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Entry version 130 (29 Sep 2021)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Sec24-related gene family, member D (S. cerevisiae)

Gene

Sec24d

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transportARBA annotation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-204005, COPII-mediated vesicle transport
R-MMU-2132295, MHC class II antigen presentation
R-MMU-5694530, Cargo concentration in the ER
R-MMU-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Sec24-related gene family, member D (S. cerevisiae)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sec24dImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1916858, Sec24d

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000039234

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q6NXL1

PRoteomics IDEntifications database

More...
PRIDEi
Q6NXL1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
339185

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NXL1

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6NXL1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000039234, Expressed in humerus cartilage element and 250 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035823

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NXL1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini360 – 398zf-Sec23_Sec24InterPro annotationAdd BLAST39
Domaini437 – 680Sec23_trunkInterPro annotationAdd BLAST244
Domaini686 – 769Sec23_BSInterPro annotationAdd BLAST84
Domaini782 – 881Sec23_helicalInterPro annotationAdd BLAST100
Domaini902 – 974Gelsolin-likeInterPro annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 263DisorderedSequence analysisAdd BLAST263

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 20Polar residuesSequence analysisAdd BLAST20
Compositional biasi50 – 90Pro residuesSequence analysisAdd BLAST41
Compositional biasi92 – 145Polar residuesSequence analysisAdd BLAST54
Compositional biasi157 – 180Pro residuesSequence analysisAdd BLAST24
Compositional biasi200 – 216Pro residuesSequence analysisAdd BLAST17
Compositional biasi217 – 231Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC24 subfamily.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1984, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182924

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004589_1_1_1

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNGAHAS

Database of Orthologous Groups

More...
OrthoDBi
330236at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NXL1

TreeFam database of animal gene trees

More...
TreeFami
TF300464

Family and domain databases

Conserved Domains Database

More...
CDDi
cd01479, Sec24-like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.20.10, 1 hit
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR006900, Sec23/24_helical_dom
IPR036175, Sec23/24_helical_dom_sf
IPR006896, Sec23/24_trunk_dom
IPR012990, Sec23_24_beta_S
IPR041742, Sec24-like_trunk_dom
IPR036465, vWFA_dom_sf
IPR006895, Znf_Sec23_Sec24

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00626, Gelsolin, 1 hit
PF08033, Sec23_BS, 1 hit
PF04815, Sec23_helical, 1 hit
PF04811, Sec23_trunk, 1 hit
PF04810, zf-Sec23_Sec24, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 1 hit
SSF81811, SSF81811, 1 hit
SSF82754, SSF82754, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6NXL1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQQGYVATP PYSQSQPGMG ISPPHYGHYG DPSHASSPPG VMKPLGPSAA
60 70 80 90 100
PSGMLPPGPL PPGPPQFGPN GAHTPGHPPQ RFPGPPPVNS VAPSYASGQT
110 120 130 140 150
LPQSSYPGPG STSSVTQLGS QFSSMQINSY GVGATPQSQG PPGPQSAGAF
160 170 180 190 200
QGPPQPAQPS ILQPGHQVPP PPPTALNGPG ASPMSPPTHR QDGLPGPAPL
210 220 230 240 250
NAQYQPPPPP GQTLGPGYPP QQATNYGPQM GGAQMSYPGG FPGGPAQMAG
260 270 280 290 300
PAPQLQRKLD PDSIPSPIQV IENDRATRGG QVYTTNTRGQ VPPLVTTECV
310 320 330 340 350
IQDQGHSSPR YIRCTTYCFP CTSDMAKQAQ IPLAAVIKPF ADIPPNETPL
360 370 380 390 400
YLVNHGESGP VRCNRCKAYM CPFMQFIEGG RRYQCGFCSC VNEVPPFYFQ
410 420 430 440 450
HLDHIGRRLD HYEKPELSLG SYEYVATLDY CRKNKPPSPP AFIFMIDVSY
460 470 480 490 500
SNIKNGLVKL ICEELKTALK RLPKEEHEET SAIRVGFITY NKVLHFFNVK
510 520 530 540 550
SNLAQPQMMV VTDVGEVFVP LLDGFLVNYE ESQSVIHNLL DQIPEMFADS
560 570 580 590 600
NENETVFAPV IQAGMEALKA AECPGKLFIF HSSLPTAEAP GKLKNRDDKK
610 620 630 640 650
LVNTDKEKIL FQPQTAVYES LAKDCVANSC SVTLFLFPSQ FVDVASLGLV
660 670 680 690 700
PLLTGGTLYK YNVFQIHSDS QRFLTDLRND IEKKIGFDAI MRVRTSTGFR
710 720 730 740 750
ATDFFGGIFM NNTTDVEMAA IDCDKAVTVE FKHDDKLSED VGALIQCAVL
760 770 780 790 800
YTTISGQRRL RIHNLALNCS TQLADLYKSC ETDALINFFA KSAFKAVLNQ
810 820 830 840 850
PLKAIREILV NQTAHMLACY RKHCASPSAA SQLILPDSMK VLPVYMNSLL
860 870 880 890 900
KNCVLLSRSE ISPDERAYQR QLVMTMGVAD SQLFFYPLLL PIHTLDVKSA
910 920 930 940 950
ALPPAVRCSE SRLSEEGIFL LANGLNMFLW FGVGSPPELI QGIFNVPSFA
960 970 980 990 1000
HINTDMTSLP EVGSPHSQQL RMIMNNIQQK KPYSMKLIVV KQREQREMAF
1010 1020 1030
RQFLVEDKGL YGGSSYVDFL CCVHKEICQL LN
Length:1,032
Mass (Da):112,676
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i35334F5F589325B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGJ5A0A0G2JGJ5_MOUSE
Sec24-related gene family, member D...
Sec24d
47Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC067020 mRNA Translation: AAH67020.1

NCBI Reference Sequences

More...
RefSeqi
NP_081411.2, NM_027135.2
XP_006502101.1, XM_006502038.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000047923; ENSMUSP00000035823; ENSMUSG00000039234

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
69608

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:69608

UCSC genome browser

More...
UCSCi
uc008rfh.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067020 mRNA Translation: AAH67020.1
RefSeqiNP_081411.2, NM_027135.2
XP_006502101.1, XM_006502038.3

3D structure databases

SMRiQ6NXL1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035823

PTM databases

PhosphoSitePlusiQ6NXL1
SwissPalmiQ6NXL1

Proteomic databases

PeptideAtlasiQ6NXL1
PRIDEiQ6NXL1
ProteomicsDBi339185

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
26618, 99 antibodies

The DNASU plasmid repository

More...
DNASUi
69608

Genome annotation databases

EnsembliENSMUST00000047923; ENSMUSP00000035823; ENSMUSG00000039234
GeneIDi69608
KEGGimmu:69608
UCSCiuc008rfh.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9871
MGIiMGI:1916858, Sec24d
VEuPathDBiHostDB:ENSMUSG00000039234

Phylogenomic databases

eggNOGiKOG1984, Eukaryota
GeneTreeiENSGT00950000182924
HOGENOMiCLU_004589_1_1_1
OMAiQNGAHAS
OrthoDBi330236at2759
PhylomeDBiQ6NXL1
TreeFamiTF300464

Enzyme and pathway databases

ReactomeiR-MMU-204005, COPII-mediated vesicle transport
R-MMU-2132295, MHC class II antigen presentation
R-MMU-5694530, Cargo concentration in the ER
R-MMU-983170, Antigen Presentation: Folding, assembly and peptide loading of class I MHC

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
69608, 1 hit in 61 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Sec24d, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000039234, Expressed in humerus cartilage element and 250 other tissues

Family and domain databases

CDDicd01479, Sec24-like, 1 hit
Gene3Di3.40.20.10, 1 hit
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR029006, ADF-H/Gelsolin-like_dom_sf
IPR007123, Gelsolin-like_dom
IPR036180, Gelsolin-like_dom_sf
IPR006900, Sec23/24_helical_dom
IPR036175, Sec23/24_helical_dom_sf
IPR006896, Sec23/24_trunk_dom
IPR012990, Sec23_24_beta_S
IPR041742, Sec24-like_trunk_dom
IPR036465, vWFA_dom_sf
IPR006895, Znf_Sec23_Sec24
PfamiView protein in Pfam
PF00626, Gelsolin, 1 hit
PF08033, Sec23_BS, 1 hit
PF04815, Sec23_helical, 1 hit
PF04811, Sec23_trunk, 1 hit
PF04810, zf-Sec23_Sec24, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
SSF81811, SSF81811, 1 hit
SSF82754, SSF82754, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6NXL1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NXL1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 29, 2021
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
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