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Protein

ATPase SWSAP1

Gene

SWSAP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

ATPase which is preferentially stimulated by single-stranded DNA and is involved in homologous recombination repair (HRR). Has a DNA-binding activity which is independent of its ATPase activity.1 Publication

GO - Molecular functioni

  • ATPase activity Source: UniProtKB
  • single-stranded DNA binding Source: UniProtKB

GO - Biological processi

  • double-strand break repair via homologous recombination Source: UniProtKB
  • protein stabilization Source: UniProtKB

Keywordsi

Molecular functionDNA-binding
Biological processDNA damage, DNA recombination, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase SWSAP1
Alternative name(s):
SWIM-type zinc finger 7-associated protein 1
SWS1-associated protein 1
ZSWIM7-associated protein 1
Short name:
ZSWIM7AP1
Gene namesi
Name:SWSAP1
Synonyms:C19orf39
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000173928.2
HGNCiHGNC:26638 SWSAP1
MIMi614536 gene
neXtProtiNX_Q6NVH7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi18K → A: Loss of function in HRR associated with altered ssDNA-stimulated ATPase activity. 1 Publication1
Mutagenesisi96D → A: Loss of function in HRR associated with altered ssDNA-stimulated ATPase activity. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000173928
PharmGKBiPA144596472

Polymorphism and mutation databases

BioMutaiSWSAP1
DMDMi74736850

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002942401 – 229ATPase SWSAP1Add BLAST229

Proteomic databases

EPDiQ6NVH7
MaxQBiQ6NVH7
PaxDbiQ6NVH7
PeptideAtlasiQ6NVH7
PRIDEiQ6NVH7
ProteomicsDBi66719

PTM databases

iPTMnetiQ6NVH7
PhosphoSitePlusiQ6NVH7

Expressioni

Gene expression databases

BgeeiENSG00000173928 Expressed in 138 organ(s), highest expression level in quadriceps femoris
CleanExiHS_C19orf39
GenevisibleiQ6NVH7 HS

Organism-specific databases

HPAiHPA052712

Interactioni

Subunit structurei

Interacts with ZSWIM7; they form a functional complex involved in homologous recombination repair and stabilize each other. Interacts with RAD51, RAD51B, RAD51C, RAD51D and XRCC3; involved in homologous recombination repair.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi125954, 11 interactors
IntActiQ6NVH7, 9 interactors
STRINGi9606.ENSP00000310008

Structurei

3D structure databases

ProteinModelPortaliQ6NVH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiENOG410IGP0 Eukaryota
ENOG41128AG LUCA
GeneTreeiENSGT00390000007170
HOGENOMiHOG000001573
HOVERGENiHBG094964
InParanoidiQ6NVH7
OMAiAQCWLQP
OrthoDBiEOG091G0F7H
PhylomeDBiQ6NVH7
TreeFamiTF337313

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR033586 SWSAP1
PANTHERiPTHR28653 PTHR28653, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NVH7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPAAGPPLLL LGTPGSGKTA LLFAAALEAA GEGQGPVLFL TRRPLQSMPR
60 70 80 90 100
GTGTTLDPMR LQKIRFQYPP STRELFRLLC SAHEAPGPAP SLLLLDGLEE
110 120 130 140 150
YLAEDPEPQE AAYLIALLLD TAAHFSHRLG PGRDCGLMVA LQTQEEAGSG
160 170 180 190 200
DVLHLALLQR YFPAQCWLQP DAPGPGEHGL RACLEPGGLG PRTEWWVTFR
210 220
SDGEMMIAPW PTQAGDPSSG KGSSSGGQP
Length:229
Mass (Da):24,311
Last modified:July 5, 2004 - v1
Checksum:iAB940178B7A4A6C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113Y → C in BAC03891 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033151171D → G. Corresponds to variant dbSNP:rs317926Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK092438 mRNA Translation: BAC03891.1
AC024575 Genomic DNA No translation available.
BC068071 mRNA Translation: AAH68071.1
BC119677 mRNA Translation: AAI19678.1
CCDSiCCDS12259.1
RefSeqiNP_787067.2, NM_175871.3
UniGeneiHs.631619

Genome annotation databases

EnsembliENST00000312423; ENSP00000310008; ENSG00000173928
GeneIDi126074
KEGGihsa:126074
UCSCiuc002mrg.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSWAP1_HUMAN
AccessioniPrimary (citable) accession number: Q6NVH7
Secondary accession number(s): Q8NAM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: September 12, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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