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Protein

RGM domain family member B

Gene

RGMB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Member of the repulsive guidance molecule (RGM) family that contributes to the patterning of the developing nervous system (By similarity). Acts as a bone morphogenetic protein (BMP) coreceptor that potentiates BMP signaling (By similarity). Promotes neuronal adhesion (By similarity). May inhibit neurite outgrowth.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-373752 Netrin-1 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
RGM domain family member B
Alternative name(s):
DRG11-responsive axonal guidance and outgrowth of neurite
Short name:
DRAGON
Gene namesi
Name:RGMB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000174136.11
HGNCiHGNC:26896 RGMB
MIMi612687 gene
neXtProtiNX_Q6NW40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi186A → R: Severely impairs interaction with NEO1. 1 Publication1
Mutagenesisi206P → N: Introduces a N-linked glycan; changes interaction with NEO1 from a 2:2 to a 1:1 stoichiometry. 1 Publication1

Organism-specific databases

DisGeNETi285704
OpenTargetsiENSG00000174136
PharmGKBiPA134868641

Polymorphism and mutation databases

BioMutaiRGMB
DMDMi327478562

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 45Sequence analysisAdd BLAST45
ChainiPRO_000003039446 – 413RGM domain family member BAdd BLAST368
PropeptideiPRO_0000030395414 – 437Removed in mature formSequence analysisAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi139 ↔ 2261 Publication
Disulfide bondi163 ↔ 3121 Publication
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi413GPI-anchor amidated asparagineSequence analysis1

Post-translational modificationi

GPI-anchored.By similarity
Autocatalytically cleaved at low pH; the two chains remain linked via two disulfide bonds.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei168 – 169Cleavage; by autolysis2

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ6NW40
PeptideAtlasiQ6NW40
PRIDEiQ6NW40
ProteomicsDBi66740

PTM databases

iPTMnetiQ6NW40
PhosphoSitePlusiQ6NW40

Expressioni

Gene expression databases

BgeeiENSG00000174136 Expressed in 204 organ(s), highest expression level in lower esophagus
CleanExiHS_RGMB
ExpressionAtlasiQ6NW40 baseline and differential
GenevisibleiQ6NW40 HS

Organism-specific databases

HPAiHPA016993

Interactioni

Subunit structurei

Homooligomer (By similarity). Interacts with DRGX (By similarity). Interacts with BMP2 and BMP4 (By similarity). Interacts with the BMP type I receptors ACVR1, BMPR1A and BMPR1B and with the BMP type II receptor ACVR2B (By similarity). The functional complex with its receptor NEO1/neogenin appears to be a heterotetramer with a 2:2 stoichiometry, RGM molecules acting as staples that brings two NEO1 receptors together without interacting themselves, this arrangement leads to activation of downstream signaling via RhoA.By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-61607N
IntActiQ6NW40, 2 interactors
STRINGi9606.ENSP00000308219

Structurei

Secondary structure

1437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ6NW40
SMRiQ6NW40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFAH Eukaryota
ENOG410ZT7E LUCA
GeneTreeiENSGT00390000008488
HOGENOMiHOG000013072
HOVERGENiHBG057627
InParanoidiQ6NW40
KOiK06847
PhylomeDBiQ6NW40

Family and domain databases

Gene3Di3.40.1000.10, 1 hit
InterProiView protein in InterPro
IPR033608 DRAGON
IPR016123 Mog1/PsbP_a/b/a-sand
IPR009496 RGM_C
IPR010536 RGM_N
PANTHERiPTHR31428:SF5 PTHR31428:SF5, 1 hit
PfamiView protein in Pfam
PF06534 RGM_C, 1 hit
PF06535 RGM_N, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q6NW40-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLRAAPSSA AAAAAEVEQR RSPGLCPPPL ELLLLLLFSL GLLHAGDCQQ
60 70 80 90 100
PAQCRIQKCT TDFVSLTSHL NSAVDGFDSE FCKALRAYAG CTQRTSKACR
110 120 130 140 150
GNLVYHSAVL GISDLMSQRN CSKDGPTSST NPEVTHDPCN YHSHAGAREH
160 170 180 190 200
RRGDQNPPSY LFCGLFGDPH LRTFKDNFQT CKVEGAWPLI DNNYLSVQVT
210 220 230 240 250
NVPVVPGSSA TATNKITIIF KAHHECTDQK VYQAVTDDLP AAFVDGTTSG
260 270 280 290 300
GDSDAKSLRI VERESGHYVE MHARYIGTTV FVRQVGRYLT LAIRMPEDLA
310 320 330 340 350
MSYEESQDLQ LCVNGCPLSE RIDDGQGQVS AILGHSLPRT SLVQAWPGYT
360 370 380 390 400
LETANTQCHE KMPVKDIYFQ SCVFDLLTTG DANFTAAAHS ALEDVEALHP
410 420 430
RKERWHIFPS SGNGTPRGGS DLSVSLGLTC LILIVFL
Length:437
Mass (Da):47,547
Last modified:April 5, 2011 - v3
Checksum:i48C26166E68DCE5F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KNF6J3KNF6_HUMAN
RGM domain family member B
RGMB
478Annotation score:

Sequence cautioni

The sequence AAH67736 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAC11268 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22S → R in AAH67736 (PubMed:15489334).Curated1
Sequence conflicti225E → G in AAH67736 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074887 mRNA Translation: BAC11268.1 Sequence problems.
AC008522 Genomic DNA No translation available.
BC067736 mRNA Translation: AAH67736.1 Different initiation.
RefSeqiNP_001012779.2, NM_001012761.2
UniGeneiHs.526902

Genome annotation databases

EnsembliENST00000513185; ENSP00000423256; ENSG00000174136
GeneIDi285704
KEGGihsa:285704
UCSCiuc063frq.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK074887 mRNA Translation: BAC11268.1 Sequence problems.
AC008522 Genomic DNA No translation available.
BC067736 mRNA Translation: AAH67736.1 Different initiation.
RefSeqiNP_001012779.2, NM_001012761.2
UniGeneiHs.526902

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4BQ6X-ray2.30C/E50-168[»]
D/F169-410[»]
4BQ7X-ray6.60C/E50-168[»]
D/F169-410[»]
4BQ8X-ray2.80B50-168[»]
C169-410[»]
4UHZX-ray2.85B53-136[»]
4UI0X-ray2.80C53-136[»]
4UI2X-ray3.15C50-168[»]
D169-410[»]
ProteinModelPortaliQ6NW40
SMRiQ6NW40
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-61607N
IntActiQ6NW40, 2 interactors
STRINGi9606.ENSP00000308219

PTM databases

iPTMnetiQ6NW40
PhosphoSitePlusiQ6NW40

Polymorphism and mutation databases

BioMutaiRGMB
DMDMi327478562

Proteomic databases

PaxDbiQ6NW40
PeptideAtlasiQ6NW40
PRIDEiQ6NW40
ProteomicsDBi66740

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000513185; ENSP00000423256; ENSG00000174136
GeneIDi285704
KEGGihsa:285704
UCSCiuc063frq.1 human

Organism-specific databases

CTDi285704
DisGeNETi285704
EuPathDBiHostDB:ENSG00000174136.11
GeneCardsiRGMB
H-InvDBiHIX0005059
HGNCiHGNC:26896 RGMB
HPAiHPA016993
MIMi612687 gene
neXtProtiNX_Q6NW40
OpenTargetsiENSG00000174136
PharmGKBiPA134868641
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFAH Eukaryota
ENOG410ZT7E LUCA
GeneTreeiENSGT00390000008488
HOGENOMiHOG000013072
HOVERGENiHBG057627
InParanoidiQ6NW40
KOiK06847
PhylomeDBiQ6NW40

Enzyme and pathway databases

ReactomeiR-HSA-373752 Netrin-1 signaling

Miscellaneous databases

ChiTaRSiRGMB human
GeneWikiiRGMB
GenomeRNAii285704
PROiPR:Q6NW40
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174136 Expressed in 204 organ(s), highest expression level in lower esophagus
CleanExiHS_RGMB
ExpressionAtlasiQ6NW40 baseline and differential
GenevisibleiQ6NW40 HS

Family and domain databases

Gene3Di3.40.1000.10, 1 hit
InterProiView protein in InterPro
IPR033608 DRAGON
IPR016123 Mog1/PsbP_a/b/a-sand
IPR009496 RGM_C
IPR010536 RGM_N
PANTHERiPTHR31428:SF5 PTHR31428:SF5, 1 hit
PfamiView protein in Pfam
PF06534 RGM_C, 1 hit
PF06535 RGM_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRGMB_HUMAN
AccessioniPrimary (citable) accession number: Q6NW40
Secondary accession number(s): D6R9A0, Q8NC92
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: April 5, 2011
Last modified: September 12, 2018
This is version 105 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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