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Entry version 129 (11 Dec 2019)
Sequence version 3 (20 Mar 2007)
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Protein

Nucleolus and neural progenitor protein

Gene

NEPRO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors. May also play a role in preimplentation embryo development.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nucleolus and neural progenitor proteinCurated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NEPROImported
Synonyms:C3orf17
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000163608.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24496 NEPRO

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NW34

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000163608

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134948355

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6NW34 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NEPRO

Domain mapping of disease mutations (DMDM)

More...
DMDMi
134047717

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002250121 – 567Nucleolus and neural progenitor proteinAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei265PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NW34

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NW34

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6NW34

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NW34

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NW34

PeptideAtlas

More...
PeptideAtlasi
Q6NW34

PRoteomics IDEntifications database

More...
PRIDEi
Q6NW34

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66738 [Q6NW34-1]
66739 [Q6NW34-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NW34

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NW34

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000163608 Expressed in 201 organ(s), highest expression level in secondary oocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NW34 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NW34 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA069654

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117387, 48 interactors

Protein interaction database and analysis system

More...
IntActi
Q6NW34, 28 interactors

Molecular INTeraction database

More...
MINTi
Q6NW34

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320251

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6NW34 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni442 – 460Nuclear localization signalBy similarityAdd BLAST19

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the nepro family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFTK Eukaryota
ENOG411118E LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007644

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015316

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NW34

Identification of Orthologs from Complete Genome Data

More...
OMAi
LEPWNRV

Database of Orthologous Groups

More...
OrthoDBi
480212at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NW34

TreeFam database of animal gene trees

More...
TreeFami
TF335999

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027951 DUF4477

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14780 DUF4477, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NW34-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAAVPPGLE PWNRVRIPKA GNRSAVTVQN PGAALDLCIA AVIKECHLVI
60 70 80 90 100
LSLKSQTLDA ETDVLCAVLY SNHNRMGRHK PHLALKQVEQ CLKRLKNMNL
110 120 130 140 150
EGSIQDLFEL FSSNENQPLT TKVCVVPSQP VVELVLMKVL GACKLLLRLL
160 170 180 190 200
DCCCKTFLLT VKHLGLQEFI ILNLVMVGLV SRLWVLYKGV LKRLILLYEP
210 220 230 240 250
LFGLLQEVAR IQPMPYFKDF TFPSDITEFL GQPYFEAFKK KMPIAFAAKG
260 270 280 290 300
INKLLNKLFL INEQSPRASE ETLLGISKKA KQMKINVQNN VDLGQPVKNK
310 320 330 340 350
RVFKEESSEF DVRAFCNQLK HKATQETSFD FKCSQSRLKT TKYSSQKVIG
360 370 380 390 400
TPHAKSFVQR FREAESFTQL SEEIQMAVVW CRSKKLKAQA IFLGNKLLKS
410 420 430 440 450
NRLKHLEAQG TSLPKKLECI KTSICNHLLR GSGIKTSKHH LRQRRSQNKF
460 470 480 490 500
LRRQRKPQRK LQSTLLREIQ QFSQGTRKSA TDTSAKWRLS HCTVHRTDLY
510 520 530 540 550
PNSKQLLNSG VSMPVIQTKE KMIHENLRGI HENETDSWTV MQINKNSTSG
560
TIKETDDIDD IFALMGV
Length:567
Mass (Da):64,552
Last modified:March 20, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88CB0CEE2A0CA0A2
GO
Isoform 2 (identifier: Q6NW34-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     114-114: N → K
     115-184: Missing.

Show »
Length:497
Mass (Da):56,749
Checksum:iC0F35B726819E62F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z3E4F2Z3E4_HUMAN
Nucleolus and neural progenitor pro...
NEPRO
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9E3C9J9E3_HUMAN
Nucleolus and neural progenitor pro...
NEPRO
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WBQ8F8WBQ8_HUMAN
Nucleolus and neural progenitor pro...
NEPRO
114Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDL7F8WDL7_HUMAN
Nucleolus and neural progenitor pro...
NEPRO
113Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFF8E9PFF8_HUMAN
Nucleolus and neural progenitor pro...
NEPRO
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WC60F8WC60_HUMAN
Nucleolus and neural progenitor pro...
NEPRO
39Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB55998 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35L → I in AAH67743 (PubMed:15489334).Curated1
Sequence conflicti509S → N in AAH67743 (PubMed:15489334).Curated1
Sequence conflicti520E → G in AAH67743 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_025418101E → K. Corresponds to variant dbSNP:rs2291465Ensembl.1
Natural variantiVAR_025419352P → S. Corresponds to variant dbSNP:rs2306858Ensembl.1
Natural variantiVAR_025420357F → I2 PublicationsCorresponds to variant dbSNP:rs2306857Ensembl.1
Natural variantiVAR_025421476T → A. Corresponds to variant dbSNP:rs3732813Ensembl.1
Natural variantiVAR_025422490S → P1 PublicationCorresponds to variant dbSNP:rs7628368Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017342114N → K in isoform 2. 1 Publication1
Alternative sequenceiVSP_017343115 – 184Missing in isoform 2. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK024325 mRNA Translation: BAB14885.1
AL117573 mRNA Translation: CAB55998.1 Different initiation.
CR749341 mRNA Translation: CAH18194.1
CH471052 Genomic DNA Translation: EAW79648.1
CH471052 Genomic DNA Translation: EAW79649.1
BC067743 mRNA Translation: AAH67743.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33824.1 [Q6NW34-1]
CCDS82820.1 [Q6NW34-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
T17308

NCBI Reference Sequences

More...
RefSeqi
NP_001306038.1, NM_001319109.1 [Q6NW34-2]
NP_001306039.1, NM_001319110.1
NP_001306040.1, NM_001319111.1
NP_001306041.1, NM_001319112.1
NP_001306043.1, NM_001319114.1
NP_001306044.1, NM_001319115.1
NP_056227.2, NM_015412.3 [Q6NW34-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314400; ENSP00000320251; ENSG00000163608 [Q6NW34-1]
ENST00000383675; ENSP00000373173; ENSG00000163608 [Q6NW34-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25871

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:25871

UCSC genome browser

More...
UCSCi
uc003dzr.4 human [Q6NW34-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK024325 mRNA Translation: BAB14885.1
AL117573 mRNA Translation: CAB55998.1 Different initiation.
CR749341 mRNA Translation: CAH18194.1
CH471052 Genomic DNA Translation: EAW79648.1
CH471052 Genomic DNA Translation: EAW79649.1
BC067743 mRNA Translation: AAH67743.1
CCDSiCCDS33824.1 [Q6NW34-1]
CCDS82820.1 [Q6NW34-2]
PIRiT17308
RefSeqiNP_001306038.1, NM_001319109.1 [Q6NW34-2]
NP_001306039.1, NM_001319110.1
NP_001306040.1, NM_001319111.1
NP_001306041.1, NM_001319112.1
NP_001306043.1, NM_001319114.1
NP_001306044.1, NM_001319115.1
NP_056227.2, NM_015412.3 [Q6NW34-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi117387, 48 interactors
IntActiQ6NW34, 28 interactors
MINTiQ6NW34
STRINGi9606.ENSP00000320251

PTM databases

iPTMnetiQ6NW34
PhosphoSitePlusiQ6NW34

Polymorphism and mutation databases

BioMutaiNEPRO
DMDMi134047717

Proteomic databases

EPDiQ6NW34
jPOSTiQ6NW34
MassIVEiQ6NW34
MaxQBiQ6NW34
PaxDbiQ6NW34
PeptideAtlasiQ6NW34
PRIDEiQ6NW34
ProteomicsDBi66738 [Q6NW34-1]
66739 [Q6NW34-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
25871

Genome annotation databases

EnsembliENST00000314400; ENSP00000320251; ENSG00000163608 [Q6NW34-1]
ENST00000383675; ENSP00000373173; ENSG00000163608 [Q6NW34-2]
GeneIDi25871
KEGGihsa:25871
UCSCiuc003dzr.4 human [Q6NW34-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
25871
EuPathDBiHostDB:ENSG00000163608.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NEPRO
HGNCiHGNC:24496 NEPRO
HPAiHPA069654
neXtProtiNX_Q6NW34
OpenTargetsiENSG00000163608
PharmGKBiPA134948355

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFTK Eukaryota
ENOG411118E LUCA
GeneTreeiENSGT00390000007644
HOGENOMiHOG000015316
InParanoidiQ6NW34
OMAiLEPWNRV
OrthoDBi480212at2759
PhylomeDBiQ6NW34
TreeFamiTF335999

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
NEPRO human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
25871
PharosiQ6NW34 Tbio

Protein Ontology

More...
PROi
PR:Q6NW34
RNActiQ6NW34 protein

Gene expression databases

BgeeiENSG00000163608 Expressed in 201 organ(s), highest expression level in secondary oocyte
ExpressionAtlasiQ6NW34 baseline and differential
GenevisibleiQ6NW34 HS

Family and domain databases

InterProiView protein in InterPro
IPR027951 DUF4477
PfamiView protein in Pfam
PF14780 DUF4477, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNEPRO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NW34
Secondary accession number(s): D3DN69
, Q68DM6, Q9H7U0, Q9UFM4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: March 20, 2007
Last modified: December 11, 2019
This is version 129 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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