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Protein

WD repeat-containing protein 44

Gene

Wdr44

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Downstream effector for RAB11. May be involved in vesicle recycling (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 44
Alternative name(s):
Rabphilin-11
Gene namesi
Name:Wdr44
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1919654 Wdr44

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002627702 – 915WD repeat-containing protein 44Add BLAST914

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei3PhosphoserineBy similarity1
Modified residuei11PhosphotyrosineBy similarity1
Modified residuei27PhosphoserineBy similarity1
Modified residuei50PhosphoserineCombined sources1
Modified residuei66PhosphoserineBy similarity1
Modified residuei71PhosphoserineBy similarity1
Modified residuei81PhosphoserineBy similarity1
Modified residuei126PhosphoserineBy similarity1
Modified residuei161PhosphothreonineBy similarity1
Modified residuei221PhosphothreonineCombined sources1
Modified residuei264PhosphoserineBy similarity1
Modified residuei273PhosphothreonineBy similarity1
Modified residuei344PhosphoserineCombined sources1
Modified residuei346PhosphoserineBy similarity1
Modified residuei351PhosphothreonineBy similarity1
Modified residuei403PhosphothreonineCombined sources1
Modified residuei405PhosphoserineCombined sources1
Modified residuei472PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei474PhosphoserineCombined sources1
Modified residuei481PhosphotyrosineCombined sources1
Modified residuei563PhosphoserineCombined sources1
Modified residuei567PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ6NVE8
PaxDbiQ6NVE8
PeptideAtlasiQ6NVE8
PRIDEiQ6NVE8

PTM databases

iPTMnetiQ6NVE8
PhosphoSitePlusiQ6NVE8

Expressioni

Gene expression databases

BgeeiENSMUSG00000036769 Expressed in 208 organ(s), highest expression level in blood
CleanExiMM_WDR44
ExpressionAtlasiQ6NVE8 baseline and differential
GenevisibleiQ6NVE8 MM

Interactioni

Subunit structurei

Interacts with the GTP-bound form of RAB11 when membrane-associated. Does not bind to other Rab and Rho small G proteins (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215359, 1 interactor
STRINGi10090.ENSMUSP00000044616

Structurei

3D structure databases

ProteinModelPortaliQ6NVE8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati511 – 550WD 1Add BLAST40
Repeati607 – 645WD 2Add BLAST39
Repeati647 – 687WD 3Add BLAST41
Repeati692 – 731WD 4Add BLAST40
Repeati742 – 781WD 5Add BLAST40
Repeati786 – 825WD 6Add BLAST40
Repeati840 – 880WD 7Add BLAST41
Repeati882 – 915WD 8Add BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 173Binding activityAdd BLAST172

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili114 – 139Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi213 – 259Pro-richAdd BLAST47

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0283 Eukaryota
ENOG410XQPJ LUCA
GeneTreeiENSGT00530000063479
HOGENOMiHOG000267152
HOVERGENiHBG080376
InParanoidiQ6NVE8
KOiK20241
OMAiKTDHTEV
OrthoDBiEOG091G0290
PhylomeDBiQ6NVE8
TreeFamiTF329226

Family and domain databases

InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q6NVE8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASESDTEEF YDAPEDVHLG TGYPVGSPGK VGLLSFKEAE NTANQAGNES
60 70 80 90 100
PVQELRQDVS KKIIESIIEE SQKVLQLEDD SLDSKGKGLS DEATAGPSVA
110 120 130 140 150
GTEFSNIPGL LAIEHELQQD SEKAESQNVA EESELETQKC FPSDETCEKS
160 170 180 190 200
EKTVDETDNL TEVSSGEQLD ASGLEAETLN KEALEVKEGD VLDPASLDTL
210 220 230 240 250
STTDFAAVEE VAPAKPPRHL TPEPDIVAST KKPVPARPPP PTNFPPPRPP
260 270 280 290 300
PPSRPAPPPR KKKSELEFEA LKTPDLDVPK ENITSDSLLT TNMASENTVR
310 320 330 340 350
DSLPSLDLAS ATSGDKIVTA QENGKAPDVQ TVAGEVMGPQ RPRSNSGREL
360 370 380 390 400
TDEEILASVM IKNLDTGEEI PLSLAEEKLP TGINPLTLHI MRRTKEYVSN
410 420 430 440 450
DATQSDDEEK LQSQQTDTDG GRLKQKTTQL KKFLGKSVKR AKHLAEEYGE
460 470 480 490 500
RAINKVKSVR DEVFHTDQDD PSSSDDEGMP YTRPVKFKAA HGFKGPYDFD
510 520 530 540 550
QIKVVQDLSG EHMGAVWTMK FSHCGRLLAS AGQDNIVRIW ALKNAFDYFN
560 570 580 590 600
NMRMKYNTEG RVSPSPSQES LSSSKSDTDM GVCSGTDEDP DDKNAPFRQR
610 620 630 640 650
PFCKYKGHTA DLLDLSWSKN YFLLSSSMDK TVRLWHISRR ECLCCFQHID
660 670 680 690 700
FVTAIAFHPR DDRYFLSGSL DGKLRLWNIP DKKVALWNEV DGQTKLITAA
710 720 730 740 750
NFCQNGKYAV IGTYDGRCIF YDTEHLKYHT QIHVRSTRGR NKVGRKITGI
760 770 780 790 800
EPLPGENKIL VTSNDSRIRL YDLRDLSLSM KYKGYVNSSS QIKASFSHDF
810 820 830 840 850
TYLVSGSEDK YVYIWSTYHD LSKFTSVRRD RNDFWEGIKA HNAVVTSAIF
860 870 880 890 900
APNPSLMLSL DVQSEKLEGI DKYEDAEVLD STSTGIVKTD NTEVLLSADF
910
TGAIKVFINK RKTVS
Length:915
Mass (Da):101,555
Last modified:July 5, 2004 - v1
Checksum:iB5FDF8A4C87295DC
GO
Isoform 2 (identifier: Q6NVE8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-478: Missing.

Note: No experimental confirmation available.
Show »
Length:437
Mass (Da):49,775
Checksum:iB1674DA4CD67F780
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RHR5D6RHR5_MOUSE
WD repeat-containing protein 44
Wdr44
43Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti629D → E in BAE24167 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0218111 – 478Missing in isoform 2. 1 PublicationAdd BLAST478

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088885 mRNA Translation: BAC40631.2
AK139877 mRNA Translation: BAE24167.1
BC068151 mRNA Translation: AAH68151.1
BC049191 mRNA Translation: AAH49191.1
CCDSiCCDS40892.1 [Q6NVE8-1]
RefSeqiNP_001292604.1, NM_001305675.1 [Q6NVE8-1]
NP_780389.2, NM_175180.3 [Q6NVE8-1]
XP_006527763.1, XM_006527700.3 [Q6NVE8-1]
UniGeneiMm.423

Genome annotation databases

EnsembliENSMUST00000035766; ENSMUSP00000044616; ENSMUSG00000036769 [Q6NVE8-1]
ENSMUST00000101670; ENSMUSP00000099193; ENSMUSG00000036769 [Q6NVE8-1]
GeneIDi72404
KEGGimmu:72404
UCSCiuc009suw.2 mouse [Q6NVE8-1]
uc009suy.1 mouse [Q6NVE8-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088885 mRNA Translation: BAC40631.2
AK139877 mRNA Translation: BAE24167.1
BC068151 mRNA Translation: AAH68151.1
BC049191 mRNA Translation: AAH49191.1
CCDSiCCDS40892.1 [Q6NVE8-1]
RefSeqiNP_001292604.1, NM_001305675.1 [Q6NVE8-1]
NP_780389.2, NM_175180.3 [Q6NVE8-1]
XP_006527763.1, XM_006527700.3 [Q6NVE8-1]
UniGeneiMm.423

3D structure databases

ProteinModelPortaliQ6NVE8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215359, 1 interactor
STRINGi10090.ENSMUSP00000044616

PTM databases

iPTMnetiQ6NVE8
PhosphoSitePlusiQ6NVE8

Proteomic databases

EPDiQ6NVE8
PaxDbiQ6NVE8
PeptideAtlasiQ6NVE8
PRIDEiQ6NVE8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035766; ENSMUSP00000044616; ENSMUSG00000036769 [Q6NVE8-1]
ENSMUST00000101670; ENSMUSP00000099193; ENSMUSG00000036769 [Q6NVE8-1]
GeneIDi72404
KEGGimmu:72404
UCSCiuc009suw.2 mouse [Q6NVE8-1]
uc009suy.1 mouse [Q6NVE8-2]

Organism-specific databases

CTDi54521
MGIiMGI:1919654 Wdr44

Phylogenomic databases

eggNOGiKOG0283 Eukaryota
ENOG410XQPJ LUCA
GeneTreeiENSGT00530000063479
HOGENOMiHOG000267152
HOVERGENiHBG080376
InParanoidiQ6NVE8
KOiK20241
OMAiKTDHTEV
OrthoDBiEOG091G0290
PhylomeDBiQ6NVE8
TreeFamiTF329226

Miscellaneous databases

PROiPR:Q6NVE8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036769 Expressed in 208 organ(s), highest expression level in blood
CleanExiMM_WDR44
ExpressionAtlasiQ6NVE8 baseline and differential
GenevisibleiQ6NVE8 MM

Family and domain databases

InterProiView protein in InterPro
IPR020472 G-protein_beta_WD-40_rep
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00400 WD40, 4 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00320 WD40, 6 hits
SUPFAMiSSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50082 WD_REPEATS_2, 4 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWDR44_MOUSE
AccessioniPrimary (citable) accession number: Q6NVE8
Secondary accession number(s): Q3UT13, Q8BTS1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: July 5, 2004
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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