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Entry version 100 (13 Feb 2019)
Sequence version 2 (18 May 2010)
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Protein

Inactive Ufm1-specific protease 1

Gene

UFSP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Although strongly related to the Ufm1-specific proteases, it is shorter in N-terminus and lacks the conserved Cys active site, suggesting that it is probably catalytically inactive.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C78.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inactive Ufm1-specific protease 1
Short name:
UfSP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:UFSP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000176125.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33821 UFSP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611481 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NVU6

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
402682

Open Targets

More...
OpenTargetsi
ENSG00000176125

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162408522

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
UFSP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452856

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002803601 – 142Inactive Ufm1-specific protease 1Add BLAST142

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NVU6

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NVU6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NVU6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NVU6

PeptideAtlas

More...
PeptideAtlasi
Q6NVU6

PRoteomics IDEntifications database

More...
PRIDEi
Q6NVU6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66720

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NVU6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NVU6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000176125 Expressed in 91 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NVU6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA027099

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
135544, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q6NVU6, 41 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373413

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q6NVU6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NVU6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C78 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2433 Eukaryota
ENOG410XTJE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162936

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000169159

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG094130

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NVU6

Identification of Orthologs from Complete Genome Data

More...
OMAi
CIGSGTE

Database of Orthologous Groups

More...
OrthoDBi
444004at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NVU6

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR012462 Peptidase_C78_UfSP1/2
IPR033502 UfSP1

The PANTHER Classification System

More...
PANTHERi
PTHR44770 PTHR44770, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07910 Peptidase_C78, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6NVU6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDKPPGFRG SRDWIGCVEA SLCLAHFGGP QGRLCHVPRG VGLHGELERL
60 70 80 90 100
YSHFAGGGGP VMVGGDADAR SKALLGVCVG SGTEAYVLVL DPHYWGTPKS
110 120 130 140
PSELQAAGWV GWQEVSAAFD PNSFYNLCLT SLSSQQQQRT LD
Length:142
Mass (Da):15,060
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9D42E879A1D3315A
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence EAL23814 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03112547L → V2 PublicationsCorresponds to variant dbSNP:rs12666989Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF312032 Genomic DNA Translation: AAK21004.1
AK292467 mRNA Translation: BAF85156.1
CH236956 Genomic DNA Translation: EAL23814.1 Sequence problems.
AC011895 Genomic DNA No translation available.
BC067904 mRNA Translation: AAH67904.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34710.1

NCBI Reference Sequences

More...
RefSeqi
NP_001015072.2, NM_001015072.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.534845

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000388761; ENSP00000373413; ENSG00000176125

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
402682

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:402682

UCSC genome browser

More...
UCSCi
uc003uxc.4 human

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312032 Genomic DNA Translation: AAK21004.1
AK292467 mRNA Translation: BAF85156.1
CH236956 Genomic DNA Translation: EAL23814.1 Sequence problems.
AC011895 Genomic DNA No translation available.
BC067904 mRNA Translation: AAH67904.1
CCDSiCCDS34710.1
RefSeqiNP_001015072.2, NM_001015072.3
UniGeneiHs.534845

3D structure databases

ProteinModelPortaliQ6NVU6
SMRiQ6NVU6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi135544, 1 interactor
IntActiQ6NVU6, 41 interactors
STRINGi9606.ENSP00000373413

Protein family/group databases

MEROPSiC78.001

PTM databases

iPTMnetiQ6NVU6
PhosphoSitePlusiQ6NVU6

Polymorphism and mutation databases

BioMutaiUFSP1
DMDMi296452856

Proteomic databases

EPDiQ6NVU6
jPOSTiQ6NVU6
MaxQBiQ6NVU6
PaxDbiQ6NVU6
PeptideAtlasiQ6NVU6
PRIDEiQ6NVU6
ProteomicsDBi66720

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
402682
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000388761; ENSP00000373413; ENSG00000176125
GeneIDi402682
KEGGihsa:402682
UCSCiuc003uxc.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
402682
DisGeNETi402682
EuPathDBiHostDB:ENSG00000176125.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
UFSP1

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0201190
HGNCiHGNC:33821 UFSP1
HPAiHPA027099
MIMi611481 gene
neXtProtiNX_Q6NVU6
OpenTargetsiENSG00000176125
PharmGKBiPA162408522

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2433 Eukaryota
ENOG410XTJE LUCA
GeneTreeiENSGT00940000162936
HOGENOMiHOG000169159
HOVERGENiHBG094130
InParanoidiQ6NVU6
OMAiCIGSGTE
OrthoDBi444004at2759
PhylomeDBiQ6NVU6

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
402682

Protein Ontology

More...
PROi
PR:Q6NVU6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000176125 Expressed in 91 organ(s), highest expression level in liver
GenevisibleiQ6NVU6 HS

Family and domain databases

InterProiView protein in InterPro
IPR012462 Peptidase_C78_UfSP1/2
IPR033502 UfSP1
PANTHERiPTHR44770 PTHR44770, 1 hit
PfamiView protein in Pfam
PF07910 Peptidase_C78, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiUFSP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NVU6
Secondary accession number(s): A4D2E4
, A8K8V2, B6ZDG6, Q9BXP6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: February 13, 2019
This is version 100 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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