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Entry version 118 (29 Sep 2021)
Sequence version 1 (05 Jul 2004)
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Protein

DnaJ homolog subfamily C member 2

Gene

dnajc2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Chaperone, Chromatin regulator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DRE-3371453, Regulation of HSF1-mediated heat shock response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DnaJ homolog subfamily C member 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dnajc2
ORF Names:zgc:85671
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-040426-1912, dnajc2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004058221 – 618DnaJ homolog subfamily C member 2Add BLAST618

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NWJ4

PRoteomics IDEntifications database

More...
PRIDEi
Q6NWJ4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSDARG00000070477, Expressed in mature ovarian follicle and 26 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NWJ4, baseline

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of ribosome-associated complex (RAC).

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000094239

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NWJ4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini85 – 158JPROSITE-ProRule annotationAdd BLAST74
Domaini445 – 507SANT 1PROSITE-ProRule annotationAdd BLAST63
Domaini548 – 603SANT 2PROSITE-ProRule annotationAdd BLAST56

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni281 – 315DisorderedSequence analysisAdd BLAST35
Regioni330 – 349DisorderedSequence analysisAdd BLAST20
Regioni419 – 448DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi432 – 448Polar residuesSequence analysisAdd BLAST17

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0724, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155441

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_019916_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NWJ4

Identification of Orthologs from Complete Genome Data

More...
OMAi
QNGVDHK

Database of Orthologous Groups

More...
OrthoDBi
1392575at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NWJ4

TreeFam database of animal gene trees

More...
TreeFami
TF105834

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06257, DnaJ, 1 hit
cd00167, SANT, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.287.110, 1 hit
1.10.8.840, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001623, DnaJ_domain
IPR009057, Homeobox-like_sf
IPR036869, J_dom_sf
IPR017930, Myb_dom
IPR032003, RAC_head
IPR042569, RAC_head_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR044634, Zuotin/DnaJC2

The PANTHER Classification System

More...
PANTHERi
PTHR43999, PTHR43999, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00226, DnaJ, 1 hit
PF00249, Myb_DNA-binding, 2 hits
PF16717, RAC_head, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00271, DnaJ, 1 hit
SM00717, SANT, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46565, SSF46565, 1 hit
SSF46689, SSF46689, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50076, DNAJ_2, 1 hit
PS51293, SANT, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6NWJ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLTEALEGQL TVVYNTVAAS VQVQVEPVGR WFEAFLKRRN RNVSASFQEL
60 70 80 90 100
EEEEELSEEE EDEELQLEEY PMLKTLDPKD WKNQDHYAVL GLAHVRYKAT
110 120 130 140 150
QKQIKAAHKA MVLKHHPDKR KAAGEQIVEG DNDYFTCITK AIEILSDPVK
160 170 180 190 200
RRAFDSVDPT FDNAVPTKAE GKENFFEVFA PVFERNARWS VKKHFPSLGT
210 220 230 240 250
MESSFEDVDN FYSFWYNFDS WREFSYLDEE EKEKAECRDE RRWIEKQNRA
260 270 280 290 300
SRAQRKKEEM NRIRTLVDTA YNADPRIKKF KEEEKARKES EKKAKVEAKK
310 320 330 340 350
REQEEKERAR QQQEEAARLL KEQQEEAARQ AAQQAKKEKE AQKKAIKKER
360 370 380 390 400
QKLRMTCKSQ NYFTDNEADS VRMMEEVEKL CDRLELISLQ TLNEALSAGN
410 420 430 440 450
KEQSKAALEK QVQEVNMQLQ KEKDAELQAQ QAARGSEHSS AAGGQNNRGW
460 470 480 490 500
SEEDLQLLIK AVNLFPAGTN ARWEVIANYM NQHSSSGVRR TAKDVINKAK
510 520 530 540 550
TLQKLDPHQK DEINRKAFEK FKKEHSAVPP TVDNAMPSER FDAVGADSNA
560 570 580 590 600
AAWTTEEQKL LEQALKTYPV STAERWERIS EAVPGRSKKD CMKRYKELVE
610
MIKAKKAAQE QVAAKNKK
Length:618
Mass (Da):71,598
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA3CED6642F15FED1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A5WUY3A5WUY3_DANRE
DnaJ homolog subfamily C member 2
dnajc2
231Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH55125 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC055125 mRNA Translation: AAH55125.1 Sequence problems.
BC067568 mRNA Translation: AAH67568.1

NCBI Reference Sequences

More...
RefSeqi
NP_997976.1, NM_212811.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSDART00000103463; ENSDARP00000094239; ENSDARG00000070477

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
403080

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:403080

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055125 mRNA Translation: AAH55125.1 Sequence problems.
BC067568 mRNA Translation: AAH67568.1
RefSeqiNP_997976.1, NM_212811.1

3D structure databases

SMRiQ6NWJ4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000094239

Proteomic databases

PaxDbiQ6NWJ4
PRIDEiQ6NWJ4

Genome annotation databases

EnsembliENSDART00000103463; ENSDARP00000094239; ENSDARG00000070477
GeneIDi403080
KEGGidre:403080

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
27000
ZFINiZDB-GENE-040426-1912, dnajc2

Phylogenomic databases

eggNOGiKOG0724, Eukaryota
GeneTreeiENSGT00940000155441
HOGENOMiCLU_019916_0_0_1
InParanoidiQ6NWJ4
OMAiQNGVDHK
OrthoDBi1392575at2759
PhylomeDBiQ6NWJ4
TreeFamiTF105834

Enzyme and pathway databases

ReactomeiR-DRE-3371453, Regulation of HSF1-mediated heat shock response

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q6NWJ4

Gene expression databases

BgeeiENSDARG00000070477, Expressed in mature ovarian follicle and 26 other tissues
ExpressionAtlasiQ6NWJ4, baseline

Family and domain databases

CDDicd06257, DnaJ, 1 hit
cd00167, SANT, 2 hits
Gene3Di1.10.287.110, 1 hit
1.10.8.840, 1 hit
InterProiView protein in InterPro
IPR001623, DnaJ_domain
IPR009057, Homeobox-like_sf
IPR036869, J_dom_sf
IPR017930, Myb_dom
IPR032003, RAC_head
IPR042569, RAC_head_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR044634, Zuotin/DnaJC2
PANTHERiPTHR43999, PTHR43999, 1 hit
PfamiView protein in Pfam
PF00226, DnaJ, 1 hit
PF00249, Myb_DNA-binding, 2 hits
PF16717, RAC_head, 1 hit
SMARTiView protein in SMART
SM00271, DnaJ, 1 hit
SM00717, SANT, 2 hits
SUPFAMiSSF46565, SSF46565, 1 hit
SSF46689, SSF46689, 2 hits
PROSITEiView protein in PROSITE
PS50076, DNAJ_2, 1 hit
PS51293, SANT, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDNJC2_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NWJ4
Secondary accession number(s): Q7SY51
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: July 5, 2004
Last modified: September 29, 2021
This is version 118 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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