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Entry version 131 (12 Aug 2020)
Sequence version 2 (16 Aug 2005)
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Protein

FRAS1-related extracellular matrix protein 2

Gene

Frem2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Extracellular matrix protein required for maintenance of the integrity of the skin epithelium and for maintenance of renal epithelia (By similarity). Required for epidermal adhesion (PubMed:15838507). Involved in the development of eyelids and the anterior segment of the eyeballs (PubMed:30802441).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processCell adhesion
LigandCalcium, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FRAS1-related extracellular matrix protein 2
Alternative name(s):
ECM3 homolog
NV domain-containing protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Frem2
Synonyms:Nv1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444465, Frem2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini40 – 3105ExtracellularSequence analysisAdd BLAST3066
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3106 – 3126HelicalSequence analysisAdd BLAST21
Topological domaini3127 – 3160CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice display cryptophthalmos, syndactyly and renal defects. Frem2 corresponds to the X-ray irradiated-induced allele 'myelencephalic blebs' (my).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 39Sequence analysisAdd BLAST39
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001012540 – 3160FRAS1-related extracellular matrix protein 2Add BLAST3121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1233N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1358N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1573N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1730N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q6NVD0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NVD0

PRoteomics IDEntifications database

More...
PRIDEi
Q6NVD0

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q6NVD0, 5 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NVD0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NVD0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

First expressed from E10 in the mesodermal core of the branchial arches, developing lens, otic vesicle and limb apical ectodermal ridge. Later, it is expressed in the vibrissae and vibrissae pad, eyelids ear and pelage follicles and, at low levels, in the epidermis (PubMed:15838507). Also expressed in caudal somites and, in later embryos, in facial, limb and intercostal muscles (PubMed:15838507). In contrast to Frem1, it is not expressed in the developing mammary glands or in the caecum (PubMed:15838507). Restricted to the epithelia in a pattern complementary to that of Frem1 (which is generally expressed in the dermis and mesenchyme) (PubMed:15838507). In the developing kidney, it is expressed At in the mesonephric and metanephric epithelia at E11.5, with a highest expression at the tips of the developing ureteric buds (PubMed:15838507). At E12.5 and E13.5, it is still expressed throughout the epithelial components of the kidney, including epithelia fated to form nephrons, which are induced by the ureter tips to differentiate from the mesenchymal condensations that surround them (PubMed:15838507). Expressed in retinal neuron-containing outer plexiform layer (PubMed:30802441).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000037016, Expressed in dorsal pancreas and 156 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NVD0, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FREM1.

By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-61241N

Protein interaction database and analysis system

More...
IntActi
Q6NVD0, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000088670

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q6NVD0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati312 – 406CSPG 1PROSITE-ProRule annotationAdd BLAST95
Repeati431 – 530CSPG 2PROSITE-ProRule annotationAdd BLAST100
Repeati553 – 664CSPG 3PROSITE-ProRule annotationAdd BLAST112
Repeati689 – 796CSPG 4PROSITE-ProRule annotationAdd BLAST108
Repeati817 – 908CSPG 5PROSITE-ProRule annotationAdd BLAST92
Repeati934 – 1026CSPG 6PROSITE-ProRule annotationAdd BLAST93
Repeati1055 – 1157CSPG 7PROSITE-ProRule annotationAdd BLAST103
Repeati1178 – 1271CSPG 8PROSITE-ProRule annotationAdd BLAST94
Repeati1292 – 1388CSPG 9PROSITE-ProRule annotationAdd BLAST97
Repeati1409 – 1501CSPG 10PROSITE-ProRule annotationAdd BLAST93
Repeati1521 – 1610CSPG 11PROSITE-ProRule annotationAdd BLAST90
Repeati1644 – 1741CSPG 12PROSITE-ProRule annotationAdd BLAST98
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1748 – 1847Calx-beta 1Add BLAST100
Domaini1860 – 1971Calx-beta 2Add BLAST112
Domaini1986 – 2092Calx-beta 3Add BLAST107
Domaini2107 – 2209Calx-beta 4Add BLAST103
Domaini2227 – 2331Calx-beta 5Add BLAST105

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FRAS1 family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1306, Eukaryota
KOG2090, Eukaryota
KOG3597, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155313

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000394_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NVD0

KEGG Orthology (KO)

More...
KOi
K23380

Identification of Orthologs from Complete Genome Data

More...
OMAi
TIFLKPV

Database of Orthologous Groups

More...
OrthoDBi
13258at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NVD0

TreeFam database of animal gene trees

More...
TreeFami
TF316876

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.2030, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR039005, CSPG_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03160, Calx-beta, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00237, Calx_beta, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF141072, SSF141072, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51854, CSPG, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q6NVD0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASRARRTAK FSSFQPILAQ SPRLLLLLLL LSLVSYVSTQ AAGPGAALQS
60 70 80 90 100
LGLSGTSGVP TEEAIVVANR GLRVPFGREV WLDPLRDLVL QVQPGDRCTV
110 120 130 140 150
TVLDNDALAQ RPGHLSPKRF ACDYGPGEVR YSHLGARSPS RDRVRLQLRY
160 170 180 190 200
DAPGGAIVLP LALEVEVVFT QLEIVTRNLP LVVEELLGTS NALDDRSLEF
210 220 230 240 250
AYQPETEECR VGILSGLSAL PRYGELLHYP QVQGGAGDRG TSKTLLMDCK
260 270 280 290 300
AFQELGVRYR HTAPSRSPNR DWLPMVVELH SRGAPEGSPA LKREHFQVLV
310 320 330 340 350
RIRGGAENTA PKPSFVAMMM MEVDQFVLTA LTPDMLAAED AESDPDLLIF
360 370 380 390 400
NLTSAFQPGQ GYLVSTDDRS LPLSSFTQRD LRLLKIAYQP PSEDSDQERL
410 420 430 440 450
FELELEIVDP EGAASDPFAF MVVVKPMNTL APVVTRNTGL ILYEGQYRPL
460 470 480 490 500
TGPIGSGPQN LVISDEDDLE AVRLEVVAGL RHGHLVILGS PSSDSAPKTF
510 520 530 540 550
TVAELAAGQV VYQHDDKDGS LSDNLVLRMS DGGGRHQVQF LFPITLVPVD
560 570 580 590 600
DQPPVLNANT GLTVAEGETV PIPPLTLSAT DIDSDDSQLV FVLLPPFSSL
610 620 630 640 650
GHLLLRQRHV PQEEQGLWQK QGSFYERTVT EWRQQDITEG KLFYRHSGPH
660 670 680 690 700
SPGPVMDQFM FRVQDNHDPP NQSGIQRFVI RIHPVDRLPP ELGSGCPLRM
710 720 730 740 750
VVQESQLTPL RKRWLHYTDL DTDDRELQYT VTQPPTDTDE NHSPAPLGTL
760 770 780 790 800
VFTDNPSVVV SHFTQAQVNH HKIAYRPPGQ ELGVAARVAQ FQFQVEDRAG
810 820 830 840 850
NVAPGTFTLY LQPVDNQPPE IVNTGFTVEE KGHHILRETE LHVSDVDTDV
860 870 880 890 900
THISFTLTQA PKHGHMQISG RPLHVGGQFH LEDIKHGRIS YWNSGDESLT
910 920 930 940 950
DSCSLEVSDR HHVVPITLRV NVRPGDREGP MSVLPAGTLE SYLDVLENGA
960 970 980 990 1000
TEVTANIIKG AYQGTDDLML TFLLEGPPSY GEILVNGAPA EQFTQRDILE
1010 1020 1030 1040 1050
GSVVYAHTSG EIGLLPKADS FNLSLSAMSQ EWRIGSSIVQ GVTVWVTILP
1060 1070 1080 1090 1100
VDSQAPEISL GEQFVVLEGD KSVISLTHLS AEDMDSLKDD LLCTIVIQPT
1110 1120 1130 1140 1150
SGYVENISPA PGSEKSRAGV AISAFTLKDL RQGHINYVQS VHRGVEPVED
1160 1170 1180 1190 1200
RFIFRCSDGI NFSERQIFPI VIIPTNDEQP EMFMREFMVM EGMSLVVNRL
1210 1220 1230 1240 1250
ILNAADADIP RDDLTFTITR FPTHGHVMNQ LINGTVLVES FTLDQIIESS
1260 1270 1280 1290 1300
SIIYEHDDSE TQEDSFVIKL TDGKHSVEKM VLIVVIPVDD ETPRMTINNG
1310 1320 1330 1340 1350
LEIEIGETKV INNKVLMATD LDSDDKSLVY IIRYGPGHGL LQRQKPLGAF
1360 1370 1380 1390 1400
ENITLGMNFT QDEVDRNLIQ YVHFGQEGIR DLIKFDVTDG TNALIDRYFY
1410 1420 1430 1440 1450
VTIGSVDIVF PDVVSKGVSL KEGGKVTLTT DLLSTSDLNS PDENLVFTIT
1460 1470 1480 1490 1500
RAPMRGHLEC TDRRGLSITS FTQLQLAGNK IYYIHTAEDE VKMDSFEFQV
1510 1520 1530 1540 1550
TDGRNPVFRT FRISISDVDN KKPVVTIHNL VVSESESKLI TPFELTVEDR
1560 1570 1580 1590 1600
DTPDRLLKFI VTQVPVHGHL LFNNTRSVMV FTKQDLNENL ISYKHDGTES
1610 1620 1630 1640 1650
TEDSFSFTVT DGTHSDFYVF PDTVFETRRP QVMKIQVLPV DNSVPQIVVN
1660 1670 1680 1690 1700
KGASTLRTLA TGHLGFMITS KILKVEDRDS LHFSLRFIVT EAPQHGYLLN
1710 1720 1730 1740 1750
LGQGNHSVTQ FTQADIDDMK ICYVLRERAN ATSDMFHFIV EDDGGNRLTN
1760 1770 1780 1790 1800
QHFRLNWAWI SFEKEYYLIN EDSKFLDIVL TRRGYLGETS FISIGTRDGT
1810 1820 1830 1840 1850
AEKDRDFKGK AQKQVQFNPG QTRASWRVRI LSDGEHEHSE TFQVVLSEPV
1860 1870 1880 1890 1900
LAILEFPTVT TVEIIDPGDE STVFIPQSEY SVEEDVGELF IPIRRSGDIS
1910 1920 1930 1940 1950
RELMVICYTQ QGTATSTVRT SVLSYSDYIS RPEDHSSVIR FDKDEREKMC
1960 1970 1980 1990 2000
RILVIDDSLY EEEETFQVLL SMPMGGRIGD KFPGANVTIL TDRDDEPAFY
2010 2020 2030 2040 2050
FGDTQYSVDE SAGYVELQVW RTGTDLSKPS SVTVRSRKTE SLSADAGTDY
2060 2070 2080 2090 2100
VGISRNLDFA PGVNMQTVRV VILDDLGRPI LEGIEKFELV LRMPMNAALG
2110 2120 2130 2140 2150
EPSKATVSIN DSASDLPKMQ FKERVYTCNE NDGRVVAMIY RSGDIQHRSS
2160 2170 2180 2190 2200
VRCYTRQGSA QVMMDFEERP NTDVSTVTFL PGEMEKPCVL ELMDDAVYED
2210 2220 2230 2240 2250
VEELRLVLGT PQGSSAFGAA VGEQNETLIK IQDEADKAVI KFGETKFSVT
2260 2270 2280 2290 2300
EPSRPGESVV VKIPVIRQGD TSKVSIVRVH TKDGSATSGE DYHPVSEEIE
2310 2320 2330 2340 2350
FKEGETQHTV EIEVIFDGVR EMREAFTVHL KPDENMVAET QATKAIVYIE
2360 2370 2380 2390 2400
EIHSMADVTF PSVPHIVSLL IYDDPSKGRE DTGPVSGYPV VCITACNPKY
2410 2420 2430 2440 2450
PDYEKTGSIC ASENINDTLT RYRWLISAPA GPDGVTSPMR EVDFDTFFTS
2460 2470 2480 2490 2500
SKMITLDSIY FQPGSRVQCA ARAVNTNGNE GLELMSPIVT IGREEGLCQP
2510 2520 2530 2540 2550
RVPGVVGAEP FSAKLRYTGP EDPDFANLIK LTVTMPHIDG MLPAISTREL
2560 2570 2580 2590 2600
SNFELTLSPD GTRVGNHKCS NLLDYNEVKT HHGFLTNATK NPEVIGETYP
2610 2620 2630 2640 2650
YQYSVPVRGS STLRFYRNLN LEACLWEFVS YYDMTELLAD CGGTIGTDGQ
2660 2670 2680 2690 2700
VLNLVQSYVT LRVPLYVSYV FHSPVGVGGW QHFDLKSELR LTFVYDTAIL
2710 2720 2730 2740 2750
WNHGIGSPPE AELQGSLYPT SMRIGEEGRL AVNFKTEAQF HGLFVLSHPA
2760 2770 2780 2790 2800
SFTSSLIVSA DHPGLTFSLR LIRSEPTYNQ PVQQWSFVSD FAVRDYSGTY
2810 2820 2830 2840 2850
TVKLVPCTTP SNQEYRLPVT CNPREPVTFD LDIRFQQVSD PVATEFSLNT
2860 2870 2880 2890 2900
HMYLLSKKNL WLSDGSMGFG QESDVAFAEG DVIYGRVMVD PVQNLGDSFY
2910 2920 2930 2940 2950
CSIEKVFLCT GDDGYVPKYS PANAEYGCLA DSPSLLHRFK IVDKAQPETQ
2960 2970 2980 2990 3000
ATSFGDVLFN AKLAVDDPEA VLLVNQPGSD GFKVDSTPLF QVALGREWYI
3010 3020 3030 3040 3050
HTIYTVKSKD NTHRGIGKRS LEYQYHSVVH PGPPQATTKS WKKRAVRSTP
3060 3070 3080 3090 3100
SLAGEIGAEN NRGTNIQHIS LNRRGKRQVP HGRIPPDGIL PWELNSPSSE
3110 3120 3130 3140 3150
VSLVTVLGGL TVGLLTVCLA VAAAVMCRNR STKGKDTPKG SGSTEPMMSP
3160
QSHYNDSSEV
Length:3,160
Mass (Da):350,640
Last modified:August 16, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i579F20BD79957E06
GO
Isoform 2 (identifier: Q6NVD0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2287: Missing.
     2288-2297: SGEDYHPVSE → MVGPGNFRKR

Show »
Length:873
Mass (Da):96,504
Checksum:i198D3BE068E6C0DB
GO
Isoform 3 (identifier: Q6NVD0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-2851: Missing.

Show »
Length:309
Mass (Da):33,633
Checksum:iB0E805BEB9A456F1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2437S → N in BAC27425 (PubMed:16141072).Curated1
Sequence conflicti2851H → N in BAC27425 (PubMed:16141072).Curated1
Sequence conflicti3031P → H in AAH46388 (PubMed:15489334).Curated1
Sequence conflicti3040S → G in AAH46388 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0150371 – 2851Missing in isoform 3. 1 PublicationAdd BLAST2851
Alternative sequenceiVSP_0150381 – 2287Missing in isoform 2. 1 PublicationAdd BLAST2287
Alternative sequenceiVSP_0150392288 – 2297SGEDYHPVSE → MVGPGNFRKR in isoform 2. 1 Publication10

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ833643 mRNA Translation: CAH55760.1
AK031494 mRNA Translation: BAC27425.1
AK082256 mRNA Translation: BAC38448.1
BC046388 mRNA Translation: AAH46388.1
BC068185 mRNA Translation: AAH68185.1
AB160988 mRNA Translation: BAD89016.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS17348.1 [Q6NVD0-1]

NCBI Reference Sequences

More...
RefSeqi
NP_766450.2, NM_172862.3 [Q6NVD0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000091137; ENSMUSP00000088670; ENSMUSG00000037016 [Q6NVD0-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
242022

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:242022

UCSC genome browser

More...
UCSCi
uc008pex.1, mouse [Q6NVD0-3]
uc008pey.1, mouse [Q6NVD0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ833643 mRNA Translation: CAH55760.1
AK031494 mRNA Translation: BAC27425.1
AK082256 mRNA Translation: BAC38448.1
BC046388 mRNA Translation: AAH46388.1
BC068185 mRNA Translation: AAH68185.1
AB160988 mRNA Translation: BAD89016.1
CCDSiCCDS17348.1 [Q6NVD0-1]
RefSeqiNP_766450.2, NM_172862.3 [Q6NVD0-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

DIPiDIP-61241N
IntActiQ6NVD0, 2 interactors
STRINGi10090.ENSMUSP00000088670

PTM databases

GlyGeniQ6NVD0, 5 sites
iPTMnetiQ6NVD0
PhosphoSitePlusiQ6NVD0

Proteomic databases

EPDiQ6NVD0
PaxDbiQ6NVD0
PRIDEiQ6NVD0

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23253, 112 antibodies

Genome annotation databases

EnsembliENSMUST00000091137; ENSMUSP00000088670; ENSMUSG00000037016 [Q6NVD0-1]
GeneIDi242022
KEGGimmu:242022
UCSCiuc008pex.1, mouse [Q6NVD0-3]
uc008pey.1, mouse [Q6NVD0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
341640
MGIiMGI:2444465, Frem2

Phylogenomic databases

eggNOGiKOG1306, Eukaryota
KOG2090, Eukaryota
KOG3597, Eukaryota
GeneTreeiENSGT00940000155313
HOGENOMiCLU_000394_0_0_1
InParanoidiQ6NVD0
KOiK23380
OMAiTIFLKPV
OrthoDBi13258at2759
PhylomeDBiQ6NVD0
TreeFamiTF316876

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
242022, 1 hit in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Frem2, mouse

Protein Ontology

More...
PROi
PR:Q6NVD0
RNActiQ6NVD0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000037016, Expressed in dorsal pancreas and 156 other tissues
GenevisibleiQ6NVD0, MM

Family and domain databases

Gene3Di2.60.40.2030, 5 hits
InterProiView protein in InterPro
IPR038081, CalX-like_sf
IPR003644, Calx_beta
IPR039005, CSPG_rpt
PfamiView protein in Pfam
PF03160, Calx-beta, 5 hits
SMARTiView protein in SMART
SM00237, Calx_beta, 5 hits
SUPFAMiSSF141072, SSF141072, 5 hits
PROSITEiView protein in PROSITE
PS51854, CSPG, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFREM2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NVD0
Secondary accession number(s): Q4W2Q5
, Q5H8C0, Q811G9, Q8C4G5, Q8CD46
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: August 12, 2020
This is version 131 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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