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Protein

T-complex protein 1 subunit epsilon

Gene

cct5

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperoneUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-390471 Association of TriC/CCT with target proteins during biosynthesis
R-DRE-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit epsilonUniRule annotation
Short name:
TCP-1-epsilonUniRule annotation
Alternative name(s):
CCT-epsilonUniRule annotation
Gene namesi
Name:cct5Imported
Synonyms:CCT5Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 24

Organism-specific databases

ZFINiZDB-GENE-030131-977 cct5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000045399 Expressed in 38 organ(s), highest expression level in paraxial mesoderm

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.UniRule annotation

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000066759

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0357 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074988
HOGENOMiHOG000226735
HOVERGENiHBG106507
KOiK09497
OMAiYATDEYG
OrthoDBiEOG091G05G4
TreeFamiTF105638

Family and domain databases

CDDicd03339 TCP1_epsilon, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012718 Chap_CCT_epsi
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF178 PTHR11353:SF178, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02343 chap_CCT_epsi, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NVI6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSALGTLAFD EYGRPFIIIK DQDKKSRLTG LEALKSHILA AKAVANTLRT
60 70 80 90 100
SLGPNGLDKM MVDKDGEVTV TNDGATILSM MDVDHQIAKL MVELSKSQDD
110 120 130 140 150
EIGDGTTGVV VLAGALLEQA EQLLDRGIHP IRIADGYDQA AKIAIEQLDK
160 170 180 190 200
IGDSFPVDPN NTESLVQTAM TTLGSKVINR CHRQMAEIAV NAILTVADME
210 220 230 240 250
RKDVDFELIK VEGKVGGKLE DTQLIKGVIV DKEFSHPQMP KVLKDTKIAI
260 270 280 290 300
LTCPFEPPKP KTKHKLDVTS VEDYKALQKY EKDKFQEMIR QVKENGANLA
310 320 330 340 350
ICQWGFDDEA NHLLLQNELP AIRWVGGPEI ELIAIATGGR IVPRFCELTP
360 370 380 390 400
EKLGTAGLVK EICFGTTKDR MLVIEECKNS RAVTIFIRGG NKMIIEEAKR
410 420 430 440 450
ALHDALCVIR NLVRDNRIVY GGGASEIACA LAVNEAADKC PSLEQYAMRA
460 470 480 490 500
FADALEVIPM ALAENSGLNP IQTMTEVRAR QVKENNSALG IDCLHLSTND
510 520 530 540
MKQQHVIETL IGKKQQISLA TQVVKMILKI DDIRGPGEPE D
Length:541
Mass (Da):59,395
Last modified:July 5, 2004 - v1
Checksum:iCB122625F602B4B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX469922 Genomic DNA No translation available.
BC068037 mRNA Translation: AAH68037.1
AY398321 mRNA Translation: AAQ97754.1
AY648807 mRNA Translation: AAT68125.1
RefSeqiNP_997778.1, NM_212613.1
UniGeneiDr.75968

Genome annotation databases

EnsembliENSDART00000066760; ENSDARP00000066759; ENSDARG00000045399
GeneIDi322258
KEGGidre:322258

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX469922 Genomic DNA No translation available.
BC068037 mRNA Translation: AAH68037.1
AY398321 mRNA Translation: AAQ97754.1
AY648807 mRNA Translation: AAT68125.1
RefSeqiNP_997778.1, NM_212613.1
UniGeneiDr.75968

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000066759

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000066760; ENSDARP00000066759; ENSDARG00000045399
GeneIDi322258
KEGGidre:322258

Organism-specific databases

CTDi22948
ZFINiZDB-GENE-030131-977 cct5

Phylogenomic databases

eggNOGiKOG0357 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074988
HOGENOMiHOG000226735
HOVERGENiHBG106507
KOiK09497
OMAiYATDEYG
OrthoDBiEOG091G05G4
TreeFamiTF105638

Enzyme and pathway databases

ReactomeiR-DRE-390471 Association of TriC/CCT with target proteins during biosynthesis
R-DRE-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Gene expression databases

BgeeiENSDARG00000045399 Expressed in 38 organ(s), highest expression level in paraxial mesoderm

Family and domain databases

CDDicd03339 TCP1_epsilon, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012718 Chap_CCT_epsi
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF178 PTHR11353:SF178, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02343 chap_CCT_epsi, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ6NVI6_DANRE
AccessioniPrimary (citable) accession number: Q6NVI6
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 10, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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