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Protein

Transmembrane protein 130

Gene

Tmem130

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protein 130
Gene namesi
Name:Tmem130
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:3607706 Tmem130

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 336ExtracellularSequence analysisAdd BLAST311
Transmembranei337 – 357HelicalSequence analysisAdd BLAST21
Topological domaini358 – 419CytoplasmicSequence analysisAdd BLAST62

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000027827726 – 419Transmembrane protein 130Add BLAST394

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi85N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6NXM3
PaxDbiQ6NXM3
PRIDEiQ6NXM3

PTM databases

iPTMnetiQ6NXM3
PhosphoSitePlusiQ6NXM3

Expressioni

Gene expression databases

BgeeiENSMUSG00000043388 Expressed in 131 organ(s), highest expression level in dorsomedial nucleus of hypothalamus
CleanExiMM_TMEM130
GenevisibleiQ6NXM3 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061100

Structurei

3D structure databases

ProteinModelPortaliQ6NXM3
SMRiQ6NXM3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini144 – 230PKDPROSITE-ProRule annotationAdd BLAST87

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IV87 Eukaryota
ENOG4111HC8 LUCA
GeneTreeiENSGT00390000016482
HOGENOMiHOG000252998
HOVERGENiHBG094054
InParanoidiQ6NXM3
OMAiIQVWPSS
OrthoDBiEOG091G0GB2
PhylomeDBiQ6NXM3
TreeFamiTF336431

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
PfamiView protein in Pfam
PF00801 PKD, 1 hit
SUPFAMiSSF49299 SSF49299, 2 hits
PROSITEiView protein in PROSITE
PS50093 PKD, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6NXM3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKATDVLVF WFACLLLLGP ARVAAGLYNL SLTADGPATV GTEVTISASL
60 70 80 90 100
EVKDNGSLPL PADTHLYRFH WIHTPLTLTA KNEKNLTSTI HVVGGVPGDF
110 120 130 140 150
PISVWVTAVD CWVCQPLARS TLLLPIKESL VGNIVVTQNT SLSWPNSYIT
160 170 180 190 200
KRSLRLSFLL HDPSDFFKSA SFFYRWDFGD GTLLITDNPV VYYNYSSPGT
210 220 230 240 250
FTVKVRVVAE WEQIKPDTTK GTIQKTGDFS ASLDLRESLQ GIQILGPTLL
260 270 280 290 300
QTFQKLTMNL NFFGSPPLHV CWGLKPQCLP LEDRECHAVL VTRTSFNLTH
310 320 330 340 350
VFQDPGDYCF IFRAENAISK AHQYHRIQVW PSSFQPFVFA FPCATLITVL
360 370 380 390 400
LVFLMYMTVR SAATQKDIVE SPGATGLKCC CQVCCGSLFL DSPSEYLEIV
410
RENHGLLPPL YKPVKTYNV
Length:419
Mass (Da):46,628
Last modified:July 5, 2004 - v1
Checksum:iEF82D04A7344D783
GO

Sequence cautioni

The sequence BAC38251 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067004 mRNA Translation: AAH67004.1
BC127616 mRNA Translation: AAI27617.1
BC127617 mRNA Translation: AAI27618.1
AK081543 mRNA Translation: BAC38251.1 Different initiation.
CCDSiCCDS19851.1
RefSeqiNP_808403.2, NM_177735.4
UniGeneiMm.126793

Genome annotation databases

EnsembliENSMUST00000061446; ENSMUSP00000061100; ENSMUSG00000043388
GeneIDi243339
KEGGimmu:243339
UCSCiuc009als.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067004 mRNA Translation: AAH67004.1
BC127616 mRNA Translation: AAI27617.1
BC127617 mRNA Translation: AAI27618.1
AK081543 mRNA Translation: BAC38251.1 Different initiation.
CCDSiCCDS19851.1
RefSeqiNP_808403.2, NM_177735.4
UniGeneiMm.126793

3D structure databases

ProteinModelPortaliQ6NXM3
SMRiQ6NXM3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000061100

PTM databases

iPTMnetiQ6NXM3
PhosphoSitePlusiQ6NXM3

Proteomic databases

MaxQBiQ6NXM3
PaxDbiQ6NXM3
PRIDEiQ6NXM3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061446; ENSMUSP00000061100; ENSMUSG00000043388
GeneIDi243339
KEGGimmu:243339
UCSCiuc009als.1 mouse

Organism-specific databases

CTDi222865
MGIiMGI:3607706 Tmem130

Phylogenomic databases

eggNOGiENOG410IV87 Eukaryota
ENOG4111HC8 LUCA
GeneTreeiENSGT00390000016482
HOGENOMiHOG000252998
HOVERGENiHBG094054
InParanoidiQ6NXM3
OMAiIQVWPSS
OrthoDBiEOG091G0GB2
PhylomeDBiQ6NXM3
TreeFamiTF336431

Miscellaneous databases

PROiPR:Q6NXM3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043388 Expressed in 131 organ(s), highest expression level in dorsomedial nucleus of hypothalamus
CleanExiMM_TMEM130
GenevisibleiQ6NXM3 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR000601 PKD_dom
IPR035986 PKD_dom_sf
PfamiView protein in Pfam
PF00801 PKD, 1 hit
SUPFAMiSSF49299 SSF49299, 2 hits
PROSITEiView protein in PROSITE
PS50093 PKD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTM130_MOUSE
AccessioniPrimary (citable) accession number: Q6NXM3
Secondary accession number(s): Q8C4P6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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