Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Regulation of nuclear pre-mRNA domain-containing protein 2

Gene

Rprd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Regulation of nuclear pre-mRNA domain-containing protein 2
Gene namesi
Name:Rprd2
Synonyms:Kiaa0460
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1922387 Rprd2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002443562 – 1469Regulation of nuclear pre-mRNA domain-containing protein 2Add BLAST1468

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei374PhosphoserineBy similarity1
Modified residuei376PhosphothreonineBy similarity1
Modified residuei392PhosphoserineCombined sources1
Modified residuei492PhosphoserineBy similarity1
Modified residuei495PhosphoserineBy similarity1
Modified residuei498PhosphoserineBy similarity1
Modified residuei504PhosphoserineBy similarity1
Modified residuei536PhosphothreonineBy similarity1
Modified residuei583PhosphoserineBy similarity1
Modified residuei612PhosphoserineCombined sources1
Modified residuei617PhosphothreonineBy similarity1
Modified residuei633PhosphoserineCombined sources1
Modified residuei682PhosphoserineBy similarity1
Modified residuei684PhosphoserineBy similarity1
Modified residuei735PhosphoserineBy similarity1
Modified residuei738PhosphoserineCombined sources1
Modified residuei742PhosphothreonineCombined sources1
Modified residuei749PhosphoserineCombined sources1
Modified residuei751PhosphothreonineCombined sources1
Modified residuei777PhosphoserineCombined sources1
Modified residuei781PhosphoserineBy similarity1
Modified residuei782PhosphothreonineBy similarity1
Modified residuei788PhosphoserineBy similarity1
Modified residuei836PhosphoserineBy similarity1
Modified residuei845PhosphoserineBy similarity1
Modified residuei919PhosphoserineBy similarity1
Modified residuei947PhosphoserineBy similarity1
Modified residuei984PhosphoserineBy similarity1
Modified residuei995PhosphoserineBy similarity1
Modified residuei1086PhosphoserineCombined sources1
Modified residuei1117PhosphoserineBy similarity1
Modified residuei1375Asymmetric dimethylarginineBy similarity1
Modified residuei1432Asymmetric dimethylarginineCombined sources1
Modified residuei1438Asymmetric dimethylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ6NXI6
PeptideAtlasiQ6NXI6
PRIDEiQ6NXI6

PTM databases

iPTMnetiQ6NXI6
PhosphoSitePlusiQ6NXI6

Expressioni

Gene expression databases

BgeeiENSMUSG00000028106 Expressed in 255 organ(s), highest expression level in cumulus cell
ExpressionAtlasiQ6NXI6 baseline and differential
GenevisibleiQ6NXI6 MM

Interactioni

Subunit structurei

Associates with the RNA polymerase II complex.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088297

Structurei

3D structure databases

ProteinModelPortaliQ6NXI6
SMRiQ6NXI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 149CIDPROSITE-ProRule annotationAdd BLAST131

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 19Gly/Ser-richAdd BLAST16
Compositional biasi476 – 836Ser-richAdd BLAST361
Compositional biasi1170 – 1176Poly-Gly7
Compositional biasi1213 – 1330Pro-richAdd BLAST118
Compositional biasi1393 – 1398Poly-Gly6

Phylogenomic databases

eggNOGiKOG2669 Eukaryota
ENOG410XRAP LUCA
GeneTreeiENSGT00400000022016
HOGENOMiHOG000154192
HOVERGENiHBG104176
InParanoidiQ6NXI6
OrthoDBiEOG091G0F8X
PhylomeDBiQ6NXI6
TreeFamiTF320926

Family and domain databases

CDDicd03562 CID, 1 hit
Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR006569 CID_dom
IPR032337 CREPT
IPR008942 ENTH_VHS
IPR006903 RNA_pol_II-bd
PfamiView protein in Pfam
PF16566 CREPT, 1 hit
PF04818 CTD_bind, 1 hit
SMARTiView protein in SMART
SM00582 RPR, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS51391 CID, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NXI6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAGGGGGSS KASSSSASSA GALESSLDRK FQSVTNTMES IQGLSSWCIE
60 70 80 90 100
NKKHHSTIVY HWMKWLRRST YPHRLNLFYL ANDVIQNCKR KNAIIFRESF
110 120 130 140 150
ADVLPEAAAL VKDPSVSKSI ERIFKIWEDR NVYPEDMIVA LREALMDRAA
160 170 180 190 200
SHNARLQKLQ CFPGTTFKTQ KQLKENLNKQ PNKQWKKSQT STNPKAALKS
210 220 230 240 250
KIVAEFRSQA LIEELLMYKR SEDQIELKEK QLSTMRVDVC STETLKCLKD
260 270 280 290 300
KTGGKKFSKE FEEASSKLEE FVNGLDKQVK NGPSLTEALE NAGIFYEAQY
310 320 330 340 350
KEVKVVANAY KTFANRVNNL KKKLDQLKST LPDPEESPVP SPSMDAPSPT
360 370 380 390 400
GSESPFQGMG GEEPQSPAME SDKSATPEPV TDNRDVEDME LSDVEDDGSK
410 420 430 440 450
IIVEDRKEKP VEKPAVSTGV PTKSTESVSK ASPCAPPSVP TTAAPPLPKP
460 470 480 490 500
LSTALLSPSP TLVLPNLANV DLAKISSILS SLTSVMKNTG VSSASRPSPG
510 520 530 540 550
IPTSPSNLSS GLKTPAPATT PSHNPLANIL SKVEITPESI LSALSKTQTQ
560 570 580 590 600
SAPALQGLSS LLQSVTANPV PASEVTSQST TASPASTTGS AVKGRNLLSS
610 620 630 640 650
TQSFIPKSFN YSPSSSTSEV SSTSASKASV GQSPVLPSTT FKLPSSSLGF
660 670 680 690 700
TGTHNPSPAA PPTEVAVCQS SEVSKPKPES ESTSPSLEMK IHNFLKGNPG
710 720 730 740 750
FSGLNLNIPI LSSLGSSAPS EGHASDFQRG PTSTSVDSID GTPVRDERSG
760 770 780 790 800
TPTQDEMMDK PTSSSVDTMS LLSKIISPGS STPSSTRSPP PGRDESYPQE
810 820 830 840 850
LPNSVSTYRP FGLGSDSPYK QPSGGVERPS SLMDSSQEKL FPDTSFQEDE
860 870 880 890 900
DYRDFEYSGP PPSAMMNLEK KPAKSILKSS KLSDATEYQP ILSSYNHRAQ
910 920 930 940 950
EFGVKSAFPP SVRALLDSSE NCDRLSSPPG LFGAFNIRGN EPGSERSPSP
960 970 980 990 1000
SKNDAFFTPD SNHSGLSQST AGHLTLPQTQ YPDSPHSVPH RSIFSSQSTL
1010 1020 1030 1040 1050
AAPAGHPPTS GVEKVLASTI STTSTIEFKN MLKNASRKPS DDKHFGQTPN
1060 1070 1080 1090 1100
KGTSSDGVSL SNLTQPSLPT TDQQQEEHYR IETRVSSSCL DLPDSTEEKG
1110 1120 1130 1140 1150
APIETLGYHN AANRRMSGEP IKTVESIRVP GKGNRGHGRE VSRVGWFDLS
1160 1170 1180 1190 1200
TPGSSFDNGP SSASELASLG GGGSGGLTGF KTTPYKERAP QFQESVTSFR
1210 1220 1230 1240 1250
SNSFNSTFEH HLPPSPLEHG APFQREPVGP SSAPPAPPKD HGGIFSREAP
1260 1270 1280 1290 1300
THLPSVDLSN PFTKEASLAH AGPPPPPGEH SGVPFPPPPP PPPPGELSSG
1310 1320 1330 1340 1350
GTGVPFATPA PPPPPVDHSG VVPFPTPPLP EHGVTGAVSV FPKDHSSLLQ
1360 1370 1380 1390 1400
GTMAEHFGVL TGPRDLNGPG LNRSRESLSL PSHPLEHLGP ALGGGGGGNT
1410 1420 1430 1440 1450
SSSGLPLSPA HRDAIGRSGM ILRSPRPDFR PREAFLGRDP FHSLKRPRPP
1460
FVRGPPFFAP KRPFFPPRY
Length:1,469
Mass (Da):156,586
Last modified:July 5, 2004 - v1
Checksum:i1EF4A65F32873748
GO
Isoform 2 (identifier: Q6NXI6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     146-189: Missing.

Show »
Length:1,425
Mass (Da):151,404
Checksum:iC9FFDF3423D8F111
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JFW6A0A0G2JFW6_MOUSE
Regulation of nuclear pre-mRNA doma...
Rprd2
1,386Annotation score:
A0A0G2JFN1A0A0G2JFN1_MOUSE
Regulation of nuclear pre-mRNA doma...
Rprd2
473Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti491V → K in BAC97960 (PubMed:16141072).Curated1
Sequence conflicti646S → N in BAE32767 (PubMed:14621295).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019548146 – 189Missing in isoform 2. 2 PublicationsAdd BLAST44

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067054 mRNA Translation: AAH67054.1
AK129150 mRNA Translation: BAC97960.1
AK154692 mRNA Translation: BAE32767.1
CCDSiCCDS38549.1 [Q6NXI6-1]
RefSeqiNP_001074762.1, NM_001081293.1 [Q6NXI6-1]
XP_006502291.1, XM_006502228.3 [Q6NXI6-2]
UniGeneiMm.196275

Genome annotation databases

EnsembliENSMUST00000090791; ENSMUSP00000088297; ENSMUSG00000028106 [Q6NXI6-1]
GeneIDi75137
KEGGimmu:75137
UCSCiuc008qkx.1 mouse [Q6NXI6-1]
uc008qky.1 mouse [Q6NXI6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067054 mRNA Translation: AAH67054.1
AK129150 mRNA Translation: BAC97960.1
AK154692 mRNA Translation: BAE32767.1
CCDSiCCDS38549.1 [Q6NXI6-1]
RefSeqiNP_001074762.1, NM_001081293.1 [Q6NXI6-1]
XP_006502291.1, XM_006502228.3 [Q6NXI6-2]
UniGeneiMm.196275

3D structure databases

ProteinModelPortaliQ6NXI6
SMRiQ6NXI6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088297

PTM databases

iPTMnetiQ6NXI6
PhosphoSitePlusiQ6NXI6

Proteomic databases

PaxDbiQ6NXI6
PeptideAtlasiQ6NXI6
PRIDEiQ6NXI6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090791; ENSMUSP00000088297; ENSMUSG00000028106 [Q6NXI6-1]
GeneIDi75137
KEGGimmu:75137
UCSCiuc008qkx.1 mouse [Q6NXI6-1]
uc008qky.1 mouse [Q6NXI6-2]

Organism-specific databases

CTDi23248
MGIiMGI:1922387 Rprd2
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2669 Eukaryota
ENOG410XRAP LUCA
GeneTreeiENSGT00400000022016
HOGENOMiHOG000154192
HOVERGENiHBG104176
InParanoidiQ6NXI6
OrthoDBiEOG091G0F8X
PhylomeDBiQ6NXI6
TreeFamiTF320926

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Miscellaneous databases

ChiTaRSiRprd2 mouse
PROiPR:Q6NXI6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028106 Expressed in 255 organ(s), highest expression level in cumulus cell
ExpressionAtlasiQ6NXI6 baseline and differential
GenevisibleiQ6NXI6 MM

Family and domain databases

CDDicd03562 CID, 1 hit
Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR006569 CID_dom
IPR032337 CREPT
IPR008942 ENTH_VHS
IPR006903 RNA_pol_II-bd
PfamiView protein in Pfam
PF16566 CREPT, 1 hit
PF04818 CTD_bind, 1 hit
SMARTiView protein in SMART
SM00582 RPR, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS51391 CID, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPRD2_MOUSE
AccessioniPrimary (citable) accession number: Q6NXI6
Secondary accession number(s): Q3U3L8, Q6ZQA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again