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Entry version 142 (16 Oct 2019)
Sequence version 1 (05 Jul 2004)
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Protein

Inositol polyphosphate 5-phosphatase OCRL

Gene

Ocrl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and phosphatidylinositol-3,4,5-bisphosphate (PtdIns(3,4,5)P3), with the greatest catalytic activity towards PtdIns(4,5)P2. Able also to hydrolyzes the 4-phosphate of inositol 1,4,5-trisphosphate and of inositol 1,3,4,5-tetrakisphosphate. Regulates traffic in the endosomal pathway by regulating the specific pool of phosphatidylinositol 4,5-bisphosphate that is associated with endosomes. Involved in primary cilia assembly. Acts as a regulator of phagocytosis, hydrolyzing PtdIns(4,5)P2 to promote phagosome closure, through attenuation of PI3K signaling.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processCilium biogenesis/degradation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-1660514 Synthesis of PIPs at the Golgi membrane
R-MMU-1855183 Synthesis of IP2, IP, and Ins in the cytosol
R-MMU-1855204 Synthesis of IP3 and IP4 in the cytosol
R-MMU-194840 Rho GTPase cycle
R-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-8856828 Clathrin-mediated endocytosis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Inositol polyphosphate 5-phosphatase OCRL (EC:3.1.3.36By similarity, EC:3.1.3.56By similarity)
Alternative name(s):
Inositol polyphosphate 5-phosphatase OCRL-1
Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase (EC:3.1.3.86By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OcrlImported
Synonyms:Ocrl1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:109589 Ocrl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Coated pit, Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004215641 – 900Inositol polyphosphate 5-phosphatase OCRLAdd BLAST900

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NVF0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NVF0

PeptideAtlas

More...
PeptideAtlasi
Q6NVF0

PRoteomics IDEntifications database

More...
PRIDEi
Q6NVF0

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NVF0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NVF0

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q6NVF0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000001173 Expressed in 231 organ(s), highest expression level in cerebral cortex

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NVF0 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NVF0 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with APPL1, PHETA1/SES1 and PHETA2/SES2; APPL1-binding and PHETA1-binding are mutually exclusive (By similarity).

Interacts with clathrin heavy chain.

Interacts with several Rab GTPases, at least RAB1B, RAB5A, RAB6A, RAB8A and RAB31; these interactions may play a dual role in targeting OCRL to the specific membranes and stimulating the phosphatase activitye (PubMed:25869668). Interaction with RAB8A modulates OCRL recruitment to cilia.

Interacts with RAB31 (By similarity).

Interacts with INPP5F (PubMed:25869668).

By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q6NVF0

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000001202

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q6NVF0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 119PHAdd BLAST119
Domaini720 – 900Rho-GAPPROSITE-ProRule annotationAdd BLAST181

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni236 – 5625-phosphataseBy similarityAdd BLAST327
Regioni563 – 677ASHBy similarityAdd BLAST115

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi73 – 77Clathrin box 15
Motifi701 – 705Clathrin box 25

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ASH (ASPM-SPD2-Hydin) and RhoGAP (Rho GTPase activating) domains form a single folding module. The ASH domain has an immunoglobulin-like fold, the Rho-GAP domain lacks the catalytic arginine and is catalytically inactive. The ASH-RhoGAP module regulates the majority of the protein-protein interactions currently described. The ASH domain mediates association with membrane-targeting Rab GTPases. The Rho-GAP domain interacts with the endocytic adapter APPL1, which is then displaced by PHETA1 and PHETA2 as endosomes mature (By similarity).By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0565 Eukaryota
COG5411 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157996

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000008071

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NVF0

KEGG Orthology (KO)

More...
KOi
K01099

Identification of Orthologs from Complete Genome Data

More...
OMAi
AHDSRLC

Database of Orthologous Groups

More...
OrthoDBi
1399831at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NVF0

TreeFam database of animal gene trees

More...
TreeFami
TF317034

Family and domain databases

Conserved Domains Database

More...
CDDi
cd09093 INPP5c_INPP5B, 1 hit
cd13382 PH_OCRL1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
2.60.40.10, 1 hit
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR013783 Ig-like_fold
IPR000300 IPPc
IPR037793 OCRL1/INPP5B_INPP5c
IPR037787 OCRL1_PH
IPR031995 OCRL_clath-bd
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03372 Exo_endo_phos, 1 hit
PF16726 OCRL_clath_bd, 1 hit
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00128 IPPc, 1 hit
SM00324 RhoGAP, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF56219 SSF56219, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50238 RHOGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NVF0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPRLPIGAQ PLAMVAGLEM KGPLREPCVL TLARRNGQYE LIIQLHGKEQ
60 70 80 90 100
HVQDIIPINS HFRCVQEAEE TLLIDIASNS GCKIRVQGDW TRERHFEIPD
110 120 130 140 150
EERCLKFLSE VLEAQEAQSQ LLVPEQKDSS SWYQKLDTMD KPAYSGLLGF
160 170 180 190 200
EDNFSSLDLD KKMNTQNPRS GSHREPPPPP SSSTRMLSRE KEASNKEQPK
210 220 230 240 250
VTNTMRKLFV PNTQTGQREG LIKHILTKRE KEYVNIQSFR FFVGTWNVNG
260 270 280 290 300
QSPDSSLEPW LDCDPNPPDI YCIGFQELDL STEAFFYFES VKEQEWSLAV
310 320 330 340 350
ERGLPSKAKY RKVQLVRLVG MMLLIFARKD QCQYIRDVAT ETTGTGIMGK
360 370 380 390 400
MGNKGGVAVR FVFHNTTFCI VNSHLAAHVE EFERRNQDYK DICARMTFSV
410 420 430 440 450
PNQTVPQVNI MKHDVVIWLG DLNYRLCMPD ASEVKSLINK NELHKLLKFD
460 470 480 490 500
QLNIQRTQKK AFADFNEGEI NFVPTYKYDS KTDRWDSSGK CRVPAWCDRI
510 520 530 540 550
LWRGINVNQL HYRSHMELKT SDHKPVSALF HIGVKVVDER RYRKVFEDIV
560 570 580 590 600
RIMDRMENDF LPSLELSRRE FFFENVKFRQ LQKEKFQISN NGQVPCHFSF
610 620 630 640 650
IPKLNDSQYC KPWLRAEPFE GYLEPNETLD ISLDVYVSKD SVTILNSGED
660 670 680 690 700
KIEDILVLHL DRGKDYFLTI GGNYLPSCFG TSLEALCRMK RPIREVPVTK
710 720 730 740 750
LIDLEEDSYL EKEKSLLQMV PLDEGTSERP LQVPKEIWLL VDHLFKYACH
760 770 780 790 800
QEDLFQTPGM QEELQQIIDC LDTSIPETIP GNNHSVAEAL LIFLEALPEP
810 820 830 840 850
VICYELYQRC LDSAHDPRIC KQVISQLPRC HRNVFRYLMA FLRELLKFSD
860 870 880 890 900
YNNINTNMIA TLFSSLLLRP PPNLMTRQTP NDRQHAIQFL LVFLLGNEED
Length:900
Mass (Da):104,285
Last modified:July 5, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8C0985161F60696
GO
Isoform 2 (identifier: Q6NVF0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     713-741: EKSLLQMVPLDEGTSERPLQVPKEIWLLV → VIQSIGGNEGFLVLD
     742-900: Missing.

Note: No experimental confirmation available.
Show »
Length:727
Mass (Da):84,012
Checksum:i8E7C1377CE09A9C8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q7TPR1Q7TPR1_MOUSE
Inositol polyphosphate 5-phosphatas...
Ocrl
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7CAV3F7CAV3_MOUSE
Inositol polyphosphate 5-phosphatas...
Ocrl
266Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_045749713 – 741EKSLL…IWLLV → VIQSIGGNEGFLVLD in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_045750742 – 900Missing in isoform 2. 1 PublicationAdd BLAST159

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK047906 mRNA Translation: BAC33188.1
AK041963 mRNA Translation: BAE20614.1
AL714010 Genomic DNA No translation available.
BC068146 mRNA Translation: AAH68146.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40957.1 [Q6NVF0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_796189.2, NM_177215.3 [Q6NVF0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000001202; ENSMUSP00000001202; ENSMUSG00000001173 [Q6NVF0-1]
ENSMUST00000115020; ENSMUSP00000110672; ENSMUSG00000001173 [Q6NVF0-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
320634

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:320634

UCSC genome browser

More...
UCSCi
uc009tbr.1 mouse [Q6NVF0-1]
uc009tbs.1 mouse [Q6NVF0-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK047906 mRNA Translation: BAC33188.1
AK041963 mRNA Translation: BAE20614.1
AL714010 Genomic DNA No translation available.
BC068146 mRNA Translation: AAH68146.1
CCDSiCCDS40957.1 [Q6NVF0-1]
RefSeqiNP_796189.2, NM_177215.3 [Q6NVF0-1]

3D structure databases

SMRiQ6NVF0
ModBaseiSearch...

Protein-protein interaction databases

CORUMiQ6NVF0
STRINGi10090.ENSMUSP00000001202

PTM databases

iPTMnetiQ6NVF0
PhosphoSitePlusiQ6NVF0
SwissPalmiQ6NVF0

Proteomic databases

EPDiQ6NVF0
PaxDbiQ6NVF0
PeptideAtlasiQ6NVF0
PRIDEiQ6NVF0

Genome annotation databases

EnsembliENSMUST00000001202; ENSMUSP00000001202; ENSMUSG00000001173 [Q6NVF0-1]
ENSMUST00000115020; ENSMUSP00000110672; ENSMUSG00000001173 [Q6NVF0-2]
GeneIDi320634
KEGGimmu:320634
UCSCiuc009tbr.1 mouse [Q6NVF0-1]
uc009tbs.1 mouse [Q6NVF0-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4952
MGIiMGI:109589 Ocrl

Phylogenomic databases

eggNOGiKOG0565 Eukaryota
COG5411 LUCA
GeneTreeiENSGT00940000157996
HOGENOMiHOG000008071
InParanoidiQ6NVF0
KOiK01099
OMAiAHDSRLC
OrthoDBi1399831at2759
PhylomeDBiQ6NVF0
TreeFamiTF317034

Enzyme and pathway databases

ReactomeiR-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-1660514 Synthesis of PIPs at the Golgi membrane
R-MMU-1855183 Synthesis of IP2, IP, and Ins in the cytosol
R-MMU-1855204 Synthesis of IP3 and IP4 in the cytosol
R-MMU-194840 Rho GTPase cycle
R-MMU-432722 Golgi Associated Vesicle Biogenesis
R-MMU-8856828 Clathrin-mediated endocytosis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Ocrl mouse

Protein Ontology

More...
PROi
PR:Q6NVF0

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000001173 Expressed in 231 organ(s), highest expression level in cerebral cortex
ExpressionAtlasiQ6NVF0 baseline and differential
GenevisibleiQ6NVF0 MM

Family and domain databases

CDDicd09093 INPP5c_INPP5B, 1 hit
cd13382 PH_OCRL1, 1 hit
Gene3Di1.10.555.10, 1 hit
2.60.40.10, 1 hit
3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
IPR013783 Ig-like_fold
IPR000300 IPPc
IPR037793 OCRL1/INPP5B_INPP5c
IPR037787 OCRL1_PH
IPR031995 OCRL_clath-bd
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
PF16726 OCRL_clath_bd, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00128 IPPc, 1 hit
SM00324 RhoGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
SSF56219 SSF56219, 1 hit
PROSITEiView protein in PROSITE
PS50238 RHOGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOCRL_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NVF0
Secondary accession number(s): Q8BXC9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: July 5, 2004
Last modified: October 16, 2019
This is version 142 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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