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Protein

Kinesin-like protein KIF24

Gene

Kif24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of microtubules of centriolar origin, possibly to suppress aberrant cilia formation. Following activation by NEK2 involved in disassembly of primary cilium during G2/M phase but does not disassemble fully formed ciliary axonemes. As cilium assembly and disassembly is proposed to coexist in a dynamic equilibrium may suppress nascent cilium assembly and, potentially, ciliar re-assembly in cells that have already disassembled their cilia ensuring the completion of cilium removal in the later stages of the cell cycle (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi308 – 315ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity Source: GO_Central
  • ATP binding Source: UniProtKB-KW
  • identical protein binding Source: MGI
  • microtubule binding Source: GO_Central
  • microtubule motor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processCilium biogenesis/degradation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-5620912 Anchoring of the basal body to the plasma membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF24
Gene namesi
Name:Kif24
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1918345 Kif24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002782491 – 1356Kinesin-like protein KIF24Add BLAST1356

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei102PhosphoserineBy similarity1
Modified residuei473PhosphoserineBy similarity1
Modified residuei579PhosphoserineCombined sources1
Modified residuei615Phosphothreonine; by NEK2By similarity1
Modified residuei616Phosphoserine; by NEK2By similarity1
Modified residuei640PhosphoserineCombined sources1
Modified residuei817PhosphoserineCombined sources1
Modified residuei820PhosphoserineCombined sources1
Modified residuei1008PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6NWW5
PeptideAtlasiQ6NWW5
PRIDEiQ6NWW5

PTM databases

iPTMnetiQ6NWW5
PhosphoSitePlusiQ6NWW5

Expressioni

Tissue specificityi

Expressed in brain, spinal cord, and small intestine.1 Publication

Gene expression databases

BgeeiENSMUSG00000028438 Expressed in 148 organ(s), highest expression level in bone marrow
CleanExiMM_KIF24
ExpressionAtlasiQ6NWW5 baseline and differential
GenevisibleiQ6NWW5 MM

Interactioni

Subunit structurei

Interacts with CCP110, CEP97, TALPID3.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103690

Structurei

3D structure databases

ProteinModelPortaliQ6NWW5
SMRiQ6NWW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 64SAMPROSITE-ProRule annotationAdd BLAST64
Domaini218 – 541Kinesin motorPROSITE-ProRule annotationAdd BLAST324

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0246 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150912
HOGENOMiHOG000232152
HOVERGENiHBG080392
InParanoidiQ6NWW5
KOiK10393
OMAiEWVIQTS
OrthoDBiEOG091G06V3
PhylomeDBiQ6NWW5
TreeFamiTF336001

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NWW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASWLYECLC EAELAQYYPH FTALGLQKID ELAKVTMKDY SRLGVHDMND
60 70 80 90 100
RKRLFQLIKI IKIMQEEDKA LGIPEHPLQA SSLYTKPREF RSGPRRQLHF
110 120 130 140 150
DSPSASKDKM ANNETGSLSN FSVDEQKSTY LKVLEHMLPD DSQCQTKIRA
160 170 180 190 200
PDASAADASM QTETNAPLFS SNYFSPQLGN CDIPVIQRVS HVSGYNYGIP
210 220 230 240 250
HSCVRQITSE NPWTEMEKIR VCVRKRPLGV REVRRGEVNV ITVEDKETLL
260 270 280 290 300
VHEKKEAVDL TQYILQHVFY FDEVFGEACS NQDVYLKTAH PLIQHIFNGG
310 320 330 340 350
SATCFAYGQT GAGKTYTMIG THQNPGLYAL AAKDIFRQLK VSQSRRNLFV
360 370 380 390 400
WISFYEIYCG QLYDLLNRRK RLFAREDSKH VVQIAGLREL QVDSVELLLQ
410 420 430 440 450
VILKGSKERS TGATGVNADS SRSHAIIQIQ IKDSAKRTFG RISFIDLAGS
460 470 480 490 500
ERAADARDSD RQTKMEGAEI NQSLLALKEC IRALDQEHTH TPFRQSKLTQ
510 520 530 540 550
VLKDSFIGNA KTCMIANISP SHIATEHTLN TLRYADRVKE LKKGVKCCAS
560 570 580 590 600
ATSQNQTSAN ASPKRIQSSP VTLPGDKCSP KKVKLGLQQS LTVAPGPTKV
610 620 630 640 650
KAHPLASHVP NVPFTSGPKT PGKKSSSRGS PTPEWDMKAS PRKGTTRSGH
660 670 680 690 700
SIKKGAESAP LCSEKSQIGS KIAVGWEGRA SDPGEGLLRV RLPTRGKKVQ
710 720 730 740 750
PVQPVQKQLL SRPRLLANSH HLEATQDSKV GTPAGLAPEA WTNPILQQKE
760 770 780 790 800
REEHLRFYHQ QFQQPPLLKQ KLNYQPLQRL LCQHRPSEGR LQSETGFPLH
810 820 830 840 850
SNPENRDGAQ AEDLDDSDFS EDSFSHGSSQ PAMKQGSTAL ERSGSSFFLH
860 870 880 890 900
QDREHSPEEQ AAERQQCLLF SSETDGSKKR PADSWVYSRD PIISHRRGAL
910 920 930 940 950
SQSHSPSMVC PDWSKEEDSA SSGPSPKDNR AQKPSSSQVD FVHHQKPGEA
960 970 980 990 1000
QVSDIRLEAF TSEVPEQAEG SLSSPSPENG LSFPLSHVAV SGSPDQRDRV
1010 1020 1030 1040 1050
CTPLREVSEN RVTHTPGRVN SSTPFQEDSG EQIQMCSANA SGLMAPLTMS
1060 1070 1080 1090 1100
LLETPCHEDL SSLEQIAQDG AGYGFMAEIV GGPAAGHTVP SYDQEAALPV
1110 1120 1130 1140 1150
SSATECLWLS SSPPDNRPSG DLPALSPSPI HQHSPDKLPG REAYQTRRPI
1160 1170 1180 1190 1200
LLPENHMGSK LYDDRAEETE LGGSLTFPRK PSSNIHAGVP YSTPFLTSCT
1210 1220 1230 1240 1250
GSSNGVGRPW AQERKHPTGV SCQELVSSTD SNKPHYNEDI AWLRHRPISR
1260 1270 1280 1290 1300
CLDSDSPVVP SCSSKALRTY CPLTPEQAQQ VIIRAHKEQL DEMAELDLKE
1310 1320 1330 1340 1350
ETLMTQMDSN DFEDFVTQLD EIMALKSRCI QSLRSQLQLY LTSHRPAAAP

ERTVVS
Length:1,356
Mass (Da):150,207
Last modified:February 20, 2007 - v2
Checksum:iCA1009620C23BF43
GO
Isoform 2 (identifier: Q6NWW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     265-398: Missing.

Show »
Length:1,222
Mass (Da):134,855
Checksum:i7CBCEDE7C7BBDA72
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2BGK7A2BGK7_MOUSE
Kinesin-like protein KIF24
Kif24
141Annotation score:

Sequence cautioni

The sequence AAH67395 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC39323 differs from that shown. Reason: Erroneous termination at position 997. Translated as Arg.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti413A → T in BAC39323 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023214265 – 398Missing in isoform 2. 1 PublicationAdd BLAST134

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084967 mRNA Translation: BAC39323.1 Sequence problems.
AL807823, BX470237 Genomic DNA Translation: CAM20982.1
BX470237, AL807823 Genomic DNA Translation: CAM23927.1
BC067395 mRNA Translation: AAH67395.1 Different initiation.
AB054028 Genomic DNA Translation: BAB32492.1
CCDSiCCDS18060.2 [Q6NWW5-1]
RefSeqiNP_077203.2, NM_024241.2 [Q6NWW5-1]
XP_006537612.1, XM_006537549.3 [Q6NWW5-1]
XP_011248205.1, XM_011249903.2 [Q6NWW5-1]
UniGeneiMm.370288

Genome annotation databases

EnsembliENSMUST00000030148; ENSMUSP00000030148; ENSMUSG00000028438 [Q6NWW5-2]
ENSMUST00000108055; ENSMUSP00000103690; ENSMUSG00000028438 [Q6NWW5-1]
GeneIDi109242
KEGGimmu:109242
UCSCiuc008sio.1 mouse [Q6NWW5-1]
uc012dcb.1 mouse [Q6NWW5-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084967 mRNA Translation: BAC39323.1 Sequence problems.
AL807823, BX470237 Genomic DNA Translation: CAM20982.1
BX470237, AL807823 Genomic DNA Translation: CAM23927.1
BC067395 mRNA Translation: AAH67395.1 Different initiation.
AB054028 Genomic DNA Translation: BAB32492.1
CCDSiCCDS18060.2 [Q6NWW5-1]
RefSeqiNP_077203.2, NM_024241.2 [Q6NWW5-1]
XP_006537612.1, XM_006537549.3 [Q6NWW5-1]
XP_011248205.1, XM_011249903.2 [Q6NWW5-1]
UniGeneiMm.370288

3D structure databases

ProteinModelPortaliQ6NWW5
SMRiQ6NWW5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000103690

PTM databases

iPTMnetiQ6NWW5
PhosphoSitePlusiQ6NWW5

Proteomic databases

PaxDbiQ6NWW5
PeptideAtlasiQ6NWW5
PRIDEiQ6NWW5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030148; ENSMUSP00000030148; ENSMUSG00000028438 [Q6NWW5-2]
ENSMUST00000108055; ENSMUSP00000103690; ENSMUSG00000028438 [Q6NWW5-1]
GeneIDi109242
KEGGimmu:109242
UCSCiuc008sio.1 mouse [Q6NWW5-1]
uc012dcb.1 mouse [Q6NWW5-2]

Organism-specific databases

CTDi347240
MGIiMGI:1918345 Kif24

Phylogenomic databases

eggNOGiKOG0246 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00930000150912
HOGENOMiHOG000232152
HOVERGENiHBG080392
InParanoidiQ6NWW5
KOiK10393
OMAiEWVIQTS
OrthoDBiEOG091G06V3
PhylomeDBiQ6NWW5
TreeFamiTF336001

Enzyme and pathway databases

ReactomeiR-MMU-5620912 Anchoring of the basal body to the plasma membrane

Miscellaneous databases

ChiTaRSiKif24 mouse
PROiPR:Q6NWW5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028438 Expressed in 148 organ(s), highest expression level in bone marrow
CleanExiMM_KIF24
ExpressionAtlasiQ6NWW5 baseline and differential
GenevisibleiQ6NWW5 MM

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR001660 SAM
IPR013761 SAM/pointed_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
PS50105 SAM_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIF24_MOUSE
AccessioniPrimary (citable) accession number: Q6NWW5
Secondary accession number(s): A2BGK6, Q8BUI2, Q99PT7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: February 20, 2007
Last modified: November 7, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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