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UniProtKB - Q6NWU0 (Q6NWU0_HUMAN)

Entry version 163 (25 May 2022)
Sequence version 1 (05 Jul 2004)
Previous versions | rss
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Protein

Cytochrome P450

Gene

CYP2D6

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

UniRule annotation

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

hemeUniRule annotationARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMonooxygenaseUniRule annotation, Oxidoreductase
LigandHemeUniRule annotationARBA annotation, Iron, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cytochrome P450UniRule annotation (EC:1.14.14.-UniRule annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CYP2D6Imported
Synonyms:cyp2d6Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:2625, CYP2D6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei6 – 23HelicalSequence analysisAdd BLAST18

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA128

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytochrome P450 family.UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.630.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR008069, Cyt_P450_E_grp-I_CYP2D-like
IPR036396, Cyt_P450_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00067, p450, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00463, EP450I
PR01686, EP450ICYP2D
PR00385, P450

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48264, SSF48264, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q6NWU0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLEALVPLA VIVAIFLLLV DLMHRRQRWA ARYPPGPLPL PGLGNLLHVD 
        60         70         80         90        100
FQNTPYCFDQ LRRRFGDVFS LQLAWTPVVV LNGLAAVREA LVTHGEDTAD 
       110        120        130        140        150
RPPVPITQIL GFGPRSQGVF LARYGPAWRE QRRFSVSTLR NLGLGKKSLE 
       160        170        180        190        200
QWVTEEAACL CAAFANHSGR PFRPNGLLDK AVSNVIASLT CGRRFEYDDP 
       210        220        230        240        250
RFLRLLDLAQ EGLKEESGFL REVLNAVPVL LHIPALAGKV LRFQKAFLTQ 
       260        270        280        290        300
LDELLTEHRM TWDPAQPPRD LTEAFLAEME KAKGNPESSF NDENLCIVVA 
       310        320        330        340        350
DLFSAGMVTT STTLAWGLLL MILHPDVQRR VQQEIDDVIG QVRRPEMGDQ 
       360        370        380        390        400
AHMPYTTAVI HEVQRFGDIV PLGVTHMTSR DIEVQGFRIP KGTTLITNLS 
       410        420        430        440        450
SVLKDEAVWE KPFRFHPEHF LDAQGHFVKP EAFLPFSAGR RACLGEPLAR 
       460        470        480        490 
MELFLFFTSL LQHFSFSVPT GQPRPSHHGV FAFLVTPSPY ELCAVPR
Length:497
Mass (Da):55,730
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i484E013AE3E6D1C9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P10635CP2D6_HUMAN
Cytochrome P450 2D6
CYP2D6 CYP2DL1
497Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q38LG0Q38LG0_HUMAN
Cytochrome P450
CYP2D6
497Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C1ID54C1ID54_HUMAN
Cytochrome P450
CYP2D6
497Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GUD8A0A1B0GUD8_HUMAN
Cytochrome P450
CYP2D6
180Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BY38H7BY38_HUMAN
Cytochrome P450
CYP2D6
180Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GU72A0A1B0GU72_HUMAN
Cytochrome P450
CYP2D6
494Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JSD7A0A0G2JSD7_HUMAN
Cytochrome P450
CYP2D6
494Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1B0GV74A0A1B0GV74_HUMAN
Cytochrome P450 2D6
CYP2D6
446Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JLK7A0A0G2JLK7_HUMAN
Cytochrome P450 2D6
CYP2D6
446Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
BX247885 Genomic DNA No translation available.
BC067432 mRNA Translation: AAH67432.1
BC126858 mRNA Translation: AAI26859.1
DQ282147 Genomic DNA Translation: ABB77898.1
DQ282156 Genomic DNA Translation: ABB77904.1
DQ282160 Genomic DNA Translation: ABB77908.1
GU586995 Genomic DNA Translation: ADF36226.1
GU587005 Genomic DNA Translation: ADF36236.1
GU587008 Genomic DNA Translation: ADF36239.1
GU587009 Genomic DNA Translation: ADF36240.1
GU587010 Genomic DNA Translation: ADF36241.1
GU587011 Genomic DNA Translation: ADF36242.1
GU587012 Genomic DNA Translation: ADF36243.1
GU587013 Genomic DNA Translation: ADF36244.1
GU587018 Genomic DNA Translation: ADF36249.1
GU587021 Genomic DNA Translation: ADF36252.1
GU587022 Genomic DNA Translation: ADF36253.1
GU587028 Genomic DNA Translation: ADF36259.1
GU587029 Genomic DNA Translation: ADF36260.1
GU587030 Genomic DNA Translation: ADF36261.1
GU587031 Genomic DNA Translation: ADF36262.1
GU587036 Genomic DNA Translation: ADF36267.1
GU587037 Genomic DNA Translation: ADF36268.1
GU587050 Genomic DNA Translation: ADF36281.1
GU587052 Genomic DNA Translation: ADF36283.1
GU587059 Genomic DNA Translation: ADF36290.1
GU587062 Genomic DNA Translation: ADF36293.1
GU587064 Genomic DNA Translation: ADF36295.1
GU587066 Genomic DNA Translation: ADF36297.1
GU587069 Genomic DNA Translation: ADF36299.1
GU587075 Genomic DNA Translation: ADF36304.1
GU587079 Genomic DNA Translation: ADF36308.1
GU587081 Genomic DNA Translation: ADF36310.1
GU587093 Genomic DNA Translation: ADF36322.1
GU587094 Genomic DNA Translation: ADF36323.1
GU587104 Genomic DNA Translation: ADF36332.1
GU587114 Genomic DNA Translation: ADF36342.1
GU587115 Genomic DNA Translation: ADF36343.1
GU587118 Genomic DNA Translation: ADF36346.1
GU587129 Genomic DNA Translation: ADF36356.1
GU587132 Genomic DNA Translation: ADF36359.1
GU587133 Genomic DNA Translation: ADF36360.1
GU587135 Genomic DNA Translation: ADF36362.1
GU587136 Genomic DNA Translation: ADF36363.1
GU587138 Genomic DNA Translation: ADF36364.1
GU587139 Genomic DNA Translation: ADF36365.1
GU587141 Genomic DNA Translation: ADF36367.1
GU587144 Genomic DNA Translation: ADF36370.1
GU587148 Genomic DNA Translation: ADF36374.1
GU587152 Genomic DNA Translation: ADF36378.1
GU587154 Genomic DNA Translation: ADF36380.1
GU587173 Genomic DNA Translation: ADF36399.1
GU587178 Genomic DNA Translation: ADF36404.1
GU587180 Genomic DNA Translation: ADF36406.1
GU587183 Genomic DNA Translation: ADF36409.1
GU587184 Genomic DNA Translation: ADF36410.1
GU587195 Genomic DNA Translation: ADF36421.1
GU587198 Genomic DNA Translation: ADF36424.1
GU587199 Genomic DNA Translation: ADF36425.1
GU587201 Genomic DNA Translation: ADF36427.1
GU587206 Genomic DNA Translation: ADF36432.1
GU587207 Genomic DNA Translation: ADF36433.1
GU587208 Genomic DNA Translation: ADF36434.1
GU587212 Genomic DNA Translation: ADF36438.1
GU587213 Genomic DNA Translation: ADF36439.1
GU587216 Genomic DNA Translation: ADF36442.1
GU587218 Genomic DNA Translation: ADF36444.1
GU587219 Genomic DNA Translation: ADF36445.1
GU587220 Genomic DNA Translation: ADF36446.1
GU587221 Genomic DNA Translation: ADF36447.1
GU587225 Genomic DNA Translation: ADF36451.1
GU587231 Genomic DNA Translation: ADF36457.1
GU587240 Genomic DNA Translation: ADF36466.1
GU587241 Genomic DNA Translation: ADF36467.1
GU587243 Genomic DNA Translation: ADF36469.1
GU587247 Genomic DNA Translation: ADF36473.1
GU587249 Genomic DNA Translation: ADF36475.1
GU587253 Genomic DNA Translation: ADF36479.1
GU587254 Genomic DNA Translation: ADF36480.1
JQ421296 Genomic DNA Translation: AFB69499.1
JN716373 Genomic DNA Translation: AFC77926.1
JN716374 Genomic DNA Translation: AFC77927.1
JN716375 Genomic DNA Translation: AFC77928.1
JN716376 Genomic DNA Translation: AFC77929.1
KF751826 Genomic DNA Translation: AIA09568.1
KR005632 Genomic DNA Translation: AKH44766.1
KU531563 Genomic DNA Translation: ANW61981.1
KU531564 Genomic DNA Translation: ANW61982.1
MT199339 Genomic DNA Translation: QRV61426.1
MT199340 Genomic DNA Translation: QRV61427.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000615454.4; ENSP00000479867.1; ENSG00000275211.4

UCSC genome browser

More...UCSCi		uc032qyr.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX247885 Genomic DNA No translation available.
BC067432 mRNA Translation: AAH67432.1
BC126858 mRNA Translation: AAI26859.1
DQ282147 Genomic DNA Translation: ABB77898.1
DQ282156 Genomic DNA Translation: ABB77904.1
DQ282160 Genomic DNA Translation: ABB77908.1
GU586995 Genomic DNA Translation: ADF36226.1
GU587005 Genomic DNA Translation: ADF36236.1
GU587008 Genomic DNA Translation: ADF36239.1
GU587009 Genomic DNA Translation: ADF36240.1
GU587010 Genomic DNA Translation: ADF36241.1
GU587011 Genomic DNA Translation: ADF36242.1
GU587012 Genomic DNA Translation: ADF36243.1
GU587013 Genomic DNA Translation: ADF36244.1
GU587018 Genomic DNA Translation: ADF36249.1
GU587021 Genomic DNA Translation: ADF36252.1
GU587022 Genomic DNA Translation: ADF36253.1
GU587028 Genomic DNA Translation: ADF36259.1
GU587029 Genomic DNA Translation: ADF36260.1
GU587030 Genomic DNA Translation: ADF36261.1
GU587031 Genomic DNA Translation: ADF36262.1
GU587036 Genomic DNA Translation: ADF36267.1
GU587037 Genomic DNA Translation: ADF36268.1
GU587050 Genomic DNA Translation: ADF36281.1
GU587052 Genomic DNA Translation: ADF36283.1
GU587059 Genomic DNA Translation: ADF36290.1
GU587062 Genomic DNA Translation: ADF36293.1
GU587064 Genomic DNA Translation: ADF36295.1
GU587066 Genomic DNA Translation: ADF36297.1
GU587069 Genomic DNA Translation: ADF36299.1
GU587075 Genomic DNA Translation: ADF36304.1
GU587079 Genomic DNA Translation: ADF36308.1
GU587081 Genomic DNA Translation: ADF36310.1
GU587093 Genomic DNA Translation: ADF36322.1
GU587094 Genomic DNA Translation: ADF36323.1
GU587104 Genomic DNA Translation: ADF36332.1
GU587114 Genomic DNA Translation: ADF36342.1
GU587115 Genomic DNA Translation: ADF36343.1
GU587118 Genomic DNA Translation: ADF36346.1
GU587129 Genomic DNA Translation: ADF36356.1
GU587132 Genomic DNA Translation: ADF36359.1
GU587133 Genomic DNA Translation: ADF36360.1
GU587135 Genomic DNA Translation: ADF36362.1
GU587136 Genomic DNA Translation: ADF36363.1
GU587138 Genomic DNA Translation: ADF36364.1
GU587139 Genomic DNA Translation: ADF36365.1
GU587141 Genomic DNA Translation: ADF36367.1
GU587144 Genomic DNA Translation: ADF36370.1
GU587148 Genomic DNA Translation: ADF36374.1
GU587152 Genomic DNA Translation: ADF36378.1
GU587154 Genomic DNA Translation: ADF36380.1
GU587173 Genomic DNA Translation: ADF36399.1
GU587178 Genomic DNA Translation: ADF36404.1
GU587180 Genomic DNA Translation: ADF36406.1
GU587183 Genomic DNA Translation: ADF36409.1
GU587184 Genomic DNA Translation: ADF36410.1
GU587195 Genomic DNA Translation: ADF36421.1
GU587198 Genomic DNA Translation: ADF36424.1
GU587199 Genomic DNA Translation: ADF36425.1
GU587201 Genomic DNA Translation: ADF36427.1
GU587206 Genomic DNA Translation: ADF36432.1
GU587207 Genomic DNA Translation: ADF36433.1
GU587208 Genomic DNA Translation: ADF36434.1
GU587212 Genomic DNA Translation: ADF36438.1
GU587213 Genomic DNA Translation: ADF36439.1
GU587216 Genomic DNA Translation: ADF36442.1
GU587218 Genomic DNA Translation: ADF36444.1
GU587219 Genomic DNA Translation: ADF36445.1
GU587220 Genomic DNA Translation: ADF36446.1
GU587221 Genomic DNA Translation: ADF36447.1
GU587225 Genomic DNA Translation: ADF36451.1
GU587231 Genomic DNA Translation: ADF36457.1
GU587240 Genomic DNA Translation: ADF36466.1
GU587241 Genomic DNA Translation: ADF36467.1
GU587243 Genomic DNA Translation: ADF36469.1
GU587247 Genomic DNA Translation: ADF36473.1
GU587249 Genomic DNA Translation: ADF36475.1
GU587253 Genomic DNA Translation: ADF36479.1
GU587254 Genomic DNA Translation: ADF36480.1
JQ421296 Genomic DNA Translation: AFB69499.1
JN716373 Genomic DNA Translation: AFC77926.1
JN716374 Genomic DNA Translation: AFC77927.1
JN716375 Genomic DNA Translation: AFC77928.1
JN716376 Genomic DNA Translation: AFC77929.1
KF751826 Genomic DNA Translation: AIA09568.1
KR005632 Genomic DNA Translation: AKH44766.1
KU531563 Genomic DNA Translation: ANW61981.1
KU531564 Genomic DNA Translation: ANW61982.1
MT199339 Genomic DNA Translation: QRV61426.1
MT199340 Genomic DNA Translation: QRV61427.1

3D structure databases

Database of comparative protein structure models

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SWISS-MODEL Interactive Workspace

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Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		1565

Genome annotation databases

EnsembliENST00000615454.4; ENSP00000479867.1; ENSG00000275211.4
UCSCiuc032qyr.2, human

Organism-specific databases

HGNCiHGNC:2625, CYP2D6
PharmGKBiPA128

GenAtlas: human gene database

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Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128, Cyt_P450
IPR017972, Cyt_P450_CS
IPR002401, Cyt_P450_E_grp-I
IPR008069, Cyt_P450_E_grp-I_CYP2D-like
IPR036396, Cyt_P450_sf
PfamiView protein in Pfam
PF00067, p450, 1 hit
PRINTSiPR00463, EP450I
PR01686, EP450ICYP2D
PR00385, P450
SUPFAMiSSF48264, SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086, CYTOCHROME_P450, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ6NWU0_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NWU0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 25, 2022
This is version 163 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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