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UniProtKB - Q6NX49 (ZN544_HUMAN)

Entry version 157 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Zinc finger protein 544

Gene

ZNF544

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri354 – 374C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST21
Zinc fingeri380 – 402C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri576 – 598C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri604 – 626C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri632 – 654C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri660 – 682C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri688 – 710C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6NX49

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 544
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF544
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16759, ZNF544

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6NX49

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000198131.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		27300

Open Targets

More...OpenTargetsi		ENSG00000198131

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134871299

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6NX49, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ZNF544

Domain mapping of disease mutations (DMDM)

More...DMDMi		74762345

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476431 – 715Zinc finger protein 544Add BLAST715

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki273Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki289Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki534Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6NX49

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6NX49

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6NX49

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6NX49

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6NX49

PeptideAtlas

More...PeptideAtlasi		Q6NX49

PRoteomics IDEntifications database

More...PRIDEi		Q6NX49

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66747

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q6NX49, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6NX49

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6NX49

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000198131, Expressed in amniotic fluid and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6NX49, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6NX49, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000198131, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118123, 14 interactors

Protein interaction database and analysis system

More...IntActi		Q6NX49, 11 interactors

Molecular INTeraction database

More...MINTi		Q6NX49

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000269829

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6NX49, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6NX49

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 85KRABPROSITE-ProRule annotationAdd BLAST72

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the krueppel C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri354 – 374C2H2-type 1; atypicalPROSITE-ProRule annotationAdd BLAST21
Zinc fingeri380 – 402C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri408 – 430C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri464 – 486C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri492 – 514C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri548 – 570C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri576 – 598C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri604 – 626C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri632 – 654C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri660 – 682C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri688 – 710C2H2-type 13PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1721, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000164425

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6NX49

Identification of Orthologs from Complete Genome Data

More...OMAi		ESHQCAR

Database of Orthologous Groups

More...OrthoDBi		1318335at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6NX49

TreeFam database of animal gene trees

More...TreeFami		TF341817

Family and domain databases

Conserved Domains Database

More...CDDi		cd07765, KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

Q6NX49-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEARSMLVPP QASVCFEDVA MAFTQEEWEQ LDLAQRTLYR EVTLETWEHI 
        60         70         80         90        100
VSLGLFLSKS DVISQLEQEE DLCRAEQEAP RDWKATLEEN RLNSEKDRAR 
       110        120        130        140        150
EELSHHVEVY RSGPEEPPSL VLGKVQDQSN QLREHQENSL RFMVLTSERL 
       160        170        180        190        200
FAQREHCELE LGGGYSLPST LSLLPTTLPT STGFPKPNSQ VKELKQNSAF 
       210        220        230        240        250
INHEKNGADG KHCESHQCAR AFCQSIYLSK LGNVETGKKN PYEYIVSGDS 
       260        270        280        290        300
LNYGSSLCFH GRTFSVKKSD DCKDYGNLFS HSVSLNEQKP VHFGKSQYEC 
       310        320        330        340        350
DECRETCSES LCLVQTERSG PGETPFRCEE RCAAFPMASS FSDCNIIQTT 
       360        370        380        390        400
EKPSVCNQCG KSFSCCKLIH QRTHTGEKPF ECTQCGKSFS QSYDLVIHQR 
       410        420        430        440        450
THTGEKPYEC DLCGKSFTQR SKLITHQRIH TGEKPYQCIE CRKSFRWNSN 
       460        470        480        490        500
LIVHQRIHTG EKPYECTHCG KSFSQSYELV THKRTHTGEK PFKCTQCGKS 
       510        520        530        540        550
FSQKYDLVVH QRTHTGEKPY ECNLCGKSFS QSSKLITHQR IHTGEKPYQC 
       560        570        580        590        600
IECGKSFRWN SNLVIHQRIH TGEKPYDCTH CGKSFSQSYQ LVAHKRTHTG 
       610        620        630        640        650
EKPYECNECG KAFNRSTQLI RHLQIHTGEK PYKCNQCNKA FARSSYLVMH 
       660        670        680        690        700
QRTHTGEKPF ECSQCGKAFS GSSNLLSHHR IHSGEKPYEC SDCGKSFRQQ 
       710 
SQLVVHRRTH TGEKP
Length:715
Mass (Da):81,742
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD0F6F775D9741E03
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0QZM7M0QZM7_HUMAN
Zinc finger protein 544
ZNF544
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KQC8J3KQC8_HUMAN
Zinc finger protein 544
ZNF544
687Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZY0M0QZY0_HUMAN
Zinc finger protein 544
ZNF544
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R2F0M0R2F0_HUMAN
Zinc finger protein 544
ZNF544
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QX86M0QX86_HUMAN
Zinc finger protein 544
ZNF544
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8IVS5Q8IVS5_HUMAN
ZNF544 protein
ZNF544
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0R0U7M0R0U7_HUMAN
Zinc finger protein 544
ZNF544
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QY11M0QY11_HUMAN
Zinc finger protein 544
ZNF544
573Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti86T → P in AAC01956 (Ref. 1) Curated1
Sequence conflicti91R → G in AAC01956 (Ref. 1) Curated1
Sequence conflicti348Q → L in AAC01956 (Ref. 1) Curated1
Sequence conflicti446R → T in AAC01956 (Ref. 1) Curated1
Sequence conflicti590Q → R in AAC01956 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_052859203H → D. Corresponds to variant dbSNP:rs6510130Ensembl.1
Natural variantiVAR_052860700Q → R3 PublicationsCorresponds to variant dbSNP:rs260462Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF020591 mRNA Translation: AAC01956.1
AK291656 mRNA Translation: BAF84345.1
CH471135 Genomic DNA Translation: EAW72568.1
BC067271 mRNA Translation: AAH67271.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12973.1

NCBI Reference Sequences

More...RefSeqi		NP_001307696.1, NM_001320767.1
NP_001307698.1, NM_001320769.1
NP_001307699.1, NM_001320770.1
NP_001307700.1, NM_001320771.1
NP_001307702.1, NM_001320773.1
NP_001307705.1, NM_001320776.1
NP_001307706.1, NM_001320777.1
NP_001307709.1, NM_001320780.1
NP_001307712.1, NM_001320783.1
NP_001307714.1, NM_001320785.1
NP_001307715.1, NM_001320786.1
NP_001307720.1, NM_001320791.1
NP_055295.2, NM_014480.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000269829; ENSP00000269829; ENSG00000198131
ENST00000596652; ENSP00000469635; ENSG00000198131

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27300

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27300

UCSC genome browser

More...UCSCi		uc061dqq.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF020591 mRNA Translation: AAC01956.1
AK291656 mRNA Translation: BAF84345.1
CH471135 Genomic DNA Translation: EAW72568.1
BC067271 mRNA Translation: AAH67271.1
CCDSiCCDS12973.1
RefSeqiNP_001307696.1, NM_001320767.1
NP_001307698.1, NM_001320769.1
NP_001307699.1, NM_001320770.1
NP_001307700.1, NM_001320771.1
NP_001307702.1, NM_001320773.1
NP_001307705.1, NM_001320776.1
NP_001307706.1, NM_001320777.1
NP_001307709.1, NM_001320780.1
NP_001307712.1, NM_001320783.1
NP_001307714.1, NM_001320785.1
NP_001307715.1, NM_001320786.1
NP_001307720.1, NM_001320791.1
NP_055295.2, NM_014480.3

3D structure databases

SMRiQ6NX49
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118123, 14 interactors
IntActiQ6NX49, 11 interactors
MINTiQ6NX49
STRINGi9606.ENSP00000269829

PTM databases

GlyGeniQ6NX49, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ6NX49
PhosphoSitePlusiQ6NX49

Genetic variation databases

BioMutaiZNF544
DMDMi74762345

Proteomic databases

EPDiQ6NX49
jPOSTiQ6NX49
MassIVEiQ6NX49
MaxQBiQ6NX49
PaxDbiQ6NX49
PeptideAtlasiQ6NX49
PRIDEiQ6NX49
ProteomicsDBi66747

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1170, 76 antibodies

Genome annotation databases

EnsembliENST00000269829; ENSP00000269829; ENSG00000198131
ENST00000596652; ENSP00000469635; ENSG00000198131
GeneIDi27300
KEGGihsa:27300
UCSCiuc061dqq.1, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27300
DisGeNETi27300

GeneCards: human genes, protein and diseases

More...GeneCardsi		ZNF544
HGNCiHGNC:16759, ZNF544
HPAiENSG00000198131, Low tissue specificity
neXtProtiNX_Q6NX49
OpenTargetsiENSG00000198131
PharmGKBiPA134871299
VEuPathDBiHostDB:ENSG00000198131.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000164425
InParanoidiQ6NX49
OMAiESHQCAR
OrthoDBi1318335at2759
PhylomeDBiQ6NX49
TreeFamiTF341817

Enzyme and pathway databases

PathwayCommonsiQ6NX49
ReactomeiR-HSA-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27300, 4 hits in 1012 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ZNF544, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27300
PharosiQ6NX49, Tdark

Protein Ontology

More...PROi		PR:Q6NX49
RNActiQ6NX49, protein

Gene expression databases

BgeeiENSG00000198131, Expressed in amniotic fluid and 234 other tissues
ExpressionAtlasiQ6NX49, baseline and differential
GenevisibleiQ6NX49, HS

Family and domain databases

CDDicd07765, KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909, KRAB
IPR036051, KRAB_dom_sf
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01352, KRAB, 1 hit
PF00096, zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00349, KRAB, 1 hit
SM00355, ZnF_C2H2, 12 hits
SUPFAMiSSF109640, SSF109640, 1 hit
SSF57667, SSF57667, 9 hits
PROSITEiView protein in PROSITE
PS50805, KRAB, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 12 hits
PS50157, ZINC_FINGER_C2H2_2, 13 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN544_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NX49
Secondary accession number(s): A8K6J1, Q9UEX4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. SIMILARITY comments
    Index of protein domains and families
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