Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Armadillo repeat-containing protein 6

Gene

ARMC6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

It is uncertain whether Met-1 or Met-26 is the initiator.Curated

GO - Biological processi

Enzyme and pathway databases

SignaLinkiQ6NXE6

Names & Taxonomyi

Protein namesi
Recommended name:
Armadillo repeat-containing protein 6
Gene namesi
Name:ARMC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000105676.13
HGNCiHGNC:25049 ARMC6
neXtProtiNX_Q6NXE6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105676
PharmGKBiPA134884604

Polymorphism and mutation databases

BioMutaiARMC6
DMDMi109940304

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002426601 – 501Armadillo repeat-containing protein 6Add BLAST501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6NXE6
MaxQBiQ6NXE6
PaxDbiQ6NXE6
PeptideAtlasiQ6NXE6
PRIDEiQ6NXE6
ProteomicsDBi66751
66752 [Q6NXE6-2]

PTM databases

iPTMnetiQ6NXE6
PhosphoSitePlusiQ6NXE6

Expressioni

Gene expression databases

BgeeiENSG00000105676
CleanExiHS_ARMC6
ExpressionAtlasiQ6NXE6 baseline and differential
GenevisibleiQ6NXE6 HS

Organism-specific databases

HPAiHPA041420
HPA041681

Interactioni

Protein-protein interaction databases

BioGridi125026, 69 interactors
IntActiQ6NXE6, 55 interactors
MINTiQ6NXE6
STRINGi9606.ENSP00000376148

Structurei

3D structure databases

ProteinModelPortaliQ6NXE6
SMRiQ6NXE6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati220 – 264ARM 1Add BLAST45
Repeati274 – 318ARM 2Add BLAST45
Repeati319 – 369ARM 3Add BLAST51
Repeati370 – 412ARM 4Add BLAST43

Sequence similaritiesi

Belongs to the ARMC6 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4199 Eukaryota
ENOG410XR4D LUCA
GeneTreeiENSGT00390000002913
HOGENOMiHOG000290683
HOVERGENiHBG057500
InParanoidiQ6NXE6
OMAiDCEDVAK
OrthoDBiEOG091G0HWM
PhylomeDBiQ6NXE6
TreeFamiTF324526

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
PfamiView protein in Pfam
PF00514 Arm, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 6 hits
SUPFAMiSSF48371 SSF48371, 1 hit
PROSITEiView protein in PROSITE
PS50176 ARM_REPEAT, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6NXE6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSERCCSRYS SGASIGCTPT STQAKMVSKR IAQETFDAAV RENIEEFAMG
60 70 80 90 100
PEEAVKEAVE QFESQGVDLS NIVKTAPKVS ADGSQEPTHD ILQMLSDLQE
110 120 130 140 150
SVASSRPQEV SAYLTRFCDQ CKQDKACRFL AAQKGAYPII FTAWKLATAG
160 170 180 190 200
DQGLLLQSLN ALSVLTDGQP DLLDAQGLQL LVATLTQNAD EADLTCSGIR
210 220 230 240 250
CVRHACLKHE QNRQDLVKAG VLPLLTGAIT HHGHHTDVVR EACWALRVMT
260 270 280 290 300
FDDDIRVPFG HAHNHAKMIV QENKGLKVLI EATKAFLDNP GILSELCGTL
310 320 330 340 350
SRLAIRNEFC QEVVDLGGLS ILVSLLADCN DHQMRDQSGV QELVKQVLST
360 370 380 390 400
LRAIAGNDDV KDAIVRAGGT ESIVAAMTQH LTSPQVCEQS CAALCFLALR
410 420 430 440 450
KPDNSRIIVE GGGAVAALQA MKAHPQKAGV QKQACMLIRN LVAHGQAFSK
460 470 480 490 500
PILDLGAEAL IMQARSAHRD CEDVAKAALR DLGCHVELRE LWTGQRGNLA

P
Length:501
Mass (Da):54,142
Last modified:June 27, 2006 - v2
Checksum:i13813F0B99AF8AFF
GO
Isoform 2 (identifier: Q6NXE6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: Missing.

Note: Gene prediction based on EST data.
Show »
Length:476
Mass (Da):51,548
Checksum:i213563493D534278
GO

Sequence cautioni

The sequence AAD03162 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAH67125 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0401031 – 25Missing in isoform 2. CuratedAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK295488 mRNA Translation: BAG58410.1
AC003038 Genomic DNA Translation: AAD03162.1 Sequence problems.
AC004447 Genomic DNA No translation available.
BC003700 mRNA Translation: AAH03700.1
BC067125 mRNA Translation: AAH67125.1 Different initiation.
CCDSiCCDS32965.1 [Q6NXE6-2]
CCDS56089.1 [Q6NXE6-1]
RefSeqiNP_001186125.1, NM_001199196.1 [Q6NXE6-1]
NP_219483.1, NM_033415.3 [Q6NXE6-2]
XP_005260214.1, XM_005260157.3 [Q6NXE6-2]
XP_016882974.1, XM_017027485.1 [Q6NXE6-2]
UniGeneiHs.77876

Genome annotation databases

EnsembliENST00000269932; ENSP00000269932; ENSG00000105676 [Q6NXE6-2]
ENST00000392335; ENSP00000376147; ENSG00000105676 [Q6NXE6-2]
ENST00000392336; ENSP00000376148; ENSG00000105676 [Q6NXE6-1]
ENST00000535612; ENSP00000444156; ENSG00000105676 [Q6NXE6-1]
GeneIDi93436
KEGGihsa:93436
UCSCiuc002nlc.4 human [Q6NXE6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiARMC6_HUMAN
AccessioniPrimary (citable) accession number: Q6NXE6
Secondary accession number(s): B4DI98, O94999, Q9BTH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: July 18, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health