UniProtKB - Q6NXR0 (IIGP5_HUMAN)
Protein
Interferon-inducible GTPase 5
Gene
IRGC
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 62 – 69 | GTP | 8 | |
Nucleotide bindingi | 87 – 91 | GTP | 5 | |
Nucleotide bindingi | 169 – 171 | GTP | 3 | |
Nucleotide bindingi | 216 – 218 | GTP | 3 |
GO - Molecular functioni
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
GO - Biological processi
- cellular response to interferon-beta Source: GO_Central
- defense response Source: GO_Central
Keywordsi
Molecular function | Hydrolase |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q6NXR0 |
Names & Taxonomyi
Protein namesi | Recommended name: Interferon-inducible GTPase 5 (EC:3.6.5.-)Alternative name(s): Immunity-related GTPase cinema 1 |
Gene namesi | Name:IRGC Synonyms:IIGP5, IRGC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:28835, IRGC |
neXtProti | NX_Q6NXR0 |
VEuPathDBi | HostDB:ENSG00000124449.6 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 56269 |
OpenTargetsi | ENSG00000124449 |
PharmGKBi | PA142671651 |
Miscellaneous databases
Pharosi | Q6NXR0, Tbio |
Chemistry databases
DrugBanki | DB03814, 2-(N-morpholino)ethanesulfonic acid DB04315, Guanosine-5'-Diphosphate |
Genetic variation databases
BioMutai | IRGC |
DMDMi | 74736988 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000285265 | 1 – 463 | Interferon-inducible GTPase 5Add BLAST | 463 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 247 | PhosphoserineBy similarity | 1 | |
Modified residuei | 304 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q6NXR0 |
MassIVEi | Q6NXR0 |
MaxQBi | Q6NXR0 |
PaxDbi | Q6NXR0 |
PeptideAtlasi | Q6NXR0 |
PRIDEi | Q6NXR0 |
ProteomicsDBi | 66764 |
PTM databases
iPTMneti | Q6NXR0 |
PhosphoSitePlusi | Q6NXR0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000124449, Expressed in right testis and 43 other tissues |
ExpressionAtlasi | Q6NXR0, baseline and differential |
Genevisiblei | Q6NXR0, HS |
Organism-specific databases
HPAi | ENSG00000124449, Tissue enriched (testis) |
Interactioni
Binary interactionsi
Hide detailsQ6NXR0
With | #Exp. | IntAct |
---|---|---|
CCNDBP1 [O95273] | 3 | EBI-12021374,EBI-748961 |
HNRNPK - isoform 2 [P61978-2] | 3 | EBI-12021374,EBI-7060731 |
Protein-protein interaction databases
BioGRIDi | 121129, 19 interactors |
IntActi | Q6NXR0, 16 interactors |
STRINGi | 9606.ENSP00000244314 |
Miscellaneous databases
RNActi | Q6NXR0, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 53 – 235 | IRG-type GPROSITE-ProRule annotationAdd BLAST | 183 |
Sequence similaritiesi
Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.PROSITE-ProRule annotationCurated
Phylogenomic databases
eggNOGi | ENOG502QS9R, Eukaryota |
GeneTreei | ENSGT00950000183007 |
HOGENOMi | CLU_015342_2_0_1 |
InParanoidi | Q6NXR0 |
OMAi | GCSADKY |
OrthoDBi | 688334at2759 |
PhylomeDBi | Q6NXR0 |
TreeFami | TF331897 |
Family and domain databases
InterProi | View protein in InterPro IPR030385, G_IRG_dom IPR007743, Immunity-related_GTPase-like IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF05049, IIGP, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51716, G_IRG, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q6NXR0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATSKLPVVP GEEENTILMA KERLEALRTA FESGDLPQAA SHLQELLAST
60 70 80 90 100
ESIRLEVGVT GESGAGKSSL INALRGLEAE DPGAALTGVM ETTMQPSPYP
110 120 130 140 150
HPQFPDVTLW DLPGAGSPGC PADKYLKQVD FSRYDFFLLV SPRRCGAVET
160 170 180 190 200
RLAAEILCQG KKFYFVRTKV DEDLAATRTQ RPSGFREAAV LQEIRDHCAE
210 220 230 240 250
RLREAGVADP RIFLVSNLSP ARYDFPTLVS TWEHDLPSHR RHAGLLSLPD
260 270 280 290 300
ISLEALQKKK AMLQEQVLKT ALVLGVIQAL PVPGLAAAYD DALLIHSLRG
310 320 330 340 350
YHRSFGLDDD SLAKLAEQVG KQAGDLRSVI RSPLANEVSP ETVLRLYSQS
360 370 380 390 400
SDGAMRVARA FERGIPVFGT LVAGGISFGA VYTMLQGCLN EMAEDAQRVR
410 420 430 440 450
IKALEDDEPQ PEVSLEVASD NGVEKGGSGE GGGEEAPLST CRKLGLLLKY
460
ILDSWKKHDS EEK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R0T1 | M0R0T1_HUMAN | Interferon-inducible GTPase 5 | IRGC | 275 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_032008 | 135 | D → N1 PublicationCorresponds to variant dbSNP:rs11555891Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005622 Genomic DNA Translation: AAC34467.1 BC033853 mRNA Translation: AAH33853.1 BC066939 mRNA Translation: AAH66939.1 |
CCDSi | CCDS12629.1 |
RefSeqi | NP_062558.1, NM_019612.3 XP_006723346.1, XM_006723283.3 XP_011525420.1, XM_011527118.2 |
Genome annotation databases
Ensembli | ENST00000244314; ENSP00000244314; ENSG00000124449 |
GeneIDi | 56269 |
KEGGi | hsa:56269 |
UCSCi | uc002oxh.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005622 Genomic DNA Translation: AAC34467.1 BC033853 mRNA Translation: AAH33853.1 BC066939 mRNA Translation: AAH66939.1 |
CCDSi | CCDS12629.1 |
RefSeqi | NP_062558.1, NM_019612.3 XP_006723346.1, XM_006723283.3 XP_011525420.1, XM_011527118.2 |
3D structure databases
SMRi | Q6NXR0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121129, 19 interactors |
IntActi | Q6NXR0, 16 interactors |
STRINGi | 9606.ENSP00000244314 |
Chemistry databases
DrugBanki | DB03814, 2-(N-morpholino)ethanesulfonic acid DB04315, Guanosine-5'-Diphosphate |
PTM databases
iPTMneti | Q6NXR0 |
PhosphoSitePlusi | Q6NXR0 |
Genetic variation databases
BioMutai | IRGC |
DMDMi | 74736988 |
Proteomic databases
jPOSTi | Q6NXR0 |
MassIVEi | Q6NXR0 |
MaxQBi | Q6NXR0 |
PaxDbi | Q6NXR0 |
PeptideAtlasi | Q6NXR0 |
PRIDEi | Q6NXR0 |
ProteomicsDBi | 66764 |
Protocols and materials databases
Antibodypediai | 31099, 192 antibodies |
Genome annotation databases
Ensembli | ENST00000244314; ENSP00000244314; ENSG00000124449 |
GeneIDi | 56269 |
KEGGi | hsa:56269 |
UCSCi | uc002oxh.4, human |
Organism-specific databases
CTDi | 56269 |
DisGeNETi | 56269 |
GeneCardsi | IRGC |
HGNCi | HGNC:28835, IRGC |
HPAi | ENSG00000124449, Tissue enriched (testis) |
neXtProti | NX_Q6NXR0 |
OpenTargetsi | ENSG00000124449 |
PharmGKBi | PA142671651 |
VEuPathDBi | HostDB:ENSG00000124449.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QS9R, Eukaryota |
GeneTreei | ENSGT00950000183007 |
HOGENOMi | CLU_015342_2_0_1 |
InParanoidi | Q6NXR0 |
OMAi | GCSADKY |
OrthoDBi | 688334at2759 |
PhylomeDBi | Q6NXR0 |
TreeFami | TF331897 |
Enzyme and pathway databases
PathwayCommonsi | Q6NXR0 |
Miscellaneous databases
BioGRID-ORCSi | 56269, 3 hits in 982 CRISPR screens |
GeneWikii | Interferon-inducible_GTPase_5 |
GenomeRNAii | 56269 |
Pharosi | Q6NXR0, Tbio |
PROi | PR:Q6NXR0 |
RNActi | Q6NXR0, protein |
Gene expression databases
Bgeei | ENSG00000124449, Expressed in right testis and 43 other tissues |
ExpressionAtlasi | Q6NXR0, baseline and differential |
Genevisiblei | Q6NXR0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR030385, G_IRG_dom IPR007743, Immunity-related_GTPase-like IPR027417, P-loop_NTPase |
Pfami | View protein in Pfam PF05049, IIGP, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51716, G_IRG, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IIGP5_HUMAN | |
Accessioni | Q6NXR0Primary (citable) accession number: Q6NXR0 Secondary accession number(s): Q05BR8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 1, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families