UniProtKB - Q6NV75 (GP153_HUMAN)
Protein
Probable G-protein coupled receptor 153
Gene
GPR153
Organism
Homo sapiens (Human)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: UniProtKB-KW
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | Q6NV75 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 153Alternative name(s): G-protein coupled receptor PGR1 |
Gene namesi | Name:GPR153 Synonyms:PGR1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000158292.6 |
HGNCi | HGNC:23618, GPR153 |
neXtProti | NX_Q6NV75 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 11 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 12 – 32 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 33 – 41 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 42 – 62 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 84 | ExtracellularSequence analysisAdd BLAST | 22 | |
Transmembranei | 85 – 105 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 106 – 126 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 127 – 147 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 148 – 175 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 176 – 196 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 197 – 243 | CytoplasmicSequence analysisAdd BLAST | 47 | |
Transmembranei | 244 – 264 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 265 – 276 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 277 – 297 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 298 – 609 | CytoplasmicSequence analysisAdd BLAST | 312 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 387509 |
OpenTargetsi | ENSG00000158292 |
PharmGKBi | PA134929175 |
Miscellaneous databases
Pharosi | Q6NV75, Tdark |
Polymorphism and mutation databases
BioMutai | GPR153 |
DMDMi | 81170632 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069637 | 1 – 609 | Probable G-protein coupled receptor 153Add BLAST | 609 |
Proteomic databases
PaxDbi | Q6NV75 |
PeptideAtlasi | Q6NV75 |
PRIDEi | Q6NV75 |
ProteomicsDBi | 66715 |
PTM databases
iPTMneti | Q6NV75 |
PhosphoSitePlusi | Q6NV75 |
Expressioni
Gene expression databases
Bgeei | ENSG00000158292, Expressed in prostate gland and 232 other tissues |
ExpressionAtlasi | Q6NV75, baseline and differential |
Genevisiblei | Q6NV75, HS |
Organism-specific databases
HPAi | ENSG00000158292, Low tissue specificity |
Interactioni
Protein-protein interaction databases
STRINGi | 9606.ENSP00000367125 |
Miscellaneous databases
RNActi | Q6NV75, protein |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 479 – 552 | Pro-richAdd BLAST | 74 | |
Compositional biasi | 579 – 582 | Poly-Gly | 4 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QQA6, Eukaryota |
GeneTreei | ENSGT00390000017213 |
HOGENOMi | CLU_031636_2_0_1 |
InParanoidi | Q6NV75 |
OMAi | YATLHSD |
OrthoDBi | 294477at2759 |
PhylomeDBi | Q6NV75 |
TreeFami | TF330832 |
Family and domain databases
InterProi | View protein in InterPro IPR022347, GCR_153/162 IPR017452, GPCR_Rhodpsn_7TM IPR022335, GPR153 |
PANTHERi | PTHR16518, PTHR16518, 1 hit PTHR16518:SF5, PTHR16518:SF5, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01992, GPR153 PR01991, GPR153GPR162 |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q6NV75-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSDERRLPGS AVGWLVCGGL SLLANAWGIL SVGAKQKKWK PLEFLLCTLA
60 70 80 90 100
ATHMLNVAVP IATYSVVQLR RQRPDFEWNE GLCKVFVSTF YTLTLATCFS
110 120 130 140 150
VTSLSYHRMW MVCWPVNYRL SNAKKQAVHT VMGIWMVSFI LSALPAVGWH
160 170 180 190 200
DTSERFYTHG CRFIVAEIGL GFGVCFLLLV GGSVAMGVIC TAIALFQTLA
210 220 230 240 250
VQVGRQADRR AFTVPTIVVE DAQGKRRSSI DGSEPAKTSL QTTGLVTTIV
260 270 280 290 300
FIYDCLMGFP VLVVSFSSLR ADASAPWMAL CVLWCSVAQA LLLPVFLWAC
310 320 330 340 350
DRYRADLKAV REKCMALMAN DEESDDETSL EGGISPDLVL ERSLDYGYGG
360 370 380 390 400
DFVALDRMAK YEISALEGGL PQLYPLRPLQ EDKMQYLQVP PTRRFSHDDA
410 420 430 440 450
DVWAAVPLPA FLPRWGSGED LAALAHLVLP AGPERRRASL LAFAEDAPPS
460 470 480 490 500
RARRRSAESL LSLRPSALDS GPRGARDSPP GSPRRRPGPG PRSASASLLP
510 520 530 540 550
DAFALTAFEC EPQALRRPPG PFPAAPAAPD GADPGEAPTP PSSAQRSPGP
560 570 580 590 600
RPSAHSHAGS LRPGLSASWG EPGGLRAAGG GGSTSSFLSS PSESSGYATL
HSDSLGSAS
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023741 | 209 | R → H2 PublicationsCorresponds to variant dbSNP:rs12735670Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031847 Genomic DNA No translation available. BC068275 mRNA Translation: AAH68275.1 AY255529 mRNA Translation: AAO85041.1 CR627473 mRNA Translation: CAH10674.1 |
CCDSi | CCDS64.1 |
RefSeqi | NP_997253.2, NM_207370.3 XP_011539736.1, XM_011541434.2 XP_016856739.1, XM_017001250.1 |
Genome annotation databases
Ensembli | ENST00000377893; ENSP00000367125; ENSG00000158292 |
GeneIDi | 387509 |
KEGGi | hsa:387509 |
UCSCi | uc001amp.2, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL031847 Genomic DNA No translation available. BC068275 mRNA Translation: AAH68275.1 AY255529 mRNA Translation: AAO85041.1 CR627473 mRNA Translation: CAH10674.1 |
CCDSi | CCDS64.1 |
RefSeqi | NP_997253.2, NM_207370.3 XP_011539736.1, XM_011541434.2 XP_016856739.1, XM_017001250.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9606.ENSP00000367125 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
iPTMneti | Q6NV75 |
PhosphoSitePlusi | Q6NV75 |
Polymorphism and mutation databases
BioMutai | GPR153 |
DMDMi | 81170632 |
Proteomic databases
PaxDbi | Q6NV75 |
PeptideAtlasi | Q6NV75 |
PRIDEi | Q6NV75 |
ProteomicsDBi | 66715 |
Protocols and materials databases
Antibodypediai | 1936, 231 antibodies |
DNASUi | 387509 |
Genome annotation databases
Ensembli | ENST00000377893; ENSP00000367125; ENSG00000158292 |
GeneIDi | 387509 |
KEGGi | hsa:387509 |
UCSCi | uc001amp.2, human |
Organism-specific databases
CTDi | 387509 |
DisGeNETi | 387509 |
EuPathDBi | HostDB:ENSG00000158292.6 |
GeneCardsi | GPR153 |
HGNCi | HGNC:23618, GPR153 |
HPAi | ENSG00000158292, Low tissue specificity |
neXtProti | NX_Q6NV75 |
OpenTargetsi | ENSG00000158292 |
PharmGKBi | PA134929175 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QQA6, Eukaryota |
GeneTreei | ENSGT00390000017213 |
HOGENOMi | CLU_031636_2_0_1 |
InParanoidi | Q6NV75 |
OMAi | YATLHSD |
OrthoDBi | 294477at2759 |
PhylomeDBi | Q6NV75 |
TreeFami | TF330832 |
Enzyme and pathway databases
PathwayCommonsi | Q6NV75 |
Miscellaneous databases
BioGRID-ORCSi | 387509, 5 hits in 840 CRISPR screens |
GeneWikii | GPR153 |
GenomeRNAii | 387509 |
Pharosi | Q6NV75, Tdark |
PROi | PR:Q6NV75 |
RNActi | Q6NV75, protein |
Gene expression databases
Bgeei | ENSG00000158292, Expressed in prostate gland and 232 other tissues |
ExpressionAtlasi | Q6NV75, baseline and differential |
Genevisiblei | Q6NV75, HS |
Family and domain databases
InterProi | View protein in InterPro IPR022347, GCR_153/162 IPR017452, GPCR_Rhodpsn_7TM IPR022335, GPR153 |
PANTHERi | PTHR16518, PTHR16518, 1 hit PTHR16518:SF5, PTHR16518:SF5, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR01992, GPR153 PR01991, GPR153GPR162 |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP153_HUMAN | |
Accessioni | Q6NV75Primary (citable) accession number: Q6NV75 Secondary accession number(s): Q5TGR5, Q6AHW8, Q86SP8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2005 |
Last sequence update: | November 8, 2005 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries