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Entry version 108 (16 Jan 2019)
Sequence version 1 (05 Jul 2004)
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Protein
Submitted name:

Dlg5 protein

Gene

Dlg5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Dlg5 proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dlg5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918478 Dlg5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NXJ3 MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q6NXJ3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini266 – 356PDZInterPro annotationAdd BLAST91
Domaini369 – 447PDZInterPro annotationAdd BLAST79
Domaini1001 – 1080PDZInterPro annotationAdd BLAST80
Domaini1155 – 1236PDZInterPro annotationAdd BLAST82
Domaini1247 – 1315SH3InterPro annotationAdd BLAST69
Domaini1428 – 1558Guanylate kinase-likeInterPro annotationAdd BLAST131

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili29 – 56Sequence analysisAdd BLAST28
Coiled coili78 – 126Sequence analysisAdd BLAST49
Coiled coili134 – 168Sequence analysisAdd BLAST35
Coiled coili190 – 245Sequence analysisAdd BLAST56

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0708 Eukaryota
KOG3528 Eukaryota
ENOG410XP9M LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081446

Database of Orthologous Groups

More...
OrthoDBi
123652at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd11860 SH3_DLG5, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035537 DLG5_SH3
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 4 hits
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 4 hits
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 4 hits
PS50002 SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q6NXJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LTQQRDTAIQ LQHQCALSLR RFETIHHELS KATAQNKDLQ WEMELLQSEL
60 70 80 90 100
TELRSKQVKT AKESEKYKEE RDAVYSEYKL IMSERDQVIS ELDKLQTEVE
110 120 130 140 150
LAESKLKSST SEKKAASEEM EALRQIKDTV TMDAGRANKE VEILRKQCKA
160 170 180 190 200
LCQELKEALQ EADVAKCRRD WAFQERDKIV AERDSIRTLC DNLRRERDRA
210 220 230 240 250
VSELAEALRS LDDTRKQKND VSRELKELKE QMECQLEKEA RFRQLMAHSS
260 270 280 290 300
HDSAIDTDSM EWETEVVEFE RETEDIDLKA LGFDMAEGVN EPCFPGDCGI
310 320 330 340 350
FVTKVDKGSI ADGRLRVNDW LLRINDVDLI NKDKKQAIKA LLNGEGAINM
360 370 380 390 400
VVRRRKSLGG KVVTPLHINL SGQKGSRPQD SGISLENGVY AAAVVPGSPA
410 420 430 440 450
AKEGSLAVGD RIVAINGIAL DNKSLNECES LLRSCQDSLT LSLLKVFPQS
460 470 480 490 500
SSWSGQNIFE NIKDSDRMLS CRAHGPEVQA HNKRNLLQHN NSTQTDIFYT
510 520 530 540 550
DRLEDRKELG HSGGSSSFLH KPFSGSSSPV SPQACPSTSE RSLNSFRSDT
560 570 580 590 600
SAERGYGLVD MRSQRPLLSF ETEVGPCGAV EVPLDKIDPE GSNSGGTWPK
610 620 630 640 650
AVLGSTSGPE KLSVYKKPKQ RKSIFDPNTF KRPQTPPKID YLLPGPGLTH
660 670 680 690 700
SPQPSKRVGS LTPPKPPRRS DSIKFQHRLE TSSESEATLV GSSPSTSPPS
710 720 730 740 750
APPPSMDPSE PTHASPPRKA RVRIASSYHS EGDGDTSYLP AKKPCDEDLT
760 770 780 790 800
SQKVDELGQK RRRPKSAPSF RPKISPVVIP AQCLEEQECV PAIGELSPEG
810 820 830 840 850
QEWSPYSPGH ASRHGNPLLY PNRPSVGTVP RSMTPGTTVG SILRNPIYTV
860 870 880 890 900
RSHRVLPCGS LPVPRDAGSQ SLSPSVQHQG RLSLDLSHRA CSDYSEMRAS
910 920 930 940 950
QGSNSLPSSA RLGSSSNLQF KAERIKIPLT PRYPRSVMGS DRGSLSHSEC
960 970 980 990 1000
STPPRSPLNI DTLSSCSQPQ TTASTLPRIA VNPSSHGERR KDRPFVEEPR
1010 1020 1030 1040 1050
HVKVQKGSEP LGISIVSGEK GGVYVSKVTL GSIAHQAGLE YGDQLLEFNG
1060 1070 1080 1090 1100
INLRSATEQQ ARLIIGQQCD TITILAQYNP HIHQLNSHSR SSSHLDPAAT
1110 1120 1130 1140 1150
PHSTLQGSSA GTPEHPSVID PLMEQDEGPG TPPAKQSASS TRSVGDTTKK
1160 1170 1180 1190 1200
TPDPRIVFIK KSQLDLGVHL CGGNLHGVFV AEVEDDSPAK CPDGLVPGDL
1210 1220 1230 1240 1250
ILEYGSLDMR SRTVEDVYVE MLKPKDSLRL KVQYRHEEFT RVKGLPGDSF
1260 1270 1280 1290 1300
YIRALYDRLA EVEPELSFKK DDILYVDDTL PQGVFGSWMA WQLDENAQKI
1310 1320 1330 1340 1350
QRGQIPSKYV MDQEFSRRLS MSEVKDDNTA KTLSAAARRS FFRRKHKHKR
1360 1370 1380 1390 1400
SGSKDGKDLL ALDTFSNDSI PLFEDSVSLA YQRVQKVDCT SLRPVLLLGP
1410 1420 1430 1440 1450
LLDVVKEMLV NEAPGKFCRC PLEVMKASQQ AIERGVKDCL FVDYKRRSGH
1460 1470 1480 1490 1500
FDVTTVASIK EITEKNRHCL LDIAPHAIER LHHMHIYPIV IFIRYKSAKH
1510 1520 1530 1540 1550
IKEQRDPVYL RDKVTQRHSK EQFETAQKID QEYSRYFTGV VQGGALSSIC
1560 1570
TQILAMVSQE QSKVLWIPAC PP
Length:1,572
Mass (Da):174,640
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD42DC63AA1BF19C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC067046 mRNA Translation: AAH67046.1

NCBI Reference Sequences

More...
RefSeqi
NP_001156985.1, NM_001163513.1
NP_082002.1, NM_027726.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.68971

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
71228

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:71228

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067046 mRNA Translation: AAH67046.1
RefSeqiNP_001156985.1, NM_001163513.1
NP_082002.1, NM_027726.1
UniGeneiMm.68971

3D structure databases

ProteinModelPortaliQ6NXJ3
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi71228
KEGGimmu:71228

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9231
MGIiMGI:1918478 Dlg5

Phylogenomic databases

eggNOGiKOG0708 Eukaryota
KOG3528 Eukaryota
ENOG410XP9M LUCA
HOVERGENiHBG081446
OrthoDBi123652at2759

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ6NXJ3 MM

Family and domain databases

CDDicd11860 SH3_DLG5, 1 hit
InterProiView protein in InterPro
IPR035537 DLG5_SH3
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR027417 P-loop_NTPase
IPR001478 PDZ
IPR036034 PDZ_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
PF00595 PDZ, 2 hits
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SM00228 PDZ, 4 hits
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
SSF50156 SSF50156, 4 hits
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50052 GUANYLATE_KINASE_2, 1 hit
PS50106 PDZ, 4 hits
PS50002 SH3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6NXJ3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NXJ3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: January 16, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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