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Protein

Zinc finger protein 774

Gene

ZNF774

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 173C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri179 – 201C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 774
Gene namesi
Name:ZNF774
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000196391.10
HGNCiHGNC:33108 ZNF774
neXtProtiNX_Q6NX45

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000196391
PharmGKBiPA162410358

Polymorphism and mutation databases

BioMutaiZNF774
DMDMi313104065

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002636531 – 483Zinc finger protein 774Add BLAST483

Proteomic databases

MaxQBiQ6NX45
PaxDbiQ6NX45
PeptideAtlasiQ6NX45
PRIDEiQ6NX45
ProteomicsDBi66746

PTM databases

iPTMnetiQ6NX45
PhosphoSitePlusiQ6NX45

Expressioni

Gene expression databases

BgeeiENSG00000196391 Expressed in 91 organ(s), highest expression level in adrenal tissue
CleanExiHS_ZNF774
ExpressionAtlasiQ6NX45 baseline and differential

Organism-specific databases

HPAiHPA030839
HPA030840

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi131165, 5 interactors
IntActiQ6NX45, 71 interactors
STRINGi9606.ENSP00000346348

Structurei

3D structure databases

ProteinModelPortaliQ6NX45
SMRiQ6NX45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 64KRABAdd BLAST64

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri151 – 173C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri179 – 201C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri207 – 229C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri235 – 257C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri263 – 285C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri291 – 313C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri319 – 341C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri347 – 369C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri375 – 397C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri403 – 425C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri431 – 453C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri459 – 481C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150882
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6NX45
OMAiHFLTHQR
OrthoDBiEOG091G02KC
PhylomeDBiQ6NX45
TreeFamiTF336942

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q6NX45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWLGTSGKSG LPGHCLENPL QECHPAQLEE WALKGISRPS VISQPEQKEE
60 70 80 90 100
PWVLPLQNFE ARKIPRESHT DCEHQVAKLN QDNSETAEQC GTSSERTNKD
110 120 130 140 150
LSHTLSWGGN WEQGLELEGQ HGTLPGEGQL ESFSQERDLN KLLDGYVGEK
160 170 180 190 200
PMCAECGKSF NQSSYLIRHL RTHTGERPYT CIECGKGFKQ SSDLVTHRRT
210 220 230 240 250
HTGEKPYQCK GCEKKFSDSS TLIKHQRTHT GERPYECPEC GKTFGRKPHL
260 270 280 290 300
IMHQRTHTGE KPYACLECHK SFSRSSNFIT HQRTHTGVKP YRCNDCGESF
310 320 330 340 350
SQSSDLIKHQ RTHTGERPFK CPECGKGFRD SSHFVAHMST HSGERPFSCP
360 370 380 390 400
DCHKSFSQSS HLVTHQRTHT GERPFKCENC GKGFADSSAL IKHQRIHTGE
410 420 430 440 450
RPYKCGECGK SFNQSSHFIT HQRIHLGDRP YRCPECGKTF NQRSHFLTHQ
460 470 480
RTHTGEKPFH CSKCNKSFRQ KAHLLCHQNT HLI
Length:483
Mass (Da):55,068
Last modified:November 30, 2010 - v2
Checksum:i88C98561DA99E7A5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YNW6H0YNW6_HUMAN
Zinc finger protein 774
ZNF774
78Annotation score:
E7EQ77E7EQ77_HUMAN
Zinc finger protein 774
ZNF774
87Annotation score:
H0YLG8H0YLG8_HUMAN
Zinc finger protein 774
ZNF774
44Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02959665P → L. Corresponds to variant dbSNP:rs16944267Ensembl.1
Natural variantiVAR_02959783N → S1 PublicationCorresponds to variant dbSNP:rs2589957Ensembl.1
Natural variantiVAR_029598147V → I. Corresponds to variant dbSNP:rs11854320Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289385 mRNA Translation: BAF82074.1
AC018946 Genomic DNA No translation available.
BC067279 mRNA Translation: AAH67279.1
CCDSiCCDS32330.1
RefSeqiNP_001004309.2, NM_001004309.2
UniGeneiHs.55307

Genome annotation databases

EnsembliENST00000354377; ENSP00000346348; ENSG00000196391
GeneIDi342132
KEGGihsa:342132
UCSCiuc002bpk.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK289385 mRNA Translation: BAF82074.1
AC018946 Genomic DNA No translation available.
BC067279 mRNA Translation: AAH67279.1
CCDSiCCDS32330.1
RefSeqiNP_001004309.2, NM_001004309.2
UniGeneiHs.55307

3D structure databases

ProteinModelPortaliQ6NX45
SMRiQ6NX45
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131165, 5 interactors
IntActiQ6NX45, 71 interactors
STRINGi9606.ENSP00000346348

PTM databases

iPTMnetiQ6NX45
PhosphoSitePlusiQ6NX45

Polymorphism and mutation databases

BioMutaiZNF774
DMDMi313104065

Proteomic databases

MaxQBiQ6NX45
PaxDbiQ6NX45
PeptideAtlasiQ6NX45
PRIDEiQ6NX45
ProteomicsDBi66746

Protocols and materials databases

DNASUi342132
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000354377; ENSP00000346348; ENSG00000196391
GeneIDi342132
KEGGihsa:342132
UCSCiuc002bpk.5 human

Organism-specific databases

CTDi342132
EuPathDBiHostDB:ENSG00000196391.10
GeneCardsiZNF774
HGNCiHGNC:33108 ZNF774
HPAiHPA030839
HPA030840
neXtProtiNX_Q6NX45
OpenTargetsiENSG00000196391
PharmGKBiPA162410358
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00930000150882
HOGENOMiHOG000234617
HOVERGENiHBG018163
InParanoidiQ6NX45
OMAiHFLTHQR
OrthoDBiEOG091G02KC
PhylomeDBiQ6NX45
TreeFamiTF336942

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

ChiTaRSiZNF774 human
GenomeRNAii342132
PROiPR:Q6NX45

Gene expression databases

BgeeiENSG00000196391 Expressed in 91 organ(s), highest expression level in adrenal tissue
CleanExiHS_ZNF774
ExpressionAtlasiQ6NX45 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 11 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 12 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 12 hits
PS50157 ZINC_FINGER_C2H2_2, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZN774_HUMAN
AccessioniPrimary (citable) accession number: Q6NX45
Secondary accession number(s): A8K020
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
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