Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Zinc finger protein 532

Gene

Znf532

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri615 – 634C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri751 – 775C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri784 – 807C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri814 – 840C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri938 – 961C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri999 – 1021C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 532
Gene namesi
Name:Znf532
Synonyms:Kiaa1629, Zfp532
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:3036282 Zfp532

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002995531 – 1036Zinc finger protein 532Add BLAST1036

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei130PhosphoserineBy similarity1
Modified residuei133PhosphoserineBy similarity1
Modified residuei134PhosphoserineBy similarity1
Modified residuei175N6-acetyllysineCombined sources1
Modified residuei306PhosphoserineBy similarity1
Modified residuei313PhosphoserineCombined sources1
Modified residuei433PhosphoserineBy similarity1
Cross-linki458Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki515Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei875PhosphoserineBy similarity1
Cross-linki879Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki902Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6NXK2
PeptideAtlasiQ6NXK2
PRIDEiQ6NXK2

PTM databases

iPTMnetiQ6NXK2
PhosphoSitePlusiQ6NXK2

Expressioni

Gene expression databases

BgeeiENSMUSG00000042439 Expressed in 268 organ(s), highest expression level in forebrain
CleanExiMM_ZFP532
ExpressionAtlasiQ6NXK2 baseline and differential
GenevisibleiQ6NXK2 MM

Interactioni

Protein-protein interaction databases

BioGridi236687, 1 interactor
STRINGi10090.ENSMUSP00000036582

Structurei

3D structure databases

ProteinModelPortaliQ6NXK2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi861 – 866Poly-Glu6

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri615 – 634C2H2-type 1; degeneratePROSITE-ProRule annotationAdd BLAST20
Zinc fingeri751 – 775C2H2-type 2; degeneratePROSITE-ProRule annotationAdd BLAST25
Zinc fingeri784 – 807C2H2-type 3PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri814 – 840C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST27
Zinc fingeri938 – 961C2H2-type 5PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri999 – 1021C2H2-type 6PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063261
HOGENOMiHOG000010306
HOVERGENiHBG062228
InParanoidiQ6NXK2
PhylomeDBiQ6NXK2
TreeFamiTF329009

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NXK2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTMGDMKTPD FDDLLAAFDI PDMVDPKAAI ESGHDDHESH IKQNAHVDDD
60 70 80 90 100
SHTPSSSDVG VSVIVKNVRN IDSSEGVEKD GHNPTGNGLH NGFLTASSLD
110 120 130 140 150
SYGKDGAKSL KGDTPASEVT LKDPAFSQFS PISSAEEFED DEKIEVDDPP
160 170 180 190 200
DKEEARAGFR SNVLTGSAPQ QDFDKLKALG GENSSKTGVS TSGHTDKNKV
210 220 230 240 250
KREAESNSIT LSVYEPFKVR KAEDKLKENS EKMLESRVLD GKPSSEKSDS
260 270 280 290 300
GIAAAASSKT KPSSKLSSCI AAIAALSAKK AASDSCKEPV ANSREASPLP
310 320 330 340 350
KEVNDSPKAA DKSPESQNLI DGTKKASLKP SDSPRSVSSE NSSKGSPSSP
360 370 380 390 400
VGSTPAIPKV RIKTIKTSSG EIKRTVTRVL PEVDLDSGKK PSEQAASVMA
410 420 430 440 450
SVTSLLSSSA SATVLSSPPR APLQTAMVTS AVSSAELTPK QVTIKPVATA
460 470 480 490 500
FLPVSAVKTA GSQVINLKLA NNTTVKATVI SAASVQSASS AIIKAANAIQ
510 520 530 540 550
QQTVVVPASS LANAKLVPKT VHLANLNLLP QGAQATSELR QVLTKPQQQI
560 570 580 590 600
KQAIINAAAS QPPKKVSRVQ VVSSLQSSVV EAFNKVLSSV NPVPVYTPNL
610 620 630 640 650
SPPANAGITL PMRGYKCLEC GDAFALEKSL SQHYDRRSVR IEVTCNHCTK
660 670 680 690 700
NLVFYNKCSL LSHARGHKEK GVVMQCSHLI LKPVPADQMI VPPSSNTAAS
710 720 730 740 750
TLQSSVGAAT HTVPKVQPGI AGAVISAPAS TPMSPAMPLD EDPSKLCRHS
760 770 780 790 800
LKCLECNEVF QDEPSLATHF QHAADTSGQQ MKKHPCRQCD KSFSSSHSLC
810 820 830 840 850
RHNRIKHKGI RKVYACSHCP DSRRTFTKRL MLERHIQLMH GIKDPDVKEL
860 870 880 890 900
SDDAGDVTND EEEEAEIKED AKVPSPKRKL EEPVLEFRPP RGAITQPLKK
910 920 930 940 950
LKINVFKVHK CAVCGFTTEN LLQFHEHIPQ HRSDGSSHQC RECGLCYTSH
960 970 980 990 1000
GSLARHLFIV HKLKEPQPVS KQNGAGEDSQ QENKPSPEDE AAEGAASDRK
1010 1020 1030
CKVCAKTFET EAALNTHMRT HGMAFIKSKR MSSAEK
Length:1,036
Mass (Da):110,949
Last modified:July 5, 2004 - v1
Checksum:i9A3B6E1F7803627B
GO
Isoform 2 (identifier: Q6NXK2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     780-1036: QMKKHPCRQC...KSKRMSSAEK → KTCTVCQMLL...PGVKIGEPNK

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:900
Mass (Da):95,450
Checksum:i6A42D6DBCCAA07CB
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R2I9S4R2I9_MOUSE
Zinc finger protein 532
Zfp532
1,304Annotation score:
S4R1H5S4R1H5_MOUSE
Zinc finger protein 532
Zfp532
779Annotation score:
S4R1B5S4R1B5_MOUSE
Zinc finger protein 532
Zfp532
95Annotation score:
S4R2M5S4R2M5_MOUSE
Zinc finger protein 532
Zfp532
170Annotation score:
S4R2D8S4R2D8_MOUSE
Zinc finger protein 532
Zfp532
219Annotation score:
S4R1F7S4R1F7_MOUSE
Zinc finger protein 532
Zfp532
28Annotation score:
S4R1P1S4R1P1_MOUSE
Zinc finger protein 532
Zfp532
65Annotation score:
S4R2T9S4R2T9_MOUSE
Zinc finger protein 532
Zfp532
174Annotation score:
S4R1F4S4R1F4_MOUSE
Zinc finger protein 532
Zfp532
83Annotation score:
S4R1U0S4R1U0_MOUSE
Zinc finger protein 532
Zfp532
26Annotation score:

Sequence cautioni

The sequence BAC98220 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_027745780 – 1036QMKKH…SSAEK → KTCTVCQMLLPNQCSYASHQ RIHQHKSPYTCPECGAICRS VHFQNHITKNCLHYTRRVGF RCVHCNVVYSDVAALKSHIQ GSHCEVFYKCPICPMAFKSA PSTHSHAYTQHPGVKIGEPN K in isoform 2. 1 PublicationAdd BLAST257

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067032 mRNA Translation: AAH67032.1
BC094671 mRNA Translation: AAH94671.1
AK129410 mRNA Translation: BAC98220.1 Different initiation.
CCDSiCCDS29307.1 [Q6NXK2-1]
RefSeqiNP_997138.1, NM_207255.2 [Q6NXK2-1]
XP_011245259.1, XM_011246957.1 [Q6NXK2-1]
XP_017173418.1, XM_017317929.1 [Q6NXK2-1]
XP_017173419.1, XM_017317930.1 [Q6NXK2-1]
UniGeneiMm.286232
Mm.419081

Genome annotation databases

EnsembliENSMUST00000049016; ENSMUSP00000036582; ENSMUSG00000042439 [Q6NXK2-1]
ENSMUST00000169679; ENSMUSP00000129390; ENSMUSG00000042439 [Q6NXK2-1]
ENSMUST00000182478; ENSMUSP00000138315; ENSMUSG00000042439 [Q6NXK2-2]
GeneIDi328977
KEGGimmu:328977
UCSCiuc008ffc.2 mouse [Q6NXK2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067032 mRNA Translation: AAH67032.1
BC094671 mRNA Translation: AAH94671.1
AK129410 mRNA Translation: BAC98220.1 Different initiation.
CCDSiCCDS29307.1 [Q6NXK2-1]
RefSeqiNP_997138.1, NM_207255.2 [Q6NXK2-1]
XP_011245259.1, XM_011246957.1 [Q6NXK2-1]
XP_017173418.1, XM_017317929.1 [Q6NXK2-1]
XP_017173419.1, XM_017317930.1 [Q6NXK2-1]
UniGeneiMm.286232
Mm.419081

3D structure databases

ProteinModelPortaliQ6NXK2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236687, 1 interactor
STRINGi10090.ENSMUSP00000036582

PTM databases

iPTMnetiQ6NXK2
PhosphoSitePlusiQ6NXK2

Proteomic databases

PaxDbiQ6NXK2
PeptideAtlasiQ6NXK2
PRIDEiQ6NXK2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049016; ENSMUSP00000036582; ENSMUSG00000042439 [Q6NXK2-1]
ENSMUST00000169679; ENSMUSP00000129390; ENSMUSG00000042439 [Q6NXK2-1]
ENSMUST00000182478; ENSMUSP00000138315; ENSMUSG00000042439 [Q6NXK2-2]
GeneIDi328977
KEGGimmu:328977
UCSCiuc008ffc.2 mouse [Q6NXK2-1]

Organism-specific databases

CTDi328977
MGIiMGI:3036282 Zfp532
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063261
HOGENOMiHOG000010306
HOVERGENiHBG062228
InParanoidiQ6NXK2
PhylomeDBiQ6NXK2
TreeFamiTF329009

Miscellaneous databases

ChiTaRSiZfp532 mouse
PROiPR:Q6NXK2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042439 Expressed in 268 organ(s), highest expression level in forebrain
CleanExiMM_ZFP532
ExpressionAtlasiQ6NXK2 baseline and differential
GenevisibleiQ6NXK2 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 8 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN532_MOUSE
AccessioniPrimary (citable) accession number: Q6NXK2
Secondary accession number(s): Q504Z6, Q6ZPL1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again