GPR153

Functionⁱ

Orphan receptor.

GO - Molecular functionⁱ

G-protein coupled receptor activity Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable G-protein coupled receptor 153 Alternative name(s): G-protein coupled receptor PGR1
Gene namesⁱ	Name:GPR153 Synonyms:PGR1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000158292.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:23618 GPR153
neXtProtⁱ	NX_Q6NV75

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 11	ExtracellularSequence analysisAdd BLAST	11
Transmembraneⁱ	12 – 32	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	33 – 41	CytoplasmicSequence analysis	9
Transmembraneⁱ	42 – 62	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	63 – 84	ExtracellularSequence analysisAdd BLAST	22
Transmembraneⁱ	85 – 105	Helical; Name=3Sequence analysisAdd BLAST	21
Topological domainⁱ	106 – 126	CytoplasmicSequence analysisAdd BLAST	21
Transmembraneⁱ	127 – 147	Helical; Name=4Sequence analysisAdd BLAST	21
Topological domainⁱ	148 – 175	ExtracellularSequence analysisAdd BLAST	28
Transmembraneⁱ	176 – 196	Helical; Name=5Sequence analysisAdd BLAST	21
Topological domainⁱ	197 – 243	CytoplasmicSequence analysisAdd BLAST	47
Transmembraneⁱ	244 – 264	Helical; Name=6Sequence analysisAdd BLAST	21
Topological domainⁱ	265 – 276	ExtracellularSequence analysisAdd BLAST	12
Transmembraneⁱ	277 – 297	Helical; Name=7Sequence analysisAdd BLAST	21
Topological domainⁱ	298 – 609	CytoplasmicSequence analysisAdd BLAST	312

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	387509
Open Targets More...OpenTargetsⁱ	ENSG00000158292
PharmGKBⁱ	PA134929175

Polymorphism and mutation databases

BioMutaⁱ	GPR153
DMDMⁱ	81170632

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069637	1 – 609	Probable G-protein coupled receptor 153Add BLAST		609

Proteomic databases

PaxDbⁱ	Q6NV75
PRIDEⁱ	Q6NV75
ProteomicsDBⁱ	66715

PTM databases

iPTMnetⁱ	Q6NV75
PhosphoSitePlusⁱ	Q6NV75

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000158292 Expressed in 217 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_GPR153
ExpressionAtlasⁱ	Q6NV75 baseline and differential
Genevisibleⁱ	Q6NV75 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA007159

HPAⁱ

HPA007159

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000367125

STRINGⁱ

9606.ENSP00000367125

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q6NV75
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	479 – 552	Pro-richAdd BLAST		74
Compositional biasⁱ	579 – 582	Poly-Gly		4

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFBH Eukaryota ENOG410XST7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000017213
HOGENOMⁱ	HOG000231123
HOVERGENⁱ	HBG080132
InParanoidⁱ	Q6NV75
KEGG Orthology (KO) More...KOⁱ	K08437
OMAⁱ	KMQYLQV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G02R9
PhylomeDBⁱ	Q6NV75
TreeFamⁱ	TF330832

Family and domain databases

InterProⁱ	View protein in InterPro IPR022347 GCR_153/162 IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR022335 GPR153
PANTHERⁱ	PTHR16518 PTHR16518, 1 hit PTHR16518:SF5 PTHR16518:SF5, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01992 GPR153 PR01991 GPR153GPR162
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q6NV75-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSDERRLPGS AVGWLVCGGL SLLANAWGIL SVGAKQKKWK PLEFLLCTLA 
        60         70         80         90        100
ATHMLNVAVP IATYSVVQLR RQRPDFEWNE GLCKVFVSTF YTLTLATCFS 
       110        120        130        140        150
VTSLSYHRMW MVCWPVNYRL SNAKKQAVHT VMGIWMVSFI LSALPAVGWH 
       160        170        180        190        200
DTSERFYTHG CRFIVAEIGL GFGVCFLLLV GGSVAMGVIC TAIALFQTLA 
       210        220        230        240        250
VQVGRQADRR AFTVPTIVVE DAQGKRRSSI DGSEPAKTSL QTTGLVTTIV 
       260        270        280        290        300
FIYDCLMGFP VLVVSFSSLR ADASAPWMAL CVLWCSVAQA LLLPVFLWAC 
       310        320        330        340        350
DRYRADLKAV REKCMALMAN DEESDDETSL EGGISPDLVL ERSLDYGYGG 
       360        370        380        390        400
DFVALDRMAK YEISALEGGL PQLYPLRPLQ EDKMQYLQVP PTRRFSHDDA 
       410        420        430        440        450
DVWAAVPLPA FLPRWGSGED LAALAHLVLP AGPERRRASL LAFAEDAPPS 
       460        470        480        490        500
RARRRSAESL LSLRPSALDS GPRGARDSPP GSPRRRPGPG PRSASASLLP 
       510        520        530        540        550
DAFALTAFEC EPQALRRPPG PFPAAPAAPD GADPGEAPTP PSSAQRSPGP 
       560        570        580        590        600
RPSAHSHAGS LRPGLSASWG EPGGLRAAGG GGSTSSFLSS PSESSGYATL 

HSDSLGSAS

Length:609

Mass (Da):65,361

Last modified:November 8, 2005 - v2

Checksum:ⁱ7FEFA536BEB5ADE2

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_023741	209	R → H2 PublicationsCorresponds to variant dbSNP:rs12735670Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL031847 Genomic DNA No translation available. BC068275 mRNA Translation: AAH68275.1 AY255529 mRNA Translation: AAO85041.1 CR627473 mRNA Translation: CAH10674.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS64.1
NCBI Reference Sequences More...RefSeqⁱ	NP_997253.2, NM_207370.3 XP_011539736.1, XM_011541434.2 XP_016856739.1, XM_017001250.1
UniGeneⁱ	Hs.531581

Genome annotation databases

Ensemblⁱ	ENST00000377893; ENSP00000367125; ENSG00000158292
GeneIDⁱ	387509
KEGGⁱ	hsa:387509
UCSC genome browser More...UCSCⁱ	uc001amp.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q6NV75	G protein-coupled receptor 153		HUMAN		609	UniRef100_Q6NV75
Putative G-protein coupled receptor 153 (Fragment)		MACMU		128

Protein	Similar proteins		Species	Score	Length	Source
Q6NV75	G protein-coupled receptor 153		HUMAN		609	UniRef90_Q6NV75
Putative G-protein coupled receptor 153 (Fragment)		MACMU		128
G protein-coupled receptor 153		GORGO		616
G protein-coupled receptor 153		CALJA		609
G protein-coupled receptor 153		PANTR		609
+17

Protein	Similar proteins		Species	Score	Length	Source
Q6NV75	Probable G-protein coupled receptor 153		MOUSE		631	UniRef50_Q6NV75
G protein-coupled receptor 153		HUMAN		609
Putative G-protein coupled receptor 153 (Fragment)		MACMU		128
G protein-coupled receptor 153		GORGO		616
Uncharacterized protein		PAPAN		609
+80

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL031847 Genomic DNA No translation available. BC068275 mRNA Translation: AAH68275.1 AY255529 mRNA Translation: AAO85041.1 CR627473 mRNA Translation: CAH10674.1
CCDSⁱ	CCDS64.1
RefSeqⁱ	NP_997253.2, NM_207370.3 XP_011539736.1, XM_011541434.2 XP_016856739.1, XM_017001250.1
UniGeneⁱ	Hs.531581

3D structure databases

ProteinModelPortalⁱ	Q6NV75
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000367125

STRINGⁱ

9606.ENSP00000367125

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	Q6NV75
PhosphoSitePlusⁱ	Q6NV75

Polymorphism and mutation databases

BioMutaⁱ	GPR153
DMDMⁱ	81170632

Proteomic databases

PaxDbⁱ	Q6NV75
PRIDEⁱ	Q6NV75
ProteomicsDBⁱ	66715

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	387509
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000377893; ENSP00000367125; ENSG00000158292
GeneIDⁱ	387509
KEGGⁱ	hsa:387509
UCSCⁱ	uc001amp.2 human

Organism-specific databases

CTDⁱ	387509
DisGeNETⁱ	387509
EuPathDBⁱ	HostDB:ENSG00000158292.6
GeneCardsⁱ	GPR153
HGNCⁱ	HGNC:23618 GPR153
HPAⁱ	HPA007159
neXtProtⁱ	NX_Q6NV75
OpenTargetsⁱ	ENSG00000158292
PharmGKBⁱ	PA134929175
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFBH Eukaryota ENOG410XST7 LUCA
GeneTreeⁱ	ENSGT00390000017213
HOGENOMⁱ	HOG000231123
HOVERGENⁱ	HBG080132
InParanoidⁱ	Q6NV75
KOⁱ	K08437
OMAⁱ	KMQYLQV
OrthoDBⁱ	EOG091G02R9
PhylomeDBⁱ	Q6NV75
TreeFamⁱ	TF330832

Miscellaneous databases

GeneWikiⁱ	GPR153
GenomeRNAiⁱ	387509
Protein Ontology More...PROⁱ	PR:Q6NV75

Gene expression databases

Bgeeⁱ	ENSG00000158292 Expressed in 217 organ(s), highest expression level in prostate gland
CleanExⁱ	HS_GPR153
ExpressionAtlasⁱ	Q6NV75 baseline and differential
Genevisibleⁱ	Q6NV75 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR022347 GCR_153/162 IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR022335 GPR153
PANTHERⁱ	PTHR16518 PTHR16518, 1 hit PTHR16518:SF5 PTHR16518:SF5, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR01992 GPR153 PR01991 GPR153GPR162
PROSITEⁱ	View protein in PROSITE PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GP153_HUMAN
Accessionⁱ	Q6NV75Primary (citable) accession number: Q6NV75 Secondary accession number(s): Q5TGR5, Q6AHW8, Q86SP8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
	Last sequence update:	November 8, 2005
	Last modified:	September 12, 2018
	This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations

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Supporting data

UniProtKB - Q6NV75 (GP153_HUMAN)

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Probable G-protein coupled receptor 153

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ