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Protein

Inactive Ufm1-specific protease 1

Gene

UFSP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Although strongly related to the Ufm1-specific proteases, it is shorter in N-terminus and lacks the conserved Cys active site, suggesting that it is probably catalytically inactive.Curated

GO - Molecular functioni

Protein family/group databases

MEROPSiC78.001

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive Ufm1-specific protease 1
Short name:
UfSP1
Gene namesi
Name:UFSP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000176125.4
HGNCiHGNC:33821 UFSP1
MIMi611481 gene
neXtProtiNX_Q6NVU6

Pathology & Biotechi

Organism-specific databases

DisGeNETi402682
OpenTargetsiENSG00000176125
PharmGKBiPA162408522

Polymorphism and mutation databases

BioMutaiUFSP1
DMDMi296452856

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002803601 – 142Inactive Ufm1-specific protease 1Add BLAST142

Proteomic databases

EPDiQ6NVU6
MaxQBiQ6NVU6
PaxDbiQ6NVU6
PeptideAtlasiQ6NVU6
PRIDEiQ6NVU6
ProteomicsDBi66720

PTM databases

iPTMnetiQ6NVU6
PhosphoSitePlusiQ6NVU6

Expressioni

Gene expression databases

BgeeiENSG00000176125
CleanExiHS_UFSP1
GenevisibleiQ6NVU6 HS

Organism-specific databases

HPAiHPA027099

Interactioni

Protein-protein interaction databases

BioGridi135544, 1 interactor
IntActiQ6NVU6, 41 interactors
STRINGi9606.ENSP00000373413

Structurei

3D structure databases

ProteinModelPortaliQ6NVU6
SMRiQ6NVU6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C78 family.Curated

Phylogenomic databases

eggNOGiKOG2433 Eukaryota
ENOG410XTJE LUCA
GeneTreeiENSGT00520000055644
HOGENOMiHOG000169159
HOVERGENiHBG094130
InParanoidiQ6NVU6
OMAiCIGSGTE
OrthoDBiEOG091G04IB
PhylomeDBiQ6NVU6

Family and domain databases

InterProiView protein in InterPro
IPR012462 Peptidase_C78_UfSP1/2
IPR033502 UfSP1
PANTHERiPTHR44770 PTHR44770, 1 hit
PfamiView protein in Pfam
PF07910 Peptidase_C78, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NVU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKPPGFRG SRDWIGCVEA SLCLAHFGGP QGRLCHVPRG VGLHGELERL
60 70 80 90 100
YSHFAGGGGP VMVGGDADAR SKALLGVCVG SGTEAYVLVL DPHYWGTPKS
110 120 130 140
PSELQAAGWV GWQEVSAAFD PNSFYNLCLT SLSSQQQQRT LD
Length:142
Mass (Da):15,060
Last modified:May 18, 2010 - v2
Checksum:i9D42E879A1D3315A
GO

Sequence cautioni

The sequence EAL23814 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03112547L → V2 PublicationsCorresponds to variant dbSNP:rs12666989Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312032 Genomic DNA Translation: AAK21004.1
AK292467 mRNA Translation: BAF85156.1
CH236956 Genomic DNA Translation: EAL23814.1 Sequence problems.
AC011895 Genomic DNA No translation available.
BC067904 mRNA Translation: AAH67904.1
CCDSiCCDS34710.1
RefSeqiNP_001015072.2, NM_001015072.3
UniGeneiHs.534845

Genome annotation databases

EnsembliENST00000388761; ENSP00000373413; ENSG00000176125
GeneIDi402682
KEGGihsa:402682
UCSCiuc003uxc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiUFSP1_HUMAN
AccessioniPrimary (citable) accession number: Q6NVU6
Secondary accession number(s): A4D2E4
, A8K8V2, B6ZDG6, Q9BXP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

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