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Entry version 110 (11 Dec 2019)
Sequence version 1 (05 Jul 2004)
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Protein

ATPase SWSAP1

Gene

SWSAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • single-stranded DNA binding Source: UniProtKB

GO - Biological processi

  • double-strand break repair via homologous recombination Source: UniProtKB
  • protein stabilization Source: UniProtKB

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATPase SWSAP1
Alternative name(s):
SWIM-type zinc finger 7-associated protein 1
SWS1-associated protein 1
ZSWIM7-associated protein 1
Short name:
ZSWIM7AP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SWSAP1
Synonyms:C19orf39
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000173928.2

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26638 SWSAP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614536 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NVH7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi18K → A: Loss of function in HRR associated with altered ssDNA-stimulated ATPase activity. 1 Publication1
Mutagenesisi96D → A: Loss of function in HRR associated with altered ssDNA-stimulated ATPase activity. 1 Publication1

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000173928

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA144596472

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q6NVH7 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SWSAP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74736850

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002942401 – 229ATPase SWSAP1Add BLAST229

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NVH7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NVH7

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q6NVH7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NVH7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NVH7

PeptideAtlas

More...
PeptideAtlasi
Q6NVH7

PRoteomics IDEntifications database

More...
PRIDEi
Q6NVH7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66719

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NVH7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NVH7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173928 Expressed in 138 organ(s), highest expression level in quadriceps femoris

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NVH7 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA052712

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ZSWIM7; they form a functional complex involved in homologous recombination repair and stabilize each other.

Interacts with RAD51, RAD51B, RAD51C, RAD51D and XRCC3; involved in homologous recombination repair.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Show more details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
125954, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q6NVH7, 12 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000310008

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6NVH7 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGP0 Eukaryota
ENOG41128AG LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007170

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000001573

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NVH7

Identification of Orthologs from Complete Genome Data

More...
OMAi
FQPDGEM

Database of Orthologous Groups

More...
OrthoDBi
1081973at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NVH7

TreeFam database of animal gene trees

More...
TreeFami
TF337313

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027417 P-loop_NTPase

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6NVH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAAGPPLLL LGTPGSGKTA LLFAAALEAA GEGQGPVLFL TRRPLQSMPR
60 70 80 90 100
GTGTTLDPMR LQKIRFQYPP STRELFRLLC SAHEAPGPAP SLLLLDGLEE
110 120 130 140 150
YLAEDPEPQE AAYLIALLLD TAAHFSHRLG PGRDCGLMVA LQTQEEAGSG
160 170 180 190 200
DVLHLALLQR YFPAQCWLQP DAPGPGEHGL RACLEPGGLG PRTEWWVTFR
210 220
SDGEMMIAPW PTQAGDPSSG KGSSSGGQP
Length:229
Mass (Da):24,311
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAB940178B7A4A6C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti113Y → C in BAC03891 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_033151171D → G. Corresponds to variant dbSNP:rs317926Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK092438 mRNA Translation: BAC03891.1
AC024575 Genomic DNA No translation available.
BC068071 mRNA Translation: AAH68071.1
BC119677 mRNA Translation: AAI19678.1

NCBI Reference Sequences

More...
RefSeqi
NP_787067.2, NM_175871.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000312423; ENSP00000310008; ENSG00000173928

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
126074

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:126074

UCSC genome browser

More...
UCSCi
uc002mrg.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092438 mRNA Translation: BAC03891.1
AC024575 Genomic DNA No translation available.
BC068071 mRNA Translation: AAH68071.1
BC119677 mRNA Translation: AAI19678.1
RefSeqiNP_787067.2, NM_175871.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi125954, 11 interactors
IntActiQ6NVH7, 12 interactors
STRINGi9606.ENSP00000310008

PTM databases

iPTMnetiQ6NVH7
PhosphoSitePlusiQ6NVH7

Polymorphism and mutation databases

BioMutaiSWSAP1
DMDMi74736850

Proteomic databases

EPDiQ6NVH7
jPOSTiQ6NVH7
MassIVEiQ6NVH7
MaxQBiQ6NVH7
PaxDbiQ6NVH7
PeptideAtlasiQ6NVH7
PRIDEiQ6NVH7
ProteomicsDBi66719

Genome annotation databases

EnsembliENST00000312423; ENSP00000310008; ENSG00000173928
GeneIDi126074
KEGGihsa:126074
UCSCiuc002mrg.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
126074
EuPathDBiHostDB:ENSG00000173928.2

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SWSAP1
HGNCiHGNC:26638 SWSAP1
HPAiHPA052712
MIMi614536 gene
neXtProtiNX_Q6NVH7
OpenTargetsiENSG00000173928
PharmGKBiPA144596472

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGP0 Eukaryota
ENOG41128AG LUCA
GeneTreeiENSGT00390000007170
HOGENOMiHOG000001573
InParanoidiQ6NVH7
OMAiFQPDGEM
OrthoDBi1081973at2759
PhylomeDBiQ6NVH7
TreeFamiTF337313

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
126074
PharosiQ6NVH7 Tbio

Protein Ontology

More...
PROi
PR:Q6NVH7
RNActiQ6NVH7 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000173928 Expressed in 138 organ(s), highest expression level in quadriceps femoris
GenevisibleiQ6NVH7 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
SUPFAMiSSF52540 SSF52540, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSWAP1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NVH7
Secondary accession number(s): Q8NAM1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: December 11, 2019
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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