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Protein

Sentrin-specific protease 5

Gene

Senp5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei640By similarity1
Active sitei657By similarity1
Active sitei707By similarity1

GO - Molecular functioni

GO - Biological processi

  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • protein desumoylation Source: GO_Central

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processCell cycle, Cell division, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-3065679 SUMO is proteolytically processed

Protein family/group databases

MEROPSiC48.008

Names & Taxonomyi

Protein namesi
Recommended name:
Sentrin-specific protease 5 (EC:3.4.22.-)
Alternative name(s):
SUMO/Smt3-specific isopeptidase 3
Short name:
Smt3ip3
Sentrin/SUMO-specific protease SENP5
Gene namesi
Name:Senp5
Synonyms:Smt3ip3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2443596 Senp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002676071 – 749Sentrin-specific protease 5Add BLAST749

Proteomic databases

MaxQBiQ6NXL6
PaxDbiQ6NXL6
PRIDEiQ6NXL6

PTM databases

iPTMnetiQ6NXL6
PhosphoSitePlusiQ6NXL6

Expressioni

Gene expression databases

BgeeiENSMUSG00000022772 Expressed in 187 organ(s), highest expression level in fibroblast
CleanExiMM_SENP5
ExpressionAtlasiQ6NXL6 baseline and differential
GenevisibleiQ6NXL6 MM

Interactioni

Subunit structurei

Interacts with CCAR2.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023457

Structurei

3D structure databases

ProteinModelPortaliQ6NXL6
SMRiQ6NXL6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni557 – 718ProteaseAdd BLAST162

Sequence similaritiesi

Belongs to the peptidase C48 family.Curated

Phylogenomic databases

eggNOGiKOG0778 Eukaryota
COG5160 LUCA
GeneTreeiENSGT00530000062941
HOGENOMiHOG000070166
HOVERGENiHBG062231
InParanoidiQ6NXL6
KOiK08594
OrthoDBiEOG091G092N
PhylomeDBiQ6NXL6
TreeFamiTF316289

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR003653 Peptidase_C48_C
IPR033465 SENP5
PANTHERiPTHR12606:SF10 PTHR12606:SF10, 1 hit
PfamiView protein in Pfam
PF02902 Peptidase_C48, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50600 ULP_PROTEASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q6NXL6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKQKKILWK KGIHLAFSEK WNAGFGSFKK FYFPQNLCFL KAKLGRPVAW
60 70 80 90 100
HRQVKHFQCN KGLHIQKTWI QDVPFCSKTK SGLATQNVST LYPKVKRKDS
110 120 130 140 150
KHFISSSRSL LKLQADKLLS SAKSLDHKYC REKSLLKAAP GLSANTVLGR
160 170 180 190 200
ANGHEPTTDP QASDFPMKFS GESQSPGDSG KTVVLNKHRK RVCHGCYQGL
210 220 230 240 250
EHHRNRRPLI PKQFQLNQHR RVRASLMMYE KLSMIRFRYR IFRSQHFRTK
260 270 280 290 300
SRVCKLRKAQ RSWVQKVTGD HQENLRDNNT EGDNCNPVPS LEPKDPCRCQ
310 320 330 340 350
PYFPDMDSSA VGKGKNCHVP DGHTKENPVL DKEHGLDDTF PDQQNGCVAY
360 370 380 390 400
NWDQSSSCPK WECTEQIHEI PLMEHPSSDK FSPETERALM ALGQESGTSA
410 420 430 440 450
VSDDREKLPV SGADKSVSSV DGPVSEEPAQ NENFQMEEDG SLKQSILSSK
460 470 480 490 500
LLDHPYCKSP LDAPLLCSEP KVENQMSGGK SSQTASPVDD EQLSTCLSGF
510 520 530 540 550
LDEVMKKYGS LVPLSEKDVL GRLKDVFNED FSNRKPFINR EITNYRARHQ
560 570 580 590 600
KCNFRIFYNK HMLDMDDLAT LDGQNWLNDQ VINMYGELIM DAVPDKVHFF
610 620 630 640 650
NSFFHRQLVT KGYNGVKRWT KKVDLFKKSL LLIPIHLEVH WSLITVTLSS
660 670 680 690 700
RIISFYDSQG IHFKFCVENI RKYLLTEARE KNRPEFLQGW QTAVTKCIPQ
710 720 730 740
QKNDSDCGVF VLQYCKCLAL EQPFQFSQED MPRVRKRIYK ELCECRLLD
Length:749
Mass (Da):86,100
Last modified:July 5, 2004 - v1
Checksum:i9356AC4FB3DE590C
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6S6C3F6S6C3_MOUSE
Sentrin-specific protease 5
Senp5
607Annotation score:
F7A4L2F7A4L2_MOUSE
Sentrin-specific protease 5
Senp5
210Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51H → P in BAC31483 (PubMed:16141072).Curated1
Sequence conflicti288V → A in AAT01901 (Ref. 1) Curated1
Sequence conflicti323H → R in AAT01901 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY522918 mRNA Translation: AAT01901.1
AK043171 mRNA Translation: BAC31483.1
BC067014 mRNA Translation: AAH67014.1
BC080830 mRNA Translation: AAH80830.1
CCDSiCCDS28111.1
RefSeqiNP_796077.2, NM_177103.4
XP_006522301.1, XM_006522238.3
XP_006522302.1, XM_006522239.3
XP_011244235.1, XM_011245933.2
UniGeneiMm.152890

Genome annotation databases

EnsembliENSMUST00000023457; ENSMUSP00000023457; ENSMUSG00000022772
ENSMUST00000231360; ENSMUSP00000156109; ENSMUSG00000022772
GeneIDi320213
KEGGimmu:320213
UCSCiuc007yya.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY522918 mRNA Translation: AAT01901.1
AK043171 mRNA Translation: BAC31483.1
BC067014 mRNA Translation: AAH67014.1
BC080830 mRNA Translation: AAH80830.1
CCDSiCCDS28111.1
RefSeqiNP_796077.2, NM_177103.4
XP_006522301.1, XM_006522238.3
XP_006522302.1, XM_006522239.3
XP_011244235.1, XM_011245933.2
UniGeneiMm.152890

3D structure databases

ProteinModelPortaliQ6NXL6
SMRiQ6NXL6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000023457

Protein family/group databases

MEROPSiC48.008

PTM databases

iPTMnetiQ6NXL6
PhosphoSitePlusiQ6NXL6

Proteomic databases

MaxQBiQ6NXL6
PaxDbiQ6NXL6
PRIDEiQ6NXL6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023457; ENSMUSP00000023457; ENSMUSG00000022772
ENSMUST00000231360; ENSMUSP00000156109; ENSMUSG00000022772
GeneIDi320213
KEGGimmu:320213
UCSCiuc007yya.2 mouse

Organism-specific databases

CTDi205564
MGIiMGI:2443596 Senp5

Phylogenomic databases

eggNOGiKOG0778 Eukaryota
COG5160 LUCA
GeneTreeiENSGT00530000062941
HOGENOMiHOG000070166
HOVERGENiHBG062231
InParanoidiQ6NXL6
KOiK08594
OrthoDBiEOG091G092N
PhylomeDBiQ6NXL6
TreeFamiTF316289

Enzyme and pathway databases

ReactomeiR-MMU-3065679 SUMO is proteolytically processed

Miscellaneous databases

PROiPR:Q6NXL6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022772 Expressed in 187 organ(s), highest expression level in fibroblast
CleanExiMM_SENP5
ExpressionAtlasiQ6NXL6 baseline and differential
GenevisibleiQ6NXL6 MM

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR003653 Peptidase_C48_C
IPR033465 SENP5
PANTHERiPTHR12606:SF10 PTHR12606:SF10, 1 hit
PfamiView protein in Pfam
PF02902 Peptidase_C48, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS50600 ULP_PROTEASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSENP5_MOUSE
AccessioniPrimary (citable) accession number: Q6NXL6
Secondary accession number(s): Q3ZTK4, Q8BXW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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