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Entry version 120 (08 May 2019)
Sequence version 2 (08 Nov 2005)
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Protein

Probable G-protein coupled receptor 153

Gene

GPR153

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Orphan receptor.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable G-protein coupled receptor 153
Alternative name(s):
G-protein coupled receptor PGR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPR153
Synonyms:PGR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23618 GPR153

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q6NV75

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 11ExtracellularSequence analysisAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini33 – 41CytoplasmicSequence analysis9
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini63 – 84ExtracellularSequence analysisAdd BLAST22
Transmembranei85 – 105Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini106 – 126CytoplasmicSequence analysisAdd BLAST21
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 175ExtracellularSequence analysisAdd BLAST28
Transmembranei176 – 196Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini197 – 243CytoplasmicSequence analysisAdd BLAST47
Transmembranei244 – 264Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini265 – 276ExtracellularSequence analysisAdd BLAST12
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 609CytoplasmicSequence analysisAdd BLAST312

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
387509

Open Targets

More...
OpenTargetsi
ENSG00000158292

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134929175

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GPR153

Domain mapping of disease mutations (DMDM)

More...
DMDMi
81170632

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000696371 – 609Probable G-protein coupled receptor 153Add BLAST609

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q6NV75

PeptideAtlas

More...
PeptideAtlasi
Q6NV75

PRoteomics IDEntifications database

More...
PRIDEi
Q6NV75

ProteomicsDB human proteome resource

More...
ProteomicsDBi
66715

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q6NV75

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q6NV75

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000158292 Expressed in 217 organ(s), highest expression level in prostate gland

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q6NV75 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q6NV75 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA007159

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367125

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi479 – 552Pro-richAdd BLAST74
Compositional biasi579 – 582Poly-Gly4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFBH Eukaryota
ENOG410XST7 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017213

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231123

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q6NV75

KEGG Orthology (KO)

More...
KOi
K08437

Identification of Orthologs from Complete Genome Data

More...
OMAi
MAKYEIS

Database of Orthologous Groups

More...
OrthoDBi
294477at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q6NV75

TreeFam database of animal gene trees

More...
TreeFami
TF330832

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022347 GCR_153/162
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR022335 GPR153

The PANTHER Classification System

More...
PANTHERi
PTHR16518 PTHR16518, 1 hit
PTHR16518:SF5 PTHR16518:SF5, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01992 GPR153
PR01991 GPR153GPR162

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q6NV75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDERRLPGS AVGWLVCGGL SLLANAWGIL SVGAKQKKWK PLEFLLCTLA
60 70 80 90 100
ATHMLNVAVP IATYSVVQLR RQRPDFEWNE GLCKVFVSTF YTLTLATCFS
110 120 130 140 150
VTSLSYHRMW MVCWPVNYRL SNAKKQAVHT VMGIWMVSFI LSALPAVGWH
160 170 180 190 200
DTSERFYTHG CRFIVAEIGL GFGVCFLLLV GGSVAMGVIC TAIALFQTLA
210 220 230 240 250
VQVGRQADRR AFTVPTIVVE DAQGKRRSSI DGSEPAKTSL QTTGLVTTIV
260 270 280 290 300
FIYDCLMGFP VLVVSFSSLR ADASAPWMAL CVLWCSVAQA LLLPVFLWAC
310 320 330 340 350
DRYRADLKAV REKCMALMAN DEESDDETSL EGGISPDLVL ERSLDYGYGG
360 370 380 390 400
DFVALDRMAK YEISALEGGL PQLYPLRPLQ EDKMQYLQVP PTRRFSHDDA
410 420 430 440 450
DVWAAVPLPA FLPRWGSGED LAALAHLVLP AGPERRRASL LAFAEDAPPS
460 470 480 490 500
RARRRSAESL LSLRPSALDS GPRGARDSPP GSPRRRPGPG PRSASASLLP
510 520 530 540 550
DAFALTAFEC EPQALRRPPG PFPAAPAAPD GADPGEAPTP PSSAQRSPGP
560 570 580 590 600
RPSAHSHAGS LRPGLSASWG EPGGLRAAGG GGSTSSFLSS PSESSGYATL

HSDSLGSAS
Length:609
Mass (Da):65,361
Last modified:November 8, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7FEFA536BEB5ADE2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_023741209R → H2 PublicationsCorresponds to variant dbSNP:rs12735670Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL031847 Genomic DNA No translation available.
BC068275 mRNA Translation: AAH68275.1
AY255529 mRNA Translation: AAO85041.1
CR627473 mRNA Translation: CAH10674.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS64.1

NCBI Reference Sequences

More...
RefSeqi
NP_997253.2, NM_207370.3
XP_011539736.1, XM_011541434.2
XP_016856739.1, XM_017001250.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377893; ENSP00000367125; ENSG00000158292

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
387509

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:387509

UCSC genome browser

More...
UCSCi
uc001amp.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031847 Genomic DNA No translation available.
BC068275 mRNA Translation: AAH68275.1
AY255529 mRNA Translation: AAO85041.1
CR627473 mRNA Translation: CAH10674.1
CCDSiCCDS64.1
RefSeqiNP_997253.2, NM_207370.3
XP_011539736.1, XM_011541434.2
XP_016856739.1, XM_017001250.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9606.ENSP00000367125

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiQ6NV75
PhosphoSitePlusiQ6NV75

Polymorphism and mutation databases

BioMutaiGPR153
DMDMi81170632

Proteomic databases

PaxDbiQ6NV75
PeptideAtlasiQ6NV75
PRIDEiQ6NV75
ProteomicsDBi66715

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
387509
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377893; ENSP00000367125; ENSG00000158292
GeneIDi387509
KEGGihsa:387509
UCSCiuc001amp.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
387509
DisGeNETi387509

GeneCards: human genes, protein and diseases

More...
GeneCardsi
GPR153
HGNCiHGNC:23618 GPR153
HPAiHPA007159
neXtProtiNX_Q6NV75
OpenTargetsiENSG00000158292
PharmGKBiPA134929175

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IFBH Eukaryota
ENOG410XST7 LUCA
GeneTreeiENSGT00390000017213
HOGENOMiHOG000231123
InParanoidiQ6NV75
KOiK08437
OMAiMAKYEIS
OrthoDBi294477at2759
PhylomeDBiQ6NV75
TreeFamiTF330832

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
GPR153

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
387509

Protein Ontology

More...
PROi
PR:Q6NV75

Gene expression databases

BgeeiENSG00000158292 Expressed in 217 organ(s), highest expression level in prostate gland
ExpressionAtlasiQ6NV75 baseline and differential
GenevisibleiQ6NV75 HS

Family and domain databases

InterProiView protein in InterPro
IPR022347 GCR_153/162
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR022335 GPR153
PANTHERiPTHR16518 PTHR16518, 1 hit
PTHR16518:SF5 PTHR16518:SF5, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01992 GPR153
PR01991 GPR153GPR162
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGP153_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q6NV75
Secondary accession number(s): Q5TGR5, Q6AHW8, Q86SP8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: May 8, 2019
This is version 120 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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