UniProtKB - Q6NY64 (2ABD_DANRE)
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform
ppp2r2d
Functioni
GO - Molecular functioni
- protein phosphatase regulator activity Source: UniProtKB
GO - Biological processi
- cell division Source: UniProtKB-KW
- exit from mitosis Source: UniProtKB
- mitotic cell cycle Source: UniProtKB
- myoblast fusion Source: ZFIN
- peptidyl-serine dephosphorylation Source: GO_Central
Keywordsi
Biological process | Cell cycle, Cell division, Mitosis |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformAlternative name(s): PP2A subunit B isoform B55-delta PP2A subunit B isoform PR55-delta PP2A subunit B isoform R2-delta PP2A subunit B isoform delta |
Gene namesi | Name:ppp2r2d ORF Names:zgc:76887 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-040426-2086, ppp2r2d |
Subcellular locationi
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: GO_Central
Other locations
- protein phosphatase type 2A complex Source: UniProtKB
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000408324 | 1 – 447 | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoformAdd BLAST | 447 |
Proteomic databases
PaxDbi | Q6NY64 |
Interactioni
Subunit structurei
PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
Interacts with ENSA (when phosphorylated at 'Ser-74') and ARPP19 (when phosphorylated at 'Ser-62'), leading to inhibit PP2A activity (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 7955.ENSDARP00000099721 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 26 – 65 | WD 1Add BLAST | 40 | |
Repeati | 91 – 132 | WD 2Add BLAST | 42 | |
Repeati | 175 – 213 | WD 3Add BLAST | 39 | |
Repeati | 224 – 264 | WD 4Add BLAST | 41 | |
Repeati | 283 – 321 | WD 5Add BLAST | 39 | |
Repeati | 338 – 379 | WD 6Add BLAST | 42 | |
Repeati | 414 – 447 | WD 7Add BLAST | 34 |
Sequence similaritiesi
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG1354, Eukaryota |
GeneTreei | ENSGT00950000182864 |
InParanoidi | Q6NY64 |
OrthoDBi | 810409at2759 |
PhylomeDBi | Q6NY64 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
10 20 30 40 50
MAGVGGGNDF QWCFSQVKGA IDEDVAEADI ISTVEFNYSG ELLATGDKGG
60 70 80 90 100
RVVIFQREQE SKNRPLSRGE YNVYSTFQSH EPEFDYLKSL EIEEKINKIR
110 120 130 140 150
WLPQQNAAHF LLSTNDKTIK LWKISERDKR AEGYNLKDED GRLRDPFRIT
160 170 180 190 200
SLRVPVLMPM DLMVEASPRR IFANAHTYHI NSISVNSDYE TYLSADDLRI
210 220 230 240 250
NLWHLEITDR SFNIVDIKPA NMEELTEVIT AAECHPHQCN VFVYSSSKGT
260 270 280 290 300
IRLCDMRAAA LCDRHSKFFE EPEDPSSRSF FSEIISSISD VKFSHSGRYM
310 320 330 340 350
MTRDYLSVKV WDLNMENRPV ETYQVHEYLR SKLCSLYEND CIFDKFECCW
360 370 380 390 400
NGSDSAIMTG SYNNFFRMFD RNTRRDITLE ASRESSKPRA MLKPRKVCTG
410 420 430 440
GKRKKDEISV DSLDFNKKIL HTAWHPKENV IAVAATNNLY IFQDKMN
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0R4IAE3 | A0A0R4IAE3_DANRE | Serine/threonine-protein phosphatas... | ppp2r2d | 448 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC066723 mRNA Translation: AAH66723.1 |
RefSeqi | NP_998045.1, NM_212880.1 |
Genome annotation databases
Ensembli | ENSDART00000172175; ENSDARP00000131091; ENSDARG00000102009 |
GeneIDi | 405816 |
KEGGi | dre:405816 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC066723 mRNA Translation: AAH66723.1 |
RefSeqi | NP_998045.1, NM_212880.1 |
3D structure databases
SMRi | Q6NY64 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000099721 |
Proteomic databases
PaxDbi | Q6NY64 |
Genome annotation databases
Ensembli | ENSDART00000172175; ENSDARP00000131091; ENSDARG00000102009 |
GeneIDi | 405816 |
KEGGi | dre:405816 |
Organism-specific databases
CTDi | 55844 |
ZFINi | ZDB-GENE-040426-2086, ppp2r2d |
Phylogenomic databases
eggNOGi | KOG1354, Eukaryota |
GeneTreei | ENSGT00950000182864 |
InParanoidi | Q6NY64 |
OrthoDBi | 810409at2759 |
PhylomeDBi | Q6NY64 |
Miscellaneous databases
PROi | PR:Q6NY64 |
Gene expression databases
ExpressionAtlasi | Q6NY64, baseline |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR000009, PP2A_PR55 IPR018067, PP2A_PR55_CS IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR036322, WD40_repeat_dom_sf |
PANTHERi | PTHR11871, PTHR11871, 1 hit |
PIRSFi | PIRSF037309, PP2A_PR55, 1 hit |
PRINTSi | PR00600, PP2APR55 |
SMARTi | View protein in SMART SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit |
PROSITEi | View protein in PROSITE PS01024, PR55_1, 1 hit PS01025, PR55_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | 2ABD_DANRE | |
Accessioni | Q6NY64Primary (citable) accession number: Q6NY64 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 3, 2011 |
Last sequence update: | July 5, 2004 | |
Last modified: | December 2, 2020 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families