UniProtKB - Q6NX49 (ZN544_HUMAN)
Protein
Zinc finger protein 544
Gene
ZNF544
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 354 – 374 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 380 – 402 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 492 – 514 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 520 – 542 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 548 – 570 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 576 – 598 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 604 – 626 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 632 – 654 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 660 – 682 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 688 – 710 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q6NX49 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 544 |
Gene namesi | Name:ZNF544 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16759, ZNF544 |
neXtProti | NX_Q6NX49 |
VEuPathDBi | HostDB:ENSG00000198131.13 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 27300 |
OpenTargetsi | ENSG00000198131 |
PharmGKBi | PA134871299 |
Miscellaneous databases
Pharosi | Q6NX49, Tdark |
Genetic variation databases
BioMutai | ZNF544 |
DMDMi | 74762345 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047643 | 1 – 715 | Zinc finger protein 544Add BLAST | 715 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 273 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 289 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 534 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q6NX49 |
jPOSTi | Q6NX49 |
MassIVEi | Q6NX49 |
MaxQBi | Q6NX49 |
PaxDbi | Q6NX49 |
PeptideAtlasi | Q6NX49 |
PRIDEi | Q6NX49 |
ProteomicsDBi | 66747 |
PTM databases
GlyGeni | Q6NX49, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q6NX49 |
PhosphoSitePlusi | Q6NX49 |
Expressioni
Gene expression databases
Bgeei | ENSG00000198131, Expressed in amniotic fluid and 234 other tissues |
ExpressionAtlasi | Q6NX49, baseline and differential |
Genevisiblei | Q6NX49, HS |
Organism-specific databases
HPAi | ENSG00000198131, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ6NX49
With | #Exp. | IntAct |
---|---|---|
GLRX3 [O76003] | 3 | EBI-2841978,EBI-374781 |
NDEL1 [Q9GZM8] | 5 | EBI-2841978,EBI-928842 |
TRAF2 [Q12933] | 4 | EBI-2841978,EBI-355744 |
TSGA10 [Q9BZW7] | 3 | EBI-2841978,EBI-744794 |
Protein-protein interaction databases
BioGRIDi | 118123, 14 interactors |
IntActi | Q6NX49, 11 interactors |
MINTi | Q6NX49 |
STRINGi | 9606.ENSP00000269829 |
Miscellaneous databases
RNActi | Q6NX49, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 14 – 85 | KRABPROSITE-ProRule annotationAdd BLAST | 72 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 354 – 374 | C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 380 – 402 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 408 – 430 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 436 – 458 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 464 – 486 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 492 – 514 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 520 – 542 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 548 – 570 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 576 – 598 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 604 – 626 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 632 – 654 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 660 – 682 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 688 – 710 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164425 |
InParanoidi | Q6NX49 |
OMAi | ESHQCAR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6NX49 |
TreeFami | TF341817 |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All
Q6NX49-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEARSMLVPP QASVCFEDVA MAFTQEEWEQ LDLAQRTLYR EVTLETWEHI
60 70 80 90 100
VSLGLFLSKS DVISQLEQEE DLCRAEQEAP RDWKATLEEN RLNSEKDRAR
110 120 130 140 150
EELSHHVEVY RSGPEEPPSL VLGKVQDQSN QLREHQENSL RFMVLTSERL
160 170 180 190 200
FAQREHCELE LGGGYSLPST LSLLPTTLPT STGFPKPNSQ VKELKQNSAF
210 220 230 240 250
INHEKNGADG KHCESHQCAR AFCQSIYLSK LGNVETGKKN PYEYIVSGDS
260 270 280 290 300
LNYGSSLCFH GRTFSVKKSD DCKDYGNLFS HSVSLNEQKP VHFGKSQYEC
310 320 330 340 350
DECRETCSES LCLVQTERSG PGETPFRCEE RCAAFPMASS FSDCNIIQTT
360 370 380 390 400
EKPSVCNQCG KSFSCCKLIH QRTHTGEKPF ECTQCGKSFS QSYDLVIHQR
410 420 430 440 450
THTGEKPYEC DLCGKSFTQR SKLITHQRIH TGEKPYQCIE CRKSFRWNSN
460 470 480 490 500
LIVHQRIHTG EKPYECTHCG KSFSQSYELV THKRTHTGEK PFKCTQCGKS
510 520 530 540 550
FSQKYDLVVH QRTHTGEKPY ECNLCGKSFS QSSKLITHQR IHTGEKPYQC
560 570 580 590 600
IECGKSFRWN SNLVIHQRIH TGEKPYDCTH CGKSFSQSYQ LVAHKRTHTG
610 620 630 640 650
EKPYECNECG KAFNRSTQLI RHLQIHTGEK PYKCNQCNKA FARSSYLVMH
660 670 680 690 700
QRTHTGEKPF ECSQCGKAFS GSSNLLSHHR IHSGEKPYEC SDCGKSFRQQ
710
SQLVVHRRTH TGEKP
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0QZM7 | M0QZM7_HUMAN | Zinc finger protein 544 | ZNF544 | 97 | Annotation score: | ||
J3KQC8 | J3KQC8_HUMAN | Zinc finger protein 544 | ZNF544 | 687 | Annotation score: | ||
M0QZY0 | M0QZY0_HUMAN | Zinc finger protein 544 | ZNF544 | 139 | Annotation score: | ||
M0R2F0 | M0R2F0_HUMAN | Zinc finger protein 544 | ZNF544 | 75 | Annotation score: | ||
M0QX86 | M0QX86_HUMAN | Zinc finger protein 544 | ZNF544 | 97 | Annotation score: | ||
Q8IVS5 | Q8IVS5_HUMAN | ZNF544 protein | ZNF544 | 106 | Annotation score: | ||
M0R0U7 | M0R0U7_HUMAN | Zinc finger protein 544 | ZNF544 | 74 | Annotation score: | ||
M0QY11 | M0QY11_HUMAN | Zinc finger protein 544 | ZNF544 | 573 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 86 | T → P in AAC01956 (Ref. 1) Curated | 1 | |
Sequence conflicti | 91 | R → G in AAC01956 (Ref. 1) Curated | 1 | |
Sequence conflicti | 348 | Q → L in AAC01956 (Ref. 1) Curated | 1 | |
Sequence conflicti | 446 | R → T in AAC01956 (Ref. 1) Curated | 1 | |
Sequence conflicti | 590 | Q → R in AAC01956 (Ref. 1) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052859 | 203 | H → D. Corresponds to variant dbSNP:rs6510130Ensembl. | 1 | |
Natural variantiVAR_052860 | 700 | Q → R3 PublicationsCorresponds to variant dbSNP:rs260462Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF020591 mRNA Translation: AAC01956.1 AK291656 mRNA Translation: BAF84345.1 CH471135 Genomic DNA Translation: EAW72568.1 BC067271 mRNA Translation: AAH67271.1 |
CCDSi | CCDS12973.1 |
RefSeqi | NP_001307696.1, NM_001320767.1 NP_001307698.1, NM_001320769.1 NP_001307699.1, NM_001320770.1 NP_001307700.1, NM_001320771.1 NP_001307702.1, NM_001320773.1 NP_001307705.1, NM_001320776.1 NP_001307706.1, NM_001320777.1 NP_001307709.1, NM_001320780.1 NP_001307712.1, NM_001320783.1 NP_001307714.1, NM_001320785.1 NP_001307715.1, NM_001320786.1 NP_001307720.1, NM_001320791.1 NP_055295.2, NM_014480.3 |
Genome annotation databases
Ensembli | ENST00000269829; ENSP00000269829; ENSG00000198131 ENST00000596652; ENSP00000469635; ENSG00000198131 |
GeneIDi | 27300 |
KEGGi | hsa:27300 |
UCSCi | uc061dqq.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF020591 mRNA Translation: AAC01956.1 AK291656 mRNA Translation: BAF84345.1 CH471135 Genomic DNA Translation: EAW72568.1 BC067271 mRNA Translation: AAH67271.1 |
CCDSi | CCDS12973.1 |
RefSeqi | NP_001307696.1, NM_001320767.1 NP_001307698.1, NM_001320769.1 NP_001307699.1, NM_001320770.1 NP_001307700.1, NM_001320771.1 NP_001307702.1, NM_001320773.1 NP_001307705.1, NM_001320776.1 NP_001307706.1, NM_001320777.1 NP_001307709.1, NM_001320780.1 NP_001307712.1, NM_001320783.1 NP_001307714.1, NM_001320785.1 NP_001307715.1, NM_001320786.1 NP_001307720.1, NM_001320791.1 NP_055295.2, NM_014480.3 |
3D structure databases
SMRi | Q6NX49 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118123, 14 interactors |
IntActi | Q6NX49, 11 interactors |
MINTi | Q6NX49 |
STRINGi | 9606.ENSP00000269829 |
PTM databases
GlyGeni | Q6NX49, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q6NX49 |
PhosphoSitePlusi | Q6NX49 |
Genetic variation databases
BioMutai | ZNF544 |
DMDMi | 74762345 |
Proteomic databases
EPDi | Q6NX49 |
jPOSTi | Q6NX49 |
MassIVEi | Q6NX49 |
MaxQBi | Q6NX49 |
PaxDbi | Q6NX49 |
PeptideAtlasi | Q6NX49 |
PRIDEi | Q6NX49 |
ProteomicsDBi | 66747 |
Protocols and materials databases
Antibodypediai | 1170, 76 antibodies |
Genome annotation databases
Ensembli | ENST00000269829; ENSP00000269829; ENSG00000198131 ENST00000596652; ENSP00000469635; ENSG00000198131 |
GeneIDi | 27300 |
KEGGi | hsa:27300 |
UCSCi | uc061dqq.1, human |
Organism-specific databases
CTDi | 27300 |
DisGeNETi | 27300 |
GeneCardsi | ZNF544 |
HGNCi | HGNC:16759, ZNF544 |
HPAi | ENSG00000198131, Low tissue specificity |
neXtProti | NX_Q6NX49 |
OpenTargetsi | ENSG00000198131 |
PharmGKBi | PA134871299 |
VEuPathDBi | HostDB:ENSG00000198131.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000164425 |
InParanoidi | Q6NX49 |
OMAi | ESHQCAR |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q6NX49 |
TreeFami | TF341817 |
Enzyme and pathway databases
PathwayCommonsi | Q6NX49 |
Reactomei | R-HSA-212436, Generic Transcription Pathway |
Miscellaneous databases
BioGRID-ORCSi | 27300, 4 hits in 1012 CRISPR screens |
ChiTaRSi | ZNF544, human |
GenomeRNAii | 27300 |
Pharosi | Q6NX49, Tdark |
PROi | PR:Q6NX49 |
RNActi | Q6NX49, protein |
Gene expression databases
Bgeei | ENSG00000198131, Expressed in amniotic fluid and 234 other tissues |
ExpressionAtlasi | Q6NX49, baseline and differential |
Genevisiblei | Q6NX49, HS |
Family and domain databases
CDDi | cd07765, KRAB_A-box, 1 hit |
InterProi | View protein in InterPro IPR001909, KRAB IPR036051, KRAB_dom_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF01352, KRAB, 1 hit PF00096, zf-C2H2, 11 hits |
SMARTi | View protein in SMART SM00349, KRAB, 1 hit SM00355, ZnF_C2H2, 12 hits |
SUPFAMi | SSF109640, SSF109640, 1 hit SSF57667, SSF57667, 9 hits |
PROSITEi | View protein in PROSITE PS50805, KRAB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 12 hits PS50157, ZINC_FINGER_C2H2_2, 13 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN544_HUMAN | |
Accessioni | Q6NX49Primary (citable) accession number: Q6NX49 Secondary accession number(s): A8K6J1, Q9UEX4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 10, 2006 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 157 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - SIMILARITY comments
Index of protein domains and families