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Entry version 114 (29 Sep 2021)
Sequence version 2 (03 Oct 2012)
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Protein

DNA helicase B

Gene

Helb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:26774285).

Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285).

As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285).

Acts independently of TP53BP1 (PubMed:26774285).

Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress (PubMed:11557815, PubMed:7596831, PubMed:7794903).

4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA helicase BCurated (EC:3.6.4.12By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HelbImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2152895, Helb

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000020228

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi462K → A: No ATPase activity. 1 Publication1
Mutagenesisi1029 – 1038VSSVFQNMRL → ASSVAQNARA: Accumulation in the nucleus due to defects in nuclear export. 1 Publication10

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003389931 – 1074DNA helicase BAdd BLAST1074

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei942PhosphoserineCombined sources1
Modified residuei946PhosphoserineCombined sources1
Modified residuei992PhosphothreonineCombined sources1
Modified residuei1015PhosphoserineCombined sources1
Modified residuei1026PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated at Ser-942 by CDK2 during the G1/S transition, resulting in its nuclear export into the cytoplasm. As S phase progresses, its exclusion from the nucleus promotes the activation of long-range resection.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NVF4

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q6NVF4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q6NVF4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NVF4

PeptideAtlas

More...
PeptideAtlasi
Q6NVF4

PRoteomics IDEntifications database

More...
PRIDEi
Q6NVF4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
269730

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NVF4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NVF4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000020228, Expressed in lens of camera-type eye and 276 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NVF4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to RPA1; this interaction promotes HELB recruitment to chromatin following DNA damage.

Interacts with at least two subunits of the DNA polymerase alpha complex.

Interacts with CDC45.

Interacts with TOPB1.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
228238, 6 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000020449

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6NVF4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 38DisorderedSequence analysisAdd BLAST38
Regioni380 – 420DisorderedSequence analysisAdd BLAST41
Regioni932 – 1014DisorderedSequence analysisAdd BLAST83
Regioni1040 – 1074DisorderedSequence analysisAdd BLAST35

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1022 – 1046Nuclear export signal1 PublicationAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 22Basic and acidic residuesSequence analysisAdd BLAST22
Compositional biasi23 – 38Acidic residuesSequence analysisAdd BLAST16
Compositional biasi932 – 950Polar residuesSequence analysisAdd BLAST19
Compositional biasi971 – 1014Basic and acidic residuesSequence analysisAdd BLAST44
Compositional biasi1040 – 1064Polar residuesSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RecD family. HELB subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QWCN, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006913

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010264_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NVF4

Identification of Orthologs from Complete Genome Data

More...
OMAi
GCVFLYD

Database of Orthologous Groups

More...
OrthoDBi
174318at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NVF4

TreeFam database of animal gene trees

More...
TreeFami
TF336223

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.300, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027044, Helb
IPR027417, P-loop_NTPase
IPR027785, UvrD-like_helicase_C

The PANTHER Classification System

More...
PANTHERi
PTHR18934:SF135, PTHR18934:SF135, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13538, UvrD_C_2, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q6NVF4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARQDRLREL LGPLHPYKSD DEEEDCAQEE EGEQEEEFVD AEELCSGGIK
60 70 80 90 100
AGSLPGRARV SIPDEYTKEK CTVYGRFPLK GPWWRVKVQV LKPQRSRSYQ
110 120 130 140 150
VQGFPAYFLQ VDMSPPDQKQ ICSLFLKECN LASERIQEFL KWVEKVSSFE
160 170 180 190 200
NLHFENLWET LRLFYRETEK KDKKLSTPRE QQGEEMRVEK SFAFISAMVA
210 220 230 240 250
LQFPKVMEFL PSLFPRHFKR LISSSSDWVL GCIEDVLGTQ PWKLGFRRIT
260 270 280 290 300
YREMKLVRCE ASWTAFSQCP SLLQLMTPLQ KNALVIYSKL RQTCREDGHT
310 320 330 340 350
YIEVKDLTSG LSEHMSFEEA CQSLAFLKDI DVVIYEKDYV FLSELYEAEQ
360 370 380 390 400
DIASSICELM SRPPWHLKVD VKNVLASIRG AKPNDPGSAE AVEGSKPEEV
410 420 430 440 450
GSEQGDSVLD AQDGDDHVRS NGEHVANAEI NDVPLDQDQV VALETICANA
460 470 480 490 500
VTVLSGKGGC GKTTIVSRLF KHMEHLEETE VQQACEDFEQ DQEASEEWLD
510 520 530 540 550
CPKQSPAGVD KAVEVLLTAP TGKAAGLLRQ RTDLPAYTLC QVNYSFYMWK
560 570 580 590 600
TKNEVDKPWK FSTVRVLVVD EGSLVSVGIF KSVLQLLCKH SKLSKLIILG
610 620 630 640 650
DVRQLPSIEP GNMLQDVFET LKSRQCAIEL KTNHRTESQL IVDNATRISR
660 670 680 690 700
RQFPKFDAEL NICGNPTLPL SIQDKTFIFV RLPEEDSRSQ SSKGEHRSNL
710 720 730 740 750
YTAVKTLLQG KDFCSFESSK TSQFIAFRRQ DCDLINDCCC KHYTGHLIKD
760 770 780 790 800
HEKKLIFAVG DKICCTRNAY LSDLLPDKDQ EAEGKGYGDA PDDDAKIKQD
810 820 830 840 850
FESSTRLCNG EIFFITRDVT DVTFKRKRLL TINNEAGLEV TVDFSKLMAN
860 870 880 890 900
CQIKHAWART IHTFQGSEEN TVVYVVGKAG RQHWQHVYTA VTRGRSRVYI
910 920 930 940 950
IAQESELRSA TRKRGFPRQT RLKHFLQKKL SGSCAPSTGF ASQPSSPRVG
960 970 980 990 1000
GRPDTQPPAS HLCRTPDNKA TADSARGDER WLSASVNDDV DTDEESAQLR
1010 1020 1030 1040 1050
GSKRIGDGFP FDEESPSKFR MVEAPSPQVS SVFQNMRLNT LTPRQLFKPT
1060 1070
DNQDTGTAGV ADDANDPSNQ EMEM
Length:1,074
Mass (Da):121,471
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D17C06D429BADC8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RGT6D6RGT6_MOUSE
DNA helicase B
Helb
571Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD21372 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti805T → I in AAH68140 (PubMed:15489334).Curated1
Sequence conflicti933S → T in BAB20809 (PubMed:11557815).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB048542 mRNA Translation: BAB20809.1
AK131122 mRNA Translation: BAD21372.1 Different initiation.
AC134326 Genomic DNA No translation available.
AC144942 Genomic DNA No translation available.
CH466578 Genomic DNA Translation: EDL24397.1
BC068140 mRNA Translation: AAH68140.1
AK043127 mRNA Translation: BAC31468.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24203.1

NCBI Reference Sequences

More...
RefSeqi
NP_536694.2, NM_080446.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000020449; ENSMUSP00000020449; ENSMUSG00000020228

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
117599

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:117599

UCSC genome browser

More...
UCSCi
uc007hes.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB048542 mRNA Translation: BAB20809.1
AK131122 mRNA Translation: BAD21372.1 Different initiation.
AC134326 Genomic DNA No translation available.
AC144942 Genomic DNA No translation available.
CH466578 Genomic DNA Translation: EDL24397.1
BC068140 mRNA Translation: AAH68140.1
AK043127 mRNA Translation: BAC31468.1
CCDSiCCDS24203.1
RefSeqiNP_536694.2, NM_080446.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi228238, 6 interactors
STRINGi10090.ENSMUSP00000020449

PTM databases

iPTMnetiQ6NVF4
PhosphoSitePlusiQ6NVF4

Proteomic databases

EPDiQ6NVF4
jPOSTiQ6NVF4
MaxQBiQ6NVF4
PaxDbiQ6NVF4
PeptideAtlasiQ6NVF4
PRIDEiQ6NVF4
ProteomicsDBi269730

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
16658, 28 antibodies

The DNASU plasmid repository

More...
DNASUi
117599

Genome annotation databases

EnsembliENSMUST00000020449; ENSMUSP00000020449; ENSMUSG00000020228
GeneIDi117599
KEGGimmu:117599
UCSCiuc007hes.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
92797
MGIiMGI:2152895, Helb
VEuPathDBiHostDB:ENSMUSG00000020228

Phylogenomic databases

eggNOGiENOG502QWCN, Eukaryota
GeneTreeiENSGT00390000006913
HOGENOMiCLU_010264_0_0_1
InParanoidiQ6NVF4
OMAiGCVFLYD
OrthoDBi174318at2759
PhylomeDBiQ6NVF4
TreeFamiTF336223

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
117599, 1 hit in 97 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Helb, mouse

Protein Ontology

More...
PROi
PR:Q6NVF4
RNActiQ6NVF4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000020228, Expressed in lens of camera-type eye and 276 other tissues
GenevisibleiQ6NVF4, MM

Family and domain databases

Gene3Di3.40.50.300, 1 hit
InterProiView protein in InterPro
IPR027044, Helb
IPR027417, P-loop_NTPase
IPR027785, UvrD-like_helicase_C
PANTHERiPTHR18934:SF135, PTHR18934:SF135, 1 hit
PfamiView protein in Pfam
PF13538, UvrD_C_2, 1 hit
SUPFAMiSSF52540, SSF52540, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHELB_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NVF4
Secondary accession number(s): G5E835
, Q6KAT5, Q8C930, Q9EQT8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 3, 2012
Last modified: September 29, 2021
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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