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Protein

Probable G-protein coupled receptor 153

Gene

GPR153

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 153
Alternative name(s):
G-protein coupled receptor PGR1
Gene namesi
Name:GPR153
Synonyms:PGR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158292.6
HGNCiHGNC:23618 GPR153
neXtProtiNX_Q6NV75

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11ExtracellularSequence analysisAdd BLAST11
Transmembranei12 – 32Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini33 – 41CytoplasmicSequence analysis9
Transmembranei42 – 62Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini63 – 84ExtracellularSequence analysisAdd BLAST22
Transmembranei85 – 105Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini106 – 126CytoplasmicSequence analysisAdd BLAST21
Transmembranei127 – 147Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini148 – 175ExtracellularSequence analysisAdd BLAST28
Transmembranei176 – 196Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini197 – 243CytoplasmicSequence analysisAdd BLAST47
Transmembranei244 – 264Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini265 – 276ExtracellularSequence analysisAdd BLAST12
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 609CytoplasmicSequence analysisAdd BLAST312

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi387509
OpenTargetsiENSG00000158292
PharmGKBiPA134929175

Polymorphism and mutation databases

BioMutaiGPR153
DMDMi81170632

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696371 – 609Probable G-protein coupled receptor 153Add BLAST609

Proteomic databases

PaxDbiQ6NV75
PRIDEiQ6NV75
ProteomicsDBi66715

PTM databases

iPTMnetiQ6NV75
PhosphoSitePlusiQ6NV75

Expressioni

Gene expression databases

BgeeiENSG00000158292 Expressed in 217 organ(s), highest expression level in prostate gland
CleanExiHS_GPR153
ExpressionAtlasiQ6NV75 baseline and differential
GenevisibleiQ6NV75 HS

Organism-specific databases

HPAiHPA007159

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000367125

Structurei

3D structure databases

ProteinModelPortaliQ6NV75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi479 – 552Pro-richAdd BLAST74
Compositional biasi579 – 582Poly-Gly4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFBH Eukaryota
ENOG410XST7 LUCA
GeneTreeiENSGT00390000017213
HOGENOMiHOG000231123
HOVERGENiHBG080132
InParanoidiQ6NV75
KOiK08437
OMAiKMQYLQV
OrthoDBiEOG091G02R9
PhylomeDBiQ6NV75
TreeFamiTF330832

Family and domain databases

InterProiView protein in InterPro
IPR022347 GCR_153/162
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR022335 GPR153
PANTHERiPTHR16518 PTHR16518, 1 hit
PTHR16518:SF5 PTHR16518:SF5, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01992 GPR153
PR01991 GPR153GPR162
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q6NV75-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDERRLPGS AVGWLVCGGL SLLANAWGIL SVGAKQKKWK PLEFLLCTLA
60 70 80 90 100
ATHMLNVAVP IATYSVVQLR RQRPDFEWNE GLCKVFVSTF YTLTLATCFS
110 120 130 140 150
VTSLSYHRMW MVCWPVNYRL SNAKKQAVHT VMGIWMVSFI LSALPAVGWH
160 170 180 190 200
DTSERFYTHG CRFIVAEIGL GFGVCFLLLV GGSVAMGVIC TAIALFQTLA
210 220 230 240 250
VQVGRQADRR AFTVPTIVVE DAQGKRRSSI DGSEPAKTSL QTTGLVTTIV
260 270 280 290 300
FIYDCLMGFP VLVVSFSSLR ADASAPWMAL CVLWCSVAQA LLLPVFLWAC
310 320 330 340 350
DRYRADLKAV REKCMALMAN DEESDDETSL EGGISPDLVL ERSLDYGYGG
360 370 380 390 400
DFVALDRMAK YEISALEGGL PQLYPLRPLQ EDKMQYLQVP PTRRFSHDDA
410 420 430 440 450
DVWAAVPLPA FLPRWGSGED LAALAHLVLP AGPERRRASL LAFAEDAPPS
460 470 480 490 500
RARRRSAESL LSLRPSALDS GPRGARDSPP GSPRRRPGPG PRSASASLLP
510 520 530 540 550
DAFALTAFEC EPQALRRPPG PFPAAPAAPD GADPGEAPTP PSSAQRSPGP
560 570 580 590 600
RPSAHSHAGS LRPGLSASWG EPGGLRAAGG GGSTSSFLSS PSESSGYATL

HSDSLGSAS
Length:609
Mass (Da):65,361
Last modified:November 8, 2005 - v2
Checksum:i7FEFA536BEB5ADE2
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023741209R → H2 PublicationsCorresponds to variant dbSNP:rs12735670Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031847 Genomic DNA No translation available.
BC068275 mRNA Translation: AAH68275.1
AY255529 mRNA Translation: AAO85041.1
CR627473 mRNA Translation: CAH10674.1
CCDSiCCDS64.1
RefSeqiNP_997253.2, NM_207370.3
XP_011539736.1, XM_011541434.2
XP_016856739.1, XM_017001250.1
UniGeneiHs.531581

Genome annotation databases

EnsembliENST00000377893; ENSP00000367125; ENSG00000158292
GeneIDi387509
KEGGihsa:387509
UCSCiuc001amp.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031847 Genomic DNA No translation available.
BC068275 mRNA Translation: AAH68275.1
AY255529 mRNA Translation: AAO85041.1
CR627473 mRNA Translation: CAH10674.1
CCDSiCCDS64.1
RefSeqiNP_997253.2, NM_207370.3
XP_011539736.1, XM_011541434.2
XP_016856739.1, XM_017001250.1
UniGeneiHs.531581

3D structure databases

ProteinModelPortaliQ6NV75
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000367125

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ6NV75
PhosphoSitePlusiQ6NV75

Polymorphism and mutation databases

BioMutaiGPR153
DMDMi81170632

Proteomic databases

PaxDbiQ6NV75
PRIDEiQ6NV75
ProteomicsDBi66715

Protocols and materials databases

DNASUi387509
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377893; ENSP00000367125; ENSG00000158292
GeneIDi387509
KEGGihsa:387509
UCSCiuc001amp.2 human

Organism-specific databases

CTDi387509
DisGeNETi387509
EuPathDBiHostDB:ENSG00000158292.6
GeneCardsiGPR153
HGNCiHGNC:23618 GPR153
HPAiHPA007159
neXtProtiNX_Q6NV75
OpenTargetsiENSG00000158292
PharmGKBiPA134929175
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFBH Eukaryota
ENOG410XST7 LUCA
GeneTreeiENSGT00390000017213
HOGENOMiHOG000231123
HOVERGENiHBG080132
InParanoidiQ6NV75
KOiK08437
OMAiKMQYLQV
OrthoDBiEOG091G02R9
PhylomeDBiQ6NV75
TreeFamiTF330832

Miscellaneous databases

GeneWikiiGPR153
GenomeRNAii387509
PROiPR:Q6NV75

Gene expression databases

BgeeiENSG00000158292 Expressed in 217 organ(s), highest expression level in prostate gland
CleanExiHS_GPR153
ExpressionAtlasiQ6NV75 baseline and differential
GenevisibleiQ6NV75 HS

Family and domain databases

InterProiView protein in InterPro
IPR022347 GCR_153/162
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR022335 GPR153
PANTHERiPTHR16518 PTHR16518, 1 hit
PTHR16518:SF5 PTHR16518:SF5, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01992 GPR153
PR01991 GPR153GPR162
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGP153_HUMAN
AccessioniPrimary (citable) accession number: Q6NV75
Secondary accession number(s): Q5TGR5, Q6AHW8, Q86SP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: September 12, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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