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UniProtKB - Q6NWY9 (PR40B_HUMAN)

Entry version 139 (07 Apr 2021)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Pre-mRNA-processing factor 40 homolog B

Gene

PRPF40B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in pre-mRNA splicing.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • RNA binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q6NWY9

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q6NWY9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Pre-mRNA-processing factor 40 homolog B
Alternative name(s):
Huntingtin yeast partner C
Huntingtin-interacting protein C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRPF40B
Synonyms:HYPC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:25031, PRPF40B

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q6NWY9

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000110844.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		25766

Open Targets

More...OpenTargetsi		ENSG00000110844

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA143485582

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q6NWY9, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRPF40B

Domain mapping of disease mutations (DMDM)

More...DMDMi		74736936

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003092821 – 871Pre-mRNA-processing factor 40 homolog BAdd BLAST871

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei148N6-acetyllysineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei764PhosphoserineCombined sources1
Modified residuei832PhosphoserineCombined sources1
Cross-linki838Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei852PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q6NWY9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q6NWY9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q6NWY9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q6NWY9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q6NWY9

PeptideAtlas

More...PeptideAtlasi		Q6NWY9

PRoteomics IDEntifications database

More...PRIDEi		Q6NWY9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		66741 [Q6NWY9-1]
66742 [Q6NWY9-2]
66743 [Q6NWY9-3]
66744 [Q6NWY9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q6NWY9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q6NWY9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the striatum and cortex of the brain (at protein level). Highly expressed in testis, fetal kidney and fetal brain. Moderately expressed in pancreas, skeletal muscle, placenta, brain and heart. Weakly expressed in colon, ileum, ovary, prostate, spleen, kidney and fetal lung.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000110844, Expressed in left lobe of thyroid gland and 163 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q6NWY9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q6NWY9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000110844, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the N-terminus of HD.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		117305, 16 interactors

Protein interaction database and analysis system

More...IntActi		Q6NWY9, 9 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000448073

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q6NWY9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q6NWY9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini92 – 125WW 1PROSITE-ProRule annotationAdd BLAST34
Domaini133 – 166WW 2PROSITE-ProRule annotationAdd BLAST34
Domaini276 – 330FF 1Add BLAST55
Domaini340 – 397FF 2Add BLAST58
Domaini410 – 470FF 3Add BLAST61
Domaini490 – 550FF 4Add BLAST61
Domaini554 – 610FF 5Add BLAST57
Domaini625 – 682FF 6Add BLAST58

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi3 – 72Pro-richAdd BLAST70

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PRPF40 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0152, Eukaryota
KOG0155, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00930000150980

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q6NWY9

Database of Orthologous Groups

More...OrthoDBi		1112854at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q6NWY9

TreeFam database of animal gene trees

More...TreeFami		TF318732

Family and domain databases

Conserved Domains Database

More...CDDi		cd00201, WW, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.440, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR002713, FF_domain
IPR036517, FF_domain_sf
IPR039726, Prp40-like
IPR001202, WW_dom
IPR036020, WW_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR11864, PTHR11864, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01846, FF, 2 hits
PF00397, WW, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00441, FF, 4 hits
SM00456, WW, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51045, SSF51045, 2 hits
SSF81698, SSF81698, 5 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51676, FF, 6 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NWY9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMPPPFMPPP GIPPPFPPMG LPPMSQRPPA IPPMPPGILP PMLPPMGAPP 
        60         70         80         90        100
PLTQIPGMVP PMMPGMLMPA VPVTAATAPG ADTASSAVAG TGPPRALWSE 
       110        120        130        140        150
HVAPDGRIYY YNADDKQSVW EKPSVLKSKA ELLLSQCPWK EYKSDTGKPY 
       160        170        180        190        200
YYNNQSKESR WTRPKDLDDL EVLVKQEAAG KQQQQLPQTL QPQPPQPQPD 
       210        220        230        240        250
PPPVPPGPTP VPTGLLEPEP GGSEDCDVLE ATQPLEQGFL QQLEEGPSSS 
       260        270        280        290        300
GQHQPQQEEE ESKPEPERSG LSWSNREKAK QAFKELLRDK AVPSNASWEQ 
       310        320        330        340        350
AMKMVVTDPR YSALPKLSEK KQAFNAYKAQ REKEEKEEAR LRAKEAKQTL 
       360        370        380        390        400
QHFLEQHERM TSTTRYRRAE QTFGELEVWA VVPERDRKEV YDDVLFFLAK 
       410        420        430        440        450
KEKEQAKQLR RRNIQALKSI LDGMSSVNFQ TTWSQAQQYL MDNPSFAQDH 
       460        470        480        490        500
QLQNMDKEDA LICFEEHIRA LEREEEEERE RARLRERRQQ RKNREAFQTF 
       510        520        530        540        550
LDELHETGQL HSMSTWMELY PAVSTDVRFA NMLGQPGSTP LDLFKFYVEE 
       560        570        580        590        600
LKARFHDEKK IIKDILKDRG FCVEVNTAFE DFAHVISFDK RAAALDAGNI 
       610        620        630        640        650
KLTFNSLLEK AEAREREREK EEARRMRRRE AAFRSMLRQA VPALELGTAW 
       660        670        680        690        700
EEVRERFVCD SAFEQITLES ERIRLFREFL QVLEQTECQH LHTKGRKHGR 
       710        720        730        740        750
KGKKHHHKRS HSPSGSESEE EELPPPSLRP PKRRRRNPSE SGSEPSSSLD 
       760        770        780        790        800
SVESGGAALG GRGSPSSHLL GADHGLRKAK KPKKKTKKRR HKSNSPESET 
       810        820        830        840        850
DPEEKAGKES DEKEQEQDKD RELQQAELPN RSPGFGIKKE KTGWDTSESE 
       860        870 
LSEGELERRR RTLLQQLDDH Q
Length:871
Mass (Da):99,358
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB62C95BEFB9D23A
GO
Isoform 2 (identifier: Q6NWY9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MMPPPFM → M
     568-574: Missing.

Show »
Length:858
Mass (Da):97,850
Checksum:i6A34A4D6ADD2E352
GO
Isoform 3 (identifier: Q6NWY9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     685-685: Missing.

Show »
Length:870
Mass (Da):99,230
Checksum:iF71680F3A1A304DF
GO
Isoform 4 (identifier: Q6NWY9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-6: MMPPPF → M
     77-200: TAPGADTASS...QPQPPQPQPD → VSTRGQQVAG...CCAFLCYRSV
     201-871: Missing.

Show »
Length:195
Mass (Da):20,892
Checksum:i7CB0B62D1D447348
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VU11F8VU11_HUMAN
PRP40 pre-mRNA processing factor 40...
PRPF40B hCG_20201
892Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YII7H0YII7_HUMAN
Pre-mRNA-processing factor 40 homol...
PRPF40B
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH50398 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB15662 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0291171 – 7MMPPPFM → M in isoform 2. 1 Publication7
Alternative sequenceiVSP_0291161 – 6MMPPPF → M in isoform 4. 1 Publication6
Alternative sequenceiVSP_02912077 – 200TAPGA…QPQPD → VSTRGQQVAGSALQSRESDL ECRTMTSILSLFSSHPPRSP AALPTLKSFSPAMYSALLVS HSSPKAYTFSCYSRALSSSL KEHTYPHRATHCGHMNIVLH ILFVPRRVSSTWGSCCAFLC YRSV in isoform 4. 1 PublicationAdd BLAST124
Alternative sequenceiVSP_029121201 – 871Missing in isoform 4. 1 PublicationAdd BLAST671
Alternative sequenceiVSP_029118568 – 574Missing in isoform 2. 1 Publication7
Alternative sequenceiVSP_029119685Missing in isoform 3. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK027117 mRNA Translation: BAB15662.1 Frameshift.
AK123353 mRNA No translation available.
AL137459 mRNA Translation: CAB70747.1
AL834216 mRNA Translation: CAD38898.1
CH471111 Genomic DNA Translation: EAW58085.1
BC050398 mRNA Translation: AAH50398.1 Sequence problems.
BC067364 mRNA Translation: AAH67364.1
AF049525 mRNA Translation: AAC27503.1

Protein sequence database of the Protein Information Resource

More...PIRi		T46402

NCBI Reference Sequences

More...RefSeqi		NP_001026868.2, NM_001031698.2
NP_036404.1, NM_012272.2 [Q6NWY9-2]
XP_011536443.1, XM_011538141.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000261897; ENSP00000261897; ENSG00000110844 [Q6NWY9-2]
ENST00000380281; ENSP00000369634; ENSG00000110844 [Q6NWY9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		25766

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:25766

UCSC genome browser

More...UCSCi		uc058nrq.1, human [Q6NWY9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027117 mRNA Translation: BAB15662.1 Frameshift.
AK123353 mRNA No translation available.
AL137459 mRNA Translation: CAB70747.1
AL834216 mRNA Translation: CAD38898.1
CH471111 Genomic DNA Translation: EAW58085.1
BC050398 mRNA Translation: AAH50398.1 Sequence problems.
BC067364 mRNA Translation: AAH67364.1
AF049525 mRNA Translation: AAC27503.1
PIRiT46402
RefSeqiNP_001026868.2, NM_001031698.2
NP_036404.1, NM_012272.2 [Q6NWY9-2]
XP_011536443.1, XM_011538141.1

3D structure databases

SMRiQ6NWY9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi117305, 16 interactors
IntActiQ6NWY9, 9 interactors
STRINGi9606.ENSP00000448073

PTM databases

iPTMnetiQ6NWY9
PhosphoSitePlusiQ6NWY9

Genetic variation databases

BioMutaiPRPF40B
DMDMi74736936

Proteomic databases

EPDiQ6NWY9
jPOSTiQ6NWY9
MassIVEiQ6NWY9
MaxQBiQ6NWY9
PaxDbiQ6NWY9
PeptideAtlasiQ6NWY9
PRIDEiQ6NWY9
ProteomicsDBi66741 [Q6NWY9-1]
66742 [Q6NWY9-2]
66743 [Q6NWY9-3]
66744 [Q6NWY9-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		42895, 31 antibodies

Genome annotation databases

EnsembliENST00000261897; ENSP00000261897; ENSG00000110844 [Q6NWY9-2]
ENST00000380281; ENSP00000369634; ENSG00000110844 [Q6NWY9-1]
GeneIDi25766
KEGGihsa:25766
UCSCiuc058nrq.1, human [Q6NWY9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25766
DisGeNETi25766

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRPF40B
HGNCiHGNC:25031, PRPF40B
HPAiENSG00000110844, Low tissue specificity
neXtProtiNX_Q6NWY9
OpenTargetsiENSG00000110844
PharmGKBiPA143485582
VEuPathDBiHostDB:ENSG00000110844.13

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0152, Eukaryota
KOG0155, Eukaryota
GeneTreeiENSGT00930000150980
InParanoidiQ6NWY9
OrthoDBi1112854at2759
PhylomeDBiQ6NWY9
TreeFamiTF318732

Enzyme and pathway databases

PathwayCommonsiQ6NWY9
SignaLinkiQ6NWY9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		25766, 26 hits in 996 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRPF40B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PRPF40B

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		25766
PharosiQ6NWY9, Tdark

Protein Ontology

More...PROi		PR:Q6NWY9
RNActiQ6NWY9, protein

Gene expression databases

BgeeiENSG00000110844, Expressed in left lobe of thyroid gland and 163 other tissues
ExpressionAtlasiQ6NWY9, baseline and differential
GenevisibleiQ6NWY9, HS

Family and domain databases

CDDicd00201, WW, 2 hits
Gene3Di1.10.10.440, 5 hits
InterProiView protein in InterPro
IPR002713, FF_domain
IPR036517, FF_domain_sf
IPR039726, Prp40-like
IPR001202, WW_dom
IPR036020, WW_dom_sf
PANTHERiPTHR11864, PTHR11864, 1 hit
PfamiView protein in Pfam
PF01846, FF, 2 hits
PF00397, WW, 2 hits
SMARTiView protein in SMART
SM00441, FF, 4 hits
SM00456, WW, 2 hits
SUPFAMiSSF51045, SSF51045, 2 hits
SSF81698, SSF81698, 5 hits
PROSITEiView protein in PROSITE
PS51676, FF, 6 hits
PS01159, WW_DOMAIN_1, 1 hit
PS50020, WW_DOMAIN_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPR40B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NWY9
Secondary accession number(s): O75401
, Q6PI09, Q6ZWB3, Q8NCZ1, Q9H5G4, Q9NT95
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: April 7, 2021
This is version 139 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
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