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Entry version 131 (29 Sep 2021)
Sequence version 1 (05 Jul 2004)
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Protein

TELO2-interacting protein 2

Gene

TTI2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs.

2 Publications

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q6NXR4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TELO2-interacting protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TTI2
Synonyms:C8orf41
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:26262, TTI2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
614426, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NXR4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000129696

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mental retardation, autosomal recessive 39 (MRT39)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. MRT39 affected individuals show delayed psychomotor development, severe speech delay, short stature, kyphoscoliosis, and dysmorphic facial features. Behavioral abnormalities include hyperactivity, aggression, and stereotypic movements.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_070671436I → N in MRT39; impaired TTT complex formation. 1 PublicationCorresponds to variant dbSNP:rs398122367Ensembl.1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Diseasei

Disease variant, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
80185

MalaCards human disease database

More...
MalaCardsi
TTI2
MIMi615541, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000129696

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
391307, Severe intellectual disability-short stature-behavioral abnormalities-facial dysmorphism syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672360

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6NXR4, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TTI2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74736990

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002794141 – 508TELO2-interacting protein 2Add BLAST508

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NXR4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NXR4

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6NXR4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NXR4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NXR4

PeptideAtlas

More...
PeptideAtlasi
Q6NXR4

PRoteomics IDEntifications database

More...
PRIDEi
Q6NXR4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66765

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6NXR4, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NXR4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NXR4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000129696, Expressed in sural nerve and 181 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NXR4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NXR4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000129696, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the TTT complex composed of TELO2, TTI1 and TTI2.

Interacts with TELO2 and TTI1 (PubMed:20801936, PubMed:20810650).

Interacts with WAC; WAC positively regulates MTOR activity by promoting the assembly of the TTT complex and the RUVBL complex composed of RUVBL1 and RUVBL2 into the TTT-RUVBL complex which leads to the dimerization of the mTORC1 complex and its subsequent activation (PubMed:26812014).

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123164, 37 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-6148, TTT complex

Protein interaction database and analysis system

More...
IntActi
Q6NXR4, 17 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000478396

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6NXR4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 20DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TTI2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QVMM, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003878

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_047507_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NXR4

Identification of Orthologs from Complete Genome Data

More...
OMAi
LLMQYAW

Database of Orthologous Groups

More...
OrthoDBi
1298755at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NXR4

TreeFam database of animal gene trees

More...
TreeFami
TF328871

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016024, ARM-type_fold
IPR018870, Tti2

The PANTHER Classification System

More...
PANTHERi
PTHR32226, PTHR32226, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10521, Tti2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371, SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6NXR4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MELDSALEAP SQEDSNLSEE LSHSAFGQAF SKILHCLARP EARRGNVKDA
60 70 80 90 100
VLKDLGDLIE ATEFDRLFEG TGARLRGMPE TLGQVAKALE KYAAPSKEEE
110 120 130 140 150
GGGDGHSEAA EKAAQVGLLF LKLLGKVETA KNSLVGPAWQ TGLHHLAGPV
160 170 180 190 200
YIFAITHSLE QPWTTPRSRE VAREVLTSLL QVTECGSVAG FLHGENEDEK
210 220 230 240 250
GRLSVILGLL KPDLYKESWK NNPAIKHVFS WTLQQVTRPW LSQHLERVLP
260 270 280 290 300
ASLVISDDYQ TENKILGVHC LHHIVLNVPA ADLLQYNRAQ VLYHAISNHL
310 320 330 340 350
YTPEHHLIQA VLLCLLDLFP ILEKTLHWKG DGARPTTHCD EVLRLILTHM
360 370 380 390 400
EPEHRLLLRR TYARNLPAFV NRLGILTVRH LKRLERVIIG YLEVYDGPEE
410 420 430 440 450
EARLKILETL KLLMQHTWPR VSCRLVVLLK ALLKLICDVA RDPNLTPESV
460 470 480 490 500
KSALLQEATD CLILLDRCSQ GRVKGLLAKI PQSCEDRKVV NYIRKVQQVS

EGAPYNGT
Length:508
Mass (Da):56,915
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6BF98826997034F7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E5RIH5E5RIH5_HUMAN
TELO2-interacting protein 2
TTI2
477Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E5RHM7E5RHM7_HUMAN
TELO2-interacting protein 2
TTI2
101Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti468C → R in BAB15590 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03088663E → G3 PublicationsCorresponds to variant dbSNP:rs2304748Ensembl.1
Natural variantiVAR_030887425L → R. Corresponds to variant dbSNP:rs3736497Ensembl.1
Natural variantiVAR_070671436I → N in MRT39; impaired TTT complex formation. 1 PublicationCorresponds to variant dbSNP:rs398122367Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK026916 mRNA Translation: BAB15590.1
AC091144 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63397.1
CH471080 Genomic DNA Translation: EAW63398.1
BC007387 mRNA Translation: AAH07387.1
BC066935 mRNA Translation: AAH66935.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS6090.1

NCBI Reference Sequences

More...
RefSeqi
NP_001095871.1, NM_001102401.2
NP_001252510.1, NM_001265581.1
NP_079391.2, NM_025115.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360742; ENSP00000353971; ENSG00000129696
ENST00000431156; ENSP00000411169; ENSG00000129696
ENST00000613904; ENSP00000478396; ENSG00000129696

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80185

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80185

UCSC genome browser

More...
UCSCi
uc003xjl.6, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK026916 mRNA Translation: BAB15590.1
AC091144 Genomic DNA No translation available.
CH471080 Genomic DNA Translation: EAW63397.1
CH471080 Genomic DNA Translation: EAW63398.1
BC007387 mRNA Translation: AAH07387.1
BC066935 mRNA Translation: AAH66935.1
CCDSiCCDS6090.1
RefSeqiNP_001095871.1, NM_001102401.2
NP_001252510.1, NM_001265581.1
NP_079391.2, NM_025115.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123164, 37 interactors
ComplexPortaliCPX-6148, TTT complex
IntActiQ6NXR4, 17 interactors
STRINGi9606.ENSP00000478396

PTM databases

GlyGeniQ6NXR4, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ6NXR4
PhosphoSitePlusiQ6NXR4

Genetic variation databases

BioMutaiTTI2
DMDMi74736990

Proteomic databases

EPDiQ6NXR4
jPOSTiQ6NXR4
MassIVEiQ6NXR4
MaxQBiQ6NXR4
PaxDbiQ6NXR4
PeptideAtlasiQ6NXR4
PRIDEiQ6NXR4
ProteomicsDBi66765

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
10728, 47 antibodies

The DNASU plasmid repository

More...
DNASUi
80185

Genome annotation databases

EnsembliENST00000360742; ENSP00000353971; ENSG00000129696
ENST00000431156; ENSP00000411169; ENSG00000129696
ENST00000613904; ENSP00000478396; ENSG00000129696
GeneIDi80185
KEGGihsa:80185
UCSCiuc003xjl.6, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80185
DisGeNETi80185

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TTI2
HGNCiHGNC:26262, TTI2
HPAiENSG00000129696, Low tissue specificity
MalaCardsiTTI2
MIMi614426, gene
615541, phenotype
neXtProtiNX_Q6NXR4
OpenTargetsiENSG00000129696
Orphaneti391307, Severe intellectual disability-short stature-behavioral abnormalities-facial dysmorphism syndrome
PharmGKBiPA142672360
VEuPathDBiHostDB:ENSG00000129696

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QVMM, Eukaryota
GeneTreeiENSGT00390000003878
HOGENOMiCLU_047507_0_0_1
InParanoidiQ6NXR4
OMAiLLMQYAW
OrthoDBi1298755at2759
PhylomeDBiQ6NXR4
TreeFamiTF328871

Enzyme and pathway databases

PathwayCommonsiQ6NXR4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
80185, 620 hits in 1036 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TTI2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80185
PharosiQ6NXR4, Tdark

Protein Ontology

More...
PROi
PR:Q6NXR4
RNActiQ6NXR4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000129696, Expressed in sural nerve and 181 other tissues
ExpressionAtlasiQ6NXR4, baseline and differential
GenevisibleiQ6NXR4, HS

Family and domain databases

InterProiView protein in InterPro
IPR016024, ARM-type_fold
IPR018870, Tti2
PANTHERiPTHR32226, PTHR32226, 1 hit
PfamiView protein in Pfam
PF10521, Tti2, 1 hit
SUPFAMiSSF48371, SSF48371, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTTI2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NXR4
Secondary accession number(s): D3DSV7, Q96IM2, Q9H5N4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2007
Last sequence update: July 5, 2004
Last modified: September 29, 2021
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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