRS EELLAERKPGPLEARERRPS PGEMRDQSPKGRESR in isoform 3. Add BLAST21

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ988947 mRNA Translation: ABL61261.1
AB075829 mRNA Translation: BAB85535.1 Different initiation.
AB073600 mRNA Translation: BAD38640.1
AK124880 mRNA Translation: BAG54110.1
AK125639 mRNA Translation: BAC86229.1
AK126182 mRNA Translation: BAC86478.1
AL832318 mRNA Translation: CAD38613.1
BX647622 mRNA Translation: CAI46080.1
AL662797 Genomic DNA No translation available.
AL662798 Genomic DNA No translation available.
AL732442 Genomic DNA No translation available.
AL845353 Genomic DNA No translation available.
BX908728 Genomic DNA No translation available.
CR753328 Genomic DNA No translation available.
CR759873 Genomic DNA No translation available.
CR788240 Genomic DNA No translation available.
CR936878 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03318.1
BC006176 mRNA Translation: AAH06176.1
BC066644 mRNA Translation: AAH66644.1
CCDSiCCDS43444.1 [Q6NYC8-1]
RefSeqiNP_001128342.1, NM_001134870.1 [Q6NYC8-1]
NP_597728.1, NM_133471.3 [Q6NYC8-1]
UniGeneiHs.101150

Genome annotation databases

EnsembliENST00000274853; ENSP00000274853; ENSG00000146112 [Q6NYC8-1]
ENST00000383573; ENSP00000373067; ENSG00000206485
ENST00000399199; ENSP00000382150; ENSG00000146112 [Q6NYC8-1]
ENST00000400554; ENSP00000383400; ENSG00000206485
ENST00000437121; ENSP00000405234; ENSG00000225060 [Q6NYC8-1]
ENST00000438815; ENSP00000413596; ENSG00000230341 [Q6NYC8-1]
ENST00000438945; ENSP00000400990; ENSG00000234000 [Q6NYC8-1]
ENST00000443517; ENSP00000404066; ENSG00000229998 [Q6NYC8-1]
ENST00000444206; ENSP00000416648; ENSG00000230341 [Q6NYC8-1]
ENST00000449705; ENSP00000388790; ENSG00000229998 [Q6NYC8-1]
ENST00000451544; ENSP00000400129; ENSG00000225060 [Q6NYC8-1]
ENST00000455935; ENSP00000412456; ENSG00000234000 [Q6NYC8-1]
ENST00000548255; ENSP00000446851; ENSG00000231247
ENST00000615527; ENSP00000480270; ENSG00000146112 [Q6NYC8-1]
ENST00000615892; ENSP00000482578; ENSG00000146112 [Q6NYC8-4]
GeneIDi170954
KEGGihsa:170954
UCSCiuc003nra.4 human [Q6NYC8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ988947 mRNA Translation: ABL61261.1
AB075829 mRNA Translation: BAB85535.1 Different initiation.
AB073600 mRNA Translation: BAD38640.1
AK124880 mRNA Translation: BAG54110.1
AK125639 mRNA Translation: BAC86229.1
AK126182 mRNA Translation: BAC86478.1
AL832318 mRNA Translation: CAD38613.1
BX647622 mRNA Translation: CAI46080.1
AL662797 Genomic DNA No translation available.
AL662798 Genomic DNA No translation available.
AL732442 Genomic DNA No translation available.
AL845353 Genomic DNA No translation available.
BX908728 Genomic DNA No translation available.
CR753328 Genomic DNA No translation available.
CR759873 Genomic DNA No translation available.
CR788240 Genomic DNA No translation available.
CR936878 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03318.1
BC006176 mRNA Translation: AAH06176.1
BC066644 mRNA Translation: AAH66644.1
CCDSiCCDS43444.1 [Q6NYC8-1]
RefSeqiNP_001128342.1, NM_001134870.1 [Q6NYC8-1]
NP_597728.1, NM_133471.3 [Q6NYC8-1]
UniGeneiHs.101150

3D structure databases

ProteinModelPortaliQ6NYC8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128092, 69 interactors
IntActiQ6NYC8, 103 interactors
MINTiQ6NYC8
STRINGi9606.ENSP00000274853

PTM databases

iPTMnetiQ6NYC8
PhosphoSitePlusiQ6NYC8

Polymorphism and mutation databases

BioMutaiPPP1R18
DMDMi68052323

Proteomic databases

EPDiQ6NYC8
MaxQBiQ6NYC8
PaxDbiQ6NYC8
PeptideAtlasiQ6NYC8
PRIDEiQ6NYC8
ProteomicsDBi66784
66785 [Q6NYC8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000274853; ENSP00000274853; ENSG00000146112 [Q6NYC8-1]
ENST00000383573; ENSP00000373067; ENSG00000206485
ENST00000399199; ENSP00000382150; ENSG00000146112 [Q6NYC8-1]
ENST00000400554; ENSP00000383400; ENSG00000206485
ENST00000437121; ENSP00000405234; ENSG00000225060 [Q6NYC8-1]
ENST00000438815; ENSP00000413596; ENSG00000230341 [Q6NYC8-1]
ENST00000438945; ENSP00000400990; ENSG00000234000 [Q6NYC8-1]
ENST00000443517; ENSP00000404066; ENSG00000229998 [Q6NYC8-1]
ENST00000444206; ENSP00000416648; ENSG00000230341 [Q6NYC8-1]
ENST00000449705; ENSP00000388790; ENSG00000229998 [Q6NYC8-1]
ENST00000451544; ENSP00000400129; ENSG00000225060 [Q6NYC8-1]
ENST00000455935; ENSP00000412456; ENSG00000234000 [Q6NYC8-1]
ENST00000548255; ENSP00000446851; ENSG00000231247
ENST00000615527; ENSP00000480270; ENSG00000146112 [Q6NYC8-1]
ENST00000615892; ENSP00000482578; ENSG00000146112 [Q6NYC8-4]
GeneIDi170954
KEGGihsa:170954
UCSCiuc003nra.4 human [Q6NYC8-1]

Organism-specific databases

CTDi170954
DisGeNETi170954
EuPathDBiHostDB:ENSG00000146112.11
GeneCardsiPPP1R18
HGNCiHGNC:29413 PPP1R18
HPAiHPA044745
HPA051000
MIMi610990 gene
neXtProtiNX_Q6NYC8
OpenTargetsiENSG00000146112
PharmGKBiPA134918172
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJQY Eukaryota
ENOG410ZUB8 LUCA
GeneTreeiENSGT00530000064035
HOVERGENiHBG080180
InParanoidiQ6NYC8
KOiK17559
OMAiWTPRDTE
OrthoDBiEOG091G0B2C
PhylomeDBiQ6NYC8
TreeFamiTF337604

Miscellaneous databases

ChiTaRSiPPP1R18 human
GeneWikiiKIAA1949
GenomeRNAii170954
PROiPR:Q6NYC8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000146112 Expressed in 178 organ(s), highest expression level in blood
ExpressionAtlasiQ6NYC8 baseline and differential
GenevisibleiQ6NYC8 HS

Family and domain databases

InterProiView protein in InterPro
IPR025903 Phostensin/Taperin_N_dom
IPR025907 Phostensin/Taperin_PP1-bd_dom
IPR026671 PPP1R18/Tprn
PANTHERiPTHR21685 PTHR21685, 1 hit
PfamiView protein in Pfam
PF13914 Phostensin, 1 hit
PF13916 Phostensin_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPR18_HUMAN
AccessioniPrimary (citable) accession number: Q6NYC8
Secondary accession number(s): A2AB01
, A2AIB8, A4UBI6, A6NCB7, A8MSS7, B7ZCV7, Q68CK8, Q6ZTV1, Q6ZUJ6, Q8NDQ4, Q8TF52, Q9BRL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again