UniProtKB - Q6NWY9 (PR40B_HUMAN)
Protein
Pre-mRNA-processing factor 40 homolog B
Gene
PRPF40B
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in pre-mRNA splicing.1 Publication
GO - Molecular functioni
- RNA binding Source: GO_Central
GO - Biological processi
- mRNA cis splicing, via spliceosome Source: InterPro
- mRNA splicing, via spliceosome Source: GO_Central
Keywordsi
Biological process | mRNA processing, mRNA splicing |
Enzyme and pathway databases
PathwayCommonsi | Q6NWY9 |
SignaLinki | Q6NWY9 |
Names & Taxonomyi
Protein namesi | Recommended name: Pre-mRNA-processing factor 40 homolog BAlternative name(s): Huntingtin yeast partner C Huntingtin-interacting protein C |
Gene namesi | Name:PRPF40B Synonyms:HYPC |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25031, PRPF40B |
neXtProti | NX_Q6NWY9 |
VEuPathDBi | HostDB:ENSG00000110844.13 |
Subcellular locationi
Nucleus
- Nucleus speckle 1 Publication
Nucleus
- nuclear speck Source: UniProtKB-SubCell
- U1 snRNP Source: GO_Central
- U2-type prespliceosome Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 25766 |
OpenTargetsi | ENSG00000110844 |
PharmGKBi | PA143485582 |
Miscellaneous databases
Pharosi | Q6NWY9, Tdark |
Genetic variation databases
BioMutai | PRPF40B |
DMDMi | 74736936 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000309282 | 1 – 871 | Pre-mRNA-processing factor 40 homolog BAdd BLAST | 871 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 148 | N6-acetyllysineCombined sources | 1 | |
Cross-linki | 175 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 764 | PhosphoserineCombined sources | 1 | |
Modified residuei | 832 | PhosphoserineCombined sources | 1 | |
Cross-linki | 838 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 852 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q6NWY9 |
jPOSTi | Q6NWY9 |
MassIVEi | Q6NWY9 |
MaxQBi | Q6NWY9 |
PaxDbi | Q6NWY9 |
PeptideAtlasi | Q6NWY9 |
PRIDEi | Q6NWY9 |
ProteomicsDBi | 66741 [Q6NWY9-1] 66742 [Q6NWY9-2] 66743 [Q6NWY9-3] 66744 [Q6NWY9-4] |
PTM databases
iPTMneti | Q6NWY9 |
PhosphoSitePlusi | Q6NWY9 |
Expressioni
Tissue specificityi
Expressed in the striatum and cortex of the brain (at protein level). Highly expressed in testis, fetal kidney and fetal brain. Moderately expressed in pancreas, skeletal muscle, placenta, brain and heart. Weakly expressed in colon, ileum, ovary, prostate, spleen, kidney and fetal lung.2 Publications
Gene expression databases
Bgeei | ENSG00000110844, Expressed in left lobe of thyroid gland and 163 other tissues |
ExpressionAtlasi | Q6NWY9, baseline and differential |
Genevisiblei | Q6NWY9, HS |
Organism-specific databases
HPAi | ENSG00000110844, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with the N-terminus of HD.
1 PublicationBinary interactionsi
Q6NWY9
With | #Exp. | IntAct |
---|---|---|
FUBP1 - isoform 2 [Q96AE4-2] | 3 | EBI-11285481,EBI-12121668 |
Protein-protein interaction databases
BioGRIDi | 117305, 16 interactors |
IntActi | Q6NWY9, 9 interactors |
STRINGi | 9606.ENSP00000448073 |
Miscellaneous databases
RNActi | Q6NWY9, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 92 – 125 | WW 1PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 133 – 166 | WW 2PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 276 – 330 | FF 1Add BLAST | 55 | |
Domaini | 340 – 397 | FF 2Add BLAST | 58 | |
Domaini | 410 – 470 | FF 3Add BLAST | 61 | |
Domaini | 490 – 550 | FF 4Add BLAST | 61 | |
Domaini | 554 – 610 | FF 5Add BLAST | 57 | |
Domaini | 625 – 682 | FF 6Add BLAST | 58 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 3 – 72 | Pro-richAdd BLAST | 70 |
Sequence similaritiesi
Belongs to the PRPF40 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0152, Eukaryota KOG0155, Eukaryota |
GeneTreei | ENSGT00930000150980 |
InParanoidi | Q6NWY9 |
OrthoDBi | 1112854at2759 |
PhylomeDBi | Q6NWY9 |
TreeFami | TF318732 |
Family and domain databases
CDDi | cd00201, WW, 2 hits |
Gene3Di | 1.10.10.440, 5 hits |
InterProi | View protein in InterPro IPR002713, FF_domain IPR036517, FF_domain_sf IPR039726, Prp40-like IPR001202, WW_dom IPR036020, WW_dom_sf |
PANTHERi | PTHR11864, PTHR11864, 1 hit |
Pfami | View protein in Pfam PF01846, FF, 2 hits PF00397, WW, 2 hits |
SMARTi | View protein in SMART SM00441, FF, 4 hits SM00456, WW, 2 hits |
SUPFAMi | SSF51045, SSF51045, 2 hits SSF81698, SSF81698, 5 hits |
PROSITEi | View protein in PROSITE PS51676, FF, 6 hits PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q6NWY9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MMPPPFMPPP GIPPPFPPMG LPPMSQRPPA IPPMPPGILP PMLPPMGAPP
60 70 80 90 100
PLTQIPGMVP PMMPGMLMPA VPVTAATAPG ADTASSAVAG TGPPRALWSE
110 120 130 140 150
HVAPDGRIYY YNADDKQSVW EKPSVLKSKA ELLLSQCPWK EYKSDTGKPY
160 170 180 190 200
YYNNQSKESR WTRPKDLDDL EVLVKQEAAG KQQQQLPQTL QPQPPQPQPD
210 220 230 240 250
PPPVPPGPTP VPTGLLEPEP GGSEDCDVLE ATQPLEQGFL QQLEEGPSSS
260 270 280 290 300
GQHQPQQEEE ESKPEPERSG LSWSNREKAK QAFKELLRDK AVPSNASWEQ
310 320 330 340 350
AMKMVVTDPR YSALPKLSEK KQAFNAYKAQ REKEEKEEAR LRAKEAKQTL
360 370 380 390 400
QHFLEQHERM TSTTRYRRAE QTFGELEVWA VVPERDRKEV YDDVLFFLAK
410 420 430 440 450
KEKEQAKQLR RRNIQALKSI LDGMSSVNFQ TTWSQAQQYL MDNPSFAQDH
460 470 480 490 500
QLQNMDKEDA LICFEEHIRA LEREEEEERE RARLRERRQQ RKNREAFQTF
510 520 530 540 550
LDELHETGQL HSMSTWMELY PAVSTDVRFA NMLGQPGSTP LDLFKFYVEE
560 570 580 590 600
LKARFHDEKK IIKDILKDRG FCVEVNTAFE DFAHVISFDK RAAALDAGNI
610 620 630 640 650
KLTFNSLLEK AEAREREREK EEARRMRRRE AAFRSMLRQA VPALELGTAW
660 670 680 690 700
EEVRERFVCD SAFEQITLES ERIRLFREFL QVLEQTECQH LHTKGRKHGR
710 720 730 740 750
KGKKHHHKRS HSPSGSESEE EELPPPSLRP PKRRRRNPSE SGSEPSSSLD
760 770 780 790 800
SVESGGAALG GRGSPSSHLL GADHGLRKAK KPKKKTKKRR HKSNSPESET
810 820 830 840 850
DPEEKAGKES DEKEQEQDKD RELQQAELPN RSPGFGIKKE KTGWDTSESE
860 870
LSEGELERRR RTLLQQLDDH Q
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VU11 | F8VU11_HUMAN | PRP40 pre-mRNA processing factor 40... | PRPF40B hCG_20201 | 892 | Annotation score: | ||
H0YII7 | H0YII7_HUMAN | Pre-mRNA-processing factor 40 homol... | PRPF40B | 137 | Annotation score: |
Sequence cautioni
The sequence AAH50398 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAB15662 differs from that shown. Reason: Frameshift.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029117 | 1 – 7 | MMPPPFM → M in isoform 2. 1 Publication | 7 | |
Alternative sequenceiVSP_029116 | 1 – 6 | MMPPPF → M in isoform 4. 1 Publication | 6 | |
Alternative sequenceiVSP_029120 | 77 – 200 | TAPGA…QPQPD → VSTRGQQVAGSALQSRESDL ECRTMTSILSLFSSHPPRSP AALPTLKSFSPAMYSALLVS HSSPKAYTFSCYSRALSSSL KEHTYPHRATHCGHMNIVLH ILFVPRRVSSTWGSCCAFLC YRSV in isoform 4. 1 PublicationAdd BLAST | 124 | |
Alternative sequenceiVSP_029121 | 201 – 871 | Missing in isoform 4. 1 PublicationAdd BLAST | 671 | |
Alternative sequenceiVSP_029118 | 568 – 574 | Missing in isoform 2. 1 Publication | 7 | |
Alternative sequenceiVSP_029119 | 685 | Missing in isoform 3. 3 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027117 mRNA Translation: BAB15662.1 Frameshift. AK123353 mRNA No translation available. AL137459 mRNA Translation: CAB70747.1 AL834216 mRNA Translation: CAD38898.1 CH471111 Genomic DNA Translation: EAW58085.1 BC050398 mRNA Translation: AAH50398.1 Sequence problems. BC067364 mRNA Translation: AAH67364.1 AF049525 mRNA Translation: AAC27503.1 |
PIRi | T46402 |
RefSeqi | NP_001026868.2, NM_001031698.2 NP_036404.1, NM_012272.2 [Q6NWY9-2] XP_011536443.1, XM_011538141.1 |
Genome annotation databases
Ensembli | ENST00000261897; ENSP00000261897; ENSG00000110844 [Q6NWY9-2] ENST00000380281; ENSP00000369634; ENSG00000110844 [Q6NWY9-1] |
GeneIDi | 25766 |
KEGGi | hsa:25766 |
UCSCi | uc058nrq.1, human [Q6NWY9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK027117 mRNA Translation: BAB15662.1 Frameshift. AK123353 mRNA No translation available. AL137459 mRNA Translation: CAB70747.1 AL834216 mRNA Translation: CAD38898.1 CH471111 Genomic DNA Translation: EAW58085.1 BC050398 mRNA Translation: AAH50398.1 Sequence problems. BC067364 mRNA Translation: AAH67364.1 AF049525 mRNA Translation: AAC27503.1 |
PIRi | T46402 |
RefSeqi | NP_001026868.2, NM_001031698.2 NP_036404.1, NM_012272.2 [Q6NWY9-2] XP_011536443.1, XM_011538141.1 |
3D structure databases
SMRi | Q6NWY9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 117305, 16 interactors |
IntActi | Q6NWY9, 9 interactors |
STRINGi | 9606.ENSP00000448073 |
PTM databases
iPTMneti | Q6NWY9 |
PhosphoSitePlusi | Q6NWY9 |
Genetic variation databases
BioMutai | PRPF40B |
DMDMi | 74736936 |
Proteomic databases
EPDi | Q6NWY9 |
jPOSTi | Q6NWY9 |
MassIVEi | Q6NWY9 |
MaxQBi | Q6NWY9 |
PaxDbi | Q6NWY9 |
PeptideAtlasi | Q6NWY9 |
PRIDEi | Q6NWY9 |
ProteomicsDBi | 66741 [Q6NWY9-1] 66742 [Q6NWY9-2] 66743 [Q6NWY9-3] 66744 [Q6NWY9-4] |
Protocols and materials databases
Antibodypediai | 42895, 31 antibodies |
Genome annotation databases
Ensembli | ENST00000261897; ENSP00000261897; ENSG00000110844 [Q6NWY9-2] ENST00000380281; ENSP00000369634; ENSG00000110844 [Q6NWY9-1] |
GeneIDi | 25766 |
KEGGi | hsa:25766 |
UCSCi | uc058nrq.1, human [Q6NWY9-1] |
Organism-specific databases
CTDi | 25766 |
DisGeNETi | 25766 |
GeneCardsi | PRPF40B |
HGNCi | HGNC:25031, PRPF40B |
HPAi | ENSG00000110844, Low tissue specificity |
neXtProti | NX_Q6NWY9 |
OpenTargetsi | ENSG00000110844 |
PharmGKBi | PA143485582 |
VEuPathDBi | HostDB:ENSG00000110844.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0152, Eukaryota KOG0155, Eukaryota |
GeneTreei | ENSGT00930000150980 |
InParanoidi | Q6NWY9 |
OrthoDBi | 1112854at2759 |
PhylomeDBi | Q6NWY9 |
TreeFami | TF318732 |
Enzyme and pathway databases
PathwayCommonsi | Q6NWY9 |
SignaLinki | Q6NWY9 |
Miscellaneous databases
BioGRID-ORCSi | 25766, 26 hits in 996 CRISPR screens |
ChiTaRSi | PRPF40B, human |
GeneWikii | PRPF40B |
GenomeRNAii | 25766 |
Pharosi | Q6NWY9, Tdark |
PROi | PR:Q6NWY9 |
RNActi | Q6NWY9, protein |
Gene expression databases
Bgeei | ENSG00000110844, Expressed in left lobe of thyroid gland and 163 other tissues |
ExpressionAtlasi | Q6NWY9, baseline and differential |
Genevisiblei | Q6NWY9, HS |
Family and domain databases
CDDi | cd00201, WW, 2 hits |
Gene3Di | 1.10.10.440, 5 hits |
InterProi | View protein in InterPro IPR002713, FF_domain IPR036517, FF_domain_sf IPR039726, Prp40-like IPR001202, WW_dom IPR036020, WW_dom_sf |
PANTHERi | PTHR11864, PTHR11864, 1 hit |
Pfami | View protein in Pfam PF01846, FF, 2 hits PF00397, WW, 2 hits |
SMARTi | View protein in SMART SM00441, FF, 4 hits SM00456, WW, 2 hits |
SUPFAMi | SSF51045, SSF51045, 2 hits SSF81698, SSF81698, 5 hits |
PROSITEi | View protein in PROSITE PS51676, FF, 6 hits PS01159, WW_DOMAIN_1, 1 hit PS50020, WW_DOMAIN_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PR40B_HUMAN | |
Accessioni | Q6NWY9Primary (citable) accession number: Q6NWY9 Secondary accession number(s): O75401 Q9NT95 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 13, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | April 7, 2021 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families