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Protein

Vasculin

Gene

Gpbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a GC-rich promoter-specific transactivating transcription factor.1 Publication

GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA-binding transcription factor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Vasculin
Alternative name(s):
GC-rich promoter-binding protein 1
Short name:
mGPBP
Gene namesi
Name:Gpbp1
Synonyms:Gpbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1920524 Gpbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003241111 – 473VasculinAdd BLAST473

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49PhosphoserineCombined sources1
Modified residuei87Omega-N-methylarginineBy similarity1
Modified residuei274PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei322PhosphoserineBy similarity1
Modified residuei381PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ6NXH3
PaxDbiQ6NXH3
PeptideAtlasiQ6NXH3
PRIDEiQ6NXH3

PTM databases

iPTMnetiQ6NXH3
PhosphoSitePlusiQ6NXH3

Expressioni

Tissue specificityi

Ubiquitously expressed (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000032745 Expressed in 281 organ(s), highest expression level in primary oocyte
CleanExiMM_GPBP1
ExpressionAtlasiQ6NXH3 baseline and differential
GenevisibleiQ6NXH3 MM

Interactioni

Subunit structurei

Interacts with GTF2B, GTF2F2, RNA polymerase II and TBP.1 Publication

Protein-protein interaction databases

BioGridi215884, 5 interactors
IntActiQ6NXH3, 1 interactor
STRINGi10090.ENSMUSP00000048240

Family & Domainsi

Sequence similaritiesi

Belongs to the vasculin family.Curated

Phylogenomic databases

eggNOGiENOG410IJH3 Eukaryota
ENOG410Y09K LUCA
GeneTreeiENSGT00420000029753
HOGENOMiHOG000049182
HOVERGENiHBG056980
InParanoidiQ6NXH3
OMAiTSVKECN
OrthoDBiEOG091G05VV
PhylomeDBiQ6NXH3
TreeFamiTF332220

Family and domain databases

InterProiView protein in InterPro
IPR028128 Vasculin_fam
PfamiView protein in Pfam
PF15337 Vasculin, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NXH3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQHDFAPAW LNFPTPPSST KSSLNFEKHS ENFSWTENRY DVSRRRHNSS
60 70 80 90 100
DGFDSGIGRP NGGNFGRKEK NGWRTHGRNG TENINHRGGY HGGNSRSRSS
110 120 130 140 150
IFHSGKSQGL HENSIPDNET GRKEDKRERR QFEAEDFPSL NPEYEREPNQ
160 170 180 190 200
NKSLAAGVWD YPPNPKSRTP RMLVIKKGNT KDLQLSGFPV AGNLQSQPVK
210 220 230 240 250
NGTGPSVYKG LVPKPAVPPT KPTQWKSQTK ENKVGTSFSH ESTYGVGNFN
260 270 280 290 300
TFKSTAKNIS PSTNSVKECN RSNSSSPVDK LNQQPRLTKL TRMRSDKKSE
310 320 330 340 350
FLKALKRDRV EEEHEDESHA GSEKDDDSFN LHNSNTTHQE RDINRNFDEN
360 370 380 390 400
EIPQENGNAS MISQQIIRSS TFPQTDVLSS SLEAEHRLLK EMGWQEDSEN
410 420 430 440 450
DETCAPLTED EMREFQVISE QLQKNGLRKN GILKNGLICD FKFGPWKNST
460 470
FKPTIENDDT ETSSSDTSDD DDV
Length:473
Mass (Da):53,423
Last modified:July 5, 2004 - v1
Checksum:iADE2CF4F36D81E1C
GO
Isoform 2 (identifier: Q6NXH3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     159-159: W → WGLHAQTHTYPTKKISQAPLL

Show »
Length:493
Mass (Da):55,610
Checksum:iEF20E34A87463EEE
GO
Isoform 3 (identifier: Q6NXH3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-137: QHDFAPAWLN...ERRQFEAEDF → LILVLDVLME
     159-159: W → WGLHAQTHTYPTKKISQAPLL

Show »
Length:368
Mass (Da):41,308
Checksum:i63E9BBA1CE3FBB26
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RCY3D6RCY3_MOUSE
Vasculin
Gpbp1
67Annotation score:

Sequence cautioni

The sequence AAH16083 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti204G → S in AAQ88446 (PubMed:14612417).Curated1
Sequence conflicti361M → I in AAQ88446 (PubMed:14612417).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0321383 – 137QHDFA…EAEDF → LILVLDVLME in isoform 3. 1 PublicationAdd BLAST135
Alternative sequenceiVSP_032139159W → WGLHAQTHTYPTKKISQAPL L in isoform 2 and isoform 3. 3 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382529 mRNA Translation: AAQ88446.1
AK082704 mRNA Translation: BAC38578.1
AK135728 mRNA Translation: BAE22631.1
AK145318 mRNA Translation: BAE26364.1
AK161928 mRNA Translation: BAE36638.1
AK163370 mRNA Translation: BAE37320.1
AK163390 mRNA Translation: BAE37330.1
AK169406 mRNA Translation: BAE41152.1
BC016083 mRNA Translation: AAH16083.1 Different initiation.
BC067075 mRNA Translation: AAH67075.1
BC094888 mRNA Translation: AAH94888.1
CCDSiCCDS26769.1 [Q6NXH3-2]
CCDS49362.1 [Q6NXH3-1]
RefSeqiNP_001116435.1, NM_001122963.1 [Q6NXH3-1]
NP_082763.3, NM_028487.4 [Q6NXH3-2]
XP_006517835.1, XM_006517772.1 [Q6NXH3-2]
XP_006517836.1, XM_006517773.3
XP_017171102.1, XM_017315613.1
XP_017171103.1, XM_017315614.1
UniGeneiMm.441830
Mm.57286

Genome annotation databases

EnsembliENSMUST00000047627; ENSMUSP00000048240; ENSMUSG00000032745 [Q6NXH3-2]
ENSMUST00000091236; ENSMUSP00000088777; ENSMUSG00000032745 [Q6NXH3-1]
GeneIDi73274
KEGGimmu:73274
UCSCiuc007rvv.2 mouse [Q6NXH3-3]
uc007rvw.2 mouse [Q6NXH3-2]
uc007rvx.2 mouse [Q6NXH3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY382529 mRNA Translation: AAQ88446.1
AK082704 mRNA Translation: BAC38578.1
AK135728 mRNA Translation: BAE22631.1
AK145318 mRNA Translation: BAE26364.1
AK161928 mRNA Translation: BAE36638.1
AK163370 mRNA Translation: BAE37320.1
AK163390 mRNA Translation: BAE37330.1
AK169406 mRNA Translation: BAE41152.1
BC016083 mRNA Translation: AAH16083.1 Different initiation.
BC067075 mRNA Translation: AAH67075.1
BC094888 mRNA Translation: AAH94888.1
CCDSiCCDS26769.1 [Q6NXH3-2]
CCDS49362.1 [Q6NXH3-1]
RefSeqiNP_001116435.1, NM_001122963.1 [Q6NXH3-1]
NP_082763.3, NM_028487.4 [Q6NXH3-2]
XP_006517835.1, XM_006517772.1 [Q6NXH3-2]
XP_006517836.1, XM_006517773.3
XP_017171102.1, XM_017315613.1
XP_017171103.1, XM_017315614.1
UniGeneiMm.441830
Mm.57286

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215884, 5 interactors
IntActiQ6NXH3, 1 interactor
STRINGi10090.ENSMUSP00000048240

PTM databases

iPTMnetiQ6NXH3
PhosphoSitePlusiQ6NXH3

Proteomic databases

EPDiQ6NXH3
PaxDbiQ6NXH3
PeptideAtlasiQ6NXH3
PRIDEiQ6NXH3

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047627; ENSMUSP00000048240; ENSMUSG00000032745 [Q6NXH3-2]
ENSMUST00000091236; ENSMUSP00000088777; ENSMUSG00000032745 [Q6NXH3-1]
GeneIDi73274
KEGGimmu:73274
UCSCiuc007rvv.2 mouse [Q6NXH3-3]
uc007rvw.2 mouse [Q6NXH3-2]
uc007rvx.2 mouse [Q6NXH3-1]

Organism-specific databases

CTDi65056
MGIiMGI:1920524 Gpbp1

Phylogenomic databases

eggNOGiENOG410IJH3 Eukaryota
ENOG410Y09K LUCA
GeneTreeiENSGT00420000029753
HOGENOMiHOG000049182
HOVERGENiHBG056980
InParanoidiQ6NXH3
OMAiTSVKECN
OrthoDBiEOG091G05VV
PhylomeDBiQ6NXH3
TreeFamiTF332220

Miscellaneous databases

ChiTaRSiGpbp1 mouse
PROiPR:Q6NXH3
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032745 Expressed in 281 organ(s), highest expression level in primary oocyte
CleanExiMM_GPBP1
ExpressionAtlasiQ6NXH3 baseline and differential
GenevisibleiQ6NXH3 MM

Family and domain databases

InterProiView protein in InterPro
IPR028128 Vasculin_fam
PfamiView protein in Pfam
PF15337 Vasculin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPBP1_MOUSE
AccessioniPrimary (citable) accession number: Q6NXH3
Secondary accession number(s): Q3TQR2
, Q3TSN7, Q6TYE7, Q8C498, Q8R252
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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