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Entry version 108 (13 Feb 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Cysteine-rich DPF motif domain-containing protein 1

Gene

CDPF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine-rich DPF motif domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDPF1
Synonyms:C22orf40
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000205643.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33710 CDPF1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NVV7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000205643

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162379006

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CDPF1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74749009

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003413601 – 123Cysteine-rich DPF motif domain-containing protein 1Add BLAST123

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NVV7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NVV7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NVV7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NVV7

PeptideAtlas

More...
PeptideAtlasi
Q6NVV7

PRoteomics IDEntifications database

More...
PRIDEi
Q6NVV7

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66725

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NVV7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NVV7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000205643 Expressed in 131 organ(s), highest expression level in quadriceps femoris

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NVV7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NVV7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018823

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
BHLHE40O145033EBI-2802782,EBI-711810

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
127293, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q6NVV7, 20 interactors

Molecular INTeraction database

More...
MINTi
Q6NVV7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6NVV7

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CDPF1 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4543 Eukaryota
ENOG4111ZD4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007925

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000006647

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG098217

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NVV7

Identification of Orthologs from Complete Genome Data

More...
OMAi
CGLTAPY

Database of Orthologous Groups

More...
OrthoDBi
1278628at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NVV7

TreeFam database of animal gene trees

More...
TreeFami
TF313933

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018785 Cys-rich_DPF

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10170 C6_DPF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01995 UPF0595

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q6NVV7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASHVECRPL GVFECELCTL TAPYSYVGQK PPNTQSMVLL EESYVMKDPF
60 70 80 90 100
TSDKDRFLVL GSCCSLCSRL VCVGPECSLF YSKRFCLPCV RENINAFPQE
110 120
IRQDLEKRKA PSKRTPSQPG SRT
Length:123
Mass (Da):13,877
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i87E30A594058235F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6RAJ7F6RAJ7_HUMAN
Cysteine-rich DPF motif domain-cont...
CDPF1
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UL18F6UL18_HUMAN
Cysteine-rich DPF motif domain-cont...
CDPF1
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H9KV78H9KV78_HUMAN
Cysteine-rich DPF motif domain-cont...
CDPF1
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti103Q → R in AAH45796 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0440585V → A. Corresponds to variant dbSNP:rs9627281Ensembl.1
Natural variantiVAR_06223770L → R. Corresponds to variant dbSNP:rs55641018Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL078611 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73407.1
BC045796 mRNA Translation: AAH45796.1
BC067871 mRNA Translation: AAH67871.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33670.1

NCBI Reference Sequences

More...
RefSeqi
NP_997210.3, NM_207327.4
XP_011528267.1, XM_011529965.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.103110
Hs.592209

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000314567; ENSP00000325301; ENSG00000205643

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
150383

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:150383

UCSC genome browser

More...
UCSCi
uc003bhe.4 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL078611 Genomic DNA No translation available.
CH471138 Genomic DNA Translation: EAW73407.1
BC045796 mRNA Translation: AAH45796.1
BC067871 mRNA Translation: AAH67871.1
CCDSiCCDS33670.1
RefSeqiNP_997210.3, NM_207327.4
XP_011528267.1, XM_011529965.2
UniGeneiHs.103110
Hs.592209

3D structure databases

ProteinModelPortaliQ6NVV7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi127293, 3 interactors
IntActiQ6NVV7, 20 interactors
MINTiQ6NVV7

PTM databases

iPTMnetiQ6NVV7
PhosphoSitePlusiQ6NVV7

Polymorphism and mutation databases

BioMutaiCDPF1
DMDMi74749009

Proteomic databases

EPDiQ6NVV7
jPOSTiQ6NVV7
MaxQBiQ6NVV7
PaxDbiQ6NVV7
PeptideAtlasiQ6NVV7
PRIDEiQ6NVV7
ProteomicsDBi66725

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
150383
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314567; ENSP00000325301; ENSG00000205643
GeneIDi150383
KEGGihsa:150383
UCSCiuc003bhe.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
150383
EuPathDBiHostDB:ENSG00000205643.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CDPF1
HGNCiHGNC:33710 CDPF1
HPAiHPA018823
neXtProtiNX_Q6NVV7
OpenTargetsiENSG00000205643
PharmGKBiPA162379006

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4543 Eukaryota
ENOG4111ZD4 LUCA
GeneTreeiENSGT00390000007925
HOGENOMiHOG000006647
HOVERGENiHBG098217
InParanoidiQ6NVV7
OMAiCGLTAPY
OrthoDBi1278628at2759
PhylomeDBiQ6NVV7
TreeFamiTF313933

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CDPF1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
150383

Protein Ontology

More...
PROi
PR:Q6NVV7

Gene expression databases

BgeeiENSG00000205643 Expressed in 131 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiQ6NVV7 baseline and differential
GenevisibleiQ6NVV7 HS

Family and domain databases

InterProiView protein in InterPro
IPR018785 Cys-rich_DPF
PfamiView protein in Pfam
PF10170 C6_DPF, 1 hit
PRINTSiPR01995 UPF0595

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDPF1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NVV7
Secondary accession number(s): A6NCA1
, A9IU12, A9IU16, Q3ZCR8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 5, 2004
Last modified: February 13, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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