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UniProtKB - Q6NWU0 (Q6NWU0_HUMAN)
Protein
Cytochrome P450
Gene
CYP2D6
Organism
Homo sapiens (Human)
Status
Functioni
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
UniRule annotationCofactori
hemeUniRule annotationARBA annotation
GO - Molecular functioni
- aromatase activity Source: UniProtKB-EC
- heme binding Source: UniProtKB-UniRule
- iron ion binding Source: UniProtKB-UniRule
Keywordsi
Molecular function | MonooxygenaseUniRule annotation, Oxidoreductase |
Ligand | HemeUniRule annotationARBA annotation, Iron, Metal-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2625, CYP2D6 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane UniRule annotation
- Microsome membrane UniRule annotation
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 6 – 23 | HelicalSequence analysisAdd BLAST | 18 |
Keywords - Cellular componenti
MembraneStructurei
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisFamily and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008069, Cyt_P450_E_grp-I_CYP2D-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01686, EP450ICYP2D PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
Q6NWU0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD
60 70 80 90 100
FQNTPYCFDQ LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD
110 120 130 140 150
RPPVPITQIL GFGPRSQGVF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE
160 170 180 190 200
QWVTEEAACL CAAFANHSGR PFRPNGLLDK AVSNVIASLT CGRRFEYDDP
210 220 230 240 250
RFLRLLDLAQ EGLKEESGFL REVLNAVPVL LHIPALAGKV LRFQKAFLTQ
260 270 280 290 300
LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLCIVVA
310 320 330 340 350
DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ
360 370 380 390 400
AHMPYTTAVI HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS
410 420 430 440 450
SVLKDEAVWE KPFRFHPEHF LDAQGHFVKP EAFLPFSAGR RACLGEPLAR
460 470 480 490
MELFLFFTSL LQHFSFSVPT GQPRPSHHGV FAFLVTPSPY ELCAVPR
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP10635 | CP2D6_HUMAN | Cytochrome P450 2D6 | CYP2D6 CYP2DL1 | 497 | Annotation score: | ||
Q38LG0 | Q38LG0_HUMAN | Cytochrome P450 | CYP2D6 | 497 | Annotation score: | ||
C1ID54 | C1ID54_HUMAN | Cytochrome P450 | CYP2D6 | 497 | Annotation score: | ||
A0A1B0GUD8 | A0A1B0GUD8_HUMAN | Cytochrome P450 | CYP2D6 | 180 | Annotation score: | ||
H7BY38 | H7BY38_HUMAN | Cytochrome P450 | CYP2D6 | 180 | Annotation score: | ||
A0A1B0GU72 | A0A1B0GU72_HUMAN | Cytochrome P450 | CYP2D6 | 494 | Annotation score: | ||
A0A0G2JSD7 | A0A0G2JSD7_HUMAN | Cytochrome P450 | CYP2D6 | 494 | Annotation score: | ||
A0A1B0GV74 | A0A1B0GV74_HUMAN | Cytochrome P450 2D6 | CYP2D6 | 446 | Annotation score: | ||
A0A0G2JLK7 | A0A0G2JLK7_HUMAN | Cytochrome P450 2D6 | CYP2D6 | 446 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX247885 Genomic DNA No translation available. BC067432 mRNA Translation: AAH67432.1 BC126858 mRNA Translation: AAI26859.1 DQ282147 Genomic DNA Translation: ABB77898.1 DQ282156 Genomic DNA Translation: ABB77904.1 DQ282160 Genomic DNA Translation: ABB77908.1 GU586995 Genomic DNA Translation: ADF36226.1 GU587005 Genomic DNA Translation: ADF36236.1 GU587008 Genomic DNA Translation: ADF36239.1 GU587009 Genomic DNA Translation: ADF36240.1 GU587010 Genomic DNA Translation: ADF36241.1 GU587011 Genomic DNA Translation: ADF36242.1 GU587012 Genomic DNA Translation: ADF36243.1 GU587013 Genomic DNA Translation: ADF36244.1 GU587018 Genomic DNA Translation: ADF36249.1 GU587021 Genomic DNA Translation: ADF36252.1 GU587022 Genomic DNA Translation: ADF36253.1 GU587028 Genomic DNA Translation: ADF36259.1 GU587029 Genomic DNA Translation: ADF36260.1 GU587030 Genomic DNA Translation: ADF36261.1 GU587031 Genomic DNA Translation: ADF36262.1 GU587036 Genomic DNA Translation: ADF36267.1 GU587037 Genomic DNA Translation: ADF36268.1 GU587050 Genomic DNA Translation: ADF36281.1 GU587052 Genomic DNA Translation: ADF36283.1 GU587059 Genomic DNA Translation: ADF36290.1 GU587062 Genomic DNA Translation: ADF36293.1 GU587064 Genomic DNA Translation: ADF36295.1 GU587066 Genomic DNA Translation: ADF36297.1 GU587069 Genomic DNA Translation: ADF36299.1 GU587075 Genomic DNA Translation: ADF36304.1 GU587079 Genomic DNA Translation: ADF36308.1 GU587081 Genomic DNA Translation: ADF36310.1 GU587093 Genomic DNA Translation: ADF36322.1 GU587094 Genomic DNA Translation: ADF36323.1 GU587104 Genomic DNA Translation: ADF36332.1 GU587114 Genomic DNA Translation: ADF36342.1 GU587115 Genomic DNA Translation: ADF36343.1 GU587118 Genomic DNA Translation: ADF36346.1 GU587129 Genomic DNA Translation: ADF36356.1 GU587132 Genomic DNA Translation: ADF36359.1 GU587133 Genomic DNA Translation: ADF36360.1 GU587135 Genomic DNA Translation: ADF36362.1 GU587136 Genomic DNA Translation: ADF36363.1 GU587138 Genomic DNA Translation: ADF36364.1 GU587139 Genomic DNA Translation: ADF36365.1 GU587141 Genomic DNA Translation: ADF36367.1 GU587144 Genomic DNA Translation: ADF36370.1 GU587148 Genomic DNA Translation: ADF36374.1 GU587152 Genomic DNA Translation: ADF36378.1 GU587154 Genomic DNA Translation: ADF36380.1 GU587173 Genomic DNA Translation: ADF36399.1 GU587178 Genomic DNA Translation: ADF36404.1 GU587180 Genomic DNA Translation: ADF36406.1 GU587183 Genomic DNA Translation: ADF36409.1 GU587184 Genomic DNA Translation: ADF36410.1 GU587195 Genomic DNA Translation: ADF36421.1 GU587198 Genomic DNA Translation: ADF36424.1 GU587199 Genomic DNA Translation: ADF36425.1 GU587201 Genomic DNA Translation: ADF36427.1 GU587206 Genomic DNA Translation: ADF36432.1 GU587207 Genomic DNA Translation: ADF36433.1 GU587208 Genomic DNA Translation: ADF36434.1 GU587212 Genomic DNA Translation: ADF36438.1 GU587213 Genomic DNA Translation: ADF36439.1 GU587216 Genomic DNA Translation: ADF36442.1 GU587218 Genomic DNA Translation: ADF36444.1 GU587219 Genomic DNA Translation: ADF36445.1 GU587220 Genomic DNA Translation: ADF36446.1 GU587221 Genomic DNA Translation: ADF36447.1 GU587225 Genomic DNA Translation: ADF36451.1 GU587231 Genomic DNA Translation: ADF36457.1 GU587240 Genomic DNA Translation: ADF36466.1 GU587241 Genomic DNA Translation: ADF36467.1 GU587243 Genomic DNA Translation: ADF36469.1 GU587247 Genomic DNA Translation: ADF36473.1 GU587249 Genomic DNA Translation: ADF36475.1 GU587253 Genomic DNA Translation: ADF36479.1 GU587254 Genomic DNA Translation: ADF36480.1 JQ421296 Genomic DNA Translation: AFB69499.1 JN716373 Genomic DNA Translation: AFC77926.1 JN716374 Genomic DNA Translation: AFC77927.1 JN716375 Genomic DNA Translation: AFC77928.1 JN716376 Genomic DNA Translation: AFC77929.1 KF751826 Genomic DNA Translation: AIA09568.1 KR005632 Genomic DNA Translation: AKH44766.1 KU531563 Genomic DNA Translation: ANW61981.1 KU531564 Genomic DNA Translation: ANW61982.1 MT199339 Genomic DNA Translation: QRV61426.1 MT199340 Genomic DNA Translation: QRV61427.1 |
Genome annotation databases
Ensembli | ENST00000615454.4; ENSP00000479867.1; ENSG00000275211.4 |
UCSCi | uc032qyr.2, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BX247885 Genomic DNA No translation available. BC067432 mRNA Translation: AAH67432.1 BC126858 mRNA Translation: AAI26859.1 DQ282147 Genomic DNA Translation: ABB77898.1 DQ282156 Genomic DNA Translation: ABB77904.1 DQ282160 Genomic DNA Translation: ABB77908.1 GU586995 Genomic DNA Translation: ADF36226.1 GU587005 Genomic DNA Translation: ADF36236.1 GU587008 Genomic DNA Translation: ADF36239.1 GU587009 Genomic DNA Translation: ADF36240.1 GU587010 Genomic DNA Translation: ADF36241.1 GU587011 Genomic DNA Translation: ADF36242.1 GU587012 Genomic DNA Translation: ADF36243.1 GU587013 Genomic DNA Translation: ADF36244.1 GU587018 Genomic DNA Translation: ADF36249.1 GU587021 Genomic DNA Translation: ADF36252.1 GU587022 Genomic DNA Translation: ADF36253.1 GU587028 Genomic DNA Translation: ADF36259.1 GU587029 Genomic DNA Translation: ADF36260.1 GU587030 Genomic DNA Translation: ADF36261.1 GU587031 Genomic DNA Translation: ADF36262.1 GU587036 Genomic DNA Translation: ADF36267.1 GU587037 Genomic DNA Translation: ADF36268.1 GU587050 Genomic DNA Translation: ADF36281.1 GU587052 Genomic DNA Translation: ADF36283.1 GU587059 Genomic DNA Translation: ADF36290.1 GU587062 Genomic DNA Translation: ADF36293.1 GU587064 Genomic DNA Translation: ADF36295.1 GU587066 Genomic DNA Translation: ADF36297.1 GU587069 Genomic DNA Translation: ADF36299.1 GU587075 Genomic DNA Translation: ADF36304.1 GU587079 Genomic DNA Translation: ADF36308.1 GU587081 Genomic DNA Translation: ADF36310.1 GU587093 Genomic DNA Translation: ADF36322.1 GU587094 Genomic DNA Translation: ADF36323.1 GU587104 Genomic DNA Translation: ADF36332.1 GU587114 Genomic DNA Translation: ADF36342.1 GU587115 Genomic DNA Translation: ADF36343.1 GU587118 Genomic DNA Translation: ADF36346.1 GU587129 Genomic DNA Translation: ADF36356.1 GU587132 Genomic DNA Translation: ADF36359.1 GU587133 Genomic DNA Translation: ADF36360.1 GU587135 Genomic DNA Translation: ADF36362.1 GU587136 Genomic DNA Translation: ADF36363.1 GU587138 Genomic DNA Translation: ADF36364.1 GU587139 Genomic DNA Translation: ADF36365.1 GU587141 Genomic DNA Translation: ADF36367.1 GU587144 Genomic DNA Translation: ADF36370.1 GU587148 Genomic DNA Translation: ADF36374.1 GU587152 Genomic DNA Translation: ADF36378.1 GU587154 Genomic DNA Translation: ADF36380.1 GU587173 Genomic DNA Translation: ADF36399.1 GU587178 Genomic DNA Translation: ADF36404.1 GU587180 Genomic DNA Translation: ADF36406.1 GU587183 Genomic DNA Translation: ADF36409.1 GU587184 Genomic DNA Translation: ADF36410.1 GU587195 Genomic DNA Translation: ADF36421.1 GU587198 Genomic DNA Translation: ADF36424.1 GU587199 Genomic DNA Translation: ADF36425.1 GU587201 Genomic DNA Translation: ADF36427.1 GU587206 Genomic DNA Translation: ADF36432.1 GU587207 Genomic DNA Translation: ADF36433.1 GU587208 Genomic DNA Translation: ADF36434.1 GU587212 Genomic DNA Translation: ADF36438.1 GU587213 Genomic DNA Translation: ADF36439.1 GU587216 Genomic DNA Translation: ADF36442.1 GU587218 Genomic DNA Translation: ADF36444.1 GU587219 Genomic DNA Translation: ADF36445.1 GU587220 Genomic DNA Translation: ADF36446.1 GU587221 Genomic DNA Translation: ADF36447.1 GU587225 Genomic DNA Translation: ADF36451.1 GU587231 Genomic DNA Translation: ADF36457.1 GU587240 Genomic DNA Translation: ADF36466.1 GU587241 Genomic DNA Translation: ADF36467.1 GU587243 Genomic DNA Translation: ADF36469.1 GU587247 Genomic DNA Translation: ADF36473.1 GU587249 Genomic DNA Translation: ADF36475.1 GU587253 Genomic DNA Translation: ADF36479.1 GU587254 Genomic DNA Translation: ADF36480.1 JQ421296 Genomic DNA Translation: AFB69499.1 JN716373 Genomic DNA Translation: AFC77926.1 JN716374 Genomic DNA Translation: AFC77927.1 JN716375 Genomic DNA Translation: AFC77928.1 JN716376 Genomic DNA Translation: AFC77929.1 KF751826 Genomic DNA Translation: AIA09568.1 KR005632 Genomic DNA Translation: AKH44766.1 KU531563 Genomic DNA Translation: ANW61981.1 KU531564 Genomic DNA Translation: ANW61982.1 MT199339 Genomic DNA Translation: QRV61426.1 MT199340 Genomic DNA Translation: QRV61427.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protocols and materials databases
DNASUi | 1565 |
Genome annotation databases
Ensembli | ENST00000615454.4; ENSP00000479867.1; ENSG00000275211.4 |
UCSCi | uc032qyr.2, human |
Organism-specific databases
HGNCi | HGNC:2625, CYP2D6 |
PharmGKBi | PA128 |
GenAtlasi | Search... |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008069, Cyt_P450_E_grp-I_CYP2D-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01686, EP450ICYP2D PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | Q6NWU0_HUMAN | |
Accessioni | Q6NWU0Primary (citable) accession number: Q6NWU0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2004 |
Last sequence update: | July 5, 2004 | |
Last modified: | May 25, 2022 | |
This is version 163 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |