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UniProtKB - Q6NY19 (KANK3_HUMAN)
Protein
KN motif and ankyrin repeat domain-containing protein 3
Gene
KANK3
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in the control of cytoskeleton formation by regulating actin polymerization.
GO - Biological processi
- negative regulation of actin filament polymerization Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q6NY19 |
SignaLinki | Q6NY19 |
Names & Taxonomyi
Protein namesi | Recommended name: KN motif and ankyrin repeat domain-containing protein 3CuratedAlternative name(s): Ankyrin repeat domain-containing protein 47 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:24796, KANK3 |
MIMi | 614611, gene |
neXtProti | NX_Q6NY19 |
VEuPathDBi | HostDB:ENSG00000186994 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 256949 |
OpenTargetsi | ENSG00000186994 |
PharmGKBi | PA162392612 |
Miscellaneous databases
Pharosi | Q6NY19, Tdark |
Genetic variation databases
BioMutai | KANK3 |
DMDMi | 74749039 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000244582 | 1 – 821 | KN motif and ankyrin repeat domain-containing protein 3Add BLAST | 821 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 152 | PhosphoserineCombined sources | 1 | |
Modified residuei | 160 | PhosphoserineBy similarity | 1 | |
Modified residuei | 164 | PhosphoserineBy similarity | 1 | |
Modified residuei | 167 | PhosphoserineCombined sources | 1 | |
Modified residuei | 168 | PhosphoserineCombined sources | 1 | |
Modified residuei | 177 | PhosphoserineCombined sources | 1 | |
Modified residuei | 271 | PhosphoserineCombined sources | 1 | |
Modified residuei | 280 | PhosphoserineBy similarity | 1 | |
Modified residuei | 293 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6NY19 |
jPOSTi | Q6NY19 |
MassIVEi | Q6NY19 |
PaxDbi | Q6NY19 |
PeptideAtlasi | Q6NY19 |
PRIDEi | Q6NY19 |
ProteomicsDBi | 66779 [Q6NY19-1] 66780 [Q6NY19-2] |
PTM databases
iPTMneti | Q6NY19 |
PhosphoSitePlusi | Q6NY19 |
Expressioni
Tissue specificityi
Strongly expressed in breast, liver, lung, skeletal muscle and kidney.1 Publication
Gene expression databases
Bgeei | ENSG00000186994, Expressed in vena cava and 210 other tissues |
ExpressionAtlasi | Q6NY19, baseline and differential |
Genevisiblei | Q6NY19, HS |
Organism-specific databases
HPAi | ENSG00000186994, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 129185, 2 interactors |
IntActi | Q6NY19, 1 interactor |
STRINGi | 9606.ENSP00000328923 |
Miscellaneous databases
RNActi | Q6NY19, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 622 – 652 | ANK 1Add BLAST | 31 | |
Repeati | 656 – 690 | ANK 2Add BLAST | 35 | |
Repeati | 695 – 724 | ANK 3Add BLAST | 30 | |
Repeati | 728 – 758 | ANK 4Add BLAST | 31 | |
Repeati | 762 – 785 | ANK 5Add BLAST | 24 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 36 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 58 – 184 | DisorderedSequence analysisAdd BLAST | 127 | |
Regioni | 224 – 333 | DisorderedSequence analysisAdd BLAST | 110 | |
Regioni | 385 – 547 | DisorderedSequence analysisAdd BLAST | 163 | |
Regioni | 784 – 821 | DisorderedSequence analysisAdd BLAST | 38 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 181 – 230 | Sequence analysisAdd BLAST | 50 | |
Coiled coili | 367 – 404 | Sequence analysisAdd BLAST | 38 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 128 – 146 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 224 – 266 | Basic and acidic residuesSequence analysisAdd BLAST | 43 | |
Compositional biasi | 397 – 411 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 418 – 432 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 459 – 481 | Polar residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 497 – 517 | Polar residuesSequence analysisAdd BLAST | 21 | |
Compositional biasi | 787 – 808 | Polar residuesSequence analysisAdd BLAST | 22 |
Keywords - Domaini
ANK repeat, Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG0514, Eukaryota |
GeneTreei | ENSGT00940000161178 |
HOGENOMi | CLU_004269_2_0_1 |
InParanoidi | Q6NY19 |
OMAi | FQQESIV |
OrthoDBi | 98668at2759 |
PhylomeDBi | Q6NY19 |
TreeFami | TF324499 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR021939, KN_motif |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF13857, Ank_5, 1 hit PF12075, KN_motif, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 2 (identifier: Q6NY19-2) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAKFALNQNL PDLGGPRLCP VPAAGGARSP SSPYSVETPY GFHLDLDFLK
60 70 80 90 100
YIEELERGPA ARRAPGPPTS RRPRAPRPGL AGARSPGAWT SSESLASDDG
110 120 130 140 150
GAPGILSQGA PSGLLMQPLS PRAPVRNPRV EHTLRETSRR LELAQTHERA
160 170 180 190 200
PSPGRGVPRS PRGSGRSSPA PNLAPASPGP AQLQLVREQM AAALRRLREL
210 220 230 240 250
EDQARTLPEL QEQVRALRAE KARLLAGRAQ PEPDGEAETR PDKLAQLRRL
260 270 280 290 300
TERLATSERG GRARASPRAD SPDGLAAGRS EGALQVLDGE VGSLDGTPQT
310 320 330 340 350
REVAAEAVPE TREAGAQAVP ETREAGVEAA PETVEADAWV TEALLGLPAA
360 370 380 390 400
AERELELLRA SLEHQRGVSE LLRGRLRELE EAREAAEEAA AGARAQLREA
410 420 430 440 450
TTQTPWSCAE KAAQTESPAE APSLTQESSP GSMDGDRAVA PAGILKSIMK
460 470 480 490 500
KRDGTPGAQP SSGPKSLQFV GVLNGEYESS SSEDASDSDG DSENGGAEPP
510 520 530 540 550
GSSSGSGDDS GGGSDSGTPG PPSGGDIRDP EPEAEAEPQQ VAQGRCELSP
560 570 580 590 600
RLREACVALQ RQLSRPRGVA SDGGAVRLVA QEWFRVSSQR RSQAEPVARM
610 620 630 640 650
LEGVRRLGPE LLAHVVNLAD GNGNTALHYS VSHGNLAIAS LLLDTGACEV
660 670 680 690 700
NRQNRAGYSA LMLAALTSVR QEEEDMAVVQ RLFCMGDVNA KASQTGQTAL
710 720 730 740 750
MLAISHGRQD MVATLLACGA DVNAQDADGA TALMCASEYG RLDTVRLLLT
760 770 780 790 800
QPGCDPAILD NEGTSALAIA LEAEQDEVAA LLHAHLSSGQ PDTQSESPPG
810 820
SQTATPGEGE CGDNGENPQV Q
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087X2C6 | A0A087X2C6_HUMAN | KN motif and ankyrin repeat domain-... | KANK3 | 212 | Annotation score: | ||
M0QZJ3 | M0QZJ3_HUMAN | KN motif and ankyrin repeat domain-... | KANK3 | 146 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026909 | 288 | D → Y1 PublicationCorresponds to variant dbSNP:rs890850Ensembl. | 1 | |
Natural variantiVAR_026910 | 359 | R → H. Corresponds to variant dbSNP:rs890853Ensembl. | 1 | |
Natural variantiVAR_026911 | 485 | A → T1 PublicationCorresponds to variant dbSNP:rs2913955Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_061119 | 795 – 821 | SESPP…NPQVQ → AGVQRHNLSSLQPPPPRFKK FSCLSLPSSWDYNSCEPSRL AQLTIF in isoform 1. Add BLAST | 27 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK128815 mRNA Translation: BAC87620.1 BC035849 mRNA Translation: AAH35849.1 BC066124 mRNA Translation: AAH66124.1 BC066775 mRNA Translation: AAH66775.1 |
CCDSi | CCDS12199.1 [Q6NY19-2] |
RefSeqi | NP_940873.2, NM_198471.2 [Q6NY19-2] XP_006722781.1, XM_006722718.3 [Q6NY19-2] XP_011526186.1, XM_011527884.2 [Q6NY19-2] |
Genome annotation databases
Ensembli | ENST00000330915; ENSP00000328923; ENSG00000186994 ENST00000593649; ENSP00000470728; ENSG00000186994 [Q6NY19-1] |
GeneIDi | 256949 |
KEGGi | hsa:256949 |
MANE-Selecti | ENST00000330915.7; ENSP00000328923.2; NM_198471.3; NP_940873.2 |
UCSCi | uc010dwa.3, human [Q6NY19-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK128815 mRNA Translation: BAC87620.1 BC035849 mRNA Translation: AAH35849.1 BC066124 mRNA Translation: AAH66124.1 BC066775 mRNA Translation: AAH66775.1 |
CCDSi | CCDS12199.1 [Q6NY19-2] |
RefSeqi | NP_940873.2, NM_198471.2 [Q6NY19-2] XP_006722781.1, XM_006722718.3 [Q6NY19-2] XP_011526186.1, XM_011527884.2 [Q6NY19-2] |
3D structure databases
SMRi | Q6NY19 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129185, 2 interactors |
IntActi | Q6NY19, 1 interactor |
STRINGi | 9606.ENSP00000328923 |
PTM databases
iPTMneti | Q6NY19 |
PhosphoSitePlusi | Q6NY19 |
Genetic variation databases
BioMutai | KANK3 |
DMDMi | 74749039 |
Proteomic databases
EPDi | Q6NY19 |
jPOSTi | Q6NY19 |
MassIVEi | Q6NY19 |
PaxDbi | Q6NY19 |
PeptideAtlasi | Q6NY19 |
PRIDEi | Q6NY19 |
ProteomicsDBi | 66779 [Q6NY19-1] 66780 [Q6NY19-2] |
Protocols and materials databases
Antibodypediai | 42728, 56 antibodies from 17 providers |
DNASUi | 256949 |
Genome annotation databases
Ensembli | ENST00000330915; ENSP00000328923; ENSG00000186994 ENST00000593649; ENSP00000470728; ENSG00000186994 [Q6NY19-1] |
GeneIDi | 256949 |
KEGGi | hsa:256949 |
MANE-Selecti | ENST00000330915.7; ENSP00000328923.2; NM_198471.3; NP_940873.2 |
UCSCi | uc010dwa.3, human [Q6NY19-1] |
Organism-specific databases
CTDi | 256949 |
DisGeNETi | 256949 |
GeneCardsi | KANK3 |
HGNCi | HGNC:24796, KANK3 |
HPAi | ENSG00000186994, Low tissue specificity |
MIMi | 614611, gene |
neXtProti | NX_Q6NY19 |
OpenTargetsi | ENSG00000186994 |
PharmGKBi | PA162392612 |
VEuPathDBi | HostDB:ENSG00000186994 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0514, Eukaryota |
GeneTreei | ENSGT00940000161178 |
HOGENOMi | CLU_004269_2_0_1 |
InParanoidi | Q6NY19 |
OMAi | FQQESIV |
OrthoDBi | 98668at2759 |
PhylomeDBi | Q6NY19 |
TreeFami | TF324499 |
Enzyme and pathway databases
PathwayCommonsi | Q6NY19 |
SignaLinki | Q6NY19 |
Miscellaneous databases
BioGRID-ORCSi | 256949, 6 hits in 1037 CRISPR screens |
ChiTaRSi | KANK3, human |
GenomeRNAii | 256949 |
Pharosi | Q6NY19, Tdark |
PROi | PR:Q6NY19 |
RNActi | Q6NY19, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000186994, Expressed in vena cava and 210 other tissues |
ExpressionAtlasi | Q6NY19, baseline and differential |
Genevisiblei | Q6NY19, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR036770, Ankyrin_rpt-contain_sf IPR021939, KN_motif |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF13857, Ank_5, 1 hit PF12075, KN_motif, 1 hit |
PRINTSi | PR01415, ANKYRIN |
SMARTi | View protein in SMART SM00248, ANK, 4 hits |
SUPFAMi | SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KANK3_HUMAN | |
Accessioni | Q6NY19Primary (citable) accession number: Q6NY19 Secondary accession number(s): Q6NZI1, Q6ZQR3, Q8IUV2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 27, 2006 |
Last sequence update: | September 29, 2021 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot