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UniProtKB - Q6NY77 (HOGA1_DANRE)
Protein
4-hydroxy-2-oxoglutarate aldolase, mitochondrial
Gene
zgc:77082
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Catalyzes the final step in the metabolic pathway of hydroxyproline.
By similarityCatalytic activityi
Activity regulationi
Inhibited by divalent cations.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 165 | Involved in proton transfer during cleavageBy similarity | 1 | |
Active sitei | 193 | Schiff-base intermediate with substrateBy similarity | 1 | |
Binding sitei | 195 | SubstrateBy similarity | 1 | |
Binding sitei | 219 | Substrate; via carbonyl oxygenBy similarity | 1 |
GO - Molecular functioni
- 4-hydroxy-2-oxoglutarate aldolase activity Source: UniProtKB
GO - Biological processi
- glyoxylate catabolic process Source: UniProtKB
Keywordsi
Molecular function | Lyase |
Ligand | Schiff base |
Enzyme and pathway databases
Reactomei | R-DRE-389661, Glyoxylate metabolism and glycine degradation |
Names & Taxonomyi
Protein namesi | Recommended name: 4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC:4.1.3.16)Alternative name(s): Dihydrodipicolinate synthase-like Short name: DHDPS-like protein Probable 2-keto-4-hydroxyglutarate aldolase Short name: Probable KHG-aldolase |
Gene namesi | ORF Names:zgc:77082 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040426-2242, hoga1 |
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: GO_Central
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 22 | MitochondrionSequence analysisAdd BLAST | 22 | |
ChainiPRO_0000273348 | 23 – 324 | 4-hydroxy-2-oxoglutarate aldolase, mitochondrialAdd BLAST | 302 |
Proteomic databases
PaxDbi | Q6NY77 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000018944, Expressed in kidney and 27 other tissues |
ExpressionAtlasi | Q6NY77, baseline and differential |
Interactioni
Subunit structurei
Homotetramer.
By similarityProtein-protein interaction databases
STRINGi | 7955.ENSDARP00000021126 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 74 – 75 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the DapA family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | ENOG502QWNS, Eukaryota |
GeneTreei | ENSGT00530000063604 |
InParanoidi | Q6NY77 |
OMAi | GMDACVP |
OrthoDBi | 1238597at2759 |
PhylomeDBi | Q6NY77 |
TreeFami | TF324600 |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR002220, DapA-like IPR020625, Schiff_base-form_aldolases_AS |
PANTHERi | PTHR12128, PTHR12128, 1 hit |
Pfami | View protein in Pfam PF00701, DHDPS, 1 hit |
PIRSFi | PIRSF001365, DHDPS, 1 hit |
PRINTSi | PR00146, DHPICSNTHASE |
SMARTi | View protein in SMART SM01130, DHDPS, 1 hit |
PROSITEi | View protein in PROSITE PS00666, DHDPS_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6NY77-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFAHRSFSLL CRRSAVTSWR SQSHTAGKRL DISGIYPPIA TPFTEPEDVD
60 70 80 90 100
YQKLDDNIRK YGRLPFRGLV VQGSNGEYPY LTAEERVEVV KRVKQALPKD
110 120 130 140 150
KLVMAGSGCE STRATIQMSQ RMADAGADCV LVVTPCFYRG RMDSRALINH
160 170 180 190 200
YSKVADSCSV PVVLYSVPAN TGLDLPVDAV IQLSKHPNIV GLKDSGGDIT
210 220 230 240 250
RIALMVQKTR SQDFQVLAGS AGFLMAAYAV GAVGGVCALA NVLGQQVCEL
260 270 280 290 300
AQLCVSGRWD EAKELQYRLI EPNTAVTRGF GVPALKLAMD WFGYHGGICR
310 320
SPLQPLSKAD LEALRGKFSS NGWL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX1WHD6 | X1WHD6_DANRE | 4-hydroxy-2-oxoglutarate aldolase, ... | hoga1 | 276 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC066708 mRNA Translation: AAH66708.1 |
RefSeqi | NP_998035.1, NM_212870.1 |
Genome annotation databases
Ensembli | ENSDART00000025820; ENSDARP00000021126; ENSDARG00000018944 |
GeneIDi | 405806 |
KEGGi | dre:405806 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC066708 mRNA Translation: AAH66708.1 |
RefSeqi | NP_998035.1, NM_212870.1 |
3D structure databases
AlphaFoldDBi | Q6NY77 |
SMRi | Q6NY77 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000021126 |
Proteomic databases
PaxDbi | Q6NY77 |
Genome annotation databases
Ensembli | ENSDART00000025820; ENSDARP00000021126; ENSDARG00000018944 |
GeneIDi | 405806 |
KEGGi | dre:405806 |
Organism-specific databases
CTDi | 112817 |
ZFINi | ZDB-GENE-040426-2242, hoga1 |
Phylogenomic databases
eggNOGi | ENOG502QWNS, Eukaryota |
GeneTreei | ENSGT00530000063604 |
InParanoidi | Q6NY77 |
OMAi | GMDACVP |
OrthoDBi | 1238597at2759 |
PhylomeDBi | Q6NY77 |
TreeFami | TF324600 |
Enzyme and pathway databases
Reactomei | R-DRE-389661, Glyoxylate metabolism and glycine degradation |
Miscellaneous databases
PROi | PR:Q6NY77 |
Gene expression databases
Bgeei | ENSDARG00000018944, Expressed in kidney and 27 other tissues |
ExpressionAtlasi | Q6NY77, baseline and differential |
Family and domain databases
Gene3Di | 3.20.20.70, 1 hit |
InterProi | View protein in InterPro IPR013785, Aldolase_TIM IPR002220, DapA-like IPR020625, Schiff_base-form_aldolases_AS |
PANTHERi | PTHR12128, PTHR12128, 1 hit |
Pfami | View protein in Pfam PF00701, DHDPS, 1 hit |
PIRSFi | PIRSF001365, DHDPS, 1 hit |
PRINTSi | PR00146, DHPICSNTHASE |
SMARTi | View protein in SMART SM01130, DHDPS, 1 hit |
PROSITEi | View protein in PROSITE PS00666, DHDPS_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HOGA1_DANRE | |
Accessioni | Q6NY77Primary (citable) accession number: Q6NY77 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families