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Entry version 67 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
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Protein

Nuclear pore complex protein Nup93

Gene

nup93

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-XTR-159227, Transport of the SLBP independent Mature mRNA
R-XTR-159230, Transport of the SLBP Dependant Mature mRNA
R-XTR-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-XTR-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-XTR-191859, snRNP Assembly
R-XTR-3108214, SUMOylation of DNA damage response and repair proteins
R-XTR-3232142, SUMOylation of ubiquitinylation proteins
R-XTR-3301854, Nuclear Pore Complex (NPC) Disassembly
R-XTR-3371453, Regulation of HSF1-mediated heat shock response
R-XTR-4085377, SUMOylation of SUMOylation proteins
R-XTR-4551638, SUMOylation of chromatin organization proteins
R-XTR-4570464, SUMOylation of RNA binding proteins
R-XTR-4615885, SUMOylation of DNA replication proteins
R-XTR-5578749, Transcriptional regulation by small RNAs
R-XTR-9615933, Postmitotic nuclear pore complex (NPC) reformation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear pore complex protein Nup93
Alternative name(s):
93 kDa nucleoporin
Nucleoporin Nup93
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:nup93
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8364 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000008143 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-5823109, nup93

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Membrane, Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003562971 – 820Nuclear pore complex protein Nup93Add BLAST820

Keywords - PTMi

Phosphoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
8364.ENSXETP00000039971

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NX12

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2168, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NX12

Identification of Orthologs from Complete Genome Data

More...
OMAi
GENYFNA

Database of Orthologous Groups

More...
OrthoDBi
187731at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007231, Nucleoporin_int_Nup93/Nic96

The PANTHER Classification System

More...
PANTHERi
PTHR11225, PTHR11225, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04097, Nic96, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q6NX12-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGEGFGELL QQAEQLAAET EGVTELPHVE RNLQEIQQAG ERLRSKTMTR
60 70 80 90 100
TSQESANVKA SVLLGSRGLD ISHISQRLES LSAATTFEPL EPVKDTDIQG
110 120 130 140 150
FLKNEKDNAL LSAIEESRKR TFVMAEEYHR ESMLVEWEQV KQRVLHTLLA
160 170 180 190 200
SGEDALDFTQ ESETSYISES GAPGRSSLDN VEMAYARQIY MYNEKVVSGH
210 220 230 240 250
LQPSLVELCT EAAERLDDKN VSDLWVMVKQ MTDVPLIPAS DSLKSRCSVQ
260 270 280 290 300
MQMAFLRQAL HFLEQSYKNY TLMSVFANLQ QAQLGGVPGT YNLVRSFLNI
310 320 330 340 350
RLPAPIPGLQ DGEVEGYPVW ALIYYCMRCG DLMAAQQVVN RAQHQLGDFK
360 370 380 390 400
NCFQEYVHSK DRRLSPTTEN KLRLHYRRAV RASTDPYKRV VYCIIGRCDV
410 420 430 440 450
TDNHSEVADK TEDYLWLKLS QVCFEDEANS SPQDRLTLPQ FQKQLFEDYG
460 470 480 490 500
ESHFAVNQQP YLYFQVLFLT AQFEAAIAFL FRLERTRCHA VHVALALFEL
510 520 530 540 550
KLLLKSTGQS AQLLSLEPGD PQGVRHLNFI RLLMLYTRKF EPTDPREALQ
560 570 580 590 600
YFYFLRNEKD SQGESMFLRC VSELVIESRE FDMLLGKLEK DGSRKPGAID
610 620 630 640 650
KFTRDTKTII NKVASVAENK GLFEEAAKLY DLAKNPDKVL ELTNKLLSPV
660 670 680 690 700
VSQISAPQSN RERLKNMALA IAERYKSQGV SAEKSINSTF YLLLDLITFF
710 720 730 740 750
DEYHAGHVDL AFDVIERLKL VPLSQDSVEE RVAAFRNFSD EIRHNLSEIL
760 770 780 790 800
LATMNILFTQ YKRLKGSGPN TLGRPQRAQE DKDSVLRSQA RALITFAGMI
810 820
PYRMSGDTNA RLVQMEVLMN
Length:820
Mass (Da):93,354
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2984D6072677795E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6V4L5F6V4L5_XENTR
Nuclear pore complex protein Nup93
nup93
823Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8PSK7A0A6I8PSK7_XENTR
Nuclear pore complex protein Nup93
nup93
834Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8QX63A0A6I8QX63_XENTR
Nuclear pore complex protein Nup93
nup93
777Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8REI6A0A6I8REI6_XENTR
Nuclear pore complex protein Nup93
nup93
799Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8RT72A0A6I8RT72_XENTR
Nuclear pore complex protein Nup93
nup93
749Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A6I8S8K8A0A6I8S8K8_XENTR
Nuclear pore complex protein Nup93
nup93
805Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC067327 mRNA Translation: AAH67327.1

NCBI Reference Sequences

More...
RefSeqi
NP_998879.1, NM_213714.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
407948

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xtr:407948

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC067327 mRNA Translation: AAH67327.1
RefSeqiNP_998879.1, NM_213714.1

3D structure databases

SMRiQ6NX12
ModBaseiSearch...

Protein-protein interaction databases

STRINGi8364.ENSXETP00000039971

Genome annotation databases

GeneIDi407948
KEGGixtr:407948

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9688
XenbaseiXB-GENE-5823109, nup93

Phylogenomic databases

eggNOGiKOG2168, Eukaryota
InParanoidiQ6NX12
OMAiGENYFNA
OrthoDBi187731at2759

Enzyme and pathway databases

ReactomeiR-XTR-159227, Transport of the SLBP independent Mature mRNA
R-XTR-159230, Transport of the SLBP Dependant Mature mRNA
R-XTR-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-XTR-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript
R-XTR-191859, snRNP Assembly
R-XTR-3108214, SUMOylation of DNA damage response and repair proteins
R-XTR-3232142, SUMOylation of ubiquitinylation proteins
R-XTR-3301854, Nuclear Pore Complex (NPC) Disassembly
R-XTR-3371453, Regulation of HSF1-mediated heat shock response
R-XTR-4085377, SUMOylation of SUMOylation proteins
R-XTR-4551638, SUMOylation of chromatin organization proteins
R-XTR-4570464, SUMOylation of RNA binding proteins
R-XTR-4615885, SUMOylation of DNA replication proteins
R-XTR-5578749, Transcriptional regulation by small RNAs
R-XTR-9615933, Postmitotic nuclear pore complex (NPC) reformation

Family and domain databases

InterProiView protein in InterPro
IPR007231, Nucleoporin_int_Nup93/Nic96
PANTHERiPTHR11225, PTHR11225, 1 hit
PfamiView protein in Pfam
PF04097, Nic96, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNUP93_XENTR
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NX12
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 67 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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